MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Protein S Deficiency

(UMLS:C0242666)

Definition:: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
UMLS ID:: C0242666
MeSH ID:: D018455

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.800|C15.378.147.890|C15.378.925.800

Synonym(s)

Protein S Deficiency

Protein S Deficiency Disease

Protein S deficiency

Protein S deficiency disease

deficiency protein s

protein S deficiency

protein s deficiencies

protein s deficiency

s protein deficiency

Associated Drug(s)

	Name	Number of Reports	Data Source
1	NuvaRing	FAERS: 32	US FAERS
2	Rivaroxaban	FAERS: 4	US FAERS
3	apixaban	FAERS: 4	US FAERS
4	Warfarin	FAERS: 3	US FAERS
5	sibutramine	FAERS: 3	US FAERS
6	Ondansetron	FAERS: 2	US FAERS
7	Warfarin	FAERS: 2	US FAERS
8	norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination	FAERS: 2	US FAERS
9	Albuterol	FAERS: 1	US FAERS
10	Bromocriptine	FAERS: 1	US FAERS
11	Carbamazepine	FAERS: 1	US FAERS
12	Dabigatran	FAERS: 1	US FAERS
13	Dimenhydrinate	FAERS: 1	US FAERS
14	Glatiramer Acetate	FAERS: 1	US FAERS
15	Isotretinoin	FAERS: 1	US FAERS
16	Ortho Evra	FAERS: 1	US FAERS
17	Pantoprazole	FAERS: 1	US FAERS
18	Pantoprazole	FAERS: 1	US FAERS
19	Raloxifene Hydrochloride	FAERS: 1	US FAERS
20	Varenicline	FAERS: 1	US FAERS
21	reviparin	FAERS: 1	US FAERS
22	rofecoxib	FAERS: 1	US FAERS
23	Albuterol	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	77.8%
2	Antithrombin III Deficiency	67.8%
3	Protein C Deficiency	67.8%
4	Thrombocythemia, Essential	64.7%
5	Activated Protein C Resistance	61.3%
6	Afibrinogenemia	53.8%
7	Factor VII Deficiency	53.8%
8	Factor X Deficiency	53.8%
9	Factor XII Deficiency	53.8%
10	Hemophilia A	53.8%
11	Factor II deficiency	53.8%
12	Factor VIII Deficiency	53.8%
13	Factor V deficiency	53.8%
14	Factor XI Deficiency	53.8%
15	Hypoprothrombinemias	53.8%
16	Thrombasthenia	52.6%
17	Vitamin K Deficiency	48.5%
18	Anemia	45.8%
19	Blood Platelet Disorders	45.8%
20	Bone Marrow Diseases	45.8%
21	Hemorrhagic Disorders	45.8%
22	Leukocyte Disorders	45.8%
23	Methemoglobinemia	45.8%
24	Pancytopenia	45.8%
25	Polycythemia	45.8%
26	Sulfhemoglobinemia	45.8%
27	Erythrocytosis	45.8%
28	Hypoproteinemia	43.3%
29	Purpura, Thrombotic Thrombocytopenic	42.5%
30	Thrombocytosis	41.7%
31	Protein S Deficiency	40%
32	Bone Marrow Neoplasms	40%
33	Transfusion Reaction	38%
34	Hypotensive Transfusion Reaction	38%
35	Polycythemia Vera	37.9%
36	Pregnancy Complications, Hematologic	37%
37	Hematologic Neoplasms	37%
38	Monoclonal Gammopathy of Undetermined Significance	36.8%
39	Agammaglobulinemia	36%
40	Wiskott-Aldrich Syndrome	35.8%
41	Hemoglobinuria, Paroxysmal	35.5%
42	Leukemoid Reaction	35.5%
43	Paraproteinemias	35.1%
44	Anemia, Diamond-Blackfan	33.6%
45	Hypoalbuminemia	32.2%
46	Cryoglobulinemia	31.1%
47	Blood Coagulation Disorders	30.5%
48	Thrombophilia	30.5%
49	Anemia, Hemolytic	30%
50	Anemia, Macrocytic	30%
51	Eosinophilia	30%
52	Leukopenia	30%
53	Thrombocytopenia	30%
54	Leukostasis	30%
55	MYELODYSPLASTIC SYNDROME	30%
56	Hypergammaglobulinemia	29.5%
57	Autoimmune thrombocytopenia	29.4%
58	Immune thrombocytopenic purpura	29.4%
59	Ecchymosis	28.9%
60	Petechiae	28.9%
61	Purpura	28.9%
62	Waldenstrom Macroglobulinemia	28.7%
63	Heavy Chain Disease	28.2%
64	Anemia, Sickle Cell	27.7%
65	Thalassemia	27.7%
66	Purpura, Hyperglobulinemic	27%
67	Lymphatic Diseases	26.3%
68	Thrombocytopenic purpura	25.8%
69	Anemia, Neonatal	24.3%
70	Leukocytosis	24.3%
71	Pelger-Huet Anomaly	24.3%
72	Pleocytosis	24.3%
73	Multiple Myeloma	24.3%
74	Hemolytic-Uremic Syndrome	23%
75	Infectious Mononucleosis	22.7%
76	Primary Myelofibrosis	22.3%
77	Agranulocytosis	22.3%
78	Anemia, Megaloblastic	22.3%
79	Lymphocytosis	22.3%
80	Myelofibrosis	22.3%
81	Myeloid Metaplasia	22.3%
82	Hypereosinophilic syndrome	22.3%
83	bone marrow fibrosis	22.3%
84	Thrombotic Microangiopathies	22.3%
85	Sickle Cell Trait	22%
86	Purpura Fulminans	21.3%
87	Fanconi Anemia	21.1%
88	Waterhouse-Friderichsen Syndrome	20.3%
89	Transfusion-Related Acute Lung Injury	20.1%
90	Atypical Hemolytic Uremic Syndrome	19.7%
91	Hydrops Fetalis	19.4%
92	Neutropenia	18.5%
93	POEMS Syndrome	18.4%
94	Lymphopenia	18.1%
95	Job Syndrome	17.9%
96	Leukemia, Myelomonocytic, Chronic	17.8%
97	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	17.8%
98	Acute Chest Syndrome	17.5%
99	Febrile Neutropenia	16.6%
100	Adenitis	15.3%
101	Histiocytosis	15.3%
102	Lymphadenitis	15.3%
103	Lymphangitis	15.3%
104	Lymphedema	15.3%
105	Splenic Diseases	15.3%
106	Thymus Hyperplasia	15.3%
107	Pseudolymphoma	15.3%
108	Lymphadenopathy	15.3%
109	Eosinophilia-Myalgia Syndrome	15.1%
110	Pulmonary Eosinophilia	15.1%
111	Eosinophilic Pneumonia	15.1%
112	Eosinophilic Granuloma	14.9%
113	Chronic granulomatous disease	14.9%
114	Shwartzman Phenomenon	14.9%
115	Hemangioma, Cavernous	14.8%
116	Scurvy	14.8%
117	Leukemia, Myeloid, Chronic-Phase	14.7%
118	Anemia, Pernicious	14.7%
119	Kernicterus	13.4%
120	Lymphangiectasis, Intestinal	13.3%
121	Lymphocele	12.3%
122	Lymphoproliferative Disorders	12.3%
123	Lymphatic Abnormalities	12.3%
124	Thymus Neoplasms	12.2%
125	Mucocutaneous Lymph Node Syndrome	10.1%
126	Elephantiasis	10%
127	Hypersplenism	10%
128	Sarcoidosis	10%
129	Elephantiasis Nostras Verrucosa	10%
130	Pseudoxanthoma Elasticum	9%
131	Granuloma	8.1%
132	Histiocytic Disorders, Malignant	8.1%
133	Splenic Infarction	8.1%
134	Splenic Neoplasms	8.1%
135	Histiocytosis, Langerhans-Cell	8%
136	Tumor Lysis Syndrome	8%
137	Sezary Syndrome	7.5%
138	Lymphohistiocytosis, Hemophagocytic	7.4%
139	Erdheim-Chester Disease	7.4%
140	Splenic Rupture	6.8%
141	Lymphoma	6.7%
142	Thymoma	6.6%
143	Malignant histiocytosis	6%
144	Sarcoidosis, Pulmonary	6%
145	Histiocytic sarcoma	6%
146	Autoimmune Lymphoproliferative Syndrome	5.8%
147	Splenosis	5%
148	Hodgkin Disease	4.9%
149	Lymphoma, Non-Hodgkin	4.9%
150	Leukemia, T-Cell	4.9%
151	Leukemia, B-Cell	4.9%
152	Composite Lymphoma	4.2%
153	Lymphangioleiomyomatosis	4.2%
154	Lymphoma, Follicular	4.1%
155	T-Cell Lymphoma	4.1%
156	Mantle cell lymphoma	4.1%
157	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.1%
158	Leukemia, Large Granular Lymphocytic	4.1%
159	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.1%
160	Lymphoma, T-Cell, Cutaneous	3.6%
161	Lymphoma, AIDS-Related	3.6%
162	Enteropathy-Associated T-Cell Lymphoma	3.6%
163	Primary Effusion Lymphoma	3.6%
164	Mycosis Fungoides	3.4%
165	Lymphomatoid Papulosis	3.4%
166	Plasmablastic lymphoma	3.4%
167	Lymphomatoid Granulomatosis	3.2%
168	Burkitt Lymphoma	2.7%
169	Niemann-Pick Disease, Type C	1.8%

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