MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypersplenism

(UMLS:C0020532)

Definition:: Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
UMLS ID:: C0020532
MeSH ID:: D006971

Classification:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.744.293

Synonym(s)

Hypersplenism

Big spleen syndrome

HYPERSPLENISM

Hypersplenia

Hypersplenism syndrome

Hypersplenism, NOS

hyperfunction; spleen

hypersplenism

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Clozapine	FAERS: 16		OFFSIDES US FAERS
2	Deferasirox	FAERS: 7		OFFSIDES US FAERS
3	Epoprostenol	FAERS: 6		US FAERS
4	Hydromorphone	FAERS: 4		US FAERS
5	Isotretinoin	FAERS: 3		US FAERS
6	Ruxolitinib phosphate	FAERS: 3		US FAERS
7	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
8	Alendronate	FAERS: 2		US FAERS
9	Bosentan	FAERS: 2		US FAERS
10	Sorafenib	FAERS: 2		US FAERS
11	Tacrolimus	FAERS: 2		US FAERS
12	Aripiprazole	FAERS: 1		US FAERS
13	Carbamazepine	FAERS: 1		US FAERS
14	Ciprofloxacin	FAERS: 1		OFFSIDES US FAERS
15	Cysteamine	FAERS: 1		US FAERS
16	Deferiprone	FAERS: 1		SIDER US FAERS
17	Dexamethasone	FAERS: 1		US FAERS
18	Didanosine	FAERS: 1		US FAERS
19	Dipyridamole	FAERS: 1		US FAERS
20	Epoprostenol	FAERS: 1		SIDER US FAERS
21	Fingolimod Hydrochloride	FAERS: 1		US FAERS
22	Imatinib Mesylate	FAERS: 1		US FAERS
23	Lamivudine	FAERS: 1		US FAERS
24	Lenalidomide	FAERS: 1		OFFSIDES US FAERS
25	Rivastigmine	FAERS: 1		US FAERS
26	Tadalafil	FAERS: 1		US FAERS
27	Telbivudine	FAERS: 1		US FAERS
28	Thalidomide	FAERS: 1		US FAERS
29	Viekira Pak	FAERS: 1		US FAERS
30	apixaban	FAERS: 1		US FAERS
31	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
32	lanreotide	FAERS: 1		US FAERS
33	tofacitinib	FAERS: 1		US FAERS
34	Bortezomib			OFFSIDES
35	Bromocriptine			OFFSIDES
36	Dacarbazine			OFFSIDES
37	Erythromycin			OFFSIDES
38	Hydroxyurea			SIDER
39	Isoniazid		448941	CTD
40	Lactulose			OFFSIDES
41	Levetiracetam			OFFSIDES
42	Methylprednisolone			OFFSIDES
43	Nelfinavir			OFFSIDES
44	Oxacillin			OFFSIDES
45	Timolol			OFFSIDES
46	Tobramycin			OFFSIDES
47	Tretinoin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Splenic Infarction	31.8%
2	Splenic Neoplasms	31.8%
3	Adenitis	31%
4	Histiocytosis	31%
5	Lymphadenitis	31%
6	Lymphangitis	31%
7	Lymphedema	31%
8	Thymus Hyperplasia	31%
9	Pseudolymphoma	31%
10	Lymphadenopathy	31%
11	Splenic Rupture	24.1%
12	Lymphocele	20.9%
13	Lymphoproliferative Disorders	20.9%
14	Lymphatic Abnormalities	20.9%
15	Thymus Neoplasms	20.5%
16	Elephantiasis	20%
17	Lymphangiectasis, Intestinal	20%
18	Sarcoidosis	20%
19	Elephantiasis Nostras Verrucosa	20%
20	Splenosis	17.4%
21	Mucocutaneous Lymph Node Syndrome	15.3%
22	Lymphohistiocytosis, Hemophagocytic	14.8%
23	Erdheim-Chester Disease	14.8%
24	Granuloma	13.6%
25	Histiocytic Disorders, Malignant	13.6%
26	Agammaglobulinemia	13.6%
27	Histiocytosis, Langerhans-Cell	13.3%
28	Tumor Lysis Syndrome	13.3%
29	Heavy Chain Disease	12.4%
30	Infectious Mononucleosis	10.6%
31	Anemia	10.3%
32	Blood Coagulation Disorders	10.3%
33	Blood Platelet Disorders	10.3%
34	Bone Marrow Diseases	10.3%
35	Hemorrhagic Disorders	10.3%
36	Leukocyte Disorders	10.3%
37	Methemoglobinemia	10.3%
38	Pancytopenia	10.3%
39	Polycythemia	10.3%
40	Sulfhemoglobinemia	10.3%
41	Thrombophilia	10.3%
42	Erythrocytosis	10.3%
43	Lymphoma	10.2%
44	Disseminated Intravascular Coagulation	10%
45	Protein S Deficiency	10%
46	Thymoma	9.9%
47	Sezary Syndrome	9.9%
48	Malignant histiocytosis	9.9%
49	Sarcoidosis, Pulmonary	9.9%
50	Histiocytic sarcoma	9.9%
51	Thrombocythemia, Essential	8.9%
52	Waldenstrom Macroglobulinemia	8.5%
53	Autoimmune Lymphoproliferative Syndrome	8.2%
54	Thrombocytosis	7.7%
55	Hodgkin Disease	7.4%
56	Lymphoma, Non-Hodgkin	7.4%
57	Leukemia, T-Cell	7.3%
58	Transfusion Reaction	7.3%
59	Leukemia, B-Cell	7.3%
60	Hypotensive Transfusion Reaction	7.3%
61	Thrombasthenia	7.3%
62	Antithrombin III Deficiency	7.3%
63	Protein C Deficiency	7.3%
64	Pregnancy Complications, Hematologic	7%
65	Hematologic Neoplasms	7%
66	Anemia, Hemolytic	6.7%
67	Anemia, Macrocytic	6.7%
68	Eosinophilia	6.7%
69	Hypoproteinemia	6.7%
70	Leukopenia	6.7%
71	Thrombocytopenia	6.7%
72	Leukostasis	6.7%
73	Bone Marrow Neoplasms	6.7%
74	MYELODYSPLASTIC SYNDROME	6.7%
75	Eosinophilic Granuloma	6.6%
76	Vitamin K Deficiency	6.6%
77	Afibrinogenemia	6.6%
78	Factor VII Deficiency	6.6%
79	Factor X Deficiency	6.6%
80	Factor XII Deficiency	6.6%
81	Hemophilia A	6.6%
82	Activated Protein C Resistance	6.6%
83	Factor II deficiency	6.6%
84	Factor VIII Deficiency	6.6%
85	Factor V deficiency	6.6%
86	Factor XI Deficiency	6.6%
87	Hypoprothrombinemias	6.6%
88	Hemoglobinuria, Paroxysmal	6.5%
89	Leukemoid Reaction	6.5%
90	Lymphoma, Follicular	6%
91	T-Cell Lymphoma	6%
92	Mantle cell lymphoma	6%
93	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	6%
94	Leukemia, Large Granular Lymphocytic	6%
95	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	6%
96	Composite Lymphoma	5.9%
97	Polycythemia Vera	5.8%
98	Lymphangioleiomyomatosis	5.8%
99	Lymphoma, T-Cell, Cutaneous	5.4%
100	Lymphoma, AIDS-Related	5.4%
101	Enteropathy-Associated T-Cell Lymphoma	5.4%
102	Primary Effusion Lymphoma	5.4%
103	Anemia, Diamond-Blackfan	5.2%
104	Mycosis Fungoides	5.1%
105	Lymphomatoid Papulosis	5.1%
106	Plasmablastic lymphoma	5.1%
107	Primary Myelofibrosis	4.9%
108	Agranulocytosis	4.9%
109	Anemia, Megaloblastic	4.9%
110	Lymphocytosis	4.9%
111	Myelofibrosis	4.9%
112	Myeloid Metaplasia	4.9%
113	Hypoalbuminemia	4.9%
114	Hypereosinophilic syndrome	4.9%
115	bone marrow fibrosis	4.9%
116	Thrombotic Microangiopathies	4.9%
117	Purpura, Thrombotic Thrombocytopenic	4.7%
118	Anemia, Neonatal	4.5%
119	Leukocytosis	4.5%
120	Paraproteinemias	4.5%
121	Pelger-Huet Anomaly	4.5%
122	Pleocytosis	4.5%
123	Wiskott-Aldrich Syndrome	4.5%
124	Lymphomatoid Granulomatosis	4.4%
125	Anemia, Sickle Cell	4.3%
126	Thalassemia	4.3%
127	Neutropenia	4.1%
128	Cryoglobulinemia	3.9%
129	Monoclonal Gammopathy of Undetermined Significance	3.9%
130	Febrile Neutropenia	3.6%
131	Burkitt Lymphoma	3.6%
132	Autoimmune thrombocytopenia	3.6%
133	Immune thrombocytopenic purpura	3.6%
134	Hemolytic-Uremic Syndrome	3.5%
135	Hypergammaglobulinemia	3.4%
136	Sickle Cell Trait	3.4%
137	Lymphopenia	3.4%
138	Transfusion-Related Acute Lung Injury	3.4%
139	Ecchymosis	3.3%
140	Petechiae	3.3%
141	Purpura	3.3%
142	Job Syndrome	3.3%
143	Fanconi Anemia	3.3%
144	Leukemia, Myelomonocytic, Chronic	3.3%
145	Purpura, Hyperglobulinemic	3.3%
146	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.3%
147	Thrombocytopenic purpura	3.1%
148	Atypical Hemolytic Uremic Syndrome	3%
149	Multiple Myeloma	2.8%
150	Pulmonary Eosinophilia	2.8%
151	Eosinophilic Pneumonia	2.8%
152	Leukemia, Myeloid, Chronic-Phase	2.7%
153	Hydrops Fetalis	2.7%
154	Anemia, Pernicious	2.7%
155	Eosinophilia-Myalgia Syndrome	2.5%
156	Acute Chest Syndrome	2.5%
157	Chronic granulomatous disease	2.5%
158	Shwartzman Phenomenon	2.5%
159	Hemangioma, Cavernous	2.5%
160	Scurvy	2.4%
161	Purpura Fulminans	2.4%
162	Waterhouse-Friderichsen Syndrome	2.3%
163	Niemann-Pick Disease, Type C	2.2%
164	POEMS Syndrome	2%
165	Kernicterus	1.9%
166	Pseudoxanthoma Elasticum	1.3%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120237