MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Transfusion-Related Acute Lung Injury

(UMLS:C0948343)

Definition:: A rare but serious transfusion-related reaction in which fluid builds up in the lungs unrelated to excessively high infusion rate and/or volume (TRANSFUSION-ASSOCIATED CIRCULATORY OVERLOAD). Signs of Transfusion-Related Acute Lung Injury include pulmonary secretions; hypotension; fever; DYSPNEA; TACHYPNEA; TACHYCARDIA; and CYANOSIS.
UMLS ID:: C0948343
MeSH ID:: D000073617

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.520.500.500

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.962.500

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.920.500

Synonym(s)

Transfusion-Related Acute Lung Injury

Acute lung injury during and following administration of blood product

TRALI - Transfusion related acute lung injury

Transfusion related acute lung injury

Transfusion related acute lung injury (TRALI)

Transfusion-related acute lung injury

Transfusion-related acute lung injury (TRALI)

transfusion-related acute lung injury

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Dabigatran	FAERS: 2	US FAERS
2	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
3	Warfarin	FAERS: 2	US FAERS
4	Azacitidine	FAERS: 1	US FAERS
5	Clofarabine	FAERS: 1	US FAERS
6	Imatinib Mesylate	FAERS: 1	US FAERS
7	Methadone	FAERS: 1	US FAERS
8	Risperidone	FAERS: 1	US FAERS
9	Rivaroxaban	FAERS: 1	US FAERS
10	Tacrolimus	FAERS: 1	US FAERS
11	Temozolomide	FAERS: 1	US FAERS
12	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
13	apixaban	FAERS: 1	US FAERS
14	Cidofovir		OFFSIDES
15	Digoxin		OFFSIDES
16	Dioctyl Sulfosuccinic Acid		OFFSIDES
17	Foscarnet		OFFSIDES
18	Ganciclovir		OFFSIDES
19	Ketamine		OFFSIDES
20	Mannitol		OFFSIDES
21	Nimodipine		OFFSIDES
22	Ursodeoxycholic Acid		OFFSIDES
23	Vincristine		OFFSIDES
24	bicalutamide		OFFSIDES
25	flunisolide		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Disseminated Intravascular Coagulation	20.1%
2	Protein S Deficiency	20.1%
3	Thrombocythemia, Essential	19.1%
4	Pneumoconiosis	17.3%
5	Thrombasthenia	15.7%
6	Antithrombin III Deficiency	15.7%
7	Protein C Deficiency	15.7%
8	Anemia	15.4%
9	Blood Coagulation Disorders	15.4%
10	Blood Platelet Disorders	15.4%
11	Bone Marrow Diseases	15.4%
12	Hemorrhagic Disorders	15.4%
13	Leukocyte Disorders	15.4%
14	Methemoglobinemia	15.4%
15	Pancytopenia	15.4%
16	Polycythemia	15.4%
17	Sulfhemoglobinemia	15.4%
18	Thrombophilia	15.4%
19	Erythrocytosis	15.4%
20	Pulmonary Eosinophilia	15.2%
21	Eosinophilic Pneumonia	15.2%
22	Radiation Pneumonitis	14.4%
23	Radiation Fibrosis	14.4%
24	Afibrinogenemia	14.2%
25	Factor VII Deficiency	14.2%
26	Factor X Deficiency	14.2%
27	Factor XII Deficiency	14.2%
28	Hemophilia A	14.2%
29	Monoclonal Gammopathy of Undetermined Significance	14.2%
30	Activated Protein C Resistance	14.2%
31	Factor II deficiency	14.2%
32	Factor VIII Deficiency	14.2%
33	Factor V deficiency	14.2%
34	Factor XI Deficiency	14.2%
35	Hypoprothrombinemias	14.2%
36	Autoimmune thrombocytopenia	14%
37	Immune thrombocytopenic purpura	14%
38	Thrombocytosis	14%
39	Pneumonia	13.8%
40	Lobar Pneumonia	13.8%
41	Respiratory Distress Syndrome, Adult	13.8%
42	Pneumonitis	13.8%
43	Paraproteinemias	13.6%
44	Agammaglobulinemia	13.6%
45	Bone Marrow Neoplasms	13.4%
46	Vitamin K Deficiency	13.3%
47	Acute Chest Syndrome	13.3%
48	Atelectasis	12.8%
49	Pulmonary Hypertension	12.8%
50	Pulmonary Alveolar Proteinosis	12.8%
51	Pulmonary Edema	12.8%
52	Pulmonary Fibrosis	12.8%
53	Hamman-Rich syndrome	12.8%
54	Lung Diseases, Interstitial	12.8%
55	Lung Diseases, Obstructive	12.8%
56	Wiskott-Aldrich Syndrome	12.7%
57	Polycythemia Vera	12.7%
58	Pregnancy Complications, Hematologic	12.4%
59	Hematologic Neoplasms	12.4%
60	Thrombocytopenic purpura	12%
61	Hemoglobinuria, Paroxysmal	11.9%
62	Leukemoid Reaction	11.9%
63	Asthma	11.7%
64	Lung Diseases, Fungal	11.6%
65	Lymphopenia	11.5%
66	Hypergammaglobulinemia	11.4%
67	Respiratory Distress Syndrome, Newborn	11.4%
68	Cryoglobulinemia	11.4%
69	Lung Abscess	11.4%
70	Lung Neoplasms	11.4%
71	Tuberculosis, Pulmonary	11.3%
72	Anemia, Diamond-Blackfan	11.3%
73	Asbestosis	11.2%
74	Berylliosis	11.2%
75	Silicosis	11.2%
76	Meconium Aspiration Syndrome	11.2%
77	Multiple Myeloma	11.1%
78	Bronchitis	10.9%
79	Purpura, Thrombotic Thrombocytopenic	10.7%
80	Autoimmune Diseases	10.6%
81	Hypersensitivity	10.6%
82	Immunologic Deficiency Syndromes	10.6%
83	Immunoproliferative Disorders	10.6%
84	Immune reconstitution syndrome	10.6%
85	Immune Reconstitution Inflammatory Syndrome	10.6%
86	Heavy Chain Disease	10.6%
87	Respiratory Hypersensitivity	10.5%
88	Infectious Mononucleosis	10.5%
89	Hepatopulmonary Syndrome	10.3%
90	Waldenstrom Macroglobulinemia	10.3%
91	Pulmonary Embolism	10.1%
92	Anemia, Hemolytic	10.1%
93	Anemia, Macrocytic	10.1%
94	Eosinophilia	10.1%
95	Hypoproteinemia	10.1%
96	Leukopenia	10.1%
97	Thrombocytopenia	10.1%
98	Leukostasis	10.1%
99	MYELODYSPLASTIC SYNDROME	10.1%
100	Idiopathic Pulmonary Fibrosis	10%
101	Job Syndrome	10%
102	Lymphoproliferative Disorders	9.7%
103	Bronchopneumonia	9.6%
104	Bronchopulmonary Dysplasia	9.3%
105	Anemia, Sickle Cell	9.3%
106	Thalassemia	9.3%
107	Hydrops Fetalis	9.1%
108	Lymphatic Diseases	8.8%
109	Autoimmune Lymphoproliferative Syndrome	8.8%
110	Histiocytosis, Langerhans-Cell	8.7%
111	Pleuropneumonia	8.6%
112	Bronchitis, Chronic	8.5%
113	Hemoptysis	8.5%
114	Chronic granulomatous disease	8.3%
115	Granulomatosis with polyangiitis	8.3%
116	Anemia, Neonatal	8.2%
117	Leukocytosis	8.2%
118	Pelger-Huet Anomaly	8.2%
119	Pleocytosis	8.2%
120	Anti-Glomerular Basement Membrane Disease	8.1%
121	Aspiration Pneumonia	8.1%
122	Sarcoidosis, Pulmonary	8%
123	Bronchial Diseases	8%
124	Pleural Diseases	8%
125	Respiration Disorders	8%
126	Thoracic Diseases	8%
127	Tracheal Diseases	8%
128	Aspergillosis, Allergic Bronchopulmonary	7.9%
129	Hemolytic-Uremic Syndrome	7.7%
130	Scimitar Syndrome	7.6%
131	Chronic Obstructive Airway Disease	7.6%
132	Middle Lobe Syndrome	7.6%
133	Asthma, Aspirin-Induced	7.5%
134	Primary Myelofibrosis	7.5%
135	Agranulocytosis	7.5%
136	Anemia, Megaloblastic	7.5%
137	Eosinophilic Granuloma	7.5%
138	Lymphocytosis	7.5%
139	Myelofibrosis	7.5%
140	Myeloid Metaplasia	7.5%
141	Hypoalbuminemia	7.5%
142	Hypereosinophilic syndrome	7.5%
143	bone marrow fibrosis	7.5%
144	Thrombotic Microangiopathies	7.5%
145	Cystic Fibrosis	7.5%
146	Kernicterus	7.5%
147	Purpura, Hyperglobulinemic	7.4%
148	Tracheobronchomegaly	7.4%
149	Sickle Cell Trait	7.4%
150	POEMS Syndrome	7.1%
151	Fanconi Anemia	7.1%
152	Pneumonia, Viral	6.9%
153	Pleurisy	6.9%
154	Tracheitis	6.9%
155	Immune Complex Diseases	6.8%
156	Antiphospholipid Syndrome	6.8%
157	Latex allergy	6.8%
158	Glomerulonephritis, Membranoproliferative	6.8%
159	Pneumonia, Bacterial	6.8%
160	Tumor Lysis Syndrome	6.7%
161	Ecchymosis	6.7%
162	Petechiae	6.7%
163	Purpura	6.7%
164	Bronchiolitis	6.7%
165	Hyaline Membrane Disease	6.7%
166	Multiple Pulmonary Nodules	6.6%
167	Sezary Syndrome	6.6%
168	Atypical Hemolytic Uremic Syndrome	6.6%
169	Laryngeal Diseases	6.6%
170	Nose Diseases	6.6%
171	Farmer's Lung	6.4%
172	Respiratory Tract Infections	6.4%
173	Granuloma, Respiratory Tract	6.3%
174	Respiratory Tract Fistula	6.3%
175	Neutropenia	6.2%
176	Persistent Fetal Circulation Syndrome	6.1%
177	Pulmonary Aspergillosis	6%
178	Bronchopulmonary Aspergillosis	6%
179	Pulmonary Infarction	6%
180	Leukemia, Myelomonocytic, Chronic	6%
181	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6%
182	Asthma, Exercise-Induced	5.8%
183	Status Asthmaticus	5.8%
184	Laryngitis	5.8%
185	Rhinitis	5.8%
186	Vocal Cord Dysfunction	5.8%
187	Primary amyloidosis	5.7%
188	Waterhouse-Friderichsen Syndrome	5.7%
189	Bronchial Fistula	5.7%
190	Pleural Neoplasms	5.7%
191	Environmental Illness	5.7%
192	Lymphoma	5.6%
193	Febrile Neutropenia	5.6%
194	Granuloma, Laryngeal	5.6%
195	Lupus Erythematosus, Systemic	5.5%
196	Overlap syndrome	5.5%
197	Addison Disease	5.4%
198	Pemphigus	5.4%
199	Autoimmune thyroiditis	5.4%
200	Primary Adrenal Insufficiency	5.4%
201	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.4%
202	Autoimmune hepatitis	5.4%
203	Pneumonia, Lipid	5.3%
204	Serum Sickness	5.2%
205	Asthma, Occupational	5.1%
206	Adenitis	5.1%
207	Histiocytosis	5.1%
208	Lymphadenitis	5.1%
209	Lymphangitis	5.1%
210	Lymphedema	5.1%
211	Splenic Diseases	5.1%
212	Thymus Hyperplasia	5.1%
213	Pseudolymphoma	5.1%
214	Lymphadenopathy	5.1%
215	Eosinophilia-Myalgia Syndrome	5.1%
216	anaphylaxis	5%
217	Food Allergy	5%
218	Anaphylactic shock	5%
219	Pulmonary Emphysema	5%
220	Shwartzman Phenomenon	5%
221	Hemangioma, Cavernous	5%
222	Scurvy	5%
223	Purpura Fulminans	4.9%
224	Leukemia, Myeloid, Chronic-Phase	4.9%
225	Choanal Atresia	4.9%
226	Laryngocele	4.9%
227	Anemia, Pernicious	4.9%
228	Tracheal Neoplasms	4.9%
229	Latent Autoimmune Diabetes in Adults	4.5%
230	Primary Ciliary Dyskinesia	4.5%
231	Dermatitis Herpetiformis	4.5%
232	Sinusitis	4.5%
233	Kounis Syndrome	4.5%
234	HIV Infections	4.5%
235	Bronchial Neoplasms	4.5%
236	Hay fever	4.5%
237	Rhinitis, Allergic, Perennial	4.5%
238	Lymphangiectasis, Intestinal	4.5%
239	Blastomycosis	4.4%
240	Hodgkin Disease	4.4%
241	Lymphoma, Non-Hodgkin	4.4%
242	Leukemia, T-Cell	4.4%
243	Leukemia, B-Cell	4.4%
244	Laryngeal neoplasm	4.3%
245	Bronchiolitis Obliterans	4.3%
246	Pleural Effusion, Malignant	4.3%
247	Altitude Sickness	4.3%
248	Bronchospasm	4.3%
249	Bronchiectasis	4.3%
250	Chylothorax	4.3%
251	Hydropneumothorax	4.3%
252	Hydrothorax	4.3%
253	Pneumothorax	4.3%
254	Respiratory Insufficiency	4.3%
255	Tracheal Stenosis	4.3%
256	Bronchial Hyperreactivity	4.3%
257	Respiratory Depression	4.3%
258	Respiratory Failure	4.3%
259	Milk Allergy	4.2%
260	Schnitzler Syndrome	4.2%
261	Wheat Hypersensitivity	4.2%
262	Lymphocele	4.1%
263	Lymphatic Abnormalities	4.1%
264	Sick Building Syndrome	4.1%
265	Multiple Chemical Sensitivity	4.1%
266	Thymus Neoplasms	4.1%
267	Plasmacytoma	4%
268	Urticaria	4%
269	Vasculitis, Leukocytoclastic, Cutaneous	4%
270	HTLV-I Infections	4%
271	Rheumatoid Arthritis	3.9%
272	Juvenile arthritis	3.9%
273	Graves Disease	3.9%
274	Lymphoma, Follicular	3.8%
275	T-Cell Lymphoma	3.8%
276	Mantle cell lymphoma	3.8%
277	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
278	Leukemia, Large Granular Lymphocytic	3.8%
279	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
280	Composite Lymphoma	3.8%
281	Lymphangioleiomyomatosis	3.8%
282	Myasthenia Gravis, Autoimmune, Experimental	3.7%
283	Lymphoma, T-Cell, Cutaneous	3.5%
284	Lymphoma, AIDS-Related	3.5%
285	Enteropathy-Associated T-Cell Lymphoma	3.5%
286	Primary Effusion Lymphoma	3.5%
287	Granuloma, Lethal Midline	3.4%
288	Laryngeal Edema	3.4%
289	Nose Deformities, Acquired	3.4%
290	Respiratory Aspiration	3.4%
291	Apnea	3.4%
292	Cheyne-Stokes Respiration	3.4%
293	Common Cold	3.4%
294	Dyspnea	3.4%
295	Hemothorax	3.4%
296	Hyperventilation	3.4%
297	Influenza	3.4%
298	Mouth Breathing	3.4%
299	Nose Neoplasms	3.4%
300	Tachypnea	3.4%
301	Catarrh	3.4%
302	Mucocutaneous Lymph Node Syndrome	3.4%
303	Myasthenia Gravis	3.4%
304	Uveomeningoencephalitic Syndrome	3.4%
305	Mycosis Fungoides	3.4%
306	Lymphomatoid Papulosis	3.4%
307	Plasmablastic lymphoma	3.4%
308	Rhinoscleroma	3.4%
309	Mastocytosis	3.4%
310	Severe Acute Respiratory Syndrome	3.4%
311	Elephantiasis	3.4%
312	Hypersplenism	3.4%
313	Sarcoidosis	3.4%
314	Elephantiasis Nostras Verrucosa	3.4%
315	Laryngopharyngeal Reflux	3.4%
316	Drug Eruptions	3.4%
317	Laryngospasm	3.4%
318	Dermatitis, Allergic Contact	3.3%
319	Invasive Pulmonary Aspergillosis	3.3%
320	HIV Seropositivity	3.3%
321	Mastocytosis, Systemic	3.3%
322	Lymphomatoid Granulomatosis	3.1%
323	Pseudoxanthoma Elasticum	3%
324	Paranasal Sinus Neoplasms	3%
325	Hoarseness	3%
326	Stiff-Person Syndrome	2.9%
327	Polyradiculoneuropathy	2.9%
328	Polyradiculoneuritis	2.9%
329	Kartagener Syndrome	2.9%
330	Pharyngitis	2.9%
331	Acquired Immunodeficiency Syndrome	2.9%
332	AIDS related complex	2.9%
333	Laryngostenosis	2.9%
334	Nasal Polyps	2.9%
335	Felty Syndrome	2.8%
336	Neuromyelitis Optica	2.8%
337	Lupus Nephritis	2.8%
338	Leukoencephalitis, Acute Hemorrhagic	2.8%
339	Pertussis	2.8%
340	Angioedema	2.8%
341	Multiple Sclerosis	2.8%
342	Leukemia, Plasma Cell	2.8%
343	Acute Generalized Exanthematous Pustulosis	2.7%
344	Granuloma	2.7%
345	Histiocytic Disorders, Malignant	2.7%
346	Splenic Infarction	2.7%
347	Splenic Neoplasms	2.7%
348	Ataxia Telangiectasia	2.7%
349	Burkitt Lymphoma	2.7%
350	Lupus Vasculitis, Central Nervous System	2.6%
351	AIDS-Related Opportunistic Infections	2.5%
352	Airway Obstruction	2.5%
353	Choking	2.5%
354	Epiglottitis	2.5%
355	Mediastinitis	2.5%
356	Vasculitis, Central Nervous System	2.5%
357	Dermatitis, Atopic	2.5%
358	Lymphohistiocytosis, Hemophagocytic	2.5%
359	Erdheim-Chester Disease	2.5%
360	HIV Wasting Syndrome	2.5%
361	Rheumatoid Vasculitis	2.5%
362	AIDS Dementia Complex	2.5%
363	AIDS-Associated Nephropathy	2.5%
364	Multiple Sclerosis, Chronic Progressive	2.5%
365	Multiple Sclerosis, Relapsing-Remitting	2.5%
366	Voice Disorders	2.5%
367	Voice Disturbance	2.5%
368	Epistaxis	2.4%
369	Encephalomyelitis, Acute Disseminated	2.4%
370	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.4%
371	Erythema Nodosum	2.4%
372	Neuritis, Autoimmune, Experimental	2.4%
373	Dermatitis, Photoallergic	2.3%
374	Hereditary Angioedema Type III	2.3%
375	Hereditary Angioedema Types I and II	2.3%
376	Splenic Rupture	2.3%
377	Lambert-Eaton Myasthenic Syndrome	2.2%
378	Thymoma	2.2%
379	Sicca Syndrome	2.2%
380	Sjogren's Syndrome	2.2%
381	HIV-Associated Lipodystrophy Syndrome	2.2%
382	Laryngomalacia	2.1%
383	Angioedemas, Hereditary	2.1%
384	Vocal Cord Paralysis	2.1%
385	Guillain-Barre Syndrome	2.1%
386	Mediastinal Cyst	2%
387	Pericardial Cyst	2%
388	Thymic Cyst	2%
389	Croup	2%
390	Mediastinal Emphysema	2%
391	Rhinitis, Vasomotor	2%
392	Hypoventilation	2%
393	Acidosis, Respiratory	2%
394	Alkalosis, Respiratory	2%
395	Malignant histiocytosis	2%
396	Sleep Apnea Syndromes	2%
397	Histiocytic sarcoma	2%
398	Maxillary Sinus Neoplasms	2%
399	Toxic Epidermal Necrolysis	1.8%
400	Stevens-Johnson Syndrome	1.8%
401	Tonsillitis	1.7%
402	Dyspnea, Paroxysmal	1.7%
403	Respiratory Paralysis	1.7%
404	Splenosis	1.7%
405	Giant Cell Arteritis	1.6%
406	Temporal Arteritis	1.6%
407	Myelitis, Transverse	1.5%
408	Aphonia	1.4%
409	Retropharyngeal Abscess	1.4%
410	Dysphonia	1.4%
411	Bronchomalacia	1.4%
412	Tracheomalacia	1.4%
413	Miller Fisher Syndrome	1.3%
414	Sleep Apnea, Obstructive	1.3%
415	Sleep Apnea, Central	1.3%
416	Nasopharyngitis	1.3%
417	Peritonsillar Abscess	0.9%
418	Niemann-Pick Disease, Type C	0.6%

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