MetaADEDB 2.0 @ LMMD
Ursodeoxycholic Acid
(RUDATBOHQWOJDD-UZVSRGJWSA-N)
Structure
SMILES
O[C@@H]1CC[C@]2([C@@H](C1)C[C@@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C
Type(s)
Approved; Investigational
ATC code(s)
A05AA02
Molecular Formula:
C24H40O4
Molecular Weight:
392.572
Log P:
4.4779
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
3
TPSA:
77.76
CAS Number(s):
128-13-2
Synonym(s)
1.
Ursodeoxycholic Acid
2.
Deoxyursocholic Acid
3.
3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid
4.
Cholit-Ursan
5.
Cholofalk
6.
Delursan
7.
Destolit
8.
Sodium Ursodeoxycholate
9.
Urdox
10.
Ursacholic Acid
11.
Urso
12.
Urso Heumann
13.
Ursobilane
14.
Ursochol
15.
Ursodiol
16.
Ursofalk
17.
Ursogal
18.
Ursolite
19.
Ursolvan
20.
3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid
21.
Acid, Deoxyursocholic
22.
Acid, Ursacholic
23.
Acid, Ursodeoxycholic
24.
Ursodeoxycholate, Sodium
External Link(s)
MeSHD014580
PubChem Compound31401
BindingDB50334960
53721
ChEBI9907
CHEMBLCHEMBL1551
DrugBankDB01586
DrugCentral2797
IUPHAR/BPS Guide to PHARMACOLOGY7104
KEGGcpd:C07880
dr:D00734
Therapeutic Target DatabaseD0G3SH
ZINC3914809
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Maternal exposure during pregnancyFAERS: 19US FAERS
2PruritusFAERS: 17
Canada Vigilance: 3

View details

10750660
12392612
15365421
16205517
22942741
 		CTD
Canada Vigilance
US FAERS
3Alanine Aminotransferase IncreasedFAERS: 13OFFSIDES
US FAERS
4Aspartate Aminotransferase IncreasedFAERS: 13US FAERS
5Disease ProgressionFAERS: 12US FAERS
6NauseaFAERS: 9
Canada Vigilance: 2		Canada Vigilance
US FAERS
7AlopeciaFAERS: 7
Canada Vigilance: 3		Canada Vigilance
US FAERS
8CholelithiasisFAERS: 71769469
8187305		CTD
US FAERS
9AngioedemaFAERS: 6US FAERS
10Atrial FibrillationFAERS: 6US FAERS
11Autoimmune hepatitisFAERS: 5US FAERS
12CholangitisFAERS: 58698195
31299240		CTD
US FAERS
13HypersensitivityFAERS: 5US FAERS
14Product substitution issueFAERS: 5
Canada Vigilance: 7		Canada Vigilance
US FAERS
15Product use in unapproved indicationFAERS: 5US FAERS
16ArthralgiaFAERS: 4US FAERS
17CholestasisFAERS: 4

View details

1751019
8143756
9411201
9487641
9562975
9857764
11922592
12187295
12532564
15122001
15539232
16487557
17938739
19619254
20960257
21274875
21362627
25418378
 		CTD
US FAERS
18DizzinessFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
19FatigueFAERS: 4
Canada Vigilance: 1		10750660
12392612		CTD
Canada Vigilance
US FAERS
20No adverse eventFAERS: 4US FAERS
21Pharmaceutical product complaintFAERS: 4US FAERS
22StillbirthFAERS: 4US FAERS
23UrticariaFAERS: 4US FAERS
24Disease recurrenceFAERS: 3OFFSIDES
US FAERS
25Drug ineffectiveFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
26Drug ineffective for unapproved indicationFAERS: 3US FAERS
27Erythema MultiformeFAERS: 3OFFSIDES
US FAERS
28ErythemaFAERS: 3US FAERS
29Hepatic EncephalopathyFAERS: 3US FAERS
30MalaiseFAERS: 3US FAERS
31PneumoniaFAERS: 322942741CTD
US FAERS
32Portal HypertensionFAERS: 3US FAERS
33Rash erythematousFAERS: 3US FAERS
34Suicide attemptFAERS: 3US FAERS
35White blood cell count decreasedFAERS: 3US FAERS
36jaundiceFAERS: 3

View details

7982642
10750660
11669021
16205517
 		CTD
US FAERS
37Abdominal PainFAERS: 2
Canada Vigilance: 3		Canada Vigilance
US FAERS
38Adverse eventFAERS: 2US FAERS
39AlkalosisFAERS: 2US FAERS
40Back PainFAERS: 2US FAERS
41Biliary ColicFAERS: 2US FAERS
42Blood alkaline phosphatase increasedFAERS: 2OFFSIDES
US FAERS
43Blood urine presentFAERS: 2US FAERS
44ConstipationFAERS: 2US FAERS
45Drug dispensing errorFAERS: 2US FAERS
46DyspepsiaFAERS: 2US FAERS
47EosinophiliaFAERS: 2US FAERS
48Eye inflammationFAERS: 2US FAERS
49Eye irritationFAERS: 2US FAERS
50FlatulenceFAERS: 2US FAERS
51FlushingFAERS: 2US FAERS
52FractureFAERS: 2US FAERS
53Gamma-Glutamyltransferase IncreasedFAERS: 2OFFSIDES
US FAERS
54Growth retardationFAERS: 2US FAERS
55HeadacheFAERS: 2US FAERS
56InfectionFAERS: 2US FAERS
57LymphadenopathyFAERS: 2US FAERS
58Lymphocyte stimulation test positiveFAERS: 2OFFSIDES
US FAERS
59Maternal exposure timing unspecifiedFAERS: 2US FAERS
60Medication ErrorFAERS: 2US FAERS
61MyalgiaFAERS: 2US FAERS
62Neck PainFAERS: 2US FAERS
63OverdoseFAERS: 2US FAERS
64PolyarthritisFAERS: 2US FAERS
65Product physical issueFAERS: 2US FAERS
66Product quality issueFAERS: 2US FAERS
67Product use complaintFAERS: 2US FAERS
68Product use issueFAERS: 2US FAERS
69Rheumatoid ArthritisFAERS: 2US FAERS
70Therapy non-responderFAERS: 2US FAERS
71TremorFAERS: 2US FAERS
72Unevaluable eventFAERS: 2US FAERS
73Urinary tract infectionFAERS: 2US FAERS
74Visual ImpairmentFAERS: 2US FAERS
75VomitingFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
76Weight decreasedFAERS: 2US FAERS
77treatment failureFAERS: 2US FAERS
78Abdominal adhesionsFAERS: 1US FAERS
79Accidental exposure to productFAERS: 1US FAERS
80AscitesFAERS: 122942741CTD
OFFSIDES
US FAERS
81AstheniaFAERS: 1US FAERS
82BacteriuriaFAERS: 1US FAERS
83Biliary cirrhosisFAERS: 1US FAERS
84Bilirubin conjugated increasedFAERS: 1US FAERS
85Blood alkaline phosphatase abnormalFAERS: 1US FAERS
86Blood chloride increasedFAERS: 1US FAERS
87Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
88Blood immunoglobulin E increasedFAERS: 1US FAERS
89Blood lactate dehydrogenase increasedFAERS: 1OFFSIDES
US FAERS
90Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
91Blood sodium decreasedFAERS: 1US FAERS
92Blood sodium increasedFAERS: 1US FAERS
93Bone painFAERS: 1US FAERS
94Breech PresentationFAERS: 1US FAERS
95BronchitisFAERS: 1US FAERS
96Burning sensationFAERS: 1US FAERS
97CardiomegalyFAERS: 1US FAERS
98Cerebral artery stenosisFAERS: 1US FAERS
99Chest discomfortFAERS: 1US FAERS
100ChokingFAERS: 1US FAERS
101CholangiocarcinomaFAERS: 1US FAERS
102CholecystitisFAERS: 1US FAERS
103CholedocholithotomyFAERS: 1US FAERS
104ChorioamnionitisFAERS: 1US FAERS
105ChromaturiaFAERS: 1US FAERS
106Complement factor decreasedFAERS: 1US FAERS
107Contraindicated drug administeredFAERS: 1US FAERS
108Cytolytic hepatitisFAERS: 1US FAERS
109DehydrationFAERS: 1US FAERS
110Device occlusionFAERS: 1US FAERS
111Device related infectionFAERS: 1OFFSIDES
US FAERS
112Drug administration errorFAERS: 1US FAERS
113Drug effect incompleteFAERS: 1US FAERS
114Drug exposure during pregnancyFAERS: 1US FAERS
115Drug prescribing errorFAERS: 1US FAERS
116Drug resistanceFAERS: 1US FAERS
117Dry skinFAERS: 1US FAERS
118DysuriaFAERS: 122942741CTD
US FAERS
119EczemaFAERS: 1US FAERS
120EnterocolitisFAERS: 1US FAERS
121Enzyme activity abnormalFAERS: 1US FAERS
122Eosinophilic PneumoniaFAERS: 1US FAERS
123Feeling abnormalFAERS: 1US FAERS
124Gastric ulcerFAERS: 1OFFSIDES
US FAERS
125Gastrointestinal motility disorderFAERS: 1US FAERS
126HELLP SyndromeFAERS: 1US FAERS
127Hepatitis B surface antigen positiveFAERS: 1US FAERS
128Hepatitis virus-associated nephropathyFAERS: 1US FAERS
129HepatitisFAERS: 122942741CTD
US FAERS
130HepatomegalyFAERS: 1US FAERS
131Hernial eventrationFAERS: 1US FAERS
132Histiocytosis haematophagicFAERS: 1US FAERS
133HypercapniaFAERS: 1US FAERS
134HypophagiaFAERS: 1US FAERS
135IleusFAERS: 1US FAERS
136Incorrect product storageFAERS: 1US FAERS
137InflammationFAERS: 121146893CTD
US FAERS
138Intentional product use issueFAERS: 1US FAERS
139Joint swellingFAERS: 1US FAERS
140LeukopeniaFAERS: 1US FAERS
141Low birth weight babyFAERS: 1US FAERS
142Lupus NephritisFAERS: 1US FAERS
143Lymphocyte count decreasedFAERS: 1OFFSIDES
US FAERS
144Malignant neoplasm progressionFAERS: 1OFFSIDES
US FAERS
145MalnutritionFAERS: 1US FAERS
146Meconium abnormalFAERS: 1US FAERS
147MiliariaFAERS: 1US FAERS
148Mood swingsFAERS: 1US FAERS
149Multiple drug overdose intentionalFAERS: 1US FAERS
150MyositisFAERS: 1US FAERS
151Neutrophil count decreasedFAERS: 1US FAERS
152PalpitationsFAERS: 1US FAERS
153Pancreatic CystFAERS: 1US FAERS
154PancreatitisFAERS: 116205517CTD
US FAERS
155PancytopeniaFAERS: 1US FAERS
156Pelvic PainFAERS: 1US FAERS
157Peripheral swellingFAERS: 1US FAERS
158Porphyria non-acuteFAERS: 1US FAERS
159Portal Vein ThrombosisFAERS: 1OFFSIDES
US FAERS
160Postoperative adhesionFAERS: 1US FAERS
161Pre-EclampsiaFAERS: 1US FAERS
162Product contamination physicalFAERS: 1US FAERS
163Product size issueFAERS: 1US FAERS
164Product taste abnormalFAERS: 1US FAERS
165ProteinuriaFAERS: 1US FAERS
166Pruritus allergicFAERS: 1US FAERS
167PseudolymphomaFAERS: 1US FAERS
168Pulmonary FibrosisFAERS: 1US FAERS
169Reaction to drug excipientsFAERS: 1US FAERS
170Renal hypertensionFAERS: 1US FAERS
171Respiratory muscle weaknessFAERS: 1US FAERS
172RestlessnessFAERS: 1US FAERS
173Reticulocyte count decreasedFAERS: 1US FAERS
174RhabdomyolysisFAERS: 1US FAERS
175SepsisFAERS: 1US FAERS
176Skin lesionFAERS: 1US FAERS
177Stevens-Johnson SyndromeFAERS: 1US FAERS
178Therapeutic response unexpectedFAERS: 1US FAERS
179ThirstFAERS: 1US FAERS
180ThrombocytopeniaFAERS: 1US FAERS
181TinnitusFAERS: 1US FAERS
182Transaminases increasedFAERS: 1US FAERS
183Urinary sediment presentFAERS: 1US FAERS
184Vanishing bile duct syndromeFAERS: 1US FAERS
185WheezingFAERS: 1US FAERS
186Wrong technique in product usage processFAERS: 1US FAERS
187Abdominal cavity drainageOFFSIDES
188Abdominal discomfortCanada Vigilance: 1Canada Vigilance
189Aberrant Crypt Foci12636105CTD
190AcidosisOFFSIDES
191Acute left ventricular failureOFFSIDES
192AdrenalitisOFFSIDES
193Alcoholic IntoxicationOFFSIDES
194Altered state of consciousnessOFFSIDES
195AlveolitisOFFSIDES
196AnorexiaOFFSIDES
197AnuriaOFFSIDES
198ApathyOFFSIDES
199Aphthous StomatitisOFFSIDES
200AspergillosisOFFSIDES
201AtelectasisOFFSIDES
202Atrioventricular BlockOFFSIDES
203Bile Duct Diseases6345281CTD
204Biliary dilatationOFFSIDES
205Biliary tract infectionOFFSIDES
206Bladder catheter temporaryOFFSIDES
207Blood GlucoseOFFSIDES
208Blood amylase increasedOFFSIDES
209Blood creatine phosphokinase increasedOFFSIDES
210Blood pressure immeasurableOFFSIDES
211Blood sodiumOFFSIDES
212Blood urea increasedOFFSIDES
213Blood uric acidOFFSIDES
214Bone marrow depressionOFFSIDES
215Brain DeathOFFSIDES
216CalcinosisOFFSIDES
217Cancer PainOFFSIDES
218Cardioactive drug levelOFFSIDES
219Catheter site infectionOFFSIDES
220Catheter site painOFFSIDES
221Cell marker increasedOFFSIDES
222Chemical and Drug Induced Liver Injury

View details

10453939
11922592
15892770
16205517
17854144
17938739
25418378
 		CTD
223CholangiolitisOFFSIDES
224Cholangitis, Sclerosing7514624
17489059
22942741		CTD
225CholedochoenterostomyOFFSIDES
226Cholestasis, progressive familial intrahepatic 110618887CTD
227CirrhosisOFFSIDES
228Clostridium difficile colitisOFFSIDES
229Cold sweatOFFSIDES
230Colonic Neoplasms

View details

10025872
12496057
17438113
18444174
21362627
 		CTD
231Colonic StenosisOFFSIDES
232Contralateral breast cancerOFFSIDES
233Crossmatch incompatibleOFFSIDES
234Cubital Tunnel SyndromeOFFSIDES
235Cystic Fibrosis2391071CTD
236Depressed Level of ConsciousnessOFFSIDES
237DiabetesOFFSIDES
238Diarrhea22942741CTD
239Disseminated Intravascular CoagulationOFFSIDES
240Distal intestinal obstruction syndromeOFFSIDES
241Drug diversionOFFSIDES
242Enterococcal infectionOFFSIDES
243Fatty Liver22154323CTD
244Febrile NeutropeniaOFFSIDES
245Fibrosis21274875
21410058		CTD
246GlaucomaOFFSIDES
247GlobulinuriaOFFSIDES
248Hepatic artery stenosisOFFSIDES
249Hepatic cancer metastaticOFFSIDES
250Hepatic infection bacterialOFFSIDES
251Hepatitis B positiveOFFSIDES
252Hepatitis BOFFSIDES
253Hepatitis C, Chronic9058296
19073151		CTD
254Hepatitis COFFSIDES
255Hepatitis, Chronic

View details

1352868
1449017
8713707
9717080
 		CTD
256HepatotoxicityOFFSIDES
257Herpes simplex serology positiveOFFSIDES
258HiccoughOFFSIDES
259Hyperglycemia22154323CTD
260Hyperthyroidism19534646CTD
261Hypertrophic CardiomyopathyOFFSIDES
262Hypothyroidism18518811CTD
263HypoxiaOFFSIDES
264Ileal ulcerOFFSIDES
265Immune System Diseases22942741CTD
266Immunosuppressant drug levelOFFSIDES
267Injection site ulcerOFFSIDES
268Insulin Resistance22154323CTD
269IntussusceptionOFFSIDES
270Jaundice, Obstructive7514624
7751579		CTD
271Kidney FailureOFFSIDES
272Leukopenia neonatalOFFSIDES
273LeukoplakiaOFFSIDES
274Liver AbscessOFFSIDES
275Liver Cirrhosis, Experimental21274875
21410058		CTD
276Liver Cirrhosis3470420
8713707		CTD
277Liver Failure, Acute21146893CTD
278Liver Failure22942741CTD
279Liver diseases

View details

2391071
15802798
17888421
19493473
19811448
21115542
 		CTD
280Liver transplant rejectionOFFSIDES
281Metastases to abdominal cavityOFFSIDES
282Movement Disorders25502462CTD
283Mucocele18518811CTD
284Multi-organ disorderOFFSIDES
285Multiple SclerosisOFFSIDES
286Multiple sclerosis relapseOFFSIDES
287Muscle tightnessOFFSIDES
288Mycobacterium fortuitum infectionOFFSIDES
289MyelitisOFFSIDES
290NasopharyngitisOFFSIDES
291Necrosis

View details

14976352
16432164
17888421
21274875
 		CTD
292Neoplasms21362627CTD
293Neuroblastoma recurrentOFFSIDES
294Neuroleptic Malignant SyndromeOFFSIDES
295OliguriaOFFSIDES
296OsteoporosisOFFSIDES
297PCO2 decreasedOFFSIDES
298PO2 decreasedOFFSIDES
299Pancreatic carcinoma recurrentOFFSIDES
300Peritoneal DialysisOFFSIDES
301PeritonitisOFFSIDES
302Porphyrias, Hepatic1751019CTD
303Post procedural complicationOFFSIDES
304Postoperative Complications18574646CTD
305Pulmonary HypertensionOFFSIDES
306Radial nerve palsyOFFSIDES
307Respiratory FailureOFFSIDES
308Septic ShockOFFSIDES
309Sick Sinus SyndromeOFFSIDES
310Stent occlusionOFFSIDES
311Subacute hepatic failureOFFSIDES
312TalipesOFFSIDES
313Transfusion microchimerismOFFSIDES
314Transfusion-Related Acute Lung InjuryOFFSIDES
315VasculitisCanada Vigilance: 1Canada Vigilance
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