MetaADEDB 2.0 @ LMMD
Pyrazinamide
(IPEHBUMCGVEMRF-UHFFFAOYSA-N)
Structure
SMILES
NC(=O)c1cnccn1
Type(s)
Approved; Investigational
ATC code(s)
J04AK01; J04AM05; J04AM06
Molecular Formula:
C5H5N3O
Molecular Weight:
123.113
Log P:
0.2758
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
68.87
CAS Number(s):
98-96-4
Synonym(s)
1.
Pyrazinamide
2.
Tisamid
External Link(s)
MeSHD011718
PubChem Compound1046
BindingDB228814
ChEBI45285
CHEMBLCHEMBL614
DrugBankDB00339
DrugCentral2328
IUPHAR/BPS Guide to PHARMACOLOGY7287
KEGGcpd:C01956
dr:D00144
Therapeutic Target DatabaseD0XF8W
ZINC2005
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1SepsisFAERS: 10US FAERS
2Intestinal ObstructionFAERS: 8US FAERS
3Septic ShockFAERS: 8US FAERS
4HepatitisFAERS: 77784827
9252856
15773037		CTD
OFFSIDES
SIDER
US FAERS
5Disease ProgressionFAERS: 4OFFSIDES
US FAERS
6Post procedural complicationFAERS: 2US FAERS
7TuberculosisFAERS: 2

View details

4340029
8584531
9661830
11471733
12006469
17373362
18397238
25231249
27071702
27255380
27933861
28063906
 		CTD
US FAERS
8Bacterial culture positiveFAERS: 1OFFSIDES
US FAERS
9Chest PainFAERS: 1US FAERS
10General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
11GoutFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
12Hilar lymphadenopathyFAERS: 1US FAERS
13InfectionFAERS: 1US FAERS
14Medication ErrorFAERS: 1US FAERS
15Paradoxical drug reactionFAERS: 1OFFSIDES
US FAERS
16PneumonitisFAERS: 1US FAERS
17PruritusFAERS: 1SIDER
US FAERS
18Rash erythematousFAERS: 1US FAERS
19StridorFAERS: 1OFFSIDES
US FAERS
20Tracheal StenosisFAERS: 1US FAERS
21VomitingFAERS: 1SIDER
US FAERS
22jaundiceFAERS: 1
Canada Vigilance: 1		20879012CTD
Canada Vigilance
US FAERS
23Abdominal PainCanada Vigilance: 1Canada Vigilance
24Acid fast bacilli infectionOFFSIDES
25Acid fast stain positiveOFFSIDES
26Acute psychosisOFFSIDES
27Alanine Aminotransferase IncreasedOFFSIDES
28Alcoholic IntoxicationOFFSIDES
29Anemia, Megaloblastic4731775CTD
30AnhedoniaOFFSIDES
31AnhidrosisOFFSIDES
32AnorexiaSIDER
33Anticholinergic SyndromeOFFSIDES
34Anticonvulsant drug level above therapeuticOFFSIDES
35Anticonvulsant drug level decreasedOFFSIDES
36Antiphospholipid AntibodiesOFFSIDES
37Arterial bypass operationOFFSIDES
38ArteritisOFFSIDES
39Arthralgia

View details

377739
2915734
6612796
10214039
 		CTD
SIDER
40Arthritis2915734CTD
41ArthropathyOFFSIDES
42AscitesOFFSIDES
43Aseptic MeningitisOFFSIDES
44Aspiration PneumoniaOFFSIDES
45AsthenopiaOFFSIDES
46Atrial tachycardiaOFFSIDES
47Atypical mycobacterial lymphadenitisOFFSIDES
48AuraOFFSIDES
49Blood alkaline phosphatase increasedOFFSIDES
50Blood chloride decreasedOFFSIDES
51Blood immunoglobulin A increasedOFFSIDES
52Blood immunoglobulin G increasedOFFSIDES
53Blood immunoglobulin MOFFSIDES
54Blood iron increasedSIDER
55Blood phosphorus decreasedOFFSIDES
56Blood potassium decreasedOFFSIDES
57Blood pressure inadequately controlledOFFSIDES
58Blood sodiumOFFSIDES
59Blood thyroid stimulating hormoneOFFSIDES
60Blood uric acidOFFSIDES
61Blunted affectOFFSIDES
62Blurred visionOFFSIDES
63Bone TuberculosisOFFSIDES
64Brain AbscessOFFSIDES
65Brain stem syndromeOFFSIDES
66Breast CystOFFSIDES
67BronchiectasisOFFSIDES
68BronchitisOFFSIDES
69BruxismOFFSIDES
70Cardiac TamponadeOFFSIDES
71Cataract operationOFFSIDES
72CatatoniaOFFSIDES
73Catheter related infectionOFFSIDES
74Cerebral atrophyOFFSIDES
75Cervical dysplasiaOFFSIDES
76Chemical and Drug Induced Liver Injury

View details

4800729
6118518
16212643
20879012
22431067
25231249
27071702
27933861
28063906
 		CTD
77Chemotherapeutic drug level increasedOFFSIDES
78CholangiolitisOFFSIDES
79CholecystitisOFFSIDES
80Chronic sinusitisOFFSIDES
81Clostridium difficile colitisOFFSIDES
82ColitisOFFSIDES
83ConfabulationOFFSIDES
84Consciousness fluctuatingOFFSIDES
85Creutzfeldt-Jakob diseaseOFFSIDES
86Dandy-Walker SyndromeOFFSIDES
87DehydrationOFFSIDES
88Delusional disorder, persecutory typeOFFSIDES
89DemyelinationOFFSIDES
90Depressed Level of ConsciousnessOFFSIDES
91Depressed moodOFFSIDES
92DermatitisSIDER
93Diastolic dysfunctionOFFSIDES
94DiscomfortSIDER
95DrowsinessOFFSIDES
96Drug Eruptions7786350CTD
97Drug ineffectiveOFFSIDES
98Drug level below therapeuticOFFSIDES
99Drug toxicityOFFSIDES
100DyspepsiaSIDER
101Dysthymic DisorderOFFSIDES
102DysuriaOFFSIDES
SIDER
103EcthymaOFFSIDES
104EncephalitisOFFSIDES
105End Stage Liver Disease7705802CTD
106Eosinophil percentage increasedOFFSIDES
107EpilepsyOFFSIDES
108Euphoric moodOFFSIDES
109Failure of implantOFFSIDES
110FatigueOFFSIDES
111Febrile NeutropeniaOFFSIDES
112Feeling abnormalSIDER
113Flank PainOFFSIDES
114Focal Nodular HyperplasiaOFFSIDES
115Fungal rashOFFSIDES
116GangreneOFFSIDES
117Gastrointestinal toxicityOFFSIDES
118Gaze palsyOFFSIDES
119GlaucomaOFFSIDES
120GlomerulonephritisOFFSIDES
121Graft dysfunctionOFFSIDES
122Granulomatous liver diseaseOFFSIDES
123Granuloma9252856CTD
OFFSIDES
124HemiparesisOFFSIDES
125Hepatic congestionOFFSIDES
126Hepatitis B positiveOFFSIDES
127Hepatomegaly22431067CTD
SIDER
128HepatotoxicityCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
129Histamine level increasedOFFSIDES
130HydrocephalusOFFSIDES
131HyperreflexiaOFFSIDES
132HypersensitivitySIDER
133Hyperuricemia10214039
18232182		CTD
134HypervigilanceOFFSIDES
135Hypocalcemia4340029CTD
136Hypokalemia4340029CTD
137Hypophosphatemia4340029CTD
138Immune reconstitution syndromeOFFSIDES
139IncontinenceOFFSIDES
140Injection site phlebitisOFFSIDES
141Intestinal PerforationOFFSIDES
142Intraocular inflammationOFFSIDES
143IridoceleOFFSIDES
144IritisOFFSIDES
145Joint Range of Motion DecreasedOFFSIDES
146Kidney FailureOFFSIDES
147Klebsiella sepsisOFFSIDES
148LeukocytosisCanada Vigilance: 1Canada Vigilance
149Liver Failure, Acute12006469
16212643		CTD
150Lung consolidationOFFSIDES
151Lung hyperinflationOFFSIDES
152Lupus NephritisOFFSIDES
153Lymph node palpableOFFSIDES
154Lymphocyte count decreasedOFFSIDES
155Lymphocyte percentage decreasedOFFSIDES
156Lymphocyte stimulation test positiveOFFSIDES
157MalaiseSIDER
158MalariaOFFSIDES
159Malignant neoplasm progressionOFFSIDES
160Massive Hepatic Necrosis6118518
22431067		CTD
161MeningiomaOFFSIDES
162MetatarsalgiaOFFSIDES
163Muscle Cramp18232182CTD
164Muscle abscessOFFSIDES
165Muscle necrosisOFFSIDES
166Musculoskeletal discomfortSIDER
167MyalgiaSIDER
168Mycobacterium abscessus InfectionOFFSIDES
169Myoglobin blood increasedOFFSIDES
170Myoglobinuria1803050CTD
171NauseaSIDER
172Necrotising granulomatous lymphadenitisOFFSIDES
173Nephrotic SyndromeOFFSIDES
174Neuroleptic Malignant SyndromeOFFSIDES
175Neutropenic sepsisOFFSIDES
176Olfaction Disorders19674115CTD
177OrthopneaOFFSIDES
178PachymeningitisOFFSIDES
179PallorOFFSIDES
180Peptic UlcerSIDER
181Pharyngeal lesionOFFSIDES
182PolyarthralgiaSIDER
183PolyuriaOFFSIDES
184Productive CoughOFFSIDES
185PseudarthrosisOFFSIDES
186Psychiatric symptomOFFSIDES
187Renal Insufficiency1803050
2915734		CTD
188Renal abscessOFFSIDES
189Renal cystOFFSIDES
190Respiratory FailureOFFSIDES
191Retinal exudatesOFFSIDES
192Shoulder PainOFFSIDES
193SinusitisOFFSIDES
194Skin lesionOFFSIDES
195Skin test positiveOFFSIDES
196Splenic abscessOFFSIDES
197SplenomegalySIDER
198SpondylitisOFFSIDES
199Sputum culture positiveOFFSIDES
200Status EpilepticusOFFSIDES
201Therapy non-responderOFFSIDES
202Thrombocytopenia5434719CTD
SIDER
203ThyroiditisOFFSIDES
204TinnitusOFFSIDES
205ToxoplasmosisOFFSIDES
206Tuberculoid leprosyOFFSIDES
207Tuberculoma of central nervous systemOFFSIDES
208Tuberculosis of peripheral lymph nodesOFFSIDES
209Tuberculosis, Central Nervous System6709824CTD
210Tuberculosis, Meningeal10962632CTD
211Tuberculosis, Multidrug-Resistant18283911CTD
212Tuberculosis, Pulmonary

View details

7786350
7924752
8918638
10214039
10962632
11473672
 		CTD
213Tuberculosis, Spinal16212643CTD
214Unevaluable eventOFFSIDES
215UrticariaSIDER
216VIIth nerve paralysisOFFSIDES
217Vaginal burning sensationOFFSIDES
218White blood cell count abnormalOFFSIDES
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.