MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Cimetidine

(AQIXAKUUQRKLND-UHFFFAOYSA-N)

Structure

SMILES: N#CNC(=NC)NCCSCc1nc[nH]c1C
Type(s): Approved; Investigational
ATC code(s): A02BA01; A02BA51
Molecular Formula:: C10H16N6S
Molecular Weight:: 252.339
Log P:: 1.3792
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 3
TPSA:: 114.19
CAS Number(s):: 2984-61-4; 51481-61-9; 76181-71-0; 943920-67-0

Synonym(s)

Cimetidine

Altramet

Biomet

Biomet400

Cimetidine HCl

Cimetidine Hydrochloride

Eureceptor

Histodil

N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine

10.

SK&F-92334

11.

SKF-92334

12.

Tagamet

13.

HCl, Cimetidine

14.

Hydrochloride, Cimetidine

15.

SK&F 92334

16.

SK&F92334

17.

SKF 92334

18.

SKF92334

External Link(s)

MeSH	D002927
PubChem Compound	2756
BindingDB	22889 181119 50018991 50103595 50403559
ChEBI	3699
CHEMBL	CHEMBL30
DrugBank	DB00501
DrugCentral	645
IUPHAR/BPS Guide to PHARMACOLOGY	1231
KEGG	dr:D00295 cpd:C06952
Therapeutic Target Database	D02DPA
ZINC	18115268

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 176		US FAERS
2	Dizziness	FAERS: 25 Canada Vigilance: 5	View details 71527 85850 509014 4042860 7241779	CTD OFFSIDES SIDER Canada Vigilance US FAERS
3	Vomiting	FAERS: 25 Canada Vigilance: 5	View details 78241 6625253 6831328 7326652	CTD SIDER Canada Vigilance US FAERS
4	Drug administration error	FAERS: 21		OFFSIDES US FAERS
5	Dyspepsia	FAERS: 21 Canada Vigilance: 1	630330 660845 6831328	CTD OFFSIDES Canada Vigilance US FAERS
6	Urticaria	FAERS: 18 Canada Vigilance: 5	2404434 6638053	CTD Canada Vigilance US FAERS
7	Nausea	FAERS: 17 Canada Vigilance: 5	7326652	CTD OFFSIDES SIDER Canada Vigilance US FAERS
8	Constipation	FAERS: 15 Canada Vigilance: 1	375397	CTD SIDER Canada Vigilance US FAERS
9	Malaise	FAERS: 14		SIDER US FAERS
10	Fatigue	FAERS: 13 Canada Vigilance: 2	375397	CTD OFFSIDES SIDER Canada Vigilance US FAERS
11	Headache	FAERS: 13 Canada Vigilance: 11	375397 7888363	CTD SIDER Canada Vigilance US FAERS
12	Somnolence	FAERS: 13 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
13	Abdominal discomfort	FAERS: 11 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
14	Hypersensitivity	FAERS: 10		SIDER US FAERS
15	Product quality issue	FAERS: 10		US FAERS
16	Pruritus	FAERS: 10 Canada Vigilance: 10	7091988	CTD Canada Vigilance US FAERS
17	Chest Pain	FAERS: 9 Canada Vigilance: 3		Canada Vigilance OFFSIDES US FAERS
18	Asthenia	FAERS: 8 Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER US FAERS
19	Drug exposure during pregnancy	FAERS: 6		US FAERS
20	Dysgeusia	FAERS: 6		US FAERS
21	Expired drug administered	FAERS: 6		US FAERS
22	Feeling abnormal	FAERS: 6		SIDER US FAERS
23	Intentional drug misuse	FAERS: 6		OFFSIDES US FAERS
24	Chromaturia	FAERS: 5		US FAERS
25	Erythema	FAERS: 5 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
26	Flatulence	FAERS: 5 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
27	Intentional misuse	FAERS: 5		US FAERS
28	Pain	FAERS: 5 Canada Vigilance: 2	View details 78241 375397 3010423 3733285 7241779 16202530	CTD OFFSIDES Canada Vigilance US FAERS
29	Abdominal Pain	FAERS: 4 Canada Vigilance: 5	View details 71527 630330 6800293 7326652 11399384	CTD OFFSIDES Canada Vigilance US FAERS
30	Angioedema	FAERS: 4 Canada Vigilance: 1	View details 431651 464432 4078029 7091988	CTD Canada Vigilance US FAERS
31	Ear discomfort	FAERS: 4		US FAERS
32	Throat irritation	FAERS: 4		US FAERS
33	jaundice	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
34	Alopecia	FAERS: 3 Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER US FAERS
35	Back Pain	FAERS: 3		US FAERS
36	Blood glucose increased	FAERS: 3		US FAERS
37	Drug screen positive	FAERS: 3		US FAERS
38	Nervousness	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
39	Pharmaceutical product complaint	FAERS: 3		OFFSIDES US FAERS
40	Therapeutic response unexpected	FAERS: 3		US FAERS
41	Vertigo	FAERS: 3	6831328	CTD US FAERS
42	Autosomal chromosome anomaly	FAERS: 2		US FAERS
43	Blood glucose decreased	FAERS: 2		OFFSIDES US FAERS
44	Burning sensation	FAERS: 2		US FAERS
45	Chest discomfort	FAERS: 2		US FAERS
46	Chills	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
47	Dehydration	FAERS: 2		US FAERS
48	Hepatotoxicity	FAERS: 2		OFFSIDES SIDER US FAERS
49	Intercepted medication error	FAERS: 2		US FAERS
50	Pharyngolaryngeal Pain	FAERS: 2		US FAERS
51	Poor quality sleep	FAERS: 2		US FAERS
52	Retching	FAERS: 2		US FAERS
53	Swelling	FAERS: 2		US FAERS
54	Tachycardia	FAERS: 2 Canada Vigilance: 1	2879194 3726792 6625253	CTD SIDER Canada Vigilance US FAERS
55	Tension	FAERS: 2		US FAERS
56	Thirst	FAERS: 2		US FAERS
57	Tremor	FAERS: 2 Canada Vigilance: 2	7205315	CTD Canada Vigilance US FAERS
58	Weight decreased	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
59	Abasia	FAERS: 1		US FAERS
60	Abdominal symptom	FAERS: 1		OFFSIDES US FAERS
61	Accidental exposure	FAERS: 1		US FAERS
62	Accidental overdose	FAERS: 1		US FAERS
63	Adverse event	FAERS: 1		US FAERS
64	Agitation	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
65	Alanine Aminotransferase Increased	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
66	Amphetamines positive	FAERS: 1		US FAERS
67	Anal discomfort	FAERS: 1		US FAERS
68	Anorectal discomfort	FAERS: 1		US FAERS
69	Anorexia	FAERS: 1		OFFSIDES US FAERS
70	Anxiety	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
71	Aspartate Aminotransferase Increased	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
72	Blood cholesterol increased	FAERS: 1		US FAERS
73	Breast hyperplasia	FAERS: 1		US FAERS
74	Breast tenderness	FAERS: 1		US FAERS
75	Cerebrovascular accident	FAERS: 1		US FAERS
76	Cholestasis	FAERS: 1	651333 3816488	CTD US FAERS
77	Crying	FAERS: 1		US FAERS
78	Delirium	FAERS: 1	View details 3605428 6833524 7220787 7463626	CTD US FAERS
79	Diabetes Mellitus	FAERS: 1		US FAERS
80	Disseminated Intravascular Coagulation	FAERS: 1		OFFSIDES US FAERS
81	Drug effect incomplete	FAERS: 1		US FAERS
82	Drug level increased	FAERS: 1		US FAERS
83	Drug toxicity	FAERS: 1		OFFSIDES US FAERS
84	Dry skin	FAERS: 1		US FAERS
85	Dysphonia	FAERS: 1		US FAERS
86	Dysuria	FAERS: 1		OFFSIDES US FAERS
87	Educational problem	FAERS: 1		US FAERS
88	Epistaxis	FAERS: 1		OFFSIDES US FAERS
89	Flank Pain	FAERS: 1		US FAERS
90	Flat chest	FAERS: 1		US FAERS
91	Flushing	FAERS: 1	2860211	CTD US FAERS
92	Foreign body trauma	FAERS: 1		US FAERS
93	Gallbladder pain	FAERS: 1		US FAERS
94	Gamma-Glutamyltransferase Increased	FAERS: 1		OFFSIDES US FAERS
95	Gastritis	FAERS: 1	View details 71529 6498719 7429155 17189874	CTD US FAERS
96	General physical health deterioration	FAERS: 1		US FAERS
97	Hepatitis	FAERS: 1 Canada Vigilance: 1	8123956	CTD SIDER Canada Vigilance US FAERS
98	Hormone level abnormal	FAERS: 1		US FAERS
99	Hunger	FAERS: 1		US FAERS
100	Impaired work ability	FAERS: 1		US FAERS
101	Incorrect dose administered	FAERS: 1		US FAERS
102	Incorrect drug administration duration	FAERS: 1		US FAERS
103	Increased upper airway secretion	FAERS: 1		US FAERS
104	Joint injury	FAERS: 1		OFFSIDES US FAERS
105	Maternal exposure during pregnancy	FAERS: 1		US FAERS
106	Mental status changes	FAERS: 1		US FAERS
107	Mood swings	FAERS: 1		US FAERS
108	Myocardial Infarction	FAERS: 1		US FAERS
109	Neck Pain	FAERS: 1		US FAERS
110	Nephrolithiasis	FAERS: 1		US FAERS
111	Nonspecific reaction	FAERS: 1		US FAERS
112	Oral pain	FAERS: 1		US FAERS
113	Palpitations	FAERS: 1 Canada Vigilance: 3		Canada Vigilance US FAERS
114	Pelvic Pain	FAERS: 1		US FAERS
115	Polydipsia	FAERS: 1		US FAERS
116	Premenstrual syndrome	FAERS: 1		US FAERS
117	Product availability issue	FAERS: 1		US FAERS
118	Product dose omission	FAERS: 1		US FAERS
119	Product package associated injury	FAERS: 1		US FAERS
120	Reaction to drug excipients	FAERS: 1		US FAERS
121	Renal pain	FAERS: 1		US FAERS
122	Rhabdomyolysis	FAERS: 1		US FAERS
123	Sexual Dysfunction	FAERS: 1		US FAERS
124	Shoulder Pain	FAERS: 1		US FAERS
125	Sinus headache	FAERS: 1		OFFSIDES US FAERS
126	Sinusitis	FAERS: 1		OFFSIDES US FAERS
127	Skin test positive	FAERS: 1		US FAERS
128	Stress	FAERS: 1		US FAERS
129	Syncope	FAERS: 1		US FAERS
130	Therapeutic product effect decreased	FAERS: 1		US FAERS
131	Therapeutic response unexpected with drug substitution	FAERS: 1		US FAERS
132	Thrombocytopenia	FAERS: 1 Canada Vigilance: 2	7427548 9059066	CTD SIDER Canada Vigilance US FAERS
133	Tinnitus	FAERS: 1		US FAERS
134	Toxic Epidermal Necrolysis	FAERS: 1		SIDER US FAERS
135	Toxicity to various agents	FAERS: 1		US FAERS
136	Urethritis	FAERS: 1		US FAERS
137	Abscess			OFFSIDES
138	Abuse			OFFSIDES
139	Acid reflux			OFFSIDES
140	Activities of daily living impaired			OFFSIDES
141	Acute bronchitis			OFFSIDES
142	Acute kidney injury		View details 3817629 6217424 6294351 6805823 6838302 7234893	CTD
143	Acute myocardial infarction			OFFSIDES
144	Acute sinusitis			OFFSIDES
145	Adiposis Dolorosa			OFFSIDES
146	Ageusia			OFFSIDES
147	Agranulocytosis	Canada Vigilance: 1		Canada Vigilance SIDER
148	Albuminuria	Canada Vigilance: 1		Canada Vigilance
149	Alcohol Intolerance	Canada Vigilance: 1		Canada Vigilance
150	Alopecia reversible			SIDER
151	Altered state of consciousness			OFFSIDES
152	Alveolitis			OFFSIDES
153	Amenorrhea			OFFSIDES
154	Amnesia			OFFSIDES
155	Anal Fissure			OFFSIDES
156	Anaphylactic shock			SIDER
157	Anastomotic Leak			OFFSIDES
158	Anemia, Hemolytic		9059066 19874564	CTD
159	Anemia		12601542	CTD
160	Anger			OFFSIDES
161	Anhidrosis			OFFSIDES
162	Anuria		552491	CTD OFFSIDES
163	Anxiety Disorders		11900817	CTD
164	Aortic valve sclerosis			OFFSIDES
165	Apathy			OFFSIDES
166	Apnea		7237324	CTD OFFSIDES
167	Application site irritation			OFFSIDES
168	Application site rash			OFFSIDES
169	Application site urticaria			OFFSIDES
170	Arthralgia			SIDER
171	Arthritis			OFFSIDES
172	Arthropathy	Canada Vigilance: 1		Canada Vigilance OFFSIDES
173	Asthenopia			OFFSIDES
174	Ataxia	Canada Vigilance: 1	4042860	CTD Canada Vigilance
175	Atelectasis			OFFSIDES
176	Atrial Fibrillation		6712387 7266638	CTD
177	Atrial tachycardia			OFFSIDES
178	Atrioventricular Block		2880057 6712387	CTD SIDER
179	Autoimmune hepatitis			OFFSIDES
180	Azotemia		7059066	CTD
181	Basal Ganglia Diseases		7134098	CTD
182	Bipolar Disorder			OFFSIDES
183	Blepharospasm			OFFSIDES
184	Blood alkaline phosphatase increased	Canada Vigilance: 1		Canada Vigilance OFFSIDES
185	Blood amylase increased			OFFSIDES
186	Blood chloride decreased			OFFSIDES
187	Blood cholesterol			OFFSIDES
188	Blood creatinine increased	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
189	Blood glucose abnormal			OFFSIDES
190	Blood lactate dehydrogenase increased			OFFSIDES
191	Blood potassium decreased			OFFSIDES
192	Blood potassium increased			OFFSIDES
193	Blood pressure inadequately controlled			OFFSIDES
194	Blood sodium			OFFSIDES
195	Blood triglycerides increased			OFFSIDES
196	Blood urea increased			OFFSIDES
197	Bone density decreased			OFFSIDES
198	Bone marrow depression			SIDER
199	Bone pain			OFFSIDES
200	Borderline Personality Disorder			OFFSIDES
201	Bradycardia	Canada Vigilance: 2	View details 26032 73922 85850 2360334 2493496 2880057 6177211 6712387 6753681 8437969	CTD SIDER Canada Vigilance
202	Bronchiolitis			OFFSIDES
203	Bronchitis			OFFSIDES
204	Burning Mouth Syndrome			OFFSIDES
205	Bursitis			OFFSIDES
206	Candidiasis of vagina			OFFSIDES
207	Candiduria			OFFSIDES
208	Carcinoma, Ovarian Epithelial		12442916	CTD
209	Catatonia		2742733	CTD
210	Cellulitis			OFFSIDES
211	Cerebellar Diseases		7134098	CTD
212	Cerebral atrophy			OFFSIDES
213	Cervicobrachial syndrome			OFFSIDES
214	Cheilitis			OFFSIDES
215	Chemical and Drug Induced Liver Injury		View details 375397 447012 1289197 3805669 6753681 7081289 7238251 20070855 20803752	CTD
216	Choking sensation			OFFSIDES
217	Chondromalacia			OFFSIDES
218	Chorea		2899203 7053695	CTD
219	Chronic Fatigue Syndrome			OFFSIDES
220	Chronic Obstructive Airway Disease			OFFSIDES
221	Chronic sinusitis			OFFSIDES
222	Chronic ulcerative colitis			OFFSIDES
223	Chylothorax			OFFSIDES
224	Cirrhosis			OFFSIDES
225	Clostridium colitis			OFFSIDES
226	Cold sweat			OFFSIDES
227	Colon adenoma			OFFSIDES
228	Confusion		View details 71527 84204 316351 434259 552491 762851 1968690 2493496 2860211 3243179 3753124 3777737 3784068 4072863 6106871 6112422 6295340 6625253 6965483 7122384 7134098 7237324 7254074 7409403 7429155 7446541 7449410	CTD
229	Congenital hypertrichosis			OFFSIDES
230	Congenital tricuspid valve incompetence			OFFSIDES
231	Conjunctival deposit			OFFSIDES
232	Conjunctivitis	Canada Vigilance: 1		Canada Vigilance
233	Craniectomy			OFFSIDES
234	Cyanosis			OFFSIDES
235	Cystocele			OFFSIDES
236	Cyst			OFFSIDES
237	Cytomegalovirus antibody positive			OFFSIDES
238	Cytoreductive Surgery			OFFSIDES
239	Decreased Libido			OFFSIDES
240	Dementia		4031401 7053303	CTD
241	Demyelination			OFFSIDES
242	Dental abscess			OFFSIDES
243	Dental caries			OFFSIDES
244	Dependence			OFFSIDES
245	Depressed Level of Consciousness			OFFSIDES
246	Depressive disorder		View details 420338 509014 6356917 7296440 7435686	CTD
247	Dermatitis	Canada Vigilance: 1		Canada Vigilance SIDER
248	Dermoid Cyst			OFFSIDES
249	Diarrhea		375397 7241779 7326652	CTD
250	Diplopia	Canada Vigilance: 1	6831328	CTD OFFSIDES Canada Vigilance
251	Disease Progression			OFFSIDES
252	Disease recurrence			OFFSIDES
253	Disorders of Excessive Somnolence		552491 2404434 7284887	CTD
254	Disorientation	Canada Vigilance: 3		Canada Vigilance SIDER
255	Diverticulitis			OFFSIDES
256	Drowsiness			SIDER
257	Drug Eruptions		464432 6638053 7091988	CTD
258	Drug withdrawal headache			OFFSIDES
259	Duodenal Ulcer		View details 375397 420338 435711 464432 630330 651333 4078029 6106871 6831328 6991375 7053695 7352543 7427672 7429155 7819942 12503773	CTD OFFSIDES
260	Duodenitis			OFFSIDES
261	Dysarthria	Canada Vigilance: 1		Canada Vigilance
262	Dyskinesia, Drug-Induced		552491 6625253	CTD
263	Dyspnea		431651	CTD
264	Dysthymic Disorder			OFFSIDES
265	Dystonia		3662164 11399384	CTD
266	Edema		19703484	CTD
267	Electrocardiogram ST-T change			OFFSIDES
268	Electrocardiogram poor R-wave progression			OFFSIDES
269	Emotional distress			OFFSIDES
270	Endocarditis			OFFSIDES
271	Endometrial Neoplasms		12601542	CTD
272	Eosinophilia		1480549	CTD
273	Epilepsy		6489391	CTD
274	Epstein-Barr virus antibody positive			OFFSIDES
275	Erectile dysfunction	Canada Vigilance: 8	View details 435711 3654561 6150641 6835285	CTD OFFSIDES SIDER Canada Vigilance
276	Erosive gastritis			OFFSIDES
277	Erythema Multiforme			SIDER
278	Esophageal Stenosis			OFFSIDES
279	Esophagitis		6831328 7220787 11764863	CTD
280	Essential Hypertension			OFFSIDES
281	Exanthema		375397 7241779	CTD
282	Eye Infection			OFFSIDES
283	Febrile Neutropenia			OFFSIDES
284	Fever		View details 375397 630330 1480549 3753124 7449410	CTD
285	Fibromyalgia			OFFSIDES
286	Folliculitis			OFFSIDES
287	Formication			OFFSIDES
288	Fungus serology test positive			OFFSIDES
289	Galactorrhea		3654561	CTD
290	Gambling			OFFSIDES
291	Gastroenteritis			OFFSIDES
292	Gastrointestinal Hemorrhage		View details 73922 78241 85851 682299 762851 3500684 6965483 6983645 7205315 7237324 7406628 7425170 7463626 18951251	CTD
293	General nutrition disorder			OFFSIDES
294	Gingival erythema			OFFSIDES
295	Gingivitis	Canada Vigilance: 1		Canada Vigilance
296	Goiter			OFFSIDES
297	Gout			OFFSIDES
298	Granulomatous liver disease			OFFSIDES
299	Gynecomastia		View details 682299 3654561 6150641 6753681 6835285 7771409	CTD
300	Hallucinations		View details 434259 660845 3243179 3777737 4042860 6498719 7122384 7425170 7429155 7446541	CTD
301	Hay fever			OFFSIDES
302	Hematemesis		View details 552491 2879194 6833524 7266638 7427548	CTD
303	Hemiparesis	Canada Vigilance: 1		Canada Vigilance
304	Hepatic Insufficiency			SIDER
305	Hepatomegaly	Canada Vigilance: 1		Canada Vigilance
306	Hernia			OFFSIDES
307	Herpes simplex serology negative			OFFSIDES
308	Hirsutism	Canada Vigilance: 1		Canada Vigilance
309	Histoplasmosis			OFFSIDES
310	Hydropneumothorax			OFFSIDES
311	Hyperglycemia		85850	CTD
312	Hyperparathyroidism			OFFSIDES
313	Hyperprolactinemia		9037573	CTD
314	Hypertensive cardiomyopathy			OFFSIDES
315	Hypertensive heart disease			OFFSIDES
316	Hyperventilation			OFFSIDES
317	Hypoglycemia		2414028	CTD
318	Hyporeflexia	Canada Vigilance: 1		Canada Vigilance
319	Hypotension	Canada Vigilance: 2	View details 26032 32359 85851 1980182 2021990 2360334 2461127 2862255 3800517 6093212 6177211 6601465 6753681 6869752	CTD Canada Vigilance
320	Hypoxia			OFFSIDES
321	Impaired driving ability			OFFSIDES
322	Impaired gastric emptying			OFFSIDES
323	Incontinence			OFFSIDES
324	Infected varicose vein			OFFSIDES
325	Infection			OFFSIDES
326	Infusion site mobility decreased			OFFSIDES
327	Infusion site reaction			OFFSIDES
328	Initial insomnia			OFFSIDES
329	Injection Site Reaction	Canada Vigilance: 2		Canada Vigilance
330	Intestinal Diseases		7460719	CTD
331	Intraductal papilloma of breast			OFFSIDES
332	Joint stiffness			OFFSIDES
333	Kidney Diseases		22525860	CTD
334	Labile hypertension			OFFSIDES
335	Left Ventricular Hypertrophy			OFFSIDES
336	Lethargy		762851 4042860	CTD
337	Leucine aminopeptidase increased			OFFSIDES
338	Leukocytoclastic vasculitis			SIDER
339	Leukopenia		630330 6939132 12601542	CTD SIDER
340	Limb injury			OFFSIDES
341	Lip erosion			OFFSIDES
342	Lip swelling	Canada Vigilance: 1		Canada Vigilance
343	Liver Abscess			OFFSIDES
344	Liver diseases		6141900	CTD
345	Lymphadenitis	Canada Vigilance: 2		Canada Vigilance
346	Lymphatic duct rupture			OFFSIDES
347	Lymphoma			OFFSIDES
348	Malignant ascites			OFFSIDES
349	Malignant neoplasm progression			OFFSIDES
350	Mammary duct ectasia			OFFSIDES
351	Mastitis	Canada Vigilance: 3		Canada Vigilance
352	Mastocytosis, Systemic		420338 18951251	CTD
353	Megacolon			OFFSIDES
354	Melena		85850 509014 6833524	CTD
355	Memory Disorders		71527 19215234	CTD
356	Memory impairment	Canada Vigilance: 1		Canada Vigilance
357	Mental disorder due to a general medical condition			SIDER
358	Mental disorders		6826535 7088058	CTD
359	Mental impairment			OFFSIDES
360	Metastases to abdominal cavity			OFFSIDES
361	Methemoglobinemia		7888363 12030789	CTD
362	Migraine with Aura			OFFSIDES
363	Modified radical mastectomy			OFFSIDES
364	Mood Disorders		6863227	CTD
365	Movement Disorders		71529 7237324	CTD
366	Multiple Endocrine Neoplasia		420338	CTD
367	Muscle Spasticity	Canada Vigilance: 1		Canada Vigilance
368	Muscle Weakness			OFFSIDES
369	Muscle tightness			OFFSIDES
370	Musculoskeletal Pain			OFFSIDES SIDER
371	Musculoskeletal chest pain			OFFSIDES
372	Musculoskeletal discomfort			SIDER
373	Musculoskeletal stiffness			OFFSIDES
374	Myalgia	Canada Vigilance: 2		Canada Vigilance SIDER
375	Mydriasis	Canada Vigilance: 1		Canada Vigilance
376	Myoclonus		2860211 6112422 7205315	CTD
377	Nasopharyngitis			OFFSIDES
378	Necrolysis epidermal			SIDER
379	Necrosis		7244370	CTD
380	Nephritis, Interstitial		View details 1294777 3933701 6217424 6294351 6753681 6805823 6838302 7059066 7081178 7234893 7326652 7409394 8352262 8352263 10074607 11219486 16362162	CTD
381	Nephrotic Syndrome			OFFSIDES
382	Nerve Block			OFFSIDES
383	Neuralgia			OFFSIDES
384	Neurobehavioral Manifestations		6489391	CTD
385	Neuroleptic Malignant Syndrome			OFFSIDES
386	Neuromuscular Diseases		3010423 7427548 7427672	CTD
387	Neuropathic pain			OFFSIDES
388	Neutropenia	Canada Vigilance: 2	12601542	CTD SIDER Canada Vigilance
389	Non-cardiac chest pain			OFFSIDES
390	Nutritional and Metabolic Diseases		375397	CTD
391	Nutritional condition abnormal			OFFSIDES
392	Ocular Motility Disorders		6831328	CTD
393	Oligospermia		435711	CTD
394	Oliguria			OFFSIDES
395	Oral Cavity Fistula			OFFSIDES
396	Organic brain syndrome			SIDER
397	Oropharyngeal discomfort			OFFSIDES
398	Oropharyngeal pain			OFFSIDES
399	Osteopenia			OFFSIDES
400	Osteoporosis			OFFSIDES
401	PROTHROMBIN TIME			OFFSIDES
402	Pancreatitis, Alcoholic		7091988	CTD
403	Pancreatitis		10484002	CTD OFFSIDES SIDER
404	Pancytopenia		2079735	CTD SIDER
405	Panic Disorder		509014	CTD OFFSIDES
406	Panic disorder with agoraphobia			OFFSIDES
407	Peptic Ulcer Perforation		6123873	CTD
408	Peptic Ulcer	Canada Vigilance: 1	View details 21785 81467 434259 509014 762851 2360334 2773966 3283917 3777737 6145972 6835285 7034155 7205315 7272161 7435686 7463626 11421865 15955208 17189874	CTD Canada Vigilance
409	Periarthritis			OFFSIDES
410	Peripheral Nervous System Diseases		3010423 12601542	CTD
411	Peritoneal lesion			OFFSIDES
412	Peritonitis			OFFSIDES
413	Phlebitis		11305068	CTD
414	Photophobia	Canada Vigilance: 1		Canada Vigilance
415	Pilonidal Cyst			OFFSIDES
416	Plasma creatinine increased			SIDER
417	Pleurisy			OFFSIDES
418	Pneumatosis Cystoides Intestinalis			OFFSIDES
419	Pneumonia			SIDER
420	Pneumothorax			OFFSIDES
421	Poisoning		22525860	CTD
422	Polymyositis		6217424	CTD SIDER
423	Polyuria	Canada Vigilance: 3	1480549	CTD Canada Vigilance
424	Postmenopause			OFFSIDES
425	Postoperative Complications		7284887	CTD
426	Postoperative infection			OFFSIDES
427	Proctitis			OFFSIDES
428	Productive Cough			OFFSIDES
429	Prostate cancer recurrent			OFFSIDES
430	Psoriasis	Canada Vigilance: 1		Canada Vigilance
431	Psychiatric symptom			OFFSIDES
432	Psychomotor Agitation		View details 2860211 6833524 6863227 7122384 7429155	CTD
433	Psychoses, Substance-Induced		View details 316351 434259 509014 6498719 7425170 7446541	CTD
434	Pulmonary Infarction			OFFSIDES
435	Pulmonary toxicity			OFFSIDES
436	Purulent discharge			OFFSIDES
437	Pyelitis	Canada Vigilance: 1		Canada Vigilance
438	Pyoderma Gangrenosum			OFFSIDES
439	Rash erythematous	Canada Vigilance: 2		Canada Vigilance
440	Renal Insufficiency		7081178 7413549	CTD
441	Renal artery occlusion			OFFSIDES
442	Renal tubular disorder			OFFSIDES
443	Renal tubular necrosis	Canada Vigilance: 1		Canada Vigilance
444	Respiratory Failure			OFFSIDES
445	Respiratory Insufficiency		7085965	CTD
446	Restlessness	Canada Vigilance: 1		Canada Vigilance
447	Rhinitis	Canada Vigilance: 1		Canada Vigilance
448	Salivary Gland Neoplasms		17273750	CTD
449	Scab			OFFSIDES
450	Scleritis		6294351	CTD
451	Scrotal cyst			OFFSIDES
452	Seizures		View details 3729019 7122384 7634817 8274150 8619239	CTD
453	Seminal vesiculitis			OFFSIDES
454	Septic Shock			OFFSIDES
455	Sinus Arrest, Cardiac		2880057 3887992 8437969	CTD
456	Sinus bradycardia			SIDER
457	Skeletal injury			OFFSIDES
458	Skin laceration			OFFSIDES
459	Sleep Talking			OFFSIDES
460	Small intestine carcinoma			OFFSIDES
461	Speech Disorders		71527 434259 3777737	CTD
462	Spinal column stenosis			OFFSIDES
463	Spondylolisthesis			OFFSIDES
464	Status Epilepticus		552491	CTD
465	Steroid withdrawal syndrome			OFFSIDES
466	Stevens-Johnson Syndrome			OFFSIDES SIDER
467	Stillbirth	Canada Vigilance: 1		Canada Vigilance
468	Stomach Neoplasms		20127008	CTD
469	Stridor			OFFSIDES
470	Strongyloidiasis			SIDER
471	Stupor	Canada Vigilance: 1	470064 7122384	CTD Canada Vigilance
472	Subcutaneous Abscess			OFFSIDES
473	Substance Withdrawal Syndrome		375397 8870037 9037573	CTD
474	Sudden Cardiac Death			OFFSIDES
475	Suture related complication			OFFSIDES
476	Synovial Cyst			OFFSIDES
477	Tachycardia, Ventricular		7266638	CTD
478	Tardive Dyskinesia			OFFSIDES
479	Tendinitis			OFFSIDES
480	Tension Headache			OFFSIDES
481	Tinea Pedis			OFFSIDES
482	Tooth Extraction			OFFSIDES
483	Tooth Infection			OFFSIDES
484	Torsades de Pointes		8257958	CTD
485	Traumatic liver injury			SIDER
486	Ulcer		7449410	CTD
487	Underweight			OFFSIDES
488	Urinary Retention			SIDER
489	Urine flow decreased			OFFSIDES
490	Vascular calcification			OFFSIDES
491	Vasculitis, Leukocytoclastic, Cutaneous		6638053 7443604	CTD
492	Vasculitis		7241779	CTD
493	Venous Thrombosis		71527	CTD
494	Ventricular Dysfunction, Left		7266638	CTD
495	Ventricular Fibrillation		7266638	CTD
496	Viral upper respiratory tract infection			OFFSIDES
497	Visual Impairment	Canada Vigilance: 3		Canada Vigilance
498	Visual disturbance			OFFSIDES
499	Vocal cord cyst			OFFSIDES
500	Vulvovaginal pain			OFFSIDES
501	Warts		10810655	CTD
502	White blood cell count decreased			SIDER
503	Wound Infection			OFFSIDES
504	Zollinger-Ellison syndrome		View details 81467 375397 420338 4042860 6835285	CTD
505	anaphylaxis		2774306 21461253	CTD
506	carbuncle			OFFSIDES
507	colonoscopy			OFFSIDES
508	muscle injury			OFFSIDES

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