MetaADEDB 2.0 @ LMMD
Biperiden
(YSXKPIUOCJLQIE-UHFFFAOYSA-N)
Structure
SMILES
OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1
Type(s)
Approved; Investigational
ATC code(s)
N04AA02
Molecular Formula:
C21H29NO
Molecular Weight:
311.461
Log P:
3.9003
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
1
TPSA:
23.47
CAS Number(s):
514-65-8
Synonym(s)
1.
Biperiden
2.
Akineton
3.
Biperiden Hydrochloride
4.
Biperiden, 1R-(1 alpha,2 alpha(R*),4 alpha)-Isomer
5.
Biperiden, 1S-(1 alpha,2 alpha(R*),4 alpha)-Isomer
6.
Biperidene
7.
alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol
8.
Hydrochloride, Biperiden
External Link(s)
MeSHD001712
PubChem Compound2381
BindingDB50240680
ChEBI3112
CHEMBLCHEMBL1101
DrugBankDB00810
DrugCentral374
IUPHAR/BPS Guide to PHARMACOLOGY7128
KEGGcpd:C07941
dr:D00779
Therapeutic Target DatabaseD0B4TN
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1OverdoseFAERS: 6OFFSIDES
US FAERS
2MydriasisFAERS: 4US FAERS
3AstheniaFAERS: 3US FAERS
4SchizophreniaFAERS: 31322069CTD
OFFSIDES
US FAERS
5Accidental overdoseFAERS: 2US FAERS
6Neuroleptic Malignant SyndromeFAERS: 2OFFSIDES
US FAERS
7RestlessnessFAERS: 2US FAERS
8Accidental exposureFAERS: 1US FAERS
9AgranulocytosisFAERS: 1US FAERS
10AmnesiaFAERS: 1US FAERS
11Anticholinergic SyndromeFAERS: 1OFFSIDES
US FAERS
12Blood creatine phosphokinase increasedFAERS: 1OFFSIDES
US FAERS
13DeliriumFAERS: 116938281
20463129		CTD
US FAERS
14Disseminated Intravascular CoagulationFAERS: 1OFFSIDES
US FAERS
15DizzinessFAERS: 1US FAERS
16Drug abuserFAERS: 1US FAERS
17Drug exposure during pregnancyFAERS: 1US FAERS
18Drug ineffectiveFAERS: 1US FAERS
19DystoniaFAERS: 1

View details

826968
1742756
1880525
3470140
7147262
7977894
8301292
8813234
10200869
10389620
11164078
11571992
16569800
16702617
17632227
18597910
18794659
19944732
20014065
 		CTD
OFFSIDES
US FAERS
20FatigueFAERS: 1US FAERS
21Feeling abnormalFAERS: 1US FAERS
22Nephrotic SyndromeFAERS: 1US FAERS
23SepsisFAERS: 1US FAERS
24SomnolenceFAERS: 1US FAERS
25Suicide attemptFAERS: 1US FAERS
26TachycardiaFAERS: 1US FAERS
27Urinary RetentionFAERS: 1US FAERS
28nervous system disorderFAERS: 1US FAERS
29AbasiaOFFSIDES
30AbuliaOFFSIDES
31AcidosisOFFSIDES
32Activated partial thromboplastin time shortenedOFFSIDES
33Activation syndromeOFFSIDES
34Akathisia, Drug-Induced

View details

4587065
7673653
10895402
16513883
 		CTD
35AkinesiaOFFSIDES
36Alanine Aminotransferase IncreasedOFFSIDES
37Alcohol poisoningOFFSIDES
38Alcoholic IntoxicationOFFSIDES
39Altered state of consciousnessOFFSIDES
40AmimiaOFFSIDES
41AmphetaminesOFFSIDES
42Antipsychotic drug level above therapeuticOFFSIDES
43Antipsychotic drug level increasedOFFSIDES
44Antiviral drug level above therapeuticOFFSIDES
45Apallic syndromeOFFSIDES
46Aspartate aminotransferase decreasedOFFSIDES
47AsphyxiaOFFSIDES
48Aspiration PneumoniaOFFSIDES
49AtaxiaOFFSIDES
50Atrioventricular extrasystolesOFFSIDES
51AuraOFFSIDES
52Bacteria sputum identifiedOFFSIDES
53Basal Ganglia Diseases

View details

1001242
3565961
4692693
6016862
16101941
20486582
 		CTD
54BedriddenOFFSIDES
55Benign Prostatic HyperplasiaOFFSIDES
56Bipolar Disorder10846716
17414256		CTD
57Blood GlucoseOFFSIDES
58Blood aldosterone decreasedOFFSIDES
59Blood alkaline phosphatase increasedOFFSIDES
60Blood amylase decreasedOFFSIDES
61Blood cholinesterase decreasedOFFSIDES
62Blood corticotrophinOFFSIDES
63Blood cortisol decreasedOFFSIDES
64Blood creatine phosphokinase decreasedOFFSIDES
65Blood creatinine increasedOFFSIDES
66Blood electrolytes abnormalOFFSIDES
67Blood glucose decreasedOFFSIDES
68Blood glucose fluctuationOFFSIDES
69Blood growth hormone increasedOFFSIDES
70Blood immunoglobulin G increasedOFFSIDES
71Blood lactate dehydrogenase increasedOFFSIDES
72Blood potassium increasedOFFSIDES
73Blood pressure orthostatic abnormalOFFSIDES
74Blood prolactin increasedOFFSIDES
75Blood sodium increasedOFFSIDES
76Blood sodiumOFFSIDES
77Blood triglycerides increasedOFFSIDES
78Blood urea increasedOFFSIDES
79Body TemperatureOFFSIDES
80Bradycardia2710809CTD
OFFSIDES
81Brain DeathOFFSIDES
82Catalepsy

View details

7200248
9201797
9808703
10888308
11180191
16047547
 		CTD
83CatatoniaOFFSIDES
84Cerebral atrophyOFFSIDES
85Cerebral circulatory failureOFFSIDES
86Chemotherapeutic drug level increasedOFFSIDES
87ChokingOFFSIDES
88Chorea8623983CTD
89Chronic sinusitisOFFSIDES
90Cognition Disorders3341962
15101567
21336581		CTD
91Cogwheel RigidityOFFSIDES
92Coma acidoticOFFSIDES
93Completed SuicideOFFSIDES
94ConfabulationOFFSIDES
95Cytomegalovirus chorioretinitisOFFSIDES
96Deglutition Disorders2710809CTD
97Delusional disorder, unspecified typeOFFSIDES
98Dental examinationOFFSIDES
99Depressed Level of ConsciousnessOFFSIDES
100Depression suicidalOFFSIDES
101Depressive disorder10967655CTD
102Diabetes InsipidusOFFSIDES
103Diet refusalOFFSIDES
104DrowsinessOFFSIDES
105Drug toxicityOFFSIDES
106Dysarthria2710809
10200869		CTD
107Dyskinesia, Drug-Induced

View details

3717542
4155220
12940655
16586284
18794659
 		CTD
108DyslaliaOFFSIDES
109DysuriaOFFSIDES
110Electrocardiogram ST-T segment abnormalOFFSIDES
111Electrocardiogram repolarisation abnormalityOFFSIDES
112Electroconvulsive TherapyOFFSIDES
113Eosinophil percentage decreasedOFFSIDES
114Eosinophilic myocarditisOFFSIDES
115EpilepsyOFFSIDES
116EpistaxisOFFSIDES
117Escherichia vaginitisOFFSIDES
118Exfoliative rashOFFSIDES
119GalactorrheaOFFSIDES
120Gamma-Glutamyltransferase IncreasedOFFSIDES
121GastroenteritisOFFSIDES
122General physical health deteriorationOFFSIDES
123Gingival HyperplasiaOFFSIDES
124Glasgow coma scaleOFFSIDES
125GlossitisOFFSIDES
126Granulocyte count decreasedOFFSIDES
127GranulocytosisOFFSIDES
128HELLP SyndromeOFFSIDES
129Haptoglobin DecreasedOFFSIDES
130Hepatitis B positiveOFFSIDES
131Hepatitis COFFSIDES
132HypertransaminasaemiaOFFSIDES
133HypertrichosisOFFSIDES
134HyperventilationOFFSIDES
135Hysterical psychosisOFFSIDES
136Iatrogenic injuryOFFSIDES
137Idiosyncratic drug reactionOFFSIDES
138Inability to crawlOFFSIDES
139IncontinenceOFFSIDES
140Infantile apnoeic attackOFFSIDES
141Intention tremorOFFSIDES
142Intentional misuseOFFSIDES
143Intestinal ObstructionOFFSIDES
144Leukopenia neonatalOFFSIDES
145Lymphocyte count decreasedOFFSIDES
146LymphomaOFFSIDES
147Macrophage ActivationOFFSIDES
148Markedly reduced dietary intakeOFFSIDES
149MegacolonOFFSIDES
150Meige Syndrome12404689CTD
151Mood Disorders852367CTD
152Motor retardationOFFSIDES
153Movement Disorders826968
2880362
4593518		CTD
154Multiple drug overdoseOFFSIDES
155Multiple drug overdose intentionalOFFSIDES
156MumpsOFFSIDES
157Muscle necrosisOFFSIDES
158Muscle tightnessOFFSIDES
159MutismOFFSIDES
160Myocardial fibrosisOFFSIDES
161Myoclonus19590258CTD
162MyofascitisOFFSIDES
163Myoglobin blood increasedOFFSIDES
164Myoglobin urine presentOFFSIDES
165Neuralgia2710809CTD
166OculogyrationOFFSIDES
167OliguriaOFFSIDES
168Orchitis noninfectiveOFFSIDES
169Oropharyngeal spasmOFFSIDES
170PCO2 decreasedOFFSIDES
171Parkinson Disease72141
8561216
9877318		CTD
172Parkinsonian Disorders4155670
10389620
12724469		CTD
173ParotitisOFFSIDES
174Paroxysmal perceptual alterationOFFSIDES
175Partner stressOFFSIDES
176PeriarthritisOFFSIDES
177PolyuriaOFFSIDES
178PoriomaniaOFFSIDES
179Potentiating drug interactionOFFSIDES
180PriapismOFFSIDES
181Protein total decreasedOFFSIDES
182Psychiatric decompensationOFFSIDES
183Psychiatric symptomOFFSIDES
184Psychomotor Agitation12724469CTD
185Psychomotor skills impairedOFFSIDES
186Psychoses, Substance-Induced4587065
17414256		CTD
187Psychotic Disorders1178807
2036482		CTD
188Pulmonary InfarctionOFFSIDES
189Pulmonary artery thrombosisOFFSIDES
190RalesOFFSIDES
191Reflex, Abnormal11920928CTD
192Renin decreasedOFFSIDES
193RhabdomyolysisOFFSIDES
194Schizoaffective DisorderOFFSIDES
195ScreamingOFFSIDES
196Seizures9877318
15919102		CTD
197Sinus bradycardiaOFFSIDES
198Skin test positiveOFFSIDES
199Sleep Initiation and Maintenance Disorders11110012CTD
200SoliloquyOFFSIDES
201Somatoform DisorderOFFSIDES
202SoporOFFSIDES
203Status EpilepticusOFFSIDES
204Substance Withdrawal Syndrome11110012
17218049		CTD
205Sudden deathOFFSIDES
206TalipesOFFSIDES
207Tinea PedisOFFSIDES
208Tongue spasmOFFSIDES
209Torticollis12724469
19590258		CTD
210Transaminases increasedOFFSIDES
211Tremor6621715
9877318		CTD
212Urinary tract infection enterococcalOFFSIDES
213Urine output increasedOFFSIDES
214Venous occlusionOFFSIDES
215Ventricular FibrillationOFFSIDES
216Water IntoxicationOFFSIDES
217Waxy flexibilityOFFSIDES
218XanthomaOFFSIDES
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