MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Metabolic Side Effects of Drugs and Substances

(UMLS:C3850157)

Definition:: Specific effects of drugs and substances on metabolic pathways such as those occurring through the CYTOCHROME P-450 ENZYME SYSTEM. These include effects that often result in DRUG INTERACTIONS; FOOD-DRUG INTERACTIONS; and HERB-DRUG INTERACTIONS.
UMLS ID:: C3850157
MeSH ID:: D065606

Classification 1:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.100.812

Classification 2:

Name:

Chemical Actions and Uses
MeSH Tree Number(s):: D27.505.389

Synonym(s)

Metabolic Side Effects of Drugs and Substances

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ketoconazole		25070100 25106415	CTD
2	Rifampin		25070100	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anticholinergic Syndrome	28.6%
2	Serotonin Syndrome	28.6%
3	Propofol Infusion Syndrome	28.6%
4	Chemical and Drug Induced Liver Injury	22.9%
5	Injection Site Reaction	21.1%
6	Infusion site reaction	21.1%
7	Diuretic Effect	17.2%
8	Chemical and Drug Induced Liver Injury, Chronic	16.4%
9	Sympathomimetic Effect	15.4%
10	Poisoning	15%
11	Akathisia, Drug-Induced	14.7%
12	Cardiotoxicity	14%
13	Dyskinesia, Drug-Induced	12.8%
14	Drug Eruptions	12.3%
15	Drug abuse	11.5%
16	Substance Dependence	11.5%
17	Substance-Related Disorders	11.5%
18	Drug Dependence	11.5%
19	Mushroom Poisoning	10.3%
20	Acute Generalized Exanthematous Pustulosis	10.1%
21	Fluoride Poisoning	9.5%
22	Food Poisoning	9.5%
23	Gas Poisoning	9.5%
24	Mycotoxicosis	9.5%
25	Plant Poisoning	9.5%
26	Organophosphate poisoning	9.5%
27	Psychoses, Substance-Induced	9.4%
28	Asthma, Aspirin-Induced	8.7%
29	Erythema Nodosum	8.4%
30	Serum Sickness	8.4%
31	Alcohol-Induced Disorders, Nervous System	7.6%
32	Bites and Stings	7.4%
33	Neurotoxicity Syndromes	7.4%
34	Marijuana Abuse	7.1%
35	Opioid-Related Disorders	7.1%
36	Nicotine Dependence	7.1%
37	Opioid abuse	7.1%
38	Phencyclidine Abuse	7.1%
39	Substance Abuse, Intravenous	7.1%
40	Substance Withdrawal Syndrome	7.1%
41	Tobacco Use Disorder	7.1%
42	Alcohol-Related Disorders	7.1%
43	Amphetamine-Related Disorders	7.1%
44	Cocaine-Related Disorders	7.1%
45	Water Intoxication	7%
46	Arsenic Poisoning	7%
47	Cadmium poisoning	7%
48	Carbon Monoxide Poisoning	7%
49	Ciguatera Poisoning	7%
50	Ergotism	7%
51	Lead Poisoning	7%
52	Mercury Poisoning	7%
53	Alcohol-Induced Disorders	7%
54	Shellfish Poisoning	7%
55	Drug Overdose	7%
56	Alcohol Withdrawal Delirium	6.5%
57	Alcohol Withdrawal Seizures	6.5%
58	Toxic Epidermal Necrolysis	6.2%
59	Stevens-Johnson Syndrome	6.2%
60	Psychoses, Alcoholic	6.2%
61	Neonatal Abstinence Syndrome	5.7%
62	Insect Bites and Stings	5.3%
63	Alcohol Use Disorder	5.2%
64	Alcoholic Intoxication	5.2%
65	Argyria	5.2%
66	Heroin Dependence	5.2%
67	Morphine Dependence	5.2%
68	Alcohol abuse	5.2%
69	Manganese Poisoning	5.2%
70	Tick Paralysis	5.1%
71	Salmonella food poisoning	5.1%
72	Cardiomyopathy, Alcoholic	4.3%
73	Pancreatitis, Alcoholic	4.3%
74	Mercury Poisoning, Nervous System	4.3%
75	Lead Poisoning, Nervous System	4.3%
76	Neuroleptic Malignant Syndrome	4.1%
77	Binge Drinking	4.1%
78	Lead Poisoning, Nervous System, Childhood	3.8%
79	Lead Poisoning, Nervous System, Adult	3.8%
80	Fetal Alcohol Spectrum Disorders	3.4%
81	Botulism	3.4%
82	MPTP Poisoning	3.4%
83	Fatty Liver, Alcoholic	3.1%
84	Hepatitis, Alcoholic	3.1%
85	Liver Cirrhosis, Alcoholic	3.1%
86	Acrodynia	3%
87	Wernicke Encephalopathy	2.9%

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