MetaADEDB 2.0 @ LMMD
Spironolactone
(LXMSZDCAJNLERA-ZHYRCANASA-N)
Structure
SMILES
CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]2[C@@H]1[C@@H]1CC[C@]3([C@]1(CC2)C)CCC(=O)O3)C
Type(s)
Approved
ATC code(s)
C03DA01
Molecular Formula:
C24H32O4S
Molecular Weight:
416.573
Log P:
4.8523
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
0
TPSA:
85.74
CAS Number(s):
52-01-7; 19000
Synonym(s)
1.
Spironolactone
2.
Spirolactone
3.
Aldactone
4.
Aldactone A
5.
Aquareduct
6.
Duraspiron
7.
Espironolactona Alter
8.
Espironolactona Mundogen
9.
Flumach
10.
Frumikal
11.
Jenaspiron
12.
Novo-Spiroton
13.
Practon
14.
SC-9420
15.
Spiractin
16.
Spiro L.U.T.
17.
Spiro Von Ct
18.
Spirobeta
19.
Spirogamma
20.
Spirolang
21.
Spirono-Isis
22.
Spironone
23.
Spirospare
24.
Veroshpiron
25.
Verospiron
26.
Verospirone
27.
Ct, Spiro Von
28.
Novo Spiroton
29.
NovoSpiroton
30.
SC 9420
31.
SC9420
32.
Spirono Isis
33.
Von Ct, Spiro
External Link(s)
MeSHD013148
PubChem Compound5833
BindingDB50228080
ChEBI9241
CHEMBLCHEMBL1393
DrugBankDB00421
DrugCentral2475
IUPHAR/BPS Guide to PHARMACOLOGY2875
KEGGcpd:C07310
dr:D00443
Therapeutic Target DatabaseD0EP0C
ZINC3861599
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 68
Canada Vigilance: 4
Canada Vigilance
US FAERS
2DizzinessFAERS: 53
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
3NauseaFAERS: 45
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
SIDER
US FAERS
4Blood potassium increasedFAERS: 39
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
5HeadacheFAERS: 3815949161CTD
SIDER
US FAERS
6FatigueFAERS: 34OFFSIDES
US FAERS
7AlopeciaFAERS: 32
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
8Product substitution issueFAERS: 28
Canada Vigilance: 2
Canada Vigilance
US FAERS
9MalaiseFAERS: 24SIDER
US FAERS
10Product use in unapproved indicationFAERS: 24
Canada Vigilance: 2
Canada Vigilance
US FAERS
11HypotensionFAERS: 23
Canada Vigilance: 1
Canada Vigilance
US FAERS
12PruritusFAERS: 23
Canada Vigilance: 5
Canada Vigilance
SIDER
US FAERS
13AstheniaFAERS: 22
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
14Breast tendernessFAERS: 22US FAERS
15VomitingFAERS: 22SIDER
US FAERS
16Drug ineffective for unapproved indicationFAERS: 21US FAERS
17UrticariaFAERS: 21
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
18HypersensitivityFAERS: 18SIDER
US FAERS
19Abdominal discomfortFAERS: 16
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
20Chest PainFAERS: 16
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
21Feeling abnormalFAERS: 16
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
22SomnolenceFAERS: 16
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
23Acute kidney injuryFAERS: 15US FAERS
24Nipple painFAERS: 15OFFSIDES
US FAERS
25Product use issueFAERS: 13US FAERS
26DehydrationFAERS: 12
Canada Vigilance: 1
4740303CTD
OFFSIDES
Canada Vigilance
US FAERS
27Drug dispensing errorFAERS: 12US FAERS
28SwellingFAERS: 12US FAERS
29Blood creatinine increasedFAERS: 10OFFSIDES
US FAERS
30DyspepsiaFAERS: 10
Canada Vigilance: 2
Canada Vigilance
US FAERS
31Product taste abnormalFAERS: 10US FAERS
32TachycardiaFAERS: 10US FAERS
33PainFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
34PalpitationsFAERS: 9
Canada Vigilance: 2
Canada Vigilance
US FAERS
35Product quality issueFAERS: 9
Canada Vigilance: 2
Canada Vigilance
US FAERS
36SyncopeFAERS: 9
Canada Vigilance: 2
Canada Vigilance
US FAERS
37TremorFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
38Abdominal PainFAERS: 8
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
39AcneFAERS: 8OFFSIDES
US FAERS
40AnxietyFAERS: 8
Canada Vigilance: 2
Canada Vigilance
US FAERS
41Back PainFAERS: 8US FAERS
42BradycardiaFAERS: 82126792CTD
OFFSIDES
US FAERS
43DysgeusiaFAERS: 8US FAERS
44Erectile dysfunctionFAERS: 84739107
22074142
CTD
SIDER
US FAERS
45Medication ErrorFAERS: 8US FAERS
46RetchingFAERS: 8US FAERS
47Unevaluable eventFAERS: 8US FAERS
48ArthralgiaFAERS: 7US FAERS
49Blood potassium decreasedFAERS: 7OFFSIDES
US FAERS
50Blood sodium decreasedFAERS: 7US FAERS
51Chest discomfortFAERS: 7US FAERS
52Electrolyte imbalanceFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
53Hepatic EncephalopathyFAERS: 7600713CTD
US FAERS
54NervousnessFAERS: 7US FAERS
55Burning sensationFAERS: 6US FAERS
56ErythemaFAERS: 6
Canada Vigilance: 2
Canada Vigilance
US FAERS
57PancreatitisFAERS: 6OFFSIDES
US FAERS
58PolyuriaFAERS: 6US FAERS
59ThrombocytopeniaFAERS: 6
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
60Vulvovaginal painFAERS: 6US FAERS
61Weight decreasedFAERS: 6US FAERS
62Acute cutaneous lupus erythematosusFAERS: 5US FAERS
63AscitesFAERS: 54951338
11356442
CTD
OFFSIDES
US FAERS
64Atrioventricular BlockFAERS: 5OFFSIDES
US FAERS
65Blood alkaline phosphatase increasedFAERS: 5OFFSIDES
US FAERS
66ChillsFAERS: 5US FAERS
67ConstipationFAERS: 5US FAERS
68DeafnessFAERS: 5US FAERS
69Diabetes MellitusFAERS: 5US FAERS
70DyspareuniaFAERS: 5US FAERS
71DysphoniaFAERS: 5US FAERS
72DysuriaFAERS: 5US FAERS
73Incorrect dose administeredFAERS: 5US FAERS
74InfarctionFAERS: 5US FAERS
75Intentional product use issueFAERS: 5US FAERS
76LethargyFAERS: 5SIDER
US FAERS
77MyalgiaFAERS: 5US FAERS
78PancytopeniaFAERS: 5US FAERS
79Therapeutic response unexpectedFAERS: 5US FAERS
80ThirstFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
81Urinary RetentionFAERS: 5US FAERS
82VertigoFAERS: 5US FAERS
83AgitationFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
84AgranulocytosisFAERS: 4SIDER
US FAERS
85Alanine Aminotransferase IncreasedFAERS: 4OFFSIDES
US FAERS
86Aspartate Aminotransferase IncreasedFAERS: 4US FAERS
87Blood aldosterone increasedFAERS: 4US FAERS
88Blood lactate dehydrogenase increasedFAERS: 4OFFSIDES
US FAERS
89Blood testosterone decreasedFAERS: 4OFFSIDES
US FAERS
90Bulbospinal muscular atrophy congenitalFAERS: 4US FAERS
91CellulitisFAERS: 4
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
92CholestasisFAERS: 4US FAERS
93CryingFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
94Drug effective for unapproved indicationFAERS: 4US FAERS
95FlushingFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
96HepatitisFAERS: 47305153
11488711
CTD
OFFSIDES
US FAERS
97Hormone level abnormalFAERS: 4US FAERS
98MastitisFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
99Maternal exposure during pregnancyFAERS: 4US FAERS
100Myocardial InfarctionFAERS: 417587755CTD
US FAERS
101NasopharyngitisFAERS: 4US FAERS
102NeutropeniaFAERS: 4US FAERS
103Oropharyngeal painFAERS: 4US FAERS
104Peripheral swellingFAERS: 4US FAERS
105Pharmaceutical product complaintFAERS: 4US FAERS
106Product formulation issueFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
107Product physical issueFAERS: 4US FAERS
108Urine output increasedFAERS: 4US FAERS
109AcidosisFAERS: 3OFFSIDES
US FAERS
110AngerFAERS: 3
Canada Vigilance: 2
Canada Vigilance
US FAERS
111Angina PectorisFAERS: 3US FAERS
112Blood glucose increasedFAERS: 3US FAERS
113Blood pressure inadequately controlledFAERS: 3US FAERS
114Blood thyroid stimulating hormone increasedFAERS: 3US FAERS
115Blood urea increasedFAERS: 3OFFSIDES
US FAERS
116Cardiac ArrestFAERS: 3US FAERS
117ChromaturiaFAERS: 3OFFSIDES
US FAERS
118Circumstance or information capable of leading to medication errorFAERS: 3US FAERS
119Disease ProgressionFAERS: 3OFFSIDES
US FAERS
120DisorientationFAERS: 3US FAERS
121Electrocardiogram T wave peakedFAERS: 3US FAERS
122Electrocardiogram abnormalFAERS: 3US FAERS
123EpistaxisFAERS: 3OFFSIDES
US FAERS
124Hepatic congestionFAERS: 3US FAERS
125HypophagiaFAERS: 3US FAERS
126Impaired work abilityFAERS: 3
Canada Vigilance: 2
Canada Vigilance
US FAERS
127Inappropriate schedule of drug administrationFAERS: 3US FAERS
128Joint swellingFAERS: 3US FAERS
129LeukocytosisFAERS: 3US FAERS
130Limb discomfortFAERS: 3US FAERS
131Lupus-like syndromeFAERS: 3US FAERS
132Mental status changesFAERS: 3OFFSIDES
US FAERS
133Metabolic acidosisFAERS: 3US FAERS
134OsteoporosisFAERS: 3US FAERS
135Pre-existing condition improvedFAERS: 3US FAERS
136Product dispensing errorFAERS: 3US FAERS
137Rash erythematousFAERS: 3SIDER
US FAERS
138Reaction to drug excipientsFAERS: 3US FAERS
139Renin increasedFAERS: 3US FAERS
140Skin lesionFAERS: 3OFFSIDES
US FAERS
141Stevens-Johnson SyndromeFAERS: 325811541CTD
OFFSIDES
SIDER
US FAERS
142Throat irritationFAERS: 3US FAERS
143Wrong technique in product usage processFAERS: 3US FAERS
144nervous system disorderFAERS: 3US FAERS
145AbasiaFAERS: 2US FAERS
146Accidental overdoseFAERS: 2US FAERS
147Activities of daily living impairedFAERS: 2OFFSIDES
US FAERS
148AmnesiaFAERS: 2US FAERS
149AngioedemaFAERS: 2US FAERS
150AphoniaFAERS: 2US FAERS
151Atrial FibrillationFAERS: 220082611CTD
US FAERS
152Blood cortisol increasedFAERS: 2US FAERS
153Blood magnesium decreasedFAERS: 2US FAERS
154Blood sodium increasedFAERS: 2US FAERS
155Blood testosterone increasedFAERS: 2US FAERS
156Breast discomfortFAERS: 2US FAERS
157BronchitisFAERS: 2OFFSIDES
US FAERS
158CataractFAERS: 2OFFSIDES
US FAERS
159Cerebrovascular accidentFAERS: 2US FAERS
160CystFAERS: 2
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
161Depressed Level of ConsciousnessFAERS: 2US FAERS
162DiverticulitisFAERS: 2OFFSIDES
US FAERS
163Drug effect incompleteFAERS: 2US FAERS
164Dry skinFAERS: 2OFFSIDES
US FAERS
165Ear discomfortFAERS: 2US FAERS
166Embolic strokeFAERS: 2OFFSIDES
US FAERS
167Emotional distressFAERS: 2
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
168Eye painFAERS: 2US FAERS
169Feeling ColdFAERS: 2US FAERS
170Female sexual arousal disorderFAERS: 2US FAERS
171FlatulenceFAERS: 2US FAERS
172Gamma-Glutamyltransferase IncreasedFAERS: 2OFFSIDES
US FAERS
173General physical health deteriorationFAERS: 2US FAERS
174Gonadal DysgenesisFAERS: 2US FAERS
175GoutFAERS: 2OFFSIDES
US FAERS
176HyperaldosteronismFAERS: 2

View details

CTD
US FAERS
177HypokinesiaFAERS: 2US FAERS
178Intentional product misuseFAERS: 2US FAERS
179Lip swellingFAERS: 2US FAERS
180Medication residue presentFAERS: 2US FAERS
181Neonatal disorderFAERS: 2US FAERS
182Nephrotic SyndromeFAERS: 2US FAERS
183Ocular discomfortFAERS: 2US FAERS
184Oral painFAERS: 2US FAERS
185OverdoseFAERS: 2US FAERS
186PemphigusFAERS: 2US FAERS
187Pericardial effusionFAERS: 2OFFSIDES
US FAERS
188PneumoniaFAERS: 2US FAERS
189Post-Traumatic Stress DisorderFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
190PresyncopeFAERS: 2US FAERS
191Pulmonary HypertensionFAERS: 2OFFSIDES
US FAERS
192Renal painFAERS: 2US FAERS
193RestlessnessFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
194RhabdomyolysisFAERS: 2OFFSIDES
US FAERS
195SinusitisFAERS: 2US FAERS
196Skin UlcerFAERS: 2US FAERS
197SneezingFAERS: 2US FAERS
198Suicide attemptFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
199Suspected counterfeit productFAERS: 2US FAERS
200Terminal stateFAERS: 2US FAERS
201Therapy non-responderFAERS: 2US FAERS
202TinnitusFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
203Toxic Epidermal NecrolysisFAERS: 2SIDER
US FAERS
204Toxicity to various agentsFAERS: 2US FAERS
205Urinary IncontinenceFAERS: 2US FAERS
206Urinary tract infectionFAERS: 2US FAERS
207VIIth nerve paralysisFAERS: 2US FAERS
208Vascular purpuraFAERS: 2US FAERS
209Visual ImpairmentFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
210Vulvovaginal discomfortFAERS: 2US FAERS
211WheezingFAERS: 2US FAERS
212jaundiceFAERS: 2US FAERS
213Abdominal rigidityFAERS: 1US FAERS
214AbscessFAERS: 1US FAERS
215Accidental exposureFAERS: 1US FAERS
216Adverse eventFAERS: 1OFFSIDES
US FAERS
217Altered state of consciousnessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
218Amniotic fluid volume decreasedFAERS: 1US FAERS
219Anal abscessFAERS: 1US FAERS
220Androgen receptor gene overexpressionFAERS: 1US FAERS
221Androgenetic AlopeciaFAERS: 1US FAERS
222AnorexiaFAERS: 1OFFSIDES
US FAERS
223AnuriaFAERS: 1OFFSIDES
US FAERS
224AphagiaFAERS: 1US FAERS
225Apparent deathFAERS: 1OFFSIDES
US FAERS
226Arterial InjuryFAERS: 1US FAERS
227AsthmaFAERS: 1OFFSIDES
US FAERS
228AtaxiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
229AzoospermiaFAERS: 1US FAERS
230B-cell lymphoma stage IFAERS: 1US FAERS
231Benign neoplasm of thyroid glandFAERS: 1US FAERS
232Bipolar DisorderFAERS: 1US FAERS
233BlepharospasmFAERS: 1US FAERS
234BlindnessFAERS: 1US FAERS
235Blood albumin decreasedFAERS: 1US FAERS
236Blood bilirubin unconjugated increasedFAERS: 1US FAERS
237Blood cholesterol increasedFAERS: 1US FAERS
238Blood creatinine decreasedFAERS: 1US FAERS
239Blood follicle stimulating hormone increasedFAERS: 1US FAERS
240Blood potassium abnormalFAERS: 1US FAERS
241Blood triglycerides increasedFAERS: 1US FAERS
242Bone painFAERS: 1OFFSIDES
US FAERS
243Breast CystFAERS: 1US FAERS
244Breast engorgementFAERS: 1US FAERS
245Bunion operationFAERS: 1US FAERS
246Calcium deficiencyFAERS: 1US FAERS
247Carbon dioxide increasedFAERS: 1US FAERS
248Cerebral calcificationFAERS: 1US FAERS
249Cervical myelopathyFAERS: 1US FAERS
250Cervical polypFAERS: 1US FAERS
251CholelithiasisFAERS: 1US FAERS
252ColitisFAERS: 1US FAERS
253Contraindicated drug administeredFAERS: 1US FAERS
254Counterfeit product administeredFAERS: 1US FAERS
255Deep Vein ThrombosisFAERS: 1US FAERS
256DeformityFAERS: 1US FAERS
257DeliriumFAERS: 1US FAERS
258DementiaFAERS: 1US FAERS
259Depressed moodFAERS: 1US FAERS
260Depression suicidalFAERS: 1US FAERS
261Device malfunctionFAERS: 1US FAERS
262Diabetic FootFAERS: 1US FAERS
263DiplopiaFAERS: 1US FAERS
264DisabilityFAERS: 1US FAERS
265DiscomfortFAERS: 1SIDER
US FAERS
266Disturbance in sexual arousalFAERS: 1US FAERS
267Drug ToleranceFAERS: 1US FAERS
268Drug administration errorFAERS: 1US FAERS
269Drug dispensed to wrong patientFAERS: 1US FAERS
270Drug dose omissionFAERS: 1US FAERS
271Drug exposure during pregnancyFAERS: 1US FAERS
272Drug prescribing errorFAERS: 1US FAERS
273Drug withdrawal headacheFAERS: 1US FAERS
274Drug withdrawal syndromeFAERS: 1US FAERS
275DysarthriaFAERS: 1US FAERS
276EclampsiaFAERS: 1US FAERS
277EczemaFAERS: 1OFFSIDES
US FAERS
278Electrocardiogram changeFAERS: 1OFFSIDES
US FAERS
279EmbolismFAERS: 1OFFSIDES
US FAERS
280Endometrial hypertrophyFAERS: 1US FAERS
281Endometriosis maleFAERS: 1US FAERS
282EosinophiliaFAERS: 1SIDER
US FAERS
283Epigastric discomfortFAERS: 1US FAERS
284EpilepsyFAERS: 1US FAERS
285ErysipelasFAERS: 1US FAERS
286Erythema MultiformeFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
287Exfoliative rashFAERS: 1US FAERS
288Eye irritationFAERS: 1US FAERS
289Facial ParesisFAERS: 1US FAERS
290Familial Periodic ParalysisFAERS: 1US FAERS
291Fat redistributionFAERS: 1US FAERS
292Feeling jitteryFAERS: 1US FAERS
293Fibrin D dimer increasedFAERS: 1US FAERS
294Flank PainFAERS: 1US FAERS
295Food AllergyFAERS: 1US FAERS
296FormicationFAERS: 1US FAERS
297Gastric FistulaFAERS: 1US FAERS
298Gastric ulcerFAERS: 1US FAERS
299GastritisFAERS: 1SIDER
US FAERS
300General physical condition abnormalFAERS: 1US FAERS
301Gingival HyperplasiaFAERS: 1US FAERS
302Gluten sensitivityFAERS: 1US FAERS
303Granulomatosis with polyangiitisFAERS: 1US FAERS
304Head titubationFAERS: 1US FAERS
305HepatotoxicityFAERS: 1OFFSIDES
US FAERS
306Hip surgeryFAERS: 1US FAERS
307HirsutismFAERS: 1
Canada Vigilance: 3
Canada Vigilance
US FAERS
308HostilityFAERS: 1US FAERS
309HungerFAERS: 1US FAERS
310HypercalciuriaFAERS: 13411401
4558012
CTD
US FAERS
311HypersomniaFAERS: 1US FAERS
312Hypothalamo-pituitary disorderFAERS: 1US FAERS
313HypothyroidismFAERS: 1US FAERS
314HysterectomyFAERS: 1US FAERS
315Iatrogenic injuryFAERS: 1US FAERS
316Idiopathic angioedemaFAERS: 1US FAERS
317Idiopathic urticariaFAERS: 1US FAERS
318Impaired driving abilityFAERS: 1US FAERS
319IncontinenceFAERS: 1US FAERS
320InflammationFAERS: 1US FAERS
321Intercepted drug administration errorFAERS: 1US FAERS
322LaryngitisFAERS: 1US FAERS
323Leukocytoclastic vasculitisFAERS: 1US FAERS
324LeukopeniaFAERS: 1SIDER
US FAERS
325Limb injuryFAERS: 1OFFSIDES
US FAERS
326Limb operationFAERS: 1US FAERS
327Loss of personal independence in daily activitiesFAERS: 1US FAERS
328Lower respiratory tract infectionFAERS: 1US FAERS
329Magnesium DeficiencyFAERS: 1US FAERS
330Medication residueFAERS: 1US FAERS
331Memory impairmentFAERS: 1US FAERS
332MeningiomaFAERS: 1US FAERS
333MenopauseFAERS: 1US FAERS
334MenorrhagiaFAERS: 1US FAERS
335Menstrual discomfortFAERS: 1US FAERS
336Mental impairmentFAERS: 1US FAERS
337Metabolic alkalosisFAERS: 1US FAERS
338Microvascular AnginaFAERS: 1US FAERS
339Middle insomniaFAERS: 1US FAERS
340Mixed Connective Tissue DiseaseFAERS: 1US FAERS
341Mood swingsFAERS: 1US FAERS
342Muscle FatigueFAERS: 1OFFSIDES
US FAERS
343Muscular DystrophyFAERS: 1US FAERS
344Musculoskeletal PainFAERS: 1OFFSIDES
US FAERS
345Musculoskeletal chest painFAERS: 1OFFSIDES
US FAERS
346Myasthenic SyndromeFAERS: 1US FAERS
347MyocarditisFAERS: 1US FAERS
348MyotoniaFAERS: 1US FAERS
349Nasal discomfortFAERS: 1US FAERS
350NephrocalcinosisFAERS: 1US FAERS
351NephrolithiasisFAERS: 1US FAERS
352No adverse effectFAERS: 1US FAERS
353No adverse eventFAERS: 1US FAERS
354NocturiaFAERS: 1US FAERS
355Oral mucosal eruptionFAERS: 1US FAERS
356Oral pruritusFAERS: 1US FAERS
357OsteomalaciaFAERS: 1US FAERS
358OsteopeniaFAERS: 1OFFSIDES
US FAERS
359Pain of skinFAERS: 1US FAERS
360PapuleFAERS: 1US FAERS
361ParanoiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
362Penile size reducedFAERS: 1US FAERS
363Penoscrotal fusionFAERS: 1US FAERS
364PericarditisFAERS: 1US FAERS
365Personality ChangeFAERS: 1US FAERS
366PetechiaeFAERS: 1US FAERS
367PolydipsiaFAERS: 1US FAERS
368Poor quality drug administeredFAERS: 1US FAERS
369Post procedural complicationFAERS: 1US FAERS
370Pre-EclampsiaFAERS: 1US FAERS
371Pregnancy test false positiveFAERS: 1US FAERS
372Premature MenopauseFAERS: 1US FAERS
373Prescribed overdoseFAERS: 1OFFSIDES
US FAERS
374Procedural site reactionFAERS: 1US FAERS
375Product coating issueFAERS: 1US FAERS
376Product dose omissionFAERS: 1US FAERS
377Product outer packaging issueFAERS: 1US FAERS
378Product substitutionFAERS: 1US FAERS
379Product use complaintFAERS: 1US FAERS
380Protein total decreasedFAERS: 1OFFSIDES
US FAERS
381Protein-losing gastroenteropathyFAERS: 1US FAERS
382PrurigoFAERS: 1US FAERS
383Pulmonary congestionFAERS: 1OFFSIDES
US FAERS
384PurpuraFAERS: 1US FAERS
385Reaction to excipientFAERS: 1US FAERS
386Renal tubular acidosisFAERS: 1US FAERS
387Respiratory distressFAERS: 1US FAERS
388Secondary sexual characteristics absenceFAERS: 1US FAERS
389SepsisFAERS: 1US FAERS
390Serum sickness-like reactionFAERS: 1US FAERS
391Sexual DysfunctionFAERS: 1US FAERS
392ShockFAERS: 1US FAERS
393Similar reaction on previous exposure to drugFAERS: 1US FAERS
394Sinoatrial BlockFAERS: 1US FAERS
395Skin WrinklingFAERS: 1US FAERS
396Skin irritationFAERS: 1US FAERS
397Skin reactionFAERS: 1US FAERS
398SluggishnessFAERS: 1US FAERS
399Spinal Muscular AtrophyFAERS: 1US FAERS
400StomatitisFAERS: 1US FAERS
401Sudden Cardiac DeathFAERS: 1US FAERS
402Sudden deathFAERS: 1US FAERS
403Suprapubic painFAERS: 1US FAERS
404Swelling of eyelidFAERS: 1US FAERS
405TetanyFAERS: 1US FAERS
406ThrombosisFAERS: 1US FAERS
407Tongue discomfortFAERS: 1US FAERS
408Tongue eruptionFAERS: 1US FAERS
409Ubiquinone decreasedFAERS: 1US FAERS
410UlcerFAERS: 1OFFSIDES
SIDER
US FAERS
411Unresponsive to stimuliFAERS: 1US FAERS
412Uterine PolypFAERS: 1US FAERS
413Vaginal hyperplasiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
414Venous occlusionFAERS: 1US FAERS
415VestibulitisFAERS: 1US FAERS
416Visual disturbanceFAERS: 1US FAERS
417Vulvovaginal mycotic infectionFAERS: 1US FAERS
418White blood cell count decreasedFAERS: 1US FAERS
419Wrong drug administeredFAERS: 1US FAERS
420Wrong technique in drug usage processFAERS: 1US FAERS
421treatment failureFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
422Abnormal cervical smearOFFSIDES
423AcanthosisOFFSIDES
424Acid refluxOFFSIDES
425Acne Vulgaris15752283CTD
426Acute bronchitisOFFSIDES
427Acute myocardial infarctionOFFSIDES
428Acute respiratory failureOFFSIDES
429Adrenal massOFFSIDES
430AgoraphobiaOFFSIDES
431Alopecia totalisOFFSIDES
432AmblyopiaOFFSIDES
433Ammonia increasedOFFSIDES
434Anaphylactic shockSIDER
435AndropauseOFFSIDES
436AngiolipomaOFFSIDES
437Anoxic EncephalopathyOFFSIDES
438Application site erythemaOFFSIDES
439Application site inflammationOFFSIDES
440ArteriosclerosisOFFSIDES
441ArthritisOFFSIDES
442Aspiration PneumoniaOFFSIDES
443AtelectasisOFFSIDES
444Atrial FlutterOFFSIDES
445Atrophic vulvovaginitisCanada Vigilance: 1Canada Vigilance
446Autistic Disorder17150311CTD
447Autoimmune thyroiditisOFFSIDES
448AutomatismOFFSIDES
449Bacteria sputum identifiedOFFSIDES
450Bacteria tissue specimen identifiedOFFSIDES
451Bacterial test positiveOFFSIDES
452Basal cell carcinomaOFFSIDES
453Bilirubin conjugated increasedOFFSIDES
454Biopsy bone abnormalOFFSIDES
455Biopsy mucosa abnormalOFFSIDES
456Blood GlucoseOFFSIDES
457Blood albumin abnormalOFFSIDES
458Blood bicarbonate abnormalOFFSIDES
459Blood count abnormalOFFSIDES
460Blood creatine phosphokinase increasedCanada Vigilance: 1Canada Vigilance
OFFSIDES
461Blood glucose decreasedOFFSIDES
462Blood iron decreasedOFFSIDES
463Blood iron increasedOFFSIDES
464Blood osmolarity increasedOFFSIDES
465Blood phosphorus increasedOFFSIDES
466Blood potassiumOFFSIDES
467Blood sodium abnormalOFFSIDES
468Blood sodiumOFFSIDES
469Blood thyroid stimulating hormone abnormalOFFSIDES
470Blood trypsin increasedOFFSIDES
471Blood urea abnormalOFFSIDES
472Blood uric acid decreasedOFFSIDES
473Blood uric acidOFFSIDES
474Blood urine presentOFFSIDES
475Blurred visionOFFSIDES
476Body TemperatureOFFSIDES
477Body temperature fluctuationOFFSIDES
478Bone SarcomaOFFSIDES
479Bone density decreasedOFFSIDES
480Bone trimmingOFFSIDES
481Brain natriuretic peptide increasedOFFSIDES
482Breakthrough PainOFFSIDES
483Bronchoalveolar LavageOFFSIDES
484BronchopneumoniaOFFSIDES
485CalciphylaxisOFFSIDES
486Cardiac TamponadeOFFSIDES
487Cardiac valve vegetationOFFSIDES
488Cardiomegaly11592866CTD
489Cardiomyopathies4909201
15741423
CTD
490Cardiomyopathy, Dilated16275882
18628775
CTD
491Cardiovascular Diseases11230374CTD
492Catheter related complicationOFFSIDES
493CausalgiaOFFSIDES
494CheilitisOFFSIDES
495Chemical and Drug Induced Liver Injury11488711CTD
496Chemotherapeutic drug level increasedOFFSIDES
497Choking sensationOFFSIDES
498ChokingOFFSIDES
499CholangiolitisOFFSIDES
500Chronic Obstructive Airway DiseaseOFFSIDES
501Chronic active hepatitisOFFSIDES
502CirrhosisOFFSIDES
503Clostridium difficile colitisOFFSIDES
504Coagulation factor VIII level increasedOFFSIDES
505Cocaine-Related Disorders19799583CTD
506Cognition Disorders9130285CTD
507ConfabulationOFFSIDES
508Congenital hypertrichosisOFFSIDES
509Congenital tricuspid valve incompetenceOFFSIDES
510Contralateral breast cancerOFFSIDES
511Cramps of lower extremitiesSIDER
512Crossmatch incompatibleOFFSIDES
513Cytolytic hepatitisOFFSIDES
514Deafness NeurosensoryCanada Vigilance: 2Canada Vigilance
OFFSIDES
515Depressive disorder15949161CTD
516DermatitisSIDER
517Device related infectionOFFSIDES
518DiabetesOFFSIDES
519Diabetic NephropathyOFFSIDES
520Diabetic RetinopathyOFFSIDES
521Diarrhea11250985
24101390
CTD
522Diastolic dysfunctionOFFSIDES
523Disease recurrenceOFFSIDES
524Disseminated Intravascular CoagulationOFFSIDES
525DiverticulosisOFFSIDES
526DrowsinessOFFSIDES
SIDER
527Drug diversionOFFSIDES
528Drug toxicityOFFSIDES
529Dry gangreneOFFSIDES
530DuodenitisOFFSIDES
531Dyslipidemias31295448CTD
532Edema2126792CTD
533Electrocardiogram QT corrected interval shortenedOFFSIDES
534Electromechanical dissociationOFFSIDES
535EncephalomalaciaOFFSIDES
536EndocarditisOFFSIDES
537Enterocutaneous FistulaOFFSIDES
538EpidermolysisOFFSIDES
539Erosive gastritisOFFSIDES
540Escherichia urinary tract infectionOFFSIDES
541Factor V Leiden mutationOFFSIDES
542Fat necrosisOFFSIDES
543Fatty LiverOFFSIDES
544Feelings of worthlessnessOFFSIDES
545Fibrosis11592866CTD
546Flight of ideasOFFSIDES
547Gallop rhythm presentOFFSIDES
548GangreneOFFSIDES
549Gastric Antral Vascular EctasiaOFFSIDES
550GastroenteritisOFFSIDES
551Gastrointestinal Diseases4740303CTD
552Genital swellingOFFSIDES
553GlobulinuriaOFFSIDES
554Glomerulonephritis, Membranoproliferative16928621CTD
555GoiterOFFSIDES
556GranulocytosisOFFSIDES
557Gynecomastia

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CTD
558Haptoglobin DecreasedOFFSIDES
559Heart Diseases10888242
17984673
19913415
CTD
560Heart failure

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CTD
561Heparin-induced thrombocytopeniaOFFSIDES
562Hyperammonemia600713CTD
563Hyperkalemia

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CTD
564Hypernatremia10100081CTD
565HyperparathyroidismOFFSIDES
566Hypertensive heart diseaseOFFSIDES
567HypertrichosisSIDER
568Hypokalemia

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CTD
569Hypokalemic periodic paralysis19822448CTD
570Hyponatremia4740303CTD
571Hypoxia20228418
21263376
CTD
OFFSIDES
572Impaired gastric emptyingOFFSIDES
573Incorrect route of product administrationCanada Vigilance: 1Canada Vigilance
574InfectionOFFSIDES
575Insulin Resistance31295448CTD
576Intervertebral disc disorderOFFSIDES
577Intraocular pressure testOFFSIDES
578Joint sprainOFFSIDES
579Joint stiffnessOFFSIDES
580Kidney Cortex Necrosis15245572CTD
581Kidney Diseases1064790
11776407
17984673
CTD
582Kidney FailureOFFSIDES
583Leukopenia neonatalOFFSIDES
584Ligament ruptureOFFSIDES
585Liver Cirrhosis25204689CTD
586Liver neoplasms25058030CTD
587Lumbar radiculopathyOFFSIDES
588Lung AbscessOFFSIDES
589Lung InjuryOFFSIDES
590Lymph nodes scan abnormalOFFSIDES
591Lymphangiosis carcinomatosaOFFSIDES
592LymphangitisOFFSIDES
593LymphedemaOFFSIDES
594Lymphocyte stimulation test positiveOFFSIDES
595Mastication disorderOFFSIDES
596Menstruation Disturbances22074142CTD
597Mesenteric arteriosclerosisOFFSIDES
598MetamorphopsiaOFFSIDES
599MetrorrhagiaCanada Vigilance: 1Canada Vigilance
600MoaningOFFSIDES
601MonoplegiaOFFSIDES
602Mouth BreathingOFFSIDES
603Multiple MyelomaOFFSIDES
604MyelodysplasiaOFFSIDES
605Neuralgia20846523CTD
606Neuroleptic Malignant SyndromeOFFSIDES
607Neurologic Manifestations4740303CTD
608Nodal osteoarthritisOFFSIDES
609Nodule on extremityOFFSIDES
610NoduleOFFSIDES
611Obesity, Abdominal31295448CTD
612Ocular icterusOFFSIDES
613OliguriaOFFSIDES
614Oral torusOFFSIDES
615Oropharyngeal blisteringOFFSIDES
616OrthopneaOFFSIDES
617OsteomyelitisOFFSIDES
618PROTHROMBIN TIMEOFFSIDES
619PallorOFFSIDES
620Pancreatic InsufficiencyOFFSIDES
621Peptic Ulcer5569832CTD
622PhlebitisOFFSIDES
623PhonophobiaOFFSIDES
624Platelet count abnormalOFFSIDES
625Polycystic Ovary Syndrome31295448CTD
626Portal Vein ThrombosisOFFSIDES
627Portal hypertensive gastropathyOFFSIDES
628Positron emission tomogram abnormalOFFSIDES
629Postoperative wound complicationOFFSIDES
630Preventive surgeryOFFSIDES
631Primary sequestrumOFFSIDES
632Propofol Infusion SyndromeOFFSIDES
633Protein total abnormalOFFSIDES
634Proteinuria15983956
18382267
21135038
CTD
635Prothrombin level decreasedOFFSIDES
636Quadriplegia2993981CTD
637Rectal ProlapseOFFSIDES
638Refusal of treatment by relativeOFFSIDES
639Renal Insufficiency15632880CTD
640Renal tubular disorderOFFSIDES
641Renal tubular necrosisOFFSIDES
642Respiratory FailureOFFSIDES
643Retinal Vascular DisorderOFFSIDES
644Retroperitoneal infectionOFFSIDES
645Rheumatoid NoduleOFFSIDES
646ScreamingOFFSIDES
647Seizures5569832CTD
648Semen abnormalSIDER
649Semen analysis abnormalSIDER
650Septic embolusOFFSIDES
651Serratia sepsisOFFSIDES
652Shunt occlusionOFFSIDES
653Sick Sinus SyndromeOFFSIDES
654Sinus headacheOFFSIDES
655Sleep Apnea, Obstructive20016520CTD
656Spleen scan abnormalOFFSIDES
657SpondylolisthesisOFFSIDES
658Subcutaneous AbscessOFFSIDES
659Subcutaneous noduleOFFSIDES
660SubileusOFFSIDES
661Substance Withdrawal Syndrome25308750CTD
662Superficial ThrombophlebitisOFFSIDES
663Synovial CystOFFSIDES
664Temperature intoleranceOFFSIDES
665Therapy regimen changedOFFSIDES
666Thoracic Outlet SyndromeOFFSIDES
667ThrombophlebitisOFFSIDES
668Tooth ExtractionOFFSIDES
669Tooth LossOFFSIDES
670TracheobronchitisOFFSIDES
671Transfusion ReactionOFFSIDES
672Vaginal DischargeCanada Vigilance: 1Canada Vigilance
673Vascular Diseases15496307CTD
674VasculitisCanada Vigilance: 1Canada Vigilance
SIDER
675Venoocclusive diseaseOFFSIDES
676Venous InsufficiencyOFFSIDES
677Venous stasisOFFSIDES
678Venous thrombosis limbOFFSIDES
679Ventricular Dysfunction, Left11300427
14725033
CTD
680Ventricular FibrillationOFFSIDES
681Ventricular Remodeling17079761CTD
682Ventriculoperitoneal shunt malfunctionOFFSIDES
683Von Willebrand's factor antigen increasedOFFSIDES
684Weight Gain31295448CTD
OFFSIDES
685Wound ComplicationOFFSIDES
686colonoscopyOFFSIDES
687keratoacanthomaOFFSIDES
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