MetaADEDB 2.0 @ LMMD
brexpiprazole
(ZKIAIYBUSXZPLP-UHFFFAOYSA-N)
Structure
SMILES
O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2
Type(s)
Approved; Investigational
ATC code(s)
N05AX16
Molecular Formula:
C25H27N3O2S
Molecular Weight:
433.566
Log P:
4.7269
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
76.81
CAS Number(s):
913611-97-9
Synonym(s)
1.
brexpiprazole
2.
7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one
External Link(s)
MeSHC000591922
PubChem Compound11978813
BindingDB194780
ChEBI134716
CHEMBLCHEMBL2105760
DrugBankDB09128
DrugCentral5014
IUPHAR/BPS Guide to PHARMACOLOGY7672
KEGGdr:D10309
Therapeutic Target DatabaseD0P0OU
ZINC84758479
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AkathisiaFAERS: 233
Canada Vigilance: 1
Canada Vigilance
US FAERS
2Drug ineffectiveFAERS: 102
Canada Vigilance: 1
Canada Vigilance
US FAERS
3No adverse eventFAERS: 99US FAERS
4Product use in unapproved indicationFAERS: 75
Canada Vigilance: 1
Canada Vigilance
US FAERS
5AnxietyFAERS: 70US FAERS
6Drug administered to patient of inappropriate ageFAERS: 68US FAERS
7TremorFAERS: 67US FAERS
8Tardive DyskinesiaFAERS: 66US FAERS
9Feeling abnormalFAERS: 64US FAERS
10NauseaFAERS: 63US FAERS
11HeadacheFAERS: 58US FAERS
12Incorrect dose administeredFAERS: 57
Canada Vigilance: 2
Canada Vigilance
US FAERS
13RestlessnessFAERS: 51US FAERS
14FatigueFAERS: 49US FAERS
15DizzinessFAERS: 44US FAERS
16Wrong technique in product usage processFAERS: 44US FAERS
17Adverse eventFAERS: 43
Canada Vigilance: 1
Canada Vigilance
US FAERS
18Drug dose omissionFAERS: 43US FAERS
19AgitationFAERS: 37
Canada Vigilance: 1
Canada Vigilance
US FAERS
20Product use issueFAERS: 34US FAERS
21Blood glucose increasedFAERS: 33US FAERS
22Inability to afford medicationFAERS: 29US FAERS
23Drug effect incompleteFAERS: 28US FAERS
24SomnolenceFAERS: 26US FAERS
25MalaiseFAERS: 25US FAERS
26Therapy cessationFAERS: 25US FAERS
27DystoniaFAERS: 23US FAERS
28VomitingFAERS: 20US FAERS
29HypersensitivityFAERS: 19
Canada Vigilance: 1
Canada Vigilance
US FAERS
30PruritusFAERS: 18US FAERS
31Abdominal discomfortFAERS: 17US FAERS
32AngerFAERS: 17US FAERS
33HungerFAERS: 17US FAERS
34Peripheral swellingFAERS: 17US FAERS
35Drug prescribing errorFAERS: 16US FAERS
36Food cravingFAERS: 16US FAERS
37PalpitationsFAERS: 16US FAERS
38ArthralgiaFAERS: 15US FAERS
39Disease recurrenceFAERS: 15US FAERS
40UrticariaFAERS: 15
Canada Vigilance: 1
Canada Vigilance
US FAERS
41MyalgiaFAERS: 14US FAERS
42Completed SuicideFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
43DysarthriaFAERS: 13US FAERS
44OverdoseFAERS: 13US FAERS
45PainFAERS: 13US FAERS
46Restless Legs SyndromeFAERS: 13US FAERS
47StressFAERS: 13US FAERS
48Therapeutic response unexpectedFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
49ConstipationFAERS: 12US FAERS
50Musculoskeletal stiffnessFAERS: 12US FAERS
51NervousnessFAERS: 12US FAERS
52SchizophreniaFAERS: 12US FAERS
53Chest PainFAERS: 11US FAERS
54HyperphagiaFAERS: 11US FAERS
55Memory impairmentFAERS: 11US FAERS
56Weight decreasedFAERS: 11US FAERS
57CryingFAERS: 10US FAERS
58Drug ineffective for unapproved indicationFAERS: 10US FAERS
59Feeling jitteryFAERS: 10US FAERS
60Unevaluable eventFAERS: 10US FAERS
61AstheniaFAERS: 9US FAERS
62Cerebrovascular accidentFAERS: 9US FAERS
63GamblingFAERS: 9US FAERS
64Neuroleptic Malignant SyndromeFAERS: 9US FAERS
65Compulsive shoppingFAERS: 8US FAERS
66HypersomniaFAERS: 8US FAERS
67HypomaniaFAERS: 8US FAERS
68Inappropriate schedule of drug administrationFAERS: 8US FAERS
69Muscle tightnessFAERS: 8US FAERS
70SwellingFAERS: 8US FAERS
71AlopeciaFAERS: 7US FAERS
72Bipolar DisorderFAERS: 7US FAERS
73Chest discomfortFAERS: 7US FAERS
74Drug effective for unapproved indicationFAERS: 7US FAERS
75HypotensionFAERS: 7US FAERS
76ParanoiaFAERS: 7US FAERS
77RhabdomyolysisFAERS: 7US FAERS
78SyncopeFAERS: 7US FAERS
79Urinary RetentionFAERS: 7US FAERS
80AmnesiaFAERS: 6US FAERS
81Depressed moodFAERS: 6US FAERS
82DisabilityFAERS: 6US FAERS
83Euphoric moodFAERS: 6US FAERS
84Lip swellingFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
85Maternal exposure during pregnancyFAERS: 6US FAERS
86Product packaging quantity issueFAERS: 6US FAERS
87TachycardiaFAERS: 6US FAERS
88ThirstFAERS: 6US FAERS
89AngioedemaFAERS: 5US FAERS
90AphasiaFAERS: 5US FAERS
91Blood cholesterol increasedFAERS: 5US FAERS
92Blood prolactin increasedFAERS: 5US FAERS
93Blood triglycerides increasedFAERS: 5US FAERS
94DroolingFAERS: 5US FAERS
95ErythemaFAERS: 5US FAERS
96Flat affectFAERS: 5US FAERS
97Impaired driving abilityFAERS: 5US FAERS
98Intentional self-injuryFAERS: 5US FAERS
99Joint swellingFAERS: 5US FAERS
100LethargyFAERS: 5US FAERS
101Suicide attemptFAERS: 5US FAERS
102TrismusFAERS: 5US FAERS
103AbasiaFAERS: 4US FAERS
104Accidental exposure to productFAERS: 4US FAERS
105Activities of daily living impairedFAERS: 4US FAERS
106ApathyFAERS: 4US FAERS
107BlepharospasmFAERS: 4US FAERS
108BruxismFAERS: 4US FAERS
109DehydrationFAERS: 4US FAERS
110Diabetes MellitusFAERS: 4US FAERS
111Drug abuseFAERS: 4US FAERS
112Drug titration errorFAERS: 4US FAERS
113DysphoniaFAERS: 4US FAERS
114Emotional disorderFAERS: 4US FAERS
115Emotional distressFAERS: 4US FAERS
116Enlarged uvulaFAERS: 4US FAERS
117EpistaxisFAERS: 4US FAERS
118Facial paralysisFAERS: 4US FAERS
119Impaired work abilityFAERS: 4US FAERS
120InfectionFAERS: 4US FAERS
121Insurance issueFAERS: 4US FAERS
122Muscle RigidityFAERS: 4US FAERS
123Oculogyric crisisFAERS: 4US FAERS
124Prescribed overdoseFAERS: 4US FAERS
125Product quality issueFAERS: 4US FAERS
126Product taste abnormalFAERS: 4US FAERS
127Psychiatric decompensationFAERS: 4US FAERS
128Serotonin SyndromeFAERS: 4US FAERS
129SomnambulismFAERS: 4US FAERS
130Tongue movement disturbanceFAERS: 4US FAERS
131Visual ImpairmentFAERS: 4US FAERS
132Abdominal PainFAERS: 3US FAERS
133Accidental overdoseFAERS: 3US FAERS
134AsthmaFAERS: 3US FAERS
135Blood creatine phosphokinase increasedFAERS: 3US FAERS
136Blood glucose abnormalFAERS: 3US FAERS
137BronchitisFAERS: 3US FAERS
138Depressed Level of ConsciousnessFAERS: 3US FAERS
139DiplopiaFAERS: 3US FAERS
140DisorientationFAERS: 3US FAERS
141Drug dose titration not performedFAERS: 3US FAERS
142DysgraphiaFAERS: 3US FAERS
143DyspepsiaFAERS: 3US FAERS
144HostilityFAERS: 3US FAERS
145Limb discomfortFAERS: 3US FAERS
146Mood swingsFAERS: 3US FAERS
147Myocardial InfarctionFAERS: 3US FAERS
148Night sweatsFAERS: 3US FAERS
149Nuchal RigidityFAERS: 3US FAERS
150Obsessive thoughtsFAERS: 3US FAERS
151Oromandibular dystoniaFAERS: 3US FAERS
152Poor quality sleepFAERS: 3US FAERS
153Prescribed underdoseFAERS: 3US FAERS
154Product dose omissionFAERS: 3US FAERS
155TensionFAERS: 3US FAERS
156Urinary IncontinenceFAERS: 3US FAERS
157Urinary tract infectionFAERS: 3US FAERS
158VertigoFAERS: 3US FAERS
159WheezingFAERS: 3US FAERS
160AcneFAERS: 2US FAERS
161Alanine Aminotransferase IncreasedFAERS: 2US FAERS
162Aspartate Aminotransferase IncreasedFAERS: 2US FAERS
163AutoscopyFAERS: 2US FAERS
164Blood glucose decreasedFAERS: 2US FAERS
165Blood potassium increasedFAERS: 2US FAERS
166Blunted affectFAERS: 2US FAERS
167BradykinesiaFAERS: 2US FAERS
168Breast tendernessFAERS: 2US FAERS
169CellulitisFAERS: 2US FAERS
170ChillsFAERS: 2US FAERS
171ChokingFAERS: 2US FAERS
172DementiaFAERS: 2US FAERS
173Drug DependenceFAERS: 2US FAERS
174Drug effect delayedFAERS: 2US FAERS
175Drug resistanceFAERS: 2US FAERS
176Drug withdrawal syndromeFAERS: 2US FAERS
177DysgeusiaFAERS: 2US FAERS
178DysphemiaFAERS: 2US FAERS
179DysuriaFAERS: 2US FAERS
180Emergency CareFAERS: 2US FAERS
181EnuresisFAERS: 2US FAERS
182Extra dose administeredFAERS: 2US FAERS
183FormicationFAERS: 2US FAERS
184Frustration tolerance decreasedFAERS: 2US FAERS
185Gastric BypassFAERS: 2US FAERS
186General physical health deteriorationFAERS: 2US FAERS
187HypokinesiaFAERS: 2US FAERS
188Impaired quality of lifeFAERS: 2US FAERS
189IncoherentFAERS: 2US FAERS
190Initial insomniaFAERS: 2US FAERS
191LeukopeniaFAERS: 2US FAERS
192Loss of personal independence in daily activitiesFAERS: 2US FAERS
193Muscle FatigueFAERS: 2US FAERS
194MydriasisFAERS: 2US FAERS
195Oral painFAERS: 2US FAERS
196PancreatitisFAERS: 2US FAERS
197Physical assaultFAERS: 2US FAERS
198PolydipsiaFAERS: 2US FAERS
199Product packaging issueFAERS: 2US FAERS
200Schizoaffective DisorderFAERS: 2US FAERS
201ScreamingFAERS: 2US FAERS
202Secretion dischargeFAERS: 2US FAERS
203Sexual DysfunctionFAERS: 2US FAERS
204Sinus bradycardiaFAERS: 2US FAERS
205SneezingFAERS: 2US FAERS
206StaringFAERS: 2US FAERS
207StuporFAERS: 2US FAERS
208TachyphreniaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
209ThrombosisFAERS: 2US FAERS
210Tongue bitingFAERS: 2US FAERS
211TorticollisFAERS: 2US FAERS
212Abnormal weight gainFAERS: 1US FAERS
213Activation syndromeFAERS: 1US FAERS
214Acute kidney injuryFAERS: 1US FAERS
215Acute respiratory failureFAERS: 1US FAERS
216AkinesiaFAERS: 1US FAERS
217AnorgasmiaFAERS: 1US FAERS
218AsterixisFAERS: 1US FAERS
219BedriddenFAERS: 1US FAERS
220Bipolar I disorderFAERS: 1US FAERS
221BlindnessFAERS: 1US FAERS
222Blood caffeine increasedFAERS: 1US FAERS
223Blood sodium decreasedFAERS: 1US FAERS
224Blood urine presentFAERS: 1US FAERS
225BoredomFAERS: 1US FAERS
226BradycardiaFAERS: 1US FAERS
227Burning sensationFAERS: 1US FAERS
228CatatoniaFAERS: 1US FAERS
229CheilitisFAERS: 1US FAERS
230ChromaturiaFAERS: 1US FAERS
231Cogwheel RigidityFAERS: 1US FAERS
232Compression fractureFAERS: 1US FAERS
233CystitisFAERS: 1US FAERS
234Deep Vein ThrombosisFAERS: 1US FAERS
235Delusional disorder, unspecified typeFAERS: 1US FAERS
236Diabetic KetoacidosisFAERS: 1US FAERS
237DiscomfortFAERS: 1US FAERS
238Disease complicationFAERS: 1US FAERS
239DiverticulitisFAERS: 1US FAERS
240Drug dispensing errorFAERS: 1US FAERS
241Drug screen positiveFAERS: 1US FAERS
242Dystonic tremorFAERS: 1US FAERS
243Ear congestionFAERS: 1US FAERS
244Eating disorder symptomFAERS: 1US FAERS
245Economic problemFAERS: 1US FAERS
246Ejection Fraction DecreasedFAERS: 1US FAERS
247Electroencephalogram abnormalFAERS: 1US FAERS
248Emotional povertyFAERS: 1US FAERS
249Eosinophilic PneumoniaFAERS: 1US FAERS
250EpilepsyFAERS: 1US FAERS
251Erectile dysfunctionFAERS: 1US FAERS
252Expired product administeredFAERS: 1US FAERS
253Feeding tube userFAERS: 1US FAERS
254Feeling of body temperature changeFAERS: 1US FAERS
255FlatulenceFAERS: 1US FAERS
256FlushingFAERS: 1US FAERS
257Fracture treatmentFAERS: 1US FAERS
258FractureFAERS: 1US FAERS
259Gait ApraxiaFAERS: 1US FAERS
260Gastrointestinal infectionFAERS: 1US FAERS
261GastrostomyFAERS: 1US FAERS
262GlaucomaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
263Head discomfortFAERS: 1US FAERS
264Head titubationFAERS: 1US FAERS
265HemiparesisFAERS: 1US FAERS
266Human chorionic gonadotropin increasedFAERS: 1US FAERS
267HyperchlorhydriaFAERS: 1US FAERS
268Hypertensive crisisFAERS: 1US FAERS
269HypophagiaFAERS: 1US FAERS
270HyporeflexiaFAERS: 1US FAERS
271HypothyroidismFAERS: 1US FAERS
272ImmobileFAERS: 1US FAERS
273Impaired self-careFAERS: 1US FAERS
274IncontinenceFAERS: 1US FAERS
275Incorrect product formulation administeredFAERS: 1US FAERS
276Intentional product use issueFAERS: 1US FAERS
277Intestinal ObstructionFAERS: 1US FAERS
278Joint injuryFAERS: 1US FAERS
279LacerationFAERS: 1US FAERS
280Lack of satietyFAERS: 1US FAERS
281Lactation DisorderFAERS: 1US FAERS
282LazinessFAERS: 1US FAERS
283Limb injuryFAERS: 1US FAERS
284Limb operationFAERS: 1US FAERS
285Lipids abnormalFAERS: 1US FAERS
286Living in residential institutionFAERS: 1US FAERS
287Low density lipoprotein increasedFAERS: 1US FAERS
288Medication ErrorFAERS: 1US FAERS
289MenorrhagiaFAERS: 1US FAERS
290Middle insomniaFAERS: 1US FAERS
291Musculoskeletal PainFAERS: 1US FAERS
292Musculoskeletal chest painFAERS: 1US FAERS
293Musculoskeletal discomfortFAERS: 1US FAERS
294MyoclonusFAERS: 1US FAERS
295MyopathyFAERS: 1US FAERS
296NasopharyngitisFAERS: 1US FAERS
297Neck PainFAERS: 1US FAERS
298Negative thoughtsFAERS: 1US FAERS
299Obsessive-Compulsive DisorderFAERS: 1US FAERS
300Ocular discomfortFAERS: 1US FAERS
301OpisthotonusFAERS: 1US FAERS
302Oropharyngeal painFAERS: 1US FAERS
303OsteoporosisFAERS: 1US FAERS
304Pain of skinFAERS: 1US FAERS
305PancytopeniaFAERS: 1US FAERS
306Panic DisorderFAERS: 1US FAERS
307PhotophobiaFAERS: 1US FAERS
308PneumoniaFAERS: 1US FAERS
309PolyuriaFAERS: 1US FAERS
310Pre-existing condition improvedFAERS: 1US FAERS
311Prescription drug used without a prescriptionFAERS: 1US FAERS
312Product administered to patient of inappropriate ageFAERS: 1US FAERS
313Product container issueFAERS: 1US FAERS
314Product storage errorFAERS: 1US FAERS
315Psychiatric symptomFAERS: 1US FAERS
316Pulmonary EmbolismFAERS: 1US FAERS
317Quality of life decreasedFAERS: 1US FAERS
318Rabbit syndromeFAERS: 1US FAERS
319Reaction to drug excipientsFAERS: 1US FAERS
320Reduced facial expressionFAERS: 1US FAERS
321Rehabilitation therapyFAERS: 1US FAERS
322Saliva alteredFAERS: 1US FAERS
323ScabFAERS: 1US FAERS
324SciaticaFAERS: 1US FAERS
325Sedation complicationFAERS: 1US FAERS
326Seizure like phenomenaFAERS: 1US FAERS
327SepsisFAERS: 1US FAERS
328SinusitisFAERS: 1US FAERS
329Skin UlcerFAERS: 1US FAERS
330Skin irritationFAERS: 1US FAERS
331Skin lesionFAERS: 1US FAERS
332Sleep ParalysisFAERS: 1US FAERS
333StarvationFAERS: 1US FAERS
334Stevens-Johnson SyndromeFAERS: 1US FAERS
335StomatitisFAERS: 1US FAERS
336Symptom recurrenceFAERS: 1US FAERS
337Temperature regulation disorderFAERS: 1US FAERS
338Therapy partial responderFAERS: 1US FAERS
339Thirst decreasedFAERS: 1US FAERS
340TinnitusFAERS: 1US FAERS
341Tongue eruptionFAERS: 1US FAERS
342Unresponsive to stimuliFAERS: 1US FAERS
343Violence-related symptomFAERS: 1US FAERS
344Vulvovaginal drynessFAERS: 1US FAERS
345Waist circumference increasedFAERS: 1US FAERS
346White blood cell count abnormalFAERS: 1US FAERS
347White blood cell count decreasedFAERS: 1US FAERS
348Wound dehiscenceFAERS: 1US FAERS
349Wrong doseFAERS: 1US FAERS
350intensive careFAERS: 1US FAERS
351nervous system disorderFAERS: 1US FAERS
352treatment failureFAERS: 1US FAERS
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