MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Prazosin

(IENZQIKPVFGBNW-UHFFFAOYSA-N)

Structure

SMILES: COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
Type(s): Approved
ATC code(s): C02CA01; C02LE01
Molecular Formula:: C19H21N5O4
Molecular Weight:: 383.401
Log P:: 2.3687
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 1
TPSA:: 106.95
CAS Number(s):: 19216-56-9; 19237-84-4

Synonym(s)

Prazosin

Furazosin

Minipress

Pratsiol

Prazosin HCL

Prazosin Hydrochloride

HCL, Prazosin

Hydrochloride, Prazosin

External Link(s)

MeSH	D011224
PubChem Compound	4893
BindingDB	29568
ChEBI	8364
CHEMBL	CHEMBL2
DrugBank	DB00457
DrugCentral	4209
IUPHAR/BPS Guide to PHARMACOLOGY	503 5385
KEGG	cpd:C07368 dr:D08411
Therapeutic Target Database	D0WV3U
ZINC	95616601

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Hypotension	FAERS: 12 Canada Vigilance: 1	View details 32005 999414 1015921 1721975 1879978 2024540 2448006 2550615 2565755 2879903 2894880 3038563 3652934 3792430 3897071 3955309 6117801 6121810 6176798 6199597 6215903 6416479 6419878 7061132 7114650 7903757 8484524 8816361 16139573	CTD Canada Vigilance US FAERS
2	Syncope	FAERS: 10	7061132 7508331 7903757	CTD SIDER US FAERS
3	Dizziness	FAERS: 8 Canada Vigilance: 1	View details 793676 7061132 7223592 7903757	CTD SIDER Canada Vigilance US FAERS
4	Priapism	FAERS: 8	16292111	CTD SIDER US FAERS
5	Headache	FAERS: 4	7061132	CTD SIDER US FAERS
6	Urticaria	FAERS: 4		SIDER US FAERS
7	Bradycardia	FAERS: 3	View details 1355091 1527734 2157035 3039113 3720846 3955309 6117801 6121810 6510469 6625796 7215068 7903757 12447456	CTD OFFSIDES SIDER US FAERS
8	Pruritus	FAERS: 3		SIDER US FAERS
9	Tachycardia	FAERS: 3	View details 793676 1791990 2894880 3539430 3955309 6110503 6193367 6625796 7023672 7215068 7903757 16139573	CTD SIDER US FAERS
10	Cold sweat	FAERS: 2		OFFSIDES US FAERS
11	Delirium	FAERS: 2		US FAERS
12	Nausea	FAERS: 2 Canada Vigilance: 1	793676	CTD SIDER Canada Vigilance US FAERS
13	Overdose	FAERS: 2		US FAERS
14	Vomiting	FAERS: 2		SIDER US FAERS
15	Agitation	FAERS: 1		US FAERS
16	Angina Pectoris	FAERS: 1	472855 7307590	CTD SIDER US FAERS
17	Angioedema	FAERS: 1		US FAERS
18	Anxiety	FAERS: 1		US FAERS
19	Asthenia	FAERS: 1	7508331	CTD SIDER US FAERS
20	Back Pain	FAERS: 1		US FAERS
21	Blood creatinine increased	FAERS: 1		US FAERS
22	Blood prolactin increased	FAERS: 1		US FAERS
23	Blood urea increased	FAERS: 1		US FAERS
24	Chest discomfort	FAERS: 1		US FAERS
25	Cyanosis	FAERS: 1		US FAERS
26	Dehydration	FAERS: 1		OFFSIDES US FAERS
27	Drug ineffective	FAERS: 1		US FAERS
28	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
29	Drug screen positive	FAERS: 1		US FAERS
30	Feeling abnormal	FAERS: 1		OFFSIDES SIDER US FAERS
31	Flank Pain	FAERS: 1		US FAERS
32	Flushing	FAERS: 1		SIDER US FAERS
33	Hypersensitivity	FAERS: 1		SIDER US FAERS
34	Hyporeflexia	FAERS: 1		US FAERS
35	Hypoxia	FAERS: 1		OFFSIDES US FAERS
36	Mental status changes	FAERS: 1		US FAERS
37	Metabolic acidosis	FAERS: 1		US FAERS
38	Pallor	FAERS: 1		US FAERS
39	Palpitations	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
40	Presyncope	FAERS: 1		US FAERS
41	Product substitution issue	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
42	Product use in unapproved indication	FAERS: 1		US FAERS
43	Reaction to drug excipients	FAERS: 1		US FAERS
44	Respiratory Depression	FAERS: 1		US FAERS
45	Sedation complication	FAERS: 1		US FAERS
46	Suicide attempt	FAERS: 1		US FAERS
47	Supraventricular tachycardia	FAERS: 1		US FAERS
48	Therapy non-responder	FAERS: 1		US FAERS
49	Tongue biting	FAERS: 1		US FAERS
50	Unevaluable event	FAERS: 1		OFFSIDES US FAERS
51	Urinary hesitation	FAERS: 1		US FAERS
52	Abdominal discomfort			SIDER
53	Acidosis			OFFSIDES
54	Acute myocardial infarction			OFFSIDES
55	Alanine Aminotransferase Increased			OFFSIDES
56	Alopecia			SIDER
57	Amnesia		20064624	CTD
58	Anhedonia			OFFSIDES
59	Anhidrosis			OFFSIDES
60	Anorexia		21989786	CTD
61	Arthralgia			SIDER
62	Arthropathy			OFFSIDES
63	Atrial hypertrophy			OFFSIDES
64	Automatism			OFFSIDES
65	Back disorder			OFFSIDES
66	Blepharoptosis		1819906	CTD
67	Blood Glucose			OFFSIDES
68	Blood alkaline phosphatase increased			OFFSIDES
69	Blood amylase increased			OFFSIDES
70	Blood glucose decreased			OFFSIDES
71	Blood lactate dehydrogenase increased			OFFSIDES
72	Blood parathyroid hormone increased			OFFSIDES
73	Blood pressure inadequately controlled			OFFSIDES
74	Body Temperature			OFFSIDES
75	Brain Concussion			OFFSIDES
76	C-reactive protein decreased			OFFSIDES
77	Cardiac Tamponade			OFFSIDES
78	Cardiac neoplasm unspecified			OFFSIDES
79	Cardiomyopathies		6928405	CTD
80	Cardiovascular Diseases		64737	CTD
81	Cartilage injury			OFFSIDES
82	Cataplexy		2740697 2900433	CTD
83	Cataract			OFFSIDES SIDER
84	Cerebral disorder			OFFSIDES
85	Cervical polyp			OFFSIDES
86	Chemical and Drug Induced Liver Injury		18071297	CTD
87	Chest Pain		793676 7061132	CTD
88	Choking			OFFSIDES
89	Chronic left ventricular failure			OFFSIDES
90	Cocaine-Related Disorders		17505018 17920248	CTD
91	Completed Suicide			OFFSIDES
92	Constipation			SIDER
93	Demyelination			OFFSIDES
94	Depressed Level of Consciousness			OFFSIDES
95	Dermatitis			SIDER
96	Diabetes mellitus inadequate control			OFFSIDES
97	Diabetic Nephropathy			OFFSIDES
98	Discomfort			SIDER
99	Disease recurrence			OFFSIDES
100	Disseminated Intravascular Coagulation			OFFSIDES
101	Drowsiness			OFFSIDES SIDER
102	Drug Eruptions		7061132	CTD
103	Drug Overdose		6124197	CTD
104	Dry skin			OFFSIDES
105	Edema		7061132	CTD
106	Electrocardiogram T wave biphasic			OFFSIDES
107	Endometrioma			OFFSIDES
108	Epistaxis			OFFSIDES SIDER
109	Erectile dysfunction			SIDER
110	Excessive sexual fantasies			OFFSIDES
111	Eye pain			OFFSIDES SIDER
112	Fatigue		7061132	CTD SIDER
113	Fecal Incontinence		1975868	CTD
114	Feeling Cold			OFFSIDES
115	Femoral artery occlusion			OFFSIDES
116	Flatulence	Canada Vigilance: 1		Canada Vigilance
117	Floppy iris syndrome			OFFSIDES SIDER
118	Fluid overload			OFFSIDES
119	Gastric ulcer			OFFSIDES
120	General physical condition			OFFSIDES
121	Gingival Hypertrophy			OFFSIDES
122	Graft infection			OFFSIDES
123	Hallucinations		17196067	CTD
124	Heart failure		View details 510213 889599 6258839 6788266 7058000 7223592 7300762 7436166 7903757 8484524 12723015	CTD
125	Hemiparesis			OFFSIDES
126	Hepatic artery occlusion			OFFSIDES
127	Hepatic necrosis			OFFSIDES
128	Hepatitis			OFFSIDES
129	Hyperalgesia		7753402 12727271 18799818	CTD
130	Hyperparathyroidism			OFFSIDES
131	Hypertensive heart disease			OFFSIDES
132	Hypopituitarism			OFFSIDES
133	Hypotension, Orthostatic		View details 64882 339373 343006 791450 793676 1355091 3230472 6110503 6162595 6193367 6876810 7508331 8931848 9639061 10699651 11145175 16650782	CTD
134	Iatrogenic injury			OFFSIDES
135	Idiopathic neutropenia			OFFSIDES
136	Incontinence			SIDER
137	Infection			OFFSIDES
138	Injection site nodule			OFFSIDES
139	Intestinal cyst			OFFSIDES
140	Intraoperative Complications		8484524	CTD
141	Intraoperative floppy iris syndrome			SIDER
142	Iodine uptake increased			OFFSIDES
143	Joint injury			OFFSIDES
144	Joint sprain			OFFSIDES
145	Joint stiffness			OFFSIDES
146	Kidney Failure			OFFSIDES
147	Lichen Planus			SIDER
148	Ligament injury			OFFSIDES
149	Malaise			SIDER
150	Mercury Poisoning, Nervous System		21377490	CTD
151	Mitral Valve Insufficiency		7378216	CTD
152	Monoparesis			OFFSIDES
153	Multiple System Atrophy		10699651	CTD
154	Muscle Rigidity		View details 2304628 2556653 2564649 8848244	CTD
155	Muscle necrosis			OFFSIDES
156	Muscle strain			OFFSIDES
157	Musculoskeletal discomfort			SIDER
158	Myoclonus		37558 6104728 11160978	CTD
159	Narcolepsy			SIDER
160	Narcotic intoxication			OFFSIDES
161	Nephrotic Syndrome			OFFSIDES
162	Nerve Degeneration		12871582	CTD
163	Nervousness			SIDER
164	Neuroleptic Malignant Syndrome			OFFSIDES
165	Neutrophil count decreased			OFFSIDES
166	Ocular vascular disorder			OFFSIDES
167	Oligohydramnios			OFFSIDES
168	Oliguria			OFFSIDES
169	Optic Disc Edema			OFFSIDES
170	Oral fungal infection			OFFSIDES
171	Pain		8773445 16563475 18799818	CTD SIDER
172	Pancreatitis			SIDER
173	Pharmaceutical product complaint			OFFSIDES
174	Pharyngeal candidiasis			OFFSIDES
175	Pheochromocytoma		7114650 8484524 9431876	CTD
176	Poor quality drug administered			OFFSIDES
177	Potentiating drug interaction			OFFSIDES
178	Prescribed overdose			OFFSIDES
179	Procedural hypotension			OFFSIDES
180	Procedural site reaction			OFFSIDES
181	Prostatic Hyperplasia		View details 1725478 1975868 7508331 7903757 11583366 26449523	CTD
182	Prostatism		7903757 9043492	CTD
183	Protein total increased			OFFSIDES
184	Psychomotor Agitation		12768274	CTD
185	Pulmonary congestion			OFFSIDES
186	Purulent discharge			OFFSIDES
187	Pyuria			OFFSIDES
188	Quadriplegia			OFFSIDES
189	Quadruple vessel bypass graft			OFFSIDES
190	Rales			OFFSIDES
191	Raynaud Disease		6124197 7903757	CTD
192	Renal Artery Stenosis			OFFSIDES
193	Renal Insufficiency		7300762	CTD
194	Renal artery occlusion			OFFSIDES
195	Renal failure neonatal			OFFSIDES
196	Renal tubular acidosis			OFFSIDES
197	Rhabdomyolysis			OFFSIDES
198	Rhinorrhea			OFFSIDES
199	Rhonchi			OFFSIDES
200	Sarcoidosis			OFFSIDES
201	Seizures		6104728 8224101	CTD
202	Shock			SIDER
203	Sjogren's Syndrome			OFFSIDES
204	Somnolence			SIDER
205	Superficial Thrombophlebitis			OFFSIDES
206	Synovitis			OFFSIDES
207	Tachycardia, Ventricular		8720421	CTD
208	Talipes			OFFSIDES
209	Tenosynovitis			OFFSIDES
210	Tension			SIDER
211	Tetany			OFFSIDES
212	Therapeutic response unexpected with drug substitution			OFFSIDES
213	Tinnitus			SIDER
214	Tremor	Canada Vigilance: 1	7990972	CTD Canada Vigilance
215	Ultrasound scan abnormal			OFFSIDES
216	Unexpected therapeutic drug effect			OFFSIDES
217	Upper respiratory fungal infection			OFFSIDES
218	Urethral Obstruction		1975868	CTD
219	Urinary Incontinence		View details 564728 1631598 3347184 6118972	CTD SIDER
220	Urination Disorders		7508331	CTD
221	Urologic Diseases		10699651	CTD
222	Uterine Cancer			OFFSIDES
223	Uterine Polyp			OFFSIDES
224	Vascular bypass graft			OFFSIDES
225	Vasculitis			SIDER
226	Ventricular Dysfunction, Left		7307590 15936005	CTD
227	Ventricular Dysfunction		12010770	CTD
228	Ventricular Fibrillation		7909562 7910510	CTD
229	Vertigo			SIDER

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