MetaADEDB 2.0 @ LMMD
Riluzole
(FTALBRSUTCGOEG-UHFFFAOYSA-N)
Structure
SMILES
Nc1nc2c(s1)cc(cc2)OC(F)(F)F
Type(s)
Approved; Investigational
ATC code(s)
N07XX02
Molecular Formula:
C8H5F3N2OS
Molecular Weight:
234.198
Log P:
3.3583
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
76.38
CAS Number(s):
1744-22-5
Synonym(s)
1.
Riluzole
2.
2-Amino-6-trifluoromethoxybenzothiazole
3.
PK-26124
4.
RP-54274
5.
Rilutek
6.
2 Amino 6 trifluoromethoxybenzothiazole
7.
PK 26124
8.
PK26124
9.
RP 54274
10.
RP54274
External Link(s)
MeSHD019782
PubChem Compound5070
BindingDB30705
ChEBI8863
CHEMBLCHEMBL744
DrugBankDB00740
DrugCentral2382
IUPHAR/BPS Guide to PHARMACOLOGY2326
KEGGcpd:C07937
dr:D00775
Therapeutic Target DatabaseD0H0KB
ZINC6481
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Disease ProgressionFAERS: 22
Canada Vigilance: 13		Canada Vigilance
OFFSIDES
US FAERS
2NauseaFAERS: 15
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
3Amyotrophic Lateral SclerosisFAERS: 14
Canada Vigilance: 12

View details

10025816
10190739
10828653
17714844
21375347
21867702
 		CTD
Canada Vigilance
US FAERS
4Pulmonary toxicityFAERS: 9OFFSIDES
US FAERS
5FatigueFAERS: 8
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
6PneumoniaFAERS: 8
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
7Respiratory FailureFAERS: 8OFFSIDES
SIDER
US FAERS
8AstheniaFAERS: 7
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
9Lymphocyte stimulation test positiveFAERS: 7OFFSIDES
US FAERS
10Portal Vein ThrombosisFAERS: 7US FAERS
11MalaiseFAERS: 6
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
12ChokingFAERS: 5OFFSIDES
US FAERS
13HepatitisFAERS: 510190739CTD
OFFSIDES
SIDER
US FAERS
14Pulmonary EmbolismFAERS: 5SIDER
US FAERS
15Abdominal PainFAERS: 4SIDER
US FAERS
16Drug ineffectiveFAERS: 4US FAERS
17Lung consolidationFAERS: 4US FAERS
18MyalgiaFAERS: 4SIDER
US FAERS
19ArthralgiaFAERS: 3SIDER
US FAERS
20DehydrationFAERS: 3
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
21HeadacheFAERS: 3SIDER
US FAERS
22InfectionFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
23No adverse eventFAERS: 3US FAERS
24PruritusFAERS: 3SIDER
US FAERS
25Respiratory arrestFAERS: 3US FAERS
26Acute myocardial infarctionFAERS: 2OFFSIDES
US FAERS
27AgranulocytosisFAERS: 2SIDER
US FAERS
28AngioedemaFAERS: 2SIDER
US FAERS
29AnorexiaFAERS: 2SIDER
US FAERS
30AphagiaFAERS: 2US FAERS
31AphoniaFAERS: 2US FAERS
32AtelectasisFAERS: 2OFFSIDES
US FAERS
33Blood pressure fluctuationFAERS: 2US FAERS
34Cerebrovascular accidentFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
35ChromaturiaFAERS: 2US FAERS
36Completed SuicideFAERS: 2OFFSIDES
SIDER
US FAERS
37Cytolytic hepatitisFAERS: 2US FAERS
38DizzinessFAERS: 2
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
39DysarthriaFAERS: 2SIDER
US FAERS
40GastroenteritisFAERS: 2OFFSIDES
US FAERS
41HypersensitivityFAERS: 2SIDER
US FAERS
42HypoventilationFAERS: 2SIDER
US FAERS
43Increased upper airway secretionFAERS: 2OFFSIDES
US FAERS
44Leukocytoclastic vasculitisFAERS: 2US FAERS
45Lower respiratory tract infectionFAERS: 2US FAERS
46Memory impairmentFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
47Musculoskeletal PainFAERS: 2US FAERS
48MyocarditisFAERS: 2US FAERS
49NasopharyngitisFAERS: 2OFFSIDES
US FAERS
50Nephrotic SyndromeFAERS: 2US FAERS
51Neuroleptic Malignant SyndromeFAERS: 2US FAERS
52PO2 decreasedFAERS: 2OFFSIDES
US FAERS
53Pancreatic PseudocystFAERS: 2US FAERS
54Patent ductus arteriosusFAERS: 2US FAERS
55Progressive bulbar palsyFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
56Pulmonary FibrosisFAERS: 2US FAERS
57Respiratory distressFAERS: 2SIDER
US FAERS
58Skin reactionFAERS: 2US FAERS
59SomnolenceFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
60TachycardiaFAERS: 2SIDER
US FAERS
61ThrombocytopeniaFAERS: 2SIDER
US FAERS
62Unevaluable eventFAERS: 2OFFSIDES
US FAERS
63Urinary RetentionFAERS: 2SIDER
US FAERS
64VomitingFAERS: 2SIDER
US FAERS
65Weight decreasedFAERS: 2SIDER
US FAERS
66jaundiceFAERS: 2SIDER
US FAERS
67Abdominal discomfortFAERS: 1SIDER
US FAERS
68AgitationFAERS: 1SIDER
US FAERS
69AnxietyFAERS: 1SIDER
US FAERS
70AphasiaFAERS: 1US FAERS
71Apparent deathFAERS: 1US FAERS
72Aspartate Aminotransferase IncreasedFAERS: 1SIDER
US FAERS
73Atrial FibrillationFAERS: 1SIDER
US FAERS
74Bacteria stool identifiedFAERS: 1OFFSIDES
US FAERS
75Blood creatine phosphokinase increasedFAERS: 1SIDER
US FAERS
76Blood creatinine increasedFAERS: 1US FAERS
77Blood fibrinogen increasedFAERS: 1OFFSIDES
US FAERS
78Blood glucose increasedFAERS: 1US FAERS
79Blood immunoglobulin A increasedFAERS: 1OFFSIDES
US FAERS
80Blood immunoglobulin E increasedFAERS: 1US FAERS
81Blood immunoglobulin G increasedFAERS: 1OFFSIDES
US FAERS
82Blood lactate dehydrogenase increasedFAERS: 1US FAERS
83Blood pH increasedFAERS: 1OFFSIDES
US FAERS
84Bone marrow myelogram abnormalFAERS: 1US FAERS
85BradycardiaFAERS: 1OFFSIDES
SIDER
US FAERS
86Bronchial ObstructionFAERS: 1OFFSIDES
US FAERS
87BronchiectasisFAERS: 1US FAERS
88Carbon dioxide increasedFAERS: 1US FAERS
89Cardiac ArrestFAERS: 1SIDER
US FAERS
90Catheter related complicationFAERS: 1US FAERS
91Chest PainFAERS: 1SIDER
US FAERS
92CholecystitisFAERS: 1SIDER
US FAERS
93CholelithiasisFAERS: 1US FAERS
94Chronic respiratory failureFAERS: 1US FAERS
95Clostridium difficile toxin test positiveFAERS: 1US FAERS
96Corneal UlcerFAERS: 1OFFSIDES
US FAERS
97Coronary Artery DiseaseFAERS: 1US FAERS
98CryingFAERS: 1US FAERS
99DeafnessFAERS: 1SIDER
US FAERS
100Deep Vein ThrombosisFAERS: 1US FAERS
101Disease complicationFAERS: 1US FAERS
102DisorientationFAERS: 1US FAERS
103Drug dose omissionFAERS: 1US FAERS
104Drug exposure during pregnancyFAERS: 1US FAERS
105Drug toxicityFAERS: 1US FAERS
106DysgeusiaFAERS: 1SIDER
US FAERS
107DyspepsiaFAERS: 1SIDER
US FAERS
108DysphoniaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
109Electrocardiogram abnormalFAERS: 1US FAERS
110Electroencephalogram abnormalFAERS: 1US FAERS
111Emotional disorderFAERS: 1US FAERS
112Eosinophilic PneumoniaFAERS: 1OFFSIDES
US FAERS
113Escherichia infectionFAERS: 1US FAERS
114Feeding tube userFAERS: 1US FAERS
115General physical health deteriorationFAERS: 1US FAERS
116HypotensionFAERS: 1SIDER
US FAERS
117HypoxiaFAERS: 1SIDER
US FAERS
118InflammationFAERS: 1US FAERS
119InfluenzaFAERS: 1SIDER
US FAERS
120LeukopeniaFAERS: 1SIDER
US FAERS
121Limb crushing injuryFAERS: 1US FAERS
122Medical device complicationFAERS: 1OFFSIDES
US FAERS
123Mental status changesFAERS: 1US FAERS
124Multifocal micronodular pneumocyte hyperplasiaFAERS: 1US FAERS
125Myocardial InfarctionFAERS: 1SIDER
US FAERS
126NephrolithiasisFAERS: 1SIDER
US FAERS
127Neuropsychological test abnormalFAERS: 1US FAERS
128OverdoseFAERS: 1US FAERS
129PallorFAERS: 1US FAERS
130PancreatitisFAERS: 1SIDER
US FAERS
131Peripheral embolismFAERS: 1US FAERS
132Portal HypertensionFAERS: 1US FAERS
133PregnancyFAERS: 1US FAERS
134Product quality issueFAERS: 1US FAERS
135Product solubility abnormalFAERS: 1US FAERS
136Product substitution issueFAERS: 1US FAERS
137Product use issueFAERS: 1US FAERS
138Productive CoughFAERS: 1US FAERS
139PseudocystFAERS: 1US FAERS
140Retrograde amnesiaFAERS: 1US FAERS
141Spinal Muscular AtrophyFAERS: 1US FAERS
142Suicide attemptFAERS: 1SIDER
US FAERS
143Tardive DyskinesiaFAERS: 1OFFSIDES
US FAERS
144Therapeutic response unexpectedFAERS: 1US FAERS
145Therapy cessationFAERS: 1US FAERS
146Therapy non-responderFAERS: 1OFFSIDES
US FAERS
147Toxicity to various agentsFAERS: 1US FAERS
148TremorFAERS: 1SIDER
US FAERS
149Unresponsive to stimuliFAERS: 1OFFSIDES
US FAERS
150Upper respiratory tract congestionFAERS: 1US FAERS
151VertigoFAERS: 1SIDER
US FAERS
152Visual disturbanceFAERS: 1US FAERS
153White blood cell count decreasedFAERS: 1SIDER
US FAERS
154Wrong technique in drug usage processFAERS: 1US FAERS
155AMYOTROPHIC LATERAL SCLEROSIS 18967745CTD
156AbscessSIDER
157AcrodyniaSIDER
158Acute Coronary SyndromeSIDER
159Acute respiratory failureOFFSIDES
160AgeusiaSIDER
161AgraphiaOFFSIDES
162Alanine Aminotransferase IncreasedOFFSIDES
SIDER
163AlopeciaSIDER
164AmblyopiaSIDER
165AmnesiaSIDER
166Anaphylactic shockSIDER
167Anaphylactoid ReactionSIDER
168Angina PectorisSIDER
169Anorectal discomfortSIDER
170ApathySIDER
171ApneaOFFSIDES
172ArteriosclerosisOFFSIDES
173ArthritisSIDER
174ArthropathySIDER
175AsphyxiaOFFSIDES
SIDER
176Aspiration PneumoniaOFFSIDES
177AsthmaSIDER
178AtaxiaSIDER
179Back PainSIDER
180Biliary ColicSIDER
181BlepharitisSIDER
182Blood alkaline phosphatase increasedOFFSIDES
SIDER
183Blood and lymphatic system disordersSIDER
184Blood bicarbonateOFFSIDES
185Blood bilirubin abnormalSIDER
186Blood immunoglobulin EOFFSIDES
187Breakthrough PainOFFSIDES
188BronchitisSIDER
189Carcinoma of lungSIDER
190CataractSIDER
191CellulitisSIDER
192Central nervous system lesionOFFSIDES
193CheilitisSIDER
194ChillsSIDER
195Choking sensationOFFSIDES
196CholangiolitisOFFSIDES
197Chronic left ventricular failureOFFSIDES
198Circumoral paresthesiaSIDER
199Clostridium difficile colitisOFFSIDES
200ConstipationSIDER
201Cor pulmonaleOFFSIDES
SIDER
202Cramps of lower extremitiesSIDER
203CyanosisOFFSIDES
SIDER
204CystSIDER
205DeliriumSIDER
206DementiaSIDER
207Dental cariesSIDER
208Depressed Level of ConsciousnessOFFSIDES
SIDER
209DermatitisSIDER
210Diabetes InsipidusSIDER
211Diabetes MellitusSIDER
212DiplopiaSIDER
213DiscomfortSIDER
214Disseminated Intravascular CoagulationSIDER
215Disturbance in sexual arousalSIDER
216Dyskinesia, Drug-Induced10347995
15899244		CTD
217Dysthymic DisorderOFFSIDES
218DysuriaSIDER
219Ear and labyrinth disordersSIDER
220EcchymosisSIDER
221EczemaSIDER
222EmbolismSIDER
223EmbolusSIDER
224EndophthalmitisSIDER
225Enlargement abdomenSIDER
226EpistaxisSIDER
227Erectile dysfunctionSIDER
228Erythema MultiformeSIDER
229ErythropeniaSIDER
230Euphoric moodSIDER
231Extremity contractureOFFSIDES
232Facial paralysisSIDER
233Feeling abnormalCanada Vigilance: 1Canada Vigilance
SIDER
234Flat affectSIDER
235FlatulenceSIDER
236Food AllergyOFFSIDES
237FurunculosisSIDER
238GamblingOFFSIDES
239Gamma-Glutamyltransferase IncreasedSIDER
240Gastric ulcerSIDER
241GastritisSIDER
242Gastrointestinal PainSIDER
243GlaucomaSIDER
244GlobulinuriaOFFSIDES
245GlossitisSIDER
246GlycosuriaSIDER
247GoutSIDER
248HemiplegiaSIDER
249HerniaSIDER
250HostilitySIDER
251HyperacusisSIDER
252HyperventilationSIDER
253HypokinesiaSIDER
254IleusSIDER
255InfestationSIDER
256Injection Site ReactionSIDER
257Injection site streakingOFFSIDES
258Intentional injurySIDER
259Intestinal ObstructionSIDER
260Intestinal resectionOFFSIDES
261Ischemia10067977CTD
262Large intestine perforationOFFSIDES
263LaryngitisSIDER
264LeukocytosisSIDER
265LymphadenopathySIDER
266LymphopeniaSIDER
267MalnutritionSIDER
268Manganese Poisoning19615351CTD
269Manic psychosisSIDER
270MeningiomaOFFSIDES
271Mercury Poisoning, Nervous System22966415CTD
272MetrorrhagiaSIDER
273Mood swingsSIDER
274Movement Disorders17306893CTD
275Muscle SpasticitySIDER
276Muscle relaxant therapySIDER
277Musculoskeletal discomfortSIDER
278Musculoskeletal stiffnessOFFSIDES
SIDER
279MyoclonusSIDER
280Neck PainSIDER
281Necrosis10067977CTD
282NephritisSIDER
283Nerve Degeneration12192617CTD
284NervousnessSIDER
285NeuritisSIDER
286NeutropeniaSIDER
287NocturiaSIDER
288Oral candidiasisSIDER
289OsteomyelitisOFFSIDES
290OsteoporosisSIDER
291PCO2 decreasedOFFSIDES
292Pain20885006CTD
SIDER
293Palliative CareCanada Vigilance: 1Canada Vigilance
294PalpitationsSIDER
295PancytopeniaSIDER
296PanophthalmitisSIDER
297ParanoiaSIDER
298Paranoid reactionSIDER
299PericarditisSIDER
300PeritonitisSIDER
301Personality ChangeSIDER
302PetechiaeSIDER
303PharyngitisSIDER
304PhlebitisSIDER
305PhotophobiaSIDER
306PneumothoraxSIDER
307PriapismSIDER
308ProctitisSIDER
309Prostate carcinomaSIDER
310PsoriasisSIDER
311Pulmonary artery thrombosisOFFSIDES
312Pulmonary function test decreasedSIDER
313PurpuraSIDER
314PyelonephritisOFFSIDES
SIDER
315Radial nerve palsySIDER
316Reaction aggravationSIDER
317Rectal tenesmusSIDER
318Renal Insufficiency10025816CTD
319Renal painSIDER
320Respiratory DepressionSIDER
321Respiratory tract congestionOFFSIDES
322Restrictive pulmonary diseaseOFFSIDES
323Retinal Diseases10067977CTD
324Retinopathy of Prematurity16303979CTD
325Rheumatoid ArthritisSIDER
326RhinitisSIDER
327RhinorrheaOFFSIDES
328Saliva alteredOFFSIDES
329Schizophrenic reactionSIDER
330Seizures17507170
20015615		CTD
331SepsisSIDER
332ShockSIDER
333SinusitisSIDER
334Skin UlcerSIDER
335Skin noduleSIDER
336StiffnessSIDER
337StomatitisSIDER
338StressOFFSIDES
339StridorSIDER
340StuporSIDER
341Sudden Cardiac DeathOFFSIDES
342Supraventricular tachycardiaSIDER
343SweatingSIDER
344SyncopeSIDER
345TalipesOFFSIDES
SIDER
346TensionSIDER
347TetanySIDER
348ThirstSIDER
349Thrombocytopenic purpuraSIDER
350ThrombosisSIDER
351Thyroid NeoplasmSIDER
352Traumatic liver injurySIDER
353TrismusSIDER
354UlcerSIDER
355Upset stomachSIDER
356Urinary IncontinenceSIDER
357Urinary tract infectionSIDER
358UrticariaSIDER
359Uterine fibroids enlargedSIDER
360VIIth nerve paralysisSIDER
361Vascular purpuraSIDER
362Ventricular FibrillationSIDER
363Vulvovaginal mycotic infectionSIDER
364YawningSIDER
365furuncleSIDER
366nervous system disorderSIDER
367pseudomembranous colitisSIDER
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