Milnacipran
(XNCDYJFPRPDERF-PBCQUBLHSA-N)
Structure
- SMILES
- NC[C@H]1C[C@@]1(c1ccccc1)C(=O)N(CC)CC.Cl
- Molecular Formula:
- C15H23ClN2O
- Molecular Weight:
- 282.809
- Log P:
- 3.2737
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 2
- TPSA:
- 46.33
- CAS Number(s):
- 101152-94-7; 175131-61-0
Synonym(s)
1.
Milnacipran
2.
1-Phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane HCl
3.
F 2207
4.
F-2207
5.
Ixel
6.
Midalcipran
7.
Milnacipran Hydrochloride
8.
Savella
9.
1 Phenyl 1 diethylaminocarbonyl 2 aminomethylcyclopropane HCl
10.
F2207
External Link(s)
| MeSH | D000078764 |
| PubChem Compound | 55480 163701 |
| ChEBI | 31854 |
| CHEMBL | CHEMBL1237129 |
| KEGG | dr:D01107 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 183 | US FAERS | |
| 2 | Headache | FAERS: 99 | US FAERS | |
| 3 | Dizziness | FAERS: 69 | US FAERS | |
| 4 | Vomiting | FAERS: 56 | US FAERS | |
| 5 | Pain | FAERS: 51 | US FAERS | |
| 6 | Anxiety | FAERS: 45 | US FAERS | |
| 7 | Drug ineffective | FAERS: 44 | US FAERS | |
| 8 | Feeling abnormal | FAERS: 42 | US FAERS | |
| 9 | Palpitations | FAERS: 42 | US FAERS | |
| 10 | Fatigue | FAERS: 36 | US FAERS | |
| 11 | Constipation | FAERS: 30 | US FAERS | |
| 12 | Tachycardia | FAERS: 29 | US FAERS | |
| 13 | Agitation | FAERS: 25 | US FAERS | |
| 14 | Tremor | FAERS: 25 | US FAERS | |
| 15 | Anger | FAERS: 21 | US FAERS | |
| 16 | Asthenia | FAERS: 21 | US FAERS | |
| 17 | Pruritus | FAERS: 21 | US FAERS | |
| 18 | Urinary Retention | FAERS: 19 | US FAERS | |
| 19 | Crying | FAERS: 18 | US FAERS | |
| 20 | Flushing | FAERS: 18 | US FAERS | |
| 21 | Malaise | FAERS: 18 | US FAERS | |
| 22 | Abdominal Pain | FAERS: 17 | US FAERS | |
| 23 | Abdominal discomfort | FAERS: 14 | US FAERS | |
| 24 | Dysuria | FAERS: 14 | US FAERS | |
| 25 | Hypersensitivity | FAERS: 14 | US FAERS | |
| 26 | Chest Pain | FAERS: 13 | US FAERS | |
| 27 | Urticaria | FAERS: 13 | US FAERS | |
| 28 | Alopecia | FAERS: 12 | US FAERS | |
| 29 | Nervousness | FAERS: 11 | US FAERS | |
| 30 | Somnolence | FAERS: 11 | US FAERS | |
| 31 | Adverse event | FAERS: 10 | US FAERS | |
| 32 | Amnesia | FAERS: 10 | US FAERS | |
| 33 | Drug dose omission | FAERS: 10 | US FAERS | |
| 34 | Night sweats | FAERS: 10 | US FAERS | |
| 35 | Chills | FAERS: 9 | US FAERS | |
| 36 | Memory impairment | FAERS: 9 | US FAERS | |
| 37 | Myalgia | FAERS: 9 | US FAERS | |
| 38 | Serotonin Syndrome | FAERS: 9 | US FAERS | |
| 39 | Arthralgia | FAERS: 8 | US FAERS | |
| 40 | Chest discomfort | FAERS: 8 | US FAERS | |
| 41 | Fibromyalgia | FAERS: 8 | US FAERS | |
| 42 | Myocardial Infarction | FAERS: 8 | US FAERS | |
| 43 | Suicide attempt | FAERS: 8 | US FAERS | |
| 44 | Unevaluable event | FAERS: 8 | US FAERS | |
| 45 | Weight decreased | FAERS: 8 | US FAERS | |
| 46 | Mood swings | FAERS: 7 | US FAERS | |
| 47 | Vertigo | FAERS: 7 | US FAERS | |
| 48 | Atrial Fibrillation | FAERS: 6 | US FAERS | |
| 49 | Dehydration | FAERS: 6 | US FAERS | |
| 50 | Feeling jittery | FAERS: 6 | US FAERS | |
| 51 | Hypotension | FAERS: 6 | US FAERS | |
| 52 | Medication Error | FAERS: 6 | US FAERS | |
| 53 | Oropharyngeal pain | FAERS: 6 | US FAERS | |
| 54 | Syncope | FAERS: 6 | US FAERS | |
| 55 | Tinnitus | FAERS: 6 | US FAERS | |
| 56 | Abasia | FAERS: 5 | US FAERS | |
| 57 | Activities of daily living impaired | FAERS: 5 | US FAERS | |
| 58 | Emotional disorder | FAERS: 5 | US FAERS | |
| 59 | Feeling Cold | FAERS: 5 | US FAERS | |
| 60 | Hostility | FAERS: 5 | US FAERS | |
| 61 | Hypertensive crisis | FAERS: 5 | US FAERS | |
| 62 | Impaired work ability | FAERS: 5 | US FAERS | |
| 63 | Maternal exposure during pregnancy | FAERS: 5 | US FAERS | |
| 64 | Musculoskeletal Pain | FAERS: 5 | US FAERS | |
| 65 | Neck Pain | FAERS: 5 | US FAERS | |
| 66 | Restlessness | FAERS: 5 | US FAERS | |
| 67 | Rhabdomyolysis | FAERS: 5 | US FAERS | |
| 68 | Wrong technique in product usage process | FAERS: 5 | US FAERS | |
| 69 | Back Pain | FAERS: 4 | US FAERS | |
| 70 | Bipolar Disorder | FAERS: 4 | US FAERS | |
| 71 | Blood glucose increased | FAERS: 4 | US FAERS | |
| 72 | Blood sodium decreased | FAERS: 4 | US FAERS | |
| 73 | Completed Suicide | FAERS: 4 | US FAERS | |
| 74 | Discomfort | FAERS: 4 | US FAERS | |
| 75 | Drug withdrawal syndrome | FAERS: 4 | US FAERS | |
| 76 | Dyspepsia | FAERS: 4 | US FAERS | |
| 77 | Erythema | FAERS: 4 | US FAERS | |
| 78 | Food Allergy | FAERS: 4 | US FAERS | |
| 79 | Musculoskeletal stiffness | FAERS: 4 | US FAERS | |
| 80 | Renal pain | FAERS: 4 | US FAERS | |
| 81 | Sexual Dysfunction | FAERS: 4 | US FAERS | |
| 82 | Urinary hesitation | FAERS: 4 | US FAERS | |
| 83 | Visual Impairment | FAERS: 4 | US FAERS | |
| 84 | Aphasia | FAERS: 3 | US FAERS | |
| 85 | Cerebrovascular accident | FAERS: 3 | US FAERS | |
| 86 | Depressed mood | FAERS: 3 | US FAERS | |
| 87 | Erectile dysfunction | FAERS: 3 | US FAERS | |
| 88 | Hypersomnia | FAERS: 3 | US FAERS | |
| 89 | Hypomania | FAERS: 3 | US FAERS | |
| 90 | Impaired driving ability | FAERS: 3 | US FAERS | |
| 91 | Lip swelling | FAERS: 3 | US FAERS | |
| 92 | Middle insomnia | FAERS: 3 | US FAERS | |
| 93 | Mydriasis | FAERS: 3 | US FAERS | |
| 94 | Paranoia | FAERS: 3 | US FAERS | |
| 95 | Product dose omission | FAERS: 3 | US FAERS | |
| 96 | Retching | FAERS: 3 | US FAERS | |
| 97 | Swelling | FAERS: 3 | US FAERS | |
| 98 | Tension | FAERS: 3 | US FAERS | |
| 99 | Urinary Incontinence | FAERS: 3 | US FAERS | |
| 100 | Urinary tract infection | FAERS: 3 | US FAERS | |
| 101 | Acne | FAERS: 2 | US FAERS | |
| 102 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 103 | Anaphylactic shock | FAERS: 2 | US FAERS | |
| 104 | Angioedema | FAERS: 2 | US FAERS | |
| 105 | Anuria | FAERS: 2 | US FAERS | |
| 106 | Aphagia | FAERS: 2 | US FAERS | |
| 107 | Blindness | FAERS: 2 | US FAERS | |
| 108 | Blood urine present | FAERS: 2 | US FAERS | |
| 109 | Burning sensation | FAERS: 2 | US FAERS | |
| 110 | Cardiac Flutter | FAERS: 2 | US FAERS | |
| 111 | Chromaturia | FAERS: 2 | US FAERS | |
| 112 | Clumsiness | FAERS: 2 | US FAERS | |
| 113 | Cold sweat | FAERS: 2 | US FAERS | |
| 114 | Drug screen positive | FAERS: 2 | US FAERS | |
| 115 | Dysgeusia | FAERS: 2 | US FAERS | |
| 116 | Emotional distress | FAERS: 2 | US FAERS | |
| 117 | Euphoric mood | FAERS: 2 | US FAERS | |
| 118 | Flatulence | FAERS: 2 | US FAERS | |
| 119 | Frustration | FAERS: 2 | US FAERS | |
| 120 | Hypothyroidism | FAERS: 2 | US FAERS | |
| 121 | Impaired gastric emptying | FAERS: 2 | US FAERS | |
| 122 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 123 | Influenza | FAERS: 2 | US FAERS | |
| 124 | Initial insomnia | FAERS: 2 | US FAERS | |
| 125 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 126 | Intentional self-injury | FAERS: 2 | US FAERS | |
| 127 | Mental status changes | FAERS: 2 | US FAERS | |
| 128 | Muscle tightness | FAERS: 2 | US FAERS | |
| 129 | Nasopharyngitis | FAERS: 2 | US FAERS | |
| 130 | Pancreatitis | FAERS: 2 | US FAERS | |
| 131 | Pericarditis | FAERS: 2 | US FAERS | |
| 132 | Personality Change | FAERS: 2 | US FAERS | |
| 133 | Piloerection | FAERS: 2 | US FAERS | |
| 134 | Product packaging issue | FAERS: 2 | US FAERS | |
| 135 | Product quality issue | FAERS: 2 | US FAERS | |
| 136 | Prostatic pain | FAERS: 2 | US FAERS | |
| 137 | Quality of life decreased | FAERS: 2 | US FAERS | |
| 138 | Restless Legs Syndrome | FAERS: 2 | US FAERS | |
| 139 | Serositis | FAERS: 2 | US FAERS | |
| 140 | Somnambulism | FAERS: 2 | US FAERS | |
| 141 | Status Asthmaticus | FAERS: 2 | US FAERS | |
| 142 | Stevens-Johnson Syndrome | FAERS: 2 | US FAERS | |
| 143 | Stress | FAERS: 2 | US FAERS | |
| 144 | Tension Headache | FAERS: 2 | US FAERS | |
| 145 | Thermal burn | FAERS: 2 | US FAERS | |
| 146 | Urine flow decreased | FAERS: 2 | US FAERS | |
| 147 | Wheelchair user | FAERS: 2 | US FAERS | |
| 148 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 149 | Acute Coronary Syndrome | FAERS: 1 | US FAERS | |
| 150 | Akathisia | FAERS: 1 | US FAERS | |
| 151 | Alcohol poisoning | FAERS: 1 | US FAERS | |
| 152 | Altered visual depth perception | FAERS: 1 | US FAERS | |
| 153 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 154 | Angle Closure Glaucoma | FAERS: 1 | US FAERS | |
| 155 | Anhedonia | FAERS: 1 | US FAERS | |
| 156 | Ankle Fracture | FAERS: 1 | US FAERS | |
| 157 | Anorgasmia | FAERS: 1 | US FAERS | |
| 158 | Apathy | FAERS: 1 | US FAERS | |
| 159 | Aphonia | FAERS: 1 | US FAERS | |
| 160 | Apparent death | FAERS: 1 | US FAERS | |
| 161 | Arthritis | FAERS: 1 | US FAERS | |
| 162 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 163 | Ataxia | FAERS: 1 | US FAERS | |
| 164 | Atrial tachycardia | FAERS: 1 | US FAERS | |
| 165 | Auricular swelling | FAERS: 1 | US FAERS | |
| 166 | Bedridden | FAERS: 1 | US FAERS | |
| 167 | Benign Prostatic Hyperplasia | FAERS: 1 | US FAERS | |
| 168 | Bladder spasm | FAERS: 1 | US FAERS | |
| 169 | Blood Pressure | FAERS: 1 | US FAERS | |
| 170 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 171 | Blood blister | FAERS: 1 | US FAERS | |
| 172 | Blood glucose decreased | FAERS: 1 | US FAERS | |
| 173 | Blood glucose fluctuation | FAERS: 1 | US FAERS | |
| 174 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 175 | Blood pressure inadequately controlled | FAERS: 1 | US FAERS | |
| 176 | Bone pain | FAERS: 1 | US FAERS | |
| 177 | Bradycardia | FAERS: 1 | US FAERS | |
| 178 | Breast tenderness | FAERS: 1 | US FAERS | |
| 179 | Burning feet syndrome | FAERS: 1 | US FAERS | |
| 180 | Capillary Fragility | FAERS: 1 | US FAERS | |
| 181 | Cardiomegaly | FAERS: 1 | US FAERS | |
| 182 | Cataract | FAERS: 1 | US FAERS | |
| 183 | Catheter site discharge | FAERS: 1 | US FAERS | |
| 184 | Choking sensation | FAERS: 1 | US FAERS | |
| 185 | Compulsive shopping | FAERS: 1 | US FAERS | |
| 186 | Creatinine renal clearance decreased | FAERS: 1 | US FAERS | |
| 187 | Creatinine renal clearance increased | FAERS: 1 | US FAERS | |
| 188 | Cyanosis | FAERS: 1 | US FAERS | |
| 189 | Cystitis | FAERS: 1 | US FAERS | |
| 190 | Delirium | FAERS: 1 | US FAERS | |
| 191 | Dental caries | FAERS: 1 | US FAERS | |
| 192 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 193 | Disorientation | FAERS: 1 | US FAERS | |
| 194 | Dissociation | FAERS: 1 | US FAERS | |
| 195 | Drug dose titration not performed | FAERS: 1 | US FAERS | |
| 196 | Drug ineffective for unapproved indication | FAERS: 1 | US FAERS | |
| 197 | Drug toxicity | FAERS: 1 | US FAERS | |
| 198 | Dry skin | FAERS: 1 | US FAERS | |
| 199 | Dysphonia | FAERS: 1 | US FAERS | |
| 200 | Dystonia | FAERS: 1 | US FAERS | |
| 201 | Ear discomfort | FAERS: 1 | US FAERS | |
| 202 | Economic problem | FAERS: 1 | US FAERS | |
| 203 | Eczema | FAERS: 1 | US FAERS | |
| 204 | Eosinophilia | FAERS: 1 | US FAERS | |
| 205 | Epistaxis | FAERS: 1 | US FAERS | |
| 206 | Eructation | FAERS: 1 | US FAERS | |
| 207 | Erythema Multiforme | FAERS: 1 | US FAERS | |
| 208 | Erythema Nodosum | FAERS: 1 | US FAERS | |
| 209 | Expired product administered | FAERS: 1 | US FAERS | |
| 210 | Eye irritation | FAERS: 1 | US FAERS | |
| 211 | Eye pain | FAERS: 1 | US FAERS | |
| 212 | False negative pregnancy test | FAERS: 1 | US FAERS | |
| 213 | Fasciitis | FAERS: 1 | US FAERS | |
| 214 | Food Poisoning | FAERS: 1 | US FAERS | |
| 215 | Formication | FAERS: 1 | US FAERS | |
| 216 | Gastritis | FAERS: 1 | US FAERS | |
| 217 | Gastrointestinal infection | FAERS: 1 | US FAERS | |
| 218 | Gastrointestinal motility disorder | FAERS: 1 | US FAERS | |
| 219 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 220 | Gingival Recession | FAERS: 1 | US FAERS | |
| 221 | Glaucoma | FAERS: 1 | US FAERS | |
| 222 | Gluten sensitivity | FAERS: 1 | US FAERS | |
| 223 | Head discomfort | FAERS: 1 | US FAERS | |
| 224 | Hepatic congestion | FAERS: 1 | US FAERS | |
| 225 | Hepatotoxicity | FAERS: 1 | US FAERS | |
| 226 | Hormone level abnormal | FAERS: 1 | US FAERS | |
| 227 | Hyperreflexia | FAERS: 1 | US FAERS | |
| 228 | Hypervigilance | FAERS: 1 | US FAERS | |
| 229 | Hypophagia | FAERS: 1 | US FAERS | |
| 230 | Hypotonic urinary bladder | FAERS: 1 | US FAERS | |
| 231 | Ileus | FAERS: 1 | US FAERS | |
| 232 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 233 | Incoherent | FAERS: 1 | US FAERS | |
| 234 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 235 | Irritable Bowel Syndrome | FAERS: 1 | US FAERS | |
| 236 | Lack of spontaneous speech | FAERS: 1 | US FAERS | |
| 237 | Lagophthalmos | FAERS: 1 | US FAERS | |
| 238 | Lethargy | FAERS: 1 | US FAERS | |
| 239 | Loss of personal independence in daily activities | FAERS: 1 | US FAERS | |
| 240 | Lupus-like syndrome | FAERS: 1 | US FAERS | |
| 241 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 242 | Meningitis | FAERS: 1 | US FAERS | |
| 243 | Menorrhagia | FAERS: 1 | US FAERS | |
| 244 | Mental impairment | FAERS: 1 | US FAERS | |
| 245 | Micropenis | FAERS: 1 | US FAERS | |
| 246 | Milk soy protein intolerance | FAERS: 1 | US FAERS | |
| 247 | Morbid thoughts | FAERS: 1 | US FAERS | |
| 248 | Motion Sickness | FAERS: 1 | US FAERS | |
| 249 | Multiple allergies | FAERS: 1 | US FAERS | |
| 250 | Multiple drug overdose intentional | FAERS: 1 | US FAERS | |
| 251 | Muscle Rigidity | FAERS: 1 | US FAERS | |
| 252 | Musculoskeletal discomfort | FAERS: 1 | US FAERS | |
| 253 | Myocarditis | FAERS: 1 | US FAERS | |
| 254 | Myoclonus | FAERS: 1 | US FAERS | |
| 255 | Myopia | FAERS: 1 | US FAERS | |
| 256 | Narcolepsy | FAERS: 1 | US FAERS | |
| 257 | Nephrolithiasis | FAERS: 1 | US FAERS | |
| 258 | Neuroleptic Malignant Syndrome | FAERS: 1 | US FAERS | |
| 259 | No adverse event | FAERS: 1 | US FAERS | |
| 260 | Ophthalmological examination abnormal | FAERS: 1 | US FAERS | |
| 261 | Pain of skin | FAERS: 1 | US FAERS | |
| 262 | Painful ejaculation | FAERS: 1 | US FAERS | |
| 263 | Pelvic Pain | FAERS: 1 | US FAERS | |
| 264 | Peptic Ulcer | FAERS: 1 | US FAERS | |
| 265 | Peripheral swelling | FAERS: 1 | US FAERS | |
| 266 | Physical assault | FAERS: 1 | US FAERS | |
| 267 | Pneumonia | FAERS: 1 | US FAERS | |
| 268 | Product formulation issue | FAERS: 1 | US FAERS | |
| 269 | Product label issue | FAERS: 1 | US FAERS | |
| 270 | Product substitution issue | FAERS: 1 | US FAERS | |
| 271 | Product use issue | FAERS: 1 | US FAERS | |
| 272 | Psychiatric symptom | FAERS: 1 | US FAERS | |
| 273 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 274 | Pyelonephritis | FAERS: 1 | US FAERS | |
| 275 | Rash erythematous | FAERS: 1 | US FAERS | |
| 276 | Respiratory distress | FAERS: 1 | US FAERS | |
| 277 | Screaming | FAERS: 1 | US FAERS | |
| 278 | Sepsis | FAERS: 1 | US FAERS | |
| 279 | Shoplifting | FAERS: 1 | US FAERS | |
| 280 | Sinus Tachycardia | FAERS: 1 | US FAERS | |
| 281 | Skin irritation | FAERS: 1 | US FAERS | |
| 282 | Sleep Talking | FAERS: 1 | US FAERS | |
| 283 | Tachyarrhythmia | FAERS: 1 | US FAERS | |
| 284 | Tardive Dyskinesia | FAERS: 1 | US FAERS | |
| 285 | Temperature regulation disorder | FAERS: 1 | US FAERS | |
| 286 | Tenosynovitis | FAERS: 1 | US FAERS | |
| 287 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 288 | Therapy cessation | FAERS: 1 | US FAERS | |
| 289 | Therapy change | FAERS: 1 | US FAERS | |
| 290 | Thirst | FAERS: 1 | US FAERS | |
| 291 | Throat irritation | FAERS: 1 | US FAERS | |
| 292 | Thrombosis | FAERS: 1 | US FAERS | |
| 293 | Tooth Erosion | FAERS: 1 | US FAERS | |
| 294 | Tooth Extraction | FAERS: 1 | US FAERS | |
| 295 | Tooth Loss | FAERS: 1 | US FAERS | |
| 296 | Toothache | FAERS: 1 | US FAERS | |
| 297 | Vascular rupture | FAERS: 1 | US FAERS | |
| 298 | Wheezing | FAERS: 1 | US FAERS | |
| 299 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 300 | prostatitis | FAERS: 1 | US FAERS |
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