MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Nicotine Dependence

(UMLS:C0028043)

UMLS ID:: C0028043
MeSH ID:: D014029

Classification 1:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.775.912

Classification 2:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.900.912

Synonym(s)

Nicotine Dependence

Addiction;nicotine

Nicotine Addiction

Nicotine addiction

Nicotine dependence

addiction nicotine

addictions nicotine

dependence nicotine

dependence; nicotine

10.

nicotine addiction

11.

nicotine dependence

12.

nicotine; dependence

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Nicotine	FAERS: 3816 Canada Vigilance: 18	Canada Vigilance OFFSIDES SIDER US FAERS
2	Varenicline	FAERS: 42 Canada Vigilance: 4	Canada Vigilance US FAERS
3	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 19	OFFSIDES US FAERS
4	Lisdexamfetamine Dimesylate	FAERS: 7	US FAERS
5	Alendronate	FAERS: 5	US FAERS
6	rofecoxib	FAERS: 4	US FAERS
7	Duloxetine Hydrochloride	FAERS: 3	US FAERS
8	Finasteride	FAERS: 3	US FAERS
9	Pregabalin	FAERS: 3	US FAERS
10	carfilzomib	FAERS: 3	US FAERS
11	Amphetamine	FAERS: 2	OFFSIDES US FAERS
12	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2	US FAERS
13	Clozapine	FAERS: 2	US FAERS
14	Methylphenidate	FAERS: 2	US FAERS
15	Naltrexone	FAERS: 2	US FAERS
16	NuvaRing	FAERS: 2	US FAERS
17	Olanzapine	FAERS: 2	OFFSIDES US FAERS
18	Paroxetine	FAERS: 2	US FAERS
19	Pramipexole	FAERS: 2	OFFSIDES US FAERS
20	Venlafaxine Hydrochloride	FAERS: 2	US FAERS
21	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
22	Aripiprazole	FAERS: 1	US FAERS
23	Bupropion	FAERS: 1	OFFSIDES US FAERS
24	Copper	FAERS: 1	US FAERS
25	Gabapentin	FAERS: 1	US FAERS
26	Lamotrigine	FAERS: 1	US FAERS
27	Leuprolide	FAERS: 1	US FAERS
28	Levetiracetam	FAERS: 1	US FAERS
29	Mesalamine	FAERS: 1	US FAERS
30	Omeprazole	FAERS: 1	US FAERS
31	Oxymorphone	FAERS: 1	US FAERS
32	Pramipexole	FAERS: 1	US FAERS
33	Sitagliptin Phosphate	FAERS: 1	US FAERS
34	Tiotropium Bromide	FAERS: 1	US FAERS
35	Varenicline	FAERS: 1	US FAERS
36	Acarbose		OFFSIDES
37	Benztropine		OFFSIDES
38	Bethanechol		OFFSIDES
39	Buspirone		OFFSIDES
40	Celecoxib		OFFSIDES
41	Chlordiazepoxide		OFFSIDES
42	Cisapride		OFFSIDES
43	Citalopram		OFFSIDES
44	Clorazepate Dipotassium		OFFSIDES
45	Cortisone		OFFSIDES
46	Dextropropoxyphene		OFFSIDES
47	Diphenhydramine		OFFSIDES
48	Fluphenazine		OFFSIDES
49	Isosorbide		OFFSIDES
50	Labetalol		OFFSIDES
51	Lithium		OFFSIDES
52	Meloxicam		OFFSIDES
53	Meperidine		OFFSIDES
54	Methyltestosterone		OFFSIDES
55	Minoxidil		OFFSIDES
56	Norethindrone		OFFSIDES
57	Nortriptyline		OFFSIDES
58	Oxcarbazepine		OFFSIDES
59	Paliperidone Palmitate	Canada Vigilance: 1	Canada Vigilance
60	Pirinitramide		OFFSIDES
61	Tamoxifen		OFFSIDES
62	Terazosin		OFFSIDES
63	Theophylline		OFFSIDES
64	Thioridazine		OFFSIDES
65	Tiagabine		OFFSIDES
66	Vardenafil Dihydrochloride		OFFSIDES
67	bicalutamide		OFFSIDES
68	fluphenazine depot		OFFSIDES
69	lamivudine, zidovudine drug combination		OFFSIDES
70	nefazodone		OFFSIDES
71	ropinirole		OFFSIDES
72	ziprasidone		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Marijuana Abuse	42.9%
2	Opioid-Related Disorders	42.9%
3	Opioid abuse	42.9%
4	Phencyclidine Abuse	42.9%
5	Substance Abuse, Intravenous	42.9%
6	Substance Withdrawal Syndrome	42.9%
7	Alcohol-Related Disorders	42.9%
8	Amphetamine-Related Disorders	42.9%
9	Cocaine-Related Disorders	42.9%
10	Psychoses, Substance-Induced	36.5%
11	Neonatal Abstinence Syndrome	34.3%
12	Alcohol Use Disorder	31%
13	Alcoholic Intoxication	31%
14	Heroin Dependence	31%
15	Morphine Dependence	31%
16	Alcohol abuse	31%
17	Alcohol Withdrawal Delirium	30.4%
18	Psychoses, Alcoholic	24.7%
19	Binge Drinking	24.5%
20	Alcohol-Induced Disorders	20.9%
21	Drug Overdose	20.9%
22	Neurotic Disorders	18.5%
23	Wernicke Encephalopathy	17.2%
24	Alcohol Withdrawal Seizures	15.2%
25	Anxiety Disorders	15%
26	Avoidant Personality Disorder	15%
27	Dissociative disorder	15%
28	Drug toxicity	15%
29	Frigidity	15%
30	Hypoactive Sexual Desire Disorder	15%
31	Disruptive, Impulse Control, and Conduct Disorders	15%
32	Intermittent Explosive Disorder	15%
33	Kleptomania	15%
34	Narcissistic Personality Disorder	15%
35	Personality Disorders	15%
36	Poisoning	15%
37	Sexual Aversion Disorder	15%
38	Somatoform Disorder	15%
39	Dissociation	15%
40	Motor Disorders	15%
41	Mood Disorders	15%
42	Schizophrenia Spectrum and Other Psychotic Disorders	15%
43	Neurodevelopmental Disorders	15%
44	Neurocognitive Disorders	15%
45	Feeding and Eating Disorders	15%
46	Alcohol-Induced Disorders, Nervous System	14.5%
47	Separation Anxiety Disorder	14.3%
48	Cardiomyopathy, Alcoholic	12.8%
49	Pancreatitis, Alcoholic	12.8%
50	Chemical and Drug Induced Liver Injury	11.4%
51	Mushroom Poisoning	10.3%
52	Fetal Alcohol Spectrum Disorders	10.3%
53	Adjustment Disorders	9.5%
54	Affective Disorders, Psychotic	9.5%
55	Agoraphobia	9.5%
56	Anorexia Nervosa	9.5%
57	Antisocial Personality Disorder	9.5%
58	Bipolar Disorder	9.5%
59	Body Dysmorphic Disorders	9.5%
60	Borderline Personality Disorder	9.5%
61	Capgras Syndrome	9.5%
62	Child Behavior Disorders	9.5%
63	Developmental Disabilities	9.5%
64	Child Development Disorders, Pervasive	9.5%
65	Claustrophobia	9.5%
66	Cognition Disorders	9.5%
67	Conversion disorder	9.5%
68	Cyclothymic Disorder	9.5%
69	Dependent Personality Disorder	9.5%
70	Depressive disorder	9.5%
71	Developmental Coordination Disorder	9.5%
72	Exhibitionism	9.5%
73	Factitious Disorders	9.5%
74	Firesetting Behavior	9.5%
75	Fluoride Poisoning	9.5%
76	Food Poisoning	9.5%
77	Gas Poisoning	9.5%
78	Head Banging	9.5%
79	Histrionic Personality Disorder	9.5%
80	Hypochondriasis	9.5%
81	Masochism	9.5%
82	Melancholia	9.5%
83	Motor Skills Disorders	9.5%
84	Dissociative Identity Disorder	9.5%
85	Mycotoxicosis	9.5%
86	Neurasthenia	9.5%
87	Obsessive-Compulsive Disorder	9.5%
88	Oppositional Defiant Disorder	9.5%
89	Panic Disorder	9.5%
90	Paranoid Personality Disorder	9.5%
91	Pedophilia	9.5%
92	Plant Poisoning	9.5%
93	Pseudodementia	9.5%
94	Psychotic Disorders	9.5%
95	Sadism	9.5%
96	Schizoaffective Disorder	9.5%
97	Schizoid Personality Disorder	9.5%
98	Schizophrenia	9.5%
99	Schizophrenia, Childhood	9.5%
100	Schizotypal Personality Disorder	9.5%
101	Stereotypic Movement Disorder	9.5%
102	Transvestism	9.5%
103	Trichotillomania	9.5%
104	Voyeurism	9.5%
105	Anticholinergic Syndrome	9.5%
106	Attention Deficit and Disruptive Behavior Disorders	9.5%
107	Hyperkinetic Heart Syndrome	9.5%
108	Reactive Attachment Disorder	9.5%
109	Sexual and Gender Disorders	9.5%
110	Gender Dysphoria	9.5%
111	Serotonin Syndrome	9.5%
112	Organophosphate poisoning	9.5%
113	Propofol Infusion Syndrome	9.5%
114	Paranoia	9.5%
115	Compulsive Personality Disorder	9.5%
116	Bulimia Nervosa	9.5%
117	Fatty Liver, Alcoholic	9.2%
118	Hepatitis, Alcoholic	9.2%
119	Liver Cirrhosis, Alcoholic	9.2%
120	Sleep Wake Disorders	9%
121	Chemical and Drug Induced Liver Injury, Chronic	8.2%
122	Bites and Stings	7.4%
123	Neurotoxicity Syndromes	7.4%
124	Parasomnia	7.1%
125	Dyssomnias	7.1%
126	Metabolic Side Effects of Drugs and Substances	7.1%
127	Gambling	7%
128	Premature Ejaculation	7%
129	Water Intoxication	7%
130	Injection Site Reaction	7%
131	Erectile dysfunction	7%
132	Arsenic Poisoning	7%
133	Dementia	7%
134	Infusion site reaction	7%
135	Cadmium poisoning	7%
136	Carbon Monoxide Poisoning	7%
137	Ciguatera Poisoning	7%
138	Combat Disorders	7%
139	Dysthymic Disorder	7%
140	Ergotism	7%
141	Hysteria	7%
142	Lead Poisoning	7%
143	Mercury Poisoning	7%
144	Schizophrenia, Catatonic	7%
145	Schizophrenia, Disorganized	7%
146	Post-Traumatic Stress Disorder	7%
147	Attention Deficit Disorder	7%
148	Seasonal Affective Disorder	7%
149	Conduct Disorder	7%
150	Social Communication Disorder	7%
151	Shellfish Poisoning	7%
152	Psychological Trauma	7%
153	Hoarding Disorder	7%
154	Phonological Disorder	7%
155	Akathisia, Drug-Induced	6.9%
156	Dyskinesia, Drug-Induced	6%
157	Autistic Disorder	5.7%
158	Asperger Syndrome	5.7%
159	Dyspareunia	5.5%
160	Restless Legs Syndrome	5.4%
161	Mutism	5.4%
162	Selective Mutism	5.4%
163	Insect Bites and Stings	5.3%
164	Argyria	5.2%
165	Depression, Postpartum	5.2%
166	Sleep Talking	5.2%
167	Manganese Poisoning	5.2%
168	Sleep Disorders, Intrinsic	5.2%
169	Tick Paralysis	5.1%
170	Kluver-Bucy Syndrome	5.1%
171	Premenstrual Dysphoric Disorder	5.1%
172	Salmonella food poisoning	5.1%
173	Cardiotoxicity	4.7%
174	Consciousness Disorders	4.6%
175	Mental Retardation	4.6%
176	Depressed Level of Consciousness	4.6%
177	Mental deficiency	4.6%
178	Intellectual Disability	4.6%
179	Enuresis	4.6%
180	Amnesia	4.5%
181	Delirium	4.5%
182	Dissociative Amnesia	4.5%
183	Global Amnesia	4.5%
184	Huntington Disease	4.5%
185	Mercury Poisoning, Nervous System	4.3%
186	Lead Poisoning, Nervous System	4.3%
187	Disorders of Excessive Somnolence	4.2%
188	Sleep Initiation and Maintenance Disorders	4.2%
189	Night Terrors	4.2%
190	Somnambulism	4.2%
191	Transient Insomnia	4.2%
192	Sleep Paralysis	4.2%
193	Chronic Insomnia	4.2%
194	REM Sleep Behavior Disorder	4.2%
195	Hypersomnia	4.2%
196	Neuroleptic Malignant Syndrome	4.1%
197	Drug Eruptions	4.1%
198	Sleep Bruxism	4.1%
199	Presenile dementia	4.1%
200	Senile dementia	4.1%
201	Creutzfeldt-Jakob disease	4.1%
202	Dyscalculia	4%
203	Alexia, Pure	4%
204	Lead Poisoning, Nervous System, Childhood	3.8%
205	Lead Poisoning, Nervous System, Adult	3.8%
206	Narcolepsy	3.8%
207	Kleine-Levin Syndrome	3.8%
208	Pick Disease of the Brain	3.8%
209	Sleep Disorders, Circadian Rhythm	3.6%
210	Cataplexy	3.6%
211	Botulism	3.4%
212	Sleep Deprivation	3.4%
213	MPTP Poisoning	3.4%
214	Acute Generalized Exanthematous Pustulosis	3.4%
215	Diurnal Enuresis	3.3%
216	Retrograde amnesia	3.3%
217	Amnesia, Anterograde	3.3%
218	Acrodynia	3%
219	Asthma, Aspirin-Induced	2.9%
220	Lewy Body Disease	2.9%
221	AIDS Dementia Complex	2.9%
222	Amnesia, Transient Global	2.9%
223	Alexia	2.8%
224	Dyslexia	2.8%
225	Erythema Nodosum	2.8%
226	Serum Sickness	2.8%
227	Frontotemporal dementia	2.8%
228	Auditory Perceptual Disorders	2.5%
229	Jet Lag Syndrome	2.4%
230	Dementia, Vascular	2.2%
231	Toxic Epidermal Necrolysis	2.1%
232	Stevens-Johnson Syndrome	2.1%

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