MetaADEDB 2.0 @ LMMD
Trimethoprim
(IEDVJHCEMCRBQM-UHFFFAOYSA-N)
Structure
SMILES
COc1cc(Cc2cnc(nc2N)N)cc(c1OC)OC
Type(s)
Approved; Vet_approved
ATC code(s)
J01EA01; J01EE01; J01EE02; J01EE03; J01EE04; J01EE05; J01EE07; J04AM08
Molecular Formula:
C14H18N4O3
Molecular Weight:
290.318
Log P:
2.4200
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
2
TPSA:
105.51
CAS Number(s):
738-70-5
Synonym(s)
1.
Trimethoprim
2.
Proloprim
3.
Trimpex
External Link(s)
MeSHD014295
PubChem Compound5578
BindingDB18069
ChEBI45924
CHEMBLCHEMBL22
DrugBankDB00440
DrugCentral2755
KEGGcpd:C01965
dr:D00145
Therapeutic Target DatabaseD0AO5H
ZINC6627681
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 33
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
SIDER
US FAERS
2HeadacheFAERS: 25
Canada Vigilance: 5
12165625CTD
SIDER
Canada Vigilance
US FAERS
3MalaiseFAERS: 25US FAERS
4PruritusFAERS: 23
Canada Vigilance: 7
Canada Vigilance
SIDER
US FAERS
5VomitingFAERS: 20
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
6TremorFAERS: 18
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
7Abdominal PainFAERS: 14
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
SIDER
US FAERS
8DizzinessFAERS: 14
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
SIDER
US FAERS
9ChillsFAERS: 13
Canada Vigilance: 1
Canada Vigilance
US FAERS
10MyalgiaFAERS: 13
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
11UrticariaFAERS: 12
Canada Vigilance: 7
Canada Vigilance
SIDER
US FAERS
12HypersensitivityFAERS: 11
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
13AstheniaFAERS: 10
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
14ErythemaFAERS: 10
Canada Vigilance: 4
Canada Vigilance
OFFSIDES
SIDER
US FAERS
15ArthralgiaFAERS: 9
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
16Lip swellingFAERS: 9US FAERS
17Eye painFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
18PainFAERS: 8OFFSIDES
US FAERS
19jaundiceFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
20AnxietyFAERS: 7
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
21Chest discomfortFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
22FatigueFAERS: 7
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
US FAERS
23PhotophobiaFAERS: 712165625CTD
US FAERS
24PancytopeniaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
25AgranulocytosisFAERS: 5
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
26Back PainFAERS: 5
Canada Vigilance: 2
Canada Vigilance
US FAERS
27DisorientationFAERS: 5US FAERS
28Drug exposure during pregnancyFAERS: 5US FAERS
29Feeling ColdFAERS: 5US FAERS
30IridocyclitisFAERS: 5US FAERS
31LethargyFAERS: 5SIDER
US FAERS
32Musculoskeletal stiffnessFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
33Abdominal discomfortFAERS: 4
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
34Burning sensationFAERS: 4US FAERS
35Chest PainFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
36DehydrationFAERS: 4OFFSIDES
US FAERS
37EosinophiliaFAERS: 4SIDER
US FAERS
38FlushingFAERS: 4US FAERS
39PalpitationsFAERS: 4US FAERS
40Rash erythematousFAERS: 4
Canada Vigilance: 3
Canada Vigilance
US FAERS
41Toxic Epidermal NecrolysisFAERS: 4SIDER
US FAERS
42Urinary tract infectionFAERS: 4US FAERS
43White blood cell count decreasedFAERS: 4US FAERS
44AgitationFAERS: 3SIDER
US FAERS
45Cardiac ArrestFAERS: 3US FAERS
46DystoniaFAERS: 3US FAERS
47Eye irritationFAERS: 3US FAERS
48HypotensionFAERS: 3US FAERS
49Joint swellingFAERS: 3US FAERS
50Stevens-Johnson SyndromeFAERS: 3
Canada Vigilance: 1
25811541CTD
SIDER
Canada Vigilance
US FAERS
51SwellingFAERS: 3US FAERS
52Visual disturbanceFAERS: 3US FAERS
53WheezingFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
54Acute kidney injuryFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
55Allergic hepatitisFAERS: 2US FAERS
56BronchopneumoniaFAERS: 2OFFSIDES
US FAERS
57ChromaturiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
58ConjunctivitisFAERS: 2US FAERS
59CryingFAERS: 2US FAERS
60DeliriumFAERS: 218303133CTD
US FAERS
61Depressed moodFAERS: 2US FAERS
62Documented hypersensitivity to administered productFAERS: 2US FAERS
63DyspepsiaFAERS: 2SIDER
US FAERS
64Exfoliative rashFAERS: 2US FAERS
65Feeling abnormalFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
66Feeling of body temperature changeFAERS: 2US FAERS
67HydronephrosisFAERS: 2OFFSIDES
US FAERS
68InfectionFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
69LymphadenopathyFAERS: 2US FAERS
70Medication ErrorFAERS: 2US FAERS
71Mouth swellingFAERS: 2US FAERS
72Neck PainFAERS: 2US FAERS
73Oropharyngeal blisteringFAERS: 2US FAERS
74Oropharyngeal painFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
75Pain of skinFAERS: 2US FAERS
76PyelonephritisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
77Skin reactionFAERS: 2US FAERS
78SomnolenceFAERS: 2US FAERS
79SyncopeFAERS: 2SIDER
US FAERS
80Throat irritationFAERS: 2US FAERS
81UveitisFAERS: 29228966CTD
SIDER
US FAERS
82Ventricular FibrillationFAERS: 2US FAERS
83Visual ImpairmentFAERS: 2US FAERS
84Abnormal clotting factorFAERS: 1US FAERS
85Activities of daily living impairedFAERS: 1US FAERS
86Acute psychosisFAERS: 1US FAERS
87Alanine Aminotransferase IncreasedFAERS: 1US FAERS
88Altered visual depth perceptionFAERS: 1US FAERS
89Anaphylactic shockFAERS: 1SIDER
US FAERS
90AngerFAERS: 1US FAERS
91AnuriaFAERS: 1US FAERS
92ArthritisFAERS: 1US FAERS
93Arthropod biteFAERS: 1US FAERS
94AsthmaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
95AuraFAERS: 1OFFSIDES
US FAERS
96BlindnessFAERS: 1US FAERS
97Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
98Blood folate decreasedFAERS: 1US FAERS
99Blood sodium decreasedFAERS: 1US FAERS
100Cerebrovascular accidentFAERS: 1US FAERS
101Cold sweatFAERS: 1US FAERS
102ColitisFAERS: 1US FAERS
103ConstipationFAERS: 1SIDER
US FAERS
104Drug administered to patient of inappropriate ageFAERS: 1US FAERS
105Drug dispensing errorFAERS: 1US FAERS
106Drug ineffectiveFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
107Drug prescribing errorFAERS: 1US FAERS
108Dry skinFAERS: 1OFFSIDES
US FAERS
109DysuriaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
110Emotional distressFAERS: 1US FAERS
111EndophthalmitisFAERS: 1US FAERS
112Enterovesical FistulaFAERS: 1US FAERS
113Eyelid margin crustingFAERS: 1US FAERS
114Eyelids pruritusFAERS: 1US FAERS
115Facial PainFAERS: 1US FAERS
116FlatulenceFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
117General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
118HepatitisFAERS: 1OFFSIDES
US FAERS
119HordeolumFAERS: 1US FAERS
120HyperacusisFAERS: 1US FAERS
121HyperpyrexiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
122HypersomniaFAERS: 1US FAERS
123Immune thrombocytopenic purpuraFAERS: 1US FAERS
124ImpetigoFAERS: 1US FAERS
125Infective glossitisFAERS: 1US FAERS
126InflammationFAERS: 1US FAERS
127Irritable Bowel SyndromeFAERS: 1US FAERS
128Laboratory test interferenceFAERS: 1US FAERS
129Lack of spontaneous speechFAERS: 1US FAERS
130LeukopeniaFAERS: 1SIDER
US FAERS
131Ligament painFAERS: 1US FAERS
132Lip exfoliationFAERS: 1US FAERS
133Lupus-like syndromeFAERS: 1US FAERS
134Memory impairmentFAERS: 1US FAERS
135MeningitisFAERS: 12320959CTD
US FAERS
136Mental impairmentFAERS: 1OFFSIDES
US FAERS
137Metabolic acidosisFAERS: 1US FAERS
138Muscle tightnessFAERS: 1US FAERS
139Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
140Myocardial InfarctionFAERS: 1US FAERS
141NeutropeniaFAERS: 1SIDER
US FAERS
142No adverse eventFAERS: 1US FAERS
143No reaction on previous exposure to drugFAERS: 1US FAERS
144Obsessive-Compulsive DisorderFAERS: 1US FAERS
145Ocular icterusFAERS: 1US FAERS
146OliguriaFAERS: 1US FAERS
147Optic NeuritisFAERS: 1US FAERS
148Oral candidiasisFAERS: 1US FAERS
149Oral mucosal exfoliationFAERS: 1US FAERS
150PallorFAERS: 1
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
151Periorbital disorderFAERS: 1US FAERS
152PetechiaeFAERS: 1US FAERS
153PneumoniaFAERS: 1US FAERS
154PresyncopeFAERS: 1US FAERS
155Product solubility abnormalFAERS: 1US FAERS
156Product substitution issueFAERS: 1US FAERS
157Purulent dischargeFAERS: 1US FAERS
158Restless Legs SyndromeFAERS: 1US FAERS
159RestlessnessFAERS: 1US FAERS
160RhabdomyolysisFAERS: 1US FAERS
161ScabFAERS: 1US FAERS
162SepsisFAERS: 1US FAERS
163Sexual inhibitionFAERS: 1US FAERS
164ShockFAERS: 1SIDER
US FAERS
165Skin irritationFAERS: 1US FAERS
166StressFAERS: 1OFFSIDES
US FAERS
167TachycardiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
168Tension HeadacheFAERS: 1US FAERS
169ThirstFAERS: 1US FAERS
170ThrombocytopeniaFAERS: 1SIDER
US FAERS
171TinnitusFAERS: 1SIDER
US FAERS
172ToothacheFAERS: 1US FAERS
173Unevaluable eventFAERS: 1US FAERS
174Urinary IncontinenceFAERS: 1US FAERS
175Vasculitic rashFAERS: 1US FAERS
176VertigoFAERS: 1SIDER
US FAERS
177Vulvovaginal burning sensationFAERS: 1US FAERS
178Vulvovaginal discomfortFAERS: 1US FAERS
179Vulvovaginal mycotic infectionFAERS: 1US FAERS
180Wrong drug administeredFAERS: 1US FAERS
181furuncleFAERS: 1OFFSIDES
US FAERS
182AIDS-Related Opportunistic Infections7481974CTD
183AbasiaOFFSIDES
184Abdominal massOFFSIDES
185Abdominal tendernessOFFSIDES
186Acid refluxOFFSIDES
187AcidosisOFFSIDES
188AdenocarcinomaOFFSIDES
189Agonal rhythmOFFSIDES
190AgraphiaOFFSIDES
191AlopeciaCanada Vigilance: 1Canada Vigilance
192AmphetaminesOFFSIDES
193Anemia, Hemolytic20589632CTD
194AngioedemaSIDER
195AnhedoniaOFFSIDES
196AnhidrosisOFFSIDES
197AnisocoriaOFFSIDES
198AnorexiaOFFSIDES
SIDER
199ApathyOFFSIDES
200Arteriovenous fistula aneurysmOFFSIDES
201Arteriovenous graft thrombosisOFFSIDES
202AscitesOFFSIDES
203AspergillosisOFFSIDES
204AtaxiaSIDER
205AtelectasisOFFSIDES
206Atrophic vulvovaginitisOFFSIDES
207Autoimmune hepatitisOFFSIDES
208Avascular necrosisOFFSIDES
209Bacillus infectionOFFSIDES
210Bacterial disease carrierOFFSIDES
211Bacterial test positiveOFFSIDES
212Bacteriuria6349046CTD
213Bilirubin conjugated increasedOFFSIDES
214Biopsy breast abnormalOFFSIDES
215Biopsy lymph gland abnormalOFFSIDES
216Bipolar DisorderOFFSIDES
217Bipolar I disorderOFFSIDES
218Blood GlucoseOFFSIDES
219Blood alkaline phosphatase increasedOFFSIDES
220Blood and lymphatic system disordersSIDER
221Blood beta-D-glucan increasedOFFSIDES
222Blood bilirubin abnormalOFFSIDES
223Blood creatine increasedOFFSIDES
224Blood glucose decreasedCanada Vigilance: 1Canada Vigilance
225Blood immunoglobulin G increasedOFFSIDES
226Blood potassium increasedOFFSIDES
227Blood sodiumOFFSIDES
228Blood triglycerides increasedOFFSIDES
229Bone density decreasedOFFSIDES
230Bone fragmentationOFFSIDES
231Bone marrow depressionSIDER
232Bone trimmingOFFSIDES
233Brain ConcussionOFFSIDES
234Breast hyperplasiaOFFSIDES
235BruxismOFFSIDES
236BursitisOFFSIDES
237Carotid artery occlusionOFFSIDES
238Catheter related infectionOFFSIDES
239Catheter sepsisOFFSIDES
240Cell DeathOFFSIDES
241CellulitisOFFSIDES
242Cerebral atrophyOFFSIDES
243Chemotherapeutic drug level increasedOFFSIDES
244Choking sensationOFFSIDES
245CholangiolitisOFFSIDES
246CirrhosisOFFSIDES
247Complex partial seizuresOFFSIDES
248Compression fractureOFFSIDES
249ConfabulationOFFSIDES
250Congenital cystic kidney diseaseOFFSIDES
251Conjunctival abrasionOFFSIDES
252CyanosisCanada Vigilance: 1Canada Vigilance
253CystOFFSIDES
254Deafness NeurosensoryOFFSIDES
255DemyelinationOFFSIDES
256Depressed Level of ConsciousnessOFFSIDES
257DermatitisCanada Vigilance: 1Canada Vigilance
SIDER
258Device related infectionOFFSIDES
259DiarrheaOFFSIDES
260DiscomfortCanada Vigilance: 1Canada Vigilance
261Disease ProgressionOFFSIDES
262Drug Eruptions6223429CTD
263Drug withdrawal headacheOFFSIDES
264DuodenitisOFFSIDES
265Dysthymic DisorderOFFSIDES
266Ejection Fraction DecreasedOFFSIDES
267Emotional disorderOFFSIDES
268Encephalitis2320959CTD
269Endometrial hypertrophyOFFSIDES
270Epigastric distressSIDER
271EpistaxisCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
272Erythema MultiformeCanada Vigilance: 1Canada Vigilance
SIDER
273Erythema Nodosum6223429CTD
274Escherichia sepsisOFFSIDES
275Eustachian tube disorderOFFSIDES
276Exanthema7481974CTD
277ExcoriationOFFSIDES
278Extremity contractureOFFSIDES
279Eye InfectionCanada Vigilance: 1Canada Vigilance
280Facial NeuralgiaOFFSIDES
281Fixed drug eruptionSIDER
282Fluid overloadOFFSIDES
283GamblingOFFSIDES
284Gamma-Glutamyltransferase IncreasedOFFSIDES
285GangreneCanada Vigilance: 1Canada Vigilance
286Gastric ulcerOFFSIDES
287GastroenteritisOFFSIDES
288Gastrointestinal PainSIDER
289Glasgow coma scaleOFFSIDES
290GlossitisSIDER
291Graft delaminationOFFSIDES
292GranulomaOFFSIDES
293Hepatic necrosisSIDER
294Hepatitis COFFSIDES
295HepatosplenomegalyOFFSIDES
296HerniaOFFSIDES
297Hip surgeryOFFSIDES
298HydrocephalusOFFSIDES
299Hyperkalemia8124180CTD
300HyperpigmentationOFFSIDES
301Hypoaesthesia facialOFFSIDES
302HypokinesiaOFFSIDES
303HypophagiaOFFSIDES
304HypoxiaOFFSIDES
305Intestinal PerforationOFFSIDES
306Jaundice, Obstructive1937651CTD
307Joint Range of Motion DecreasedOFFSIDES
308Joint sprainOFFSIDES
309Joint stiffnessOFFSIDES
310Kidney Diseases6349046CTD
311Kidney FailureOFFSIDES
312Large intestine perforationOFFSIDES
313Leukocytoclastic vasculitisSIDER
314Liver diseases7479194CTD
315Loose toothOFFSIDES
316Lumbar radiculopathyOFFSIDES
317Lung InjuryOFFSIDES
318LymphedemaOFFSIDES
319MacrocytosisOFFSIDES
320MacroglossiaOFFSIDES
321Malignant mesenteric neoplasmOFFSIDES
322MalnutritionSIDER
323MastectomyOFFSIDES
324Medical device removalOFFSIDES
325Meningism12165625CTD
326Mental status changesOFFSIDES
327MetaplasiaOFFSIDES
328Metastatic Renal Cell CarcinomaOFFSIDES
329MononeuritisOFFSIDES
330Mucosal erosionOFFSIDES
331Multiple MyelomaOFFSIDES
332Multiple SclerosisOFFSIDES
333Musculoskeletal chest painOFFSIDES
334Myoclonus18303133CTD
335Nasal mucosal disorderOFFSIDES
336Nephrogenic Fibrosing DermopathyOFFSIDES
337Neural Tube Defects8318756CTD
338NeuralgiaOFFSIDES
339NeuritisSIDER
340Neuroleptic Malignant SyndromeOFFSIDES
341NoduleOFFSIDES
342Ocular discomfortCanada Vigilance: 1Canada Vigilance
343Open woundOFFSIDES
344Optic Disc EdemaOFFSIDES
345Oral infectionOFFSIDES
346Oropharyngeal swellingOFFSIDES
347OsteopeniaOFFSIDES
348PancreatitisSIDER
349ParathyroidectomyOFFSIDES
350Performance status decreasedOFFSIDES
351PeriodontitisOFFSIDES
352Peritoneal InfectionOFFSIDES
353PeritonitisOFFSIDES
354Pneumocystis jiroveci pneumoniaOFFSIDES
355PneumothoraxOFFSIDES
356PolymyositisOFFSIDES
357Poor quality sleepOFFSIDES
358Post procedural infectionOFFSIDES
359Postmenopausal bleedingOFFSIDES
360PresbyopiaOFFSIDES
361Prosthesis ImplantationOFFSIDES
362Pulmonary congestionOFFSIDES
363PurpuraCanada Vigilance: 1Canada Vigilance
SIDER
364Pyuria3502034CTD
365Radiation skin injuryOFFSIDES
366RalesOFFSIDES
367Reaction gastrointestinalSIDER
368Reflux gastritisOFFSIDES
369Renal Insufficiency8124180CTD
370Renal cystOFFSIDES
371Renal tubular necrosisOFFSIDES
372Residual urineOFFSIDES
373Respiratory FailureOFFSIDES
374RhinitisOFFSIDES
375RhinorrheaOFFSIDES
376Right Ventricular HypertrophyOFFSIDES
377SarcoidosisOFFSIDES
378Schizoaffective DisorderOFFSIDES
379Secretion dischargeOFFSIDES
380Septic ShockOFFSIDES
381SequestrectomyOFFSIDES
382SeromaOFFSIDES
383Sinus headacheOFFSIDES
384Sinus rhythmOFFSIDES
385Sinusitis10888991CTD
386Skin IndurationOFFSIDES
387Skin hypertrophyOFFSIDES
388Skin lesionOFFSIDES
389Skin tightnessOFFSIDES
390SnoringOFFSIDES
391Spinal column stenosisOFFSIDES
392Spinal fusion surgeryOFFSIDES
393Stasis dermatitisOFFSIDES
394StomatitisSIDER
395SunburnCanada Vigilance: 1Canada Vigilance
396TendinitisOFFSIDES
397Tooth ExtractionOFFSIDES
398Tooth ResorptionOFFSIDES
399TorticollisCanada Vigilance: 1Canada Vigilance
400Upper respiratory tract inflammationOFFSIDES
401Urine viscosity increasedOFFSIDES
402Vascular purpuraSIDER
403VasculitisCanada Vigilance: 11630995CTD
Canada Vigilance
404Venous stasisOFFSIDES
405Walking aid userOFFSIDES
406Wound dehiscenceOFFSIDES
407colonoscopyOFFSIDES
408nervous system disorderSIDER
409prostatitisOFFSIDES
410pseudomembranous colitisSIDER
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