MetaADEDB 2.0 @ LMMD
Desipramine
(HCYAFALTSJYZDH-UHFFFAOYSA-N)
Structure
SMILES
CNCCCN1c2ccccc2CCc2c1cccc2
Type(s)
Approved; Investigational
ATC code(s)
N06AA01
Molecular Formula:
C18H22N2
Molecular Weight:
266.381
Log P:
3.9887
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
1
TPSA:
15.27
CAS Number(s):
50-47-5; 58-28-6
Synonym(s)
1.
Desipramine
2.
Desmethylimipramine
3.
Apo-Desipramine
4.
Demethylimipramine
5.
Desipramine Hydrochloride
6.
Norpramin
7.
Novo-Desipramine
8.
Nu-Desipramine
9.
PMS-Desipramine
10.
Pertofran
11.
Pertofrane
12.
Pertrofran
13.
Petylyl
14.
Ratio-Desipramine
15.
Apo Desipramine
16.
Hydrochloride, Desipramine
17.
Novo Desipramine
18.
Nu Desipramine
19.
PMS Desipramine
20.
Ratio Desipramine
External Link(s)
MeSHD003891
PubChem Compound2995
BindingDB35229
50010869
ChEBI47781
CHEMBLCHEMBL72
DrugBankDB01151
DrugCentral812
IUPHAR/BPS Guide to PHARMACOLOGY2399
KEGGcpd:C06943
dr:D07791
Therapeutic Target DatabaseD01UTL
ZINC1530611
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DizzinessFAERS: 3
Canada Vigilance: 1		6375400
6691785		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
2HeadacheFAERS: 2
Canada Vigilance: 2		16680561CTD
SIDER
Canada Vigilance
US FAERS
3Product quality issueFAERS: 2US FAERS
4Anticholinergic SyndromeFAERS: 1US FAERS
5Blood glucose increasedFAERS: 1US FAERS
6Cardiac FlutterFAERS: 1US FAERS
7Drug ineffectiveFAERS: 1US FAERS
8Drug level below therapeuticFAERS: 1US FAERS
9Drug level decreasedFAERS: 1US FAERS
10DyspepsiaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
11Feeling jitteryFAERS: 1US FAERS
12Memory impairmentFAERS: 1US FAERS
13ScabFAERS: 1US FAERS
14SomnolenceFAERS: 1SIDER
US FAERS
15TachycardiaFAERS: 1
Canada Vigilance: 1		1810269
2429074		CTD
SIDER
Canada Vigilance
US FAERS
16Throat irritationFAERS: 1US FAERS
17Unevaluable eventFAERS: 1US FAERS
18Vitreous floatersFAERS: 1US FAERS
19Weight decreasedFAERS: 1US FAERS
20AbasiaOFFSIDES
21Abdominal CrampsSIDER
22Abdominal PainOFFSIDES
SIDER
23Abdominal discomfortOFFSIDES
24Acute Coronary SyndromeSIDER
25AdenitisSIDER
26Adenocarcinoma18025841CTD
27Affective Disorders, Psychotic7893862CTD
28AgitationCanada Vigilance: 3Canada Vigilance
SIDER
29AgranulocytosisSIDER
30Alcohol withdrawal syndromeOFFSIDES
31AlopeciaSIDER
32AmnesiaOFFSIDES
33Angioedema3584083CTD
34Anorexia1592843
6586424		CTD
OFFSIDES
SIDER
35Anxiety Disorders3137614CTD
36AnxietyCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
37Aphasia2107764CTD
38AstheniaSIDER
39Ataxia2107764CTD
SIDER
40Atrioventricular Block2005043CTD
SIDER
41Basal Ganglia Diseases4671924
5526730		CTD
42Biopsy bone marrow abnormalOFFSIDES
43Bipolar Disorder

View details

435015
3435883
3970283
6512008
6846597
7929019
 		CTD
44Black hairy tongueSIDER
45Blepharoptosis5526730CTD
46Blood GlucoseOFFSIDES
47Blood alkaline phosphatase increasedSIDER
48Blood glucose decreasedOFFSIDES
49Blood glucose fluctuationOFFSIDES
50Blood sodiumOFFSIDES
51Body TemperatureOFFSIDES
52Bradycardia8800187CTD
53Bulimia Nervosa1629381CTD
54Bulimia3631331CTD
55Bundle-Branch Block2808261CTD
56Cardiac ArrestCanada Vigilance: 1Canada Vigilance
57Catalepsy3031535
9567763		CTD
58Cerebrovascular accidentSIDER
59Chemical and Drug Induced Liver Injury6886037
27485346		CTD
60CholecystitisOFFSIDES
61Cocaine-Related Disorders

View details

3172429
12028741
12757969
12884887
14510037
14713135
14762242
15799010
15804873
 		CTD
62ColitisOFFSIDES
63Colonic Neoplasms18025841CTD
64Completed SuicideCanada Vigilance: 14Canada Vigilance
OFFSIDES
65ConfabulationOFFSIDES
66Confusion3578343CTD
67Consciousness Disorders6146154CTD
68Constipation3953878
6126171		CTD
SIDER
69DebridementOFFSIDES
70Decreased LibidoOFFSIDES
71Delirium2107764
4027862
6126171		CTD
72DemyelinationOFFSIDES
73Dental cariesOFFSIDES
74Depressive disorder

View details

33968
1636811
1664741
2107764
2553044
2960986
3172429
3435883
3578343
3631331
3690436
3953878
4073318
5578096
6384205
6384206
6691785
6822481
6829452
6833205
7201341
7413917
7929019
8294386
8955926
12527476
15014590
15172931
15913920
18625256
 		CTD
75DermatitisSIDER
76DiabetesOFFSIDES
77DiscomfortSIDER
78DisorientationCanada Vigilance: 2Canada Vigilance
SIDER
79Disturbance in sexual arousalSIDER
80DrowsinessOFFSIDES
SIDER
81Drug dispensing errorOFFSIDES
82Drug screen positiveOFFSIDES
83Drug withdrawal headacheOFFSIDES
84Drug withdrawal syndromeSIDER
85DysgeusiaCanada Vigilance: 1Canada Vigilance
SIDER
86Dyskinesia, Drug-Induced3690436CTD
87DysphoniaOFFSIDES
88Dysthymic DisorderOFFSIDES
89Ejection Fraction DecreasedOFFSIDES
90Eosinophilia3598027CTD
SIDER
91Epigastric distressSIDER
92Erectile dysfunction17874315CTD
OFFSIDES
SIDER
93FatigueOFFSIDES
SIDER
94Feeling abnormalSIDER
95FlushingCanada Vigilance: 2Canada Vigilance
SIDER
96FormicationOFFSIDES
97Heart Block3387361CTD
98Heart Diseases7661425
8422746		CTD
99Hepatitis2760582CTD
SIDER
100HerniaOFFSIDES
101HyperkinesiaSIDER
102Hypokinesia5307899CTD
103HypomaniaSIDER
104HypopituitarismOFFSIDES
105Hypotension, Orthostatic

View details

1629381
2708559
6126171
6480574
 		CTD
106Hypotension

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1312169
2576315
8800187
8845222
15172931
 		CTD
SIDER
107Idiosyncratic drug reactionOFFSIDES
108IncoherentOFFSIDES
109Infectious MononucleosisOFFSIDES
110Injection site pruritusOFFSIDES
111Intervertebral disc disorderOFFSIDES
112Leukopenia7864268CTD
113LightheadednessSIDER
114Long QT Syndrome

View details

8426895
16178046
20211602
24052561
 		CTD
115LymphadenitisSIDER
116MalaiseSIDER
117Mental disorders16856516CTD
118Mental impairmentOFFSIDES
119Mood Disorders3266222
7929019		CTD
120Multiple MyelomaOFFSIDES
121Muscle Hypertonia5526730CTD
122MydriasisCanada Vigilance: 1Canada Vigilance
SIDER
123Myocardial InfarctionSIDER
124Myocarditis2760582CTD
125Myoclonus1474184
3827519		CTD
126NauseaCanada Vigilance: 316680561CTD
OFFSIDES
SIDER
Canada Vigilance
127Nerve Degeneration1236760
20079841		CTD
128Neuralgia2178851CTD
129Neuroleptic Malignant SyndromeSIDER
130Night sweatsCanada Vigilance: 1Canada Vigilance
131NocturiaSIDER
132NumbnessSIDER
133Ocular icterusOFFSIDES
134OliguriaCanada Vigilance: 1Canada Vigilance
135Opioid-Related Disorders

View details

12028741
12757969
12884887
14713135
 		CTD
136OsteomyelitisOFFSIDES
137OverdoseCanada Vigilance: 3Canada Vigilance
138Painful ejaculationSIDER
139Pain3335488
3963266		CTD
OFFSIDES
140PalpitationsCanada Vigilance: 2Canada Vigilance
SIDER
141Pancreatic enzymes increasedSIDER
142Panic Disorder

View details

1744635
2731426
6384206
9004064
 		CTD
143Paresthesia of limbsSIDER
144Parkinson Disease10965161CTD
145Parotid swellingSIDER
146Peripheral Nervous System Diseases9283933CTD
147Personality Disorders575199
9512081		CTD
148PetechiaeSIDER
149PlasmacytomaOFFSIDES
150Pneumonia17477857CTD
151Prescribed overdoseOFFSIDES
152PruritusCanada Vigilance: 2Canada Vigilance
SIDER
153Psychomotor skills impairedOFFSIDES
154Psychoses, Substance-Induced3760855CTD
155Pulmonary thrombosisOFFSIDES
156PurpuraSIDER
157Radicular painOFFSIDES
158Seizures

View details

1734754
1880990
2978064
3121163
4069320
6126171
6442931
10743914
12573515
16725121
 		CTD
159Sleep Initiation and Maintenance Disorders3346196CTD
160Sleep Wake Disorders6625009
7369424		CTD
161Spinal column stenosisOFFSIDES
162Stem cell transplantOFFSIDES
163Stereotypic Movement Disorder6586424CTD
164StomatitisSIDER
165Stuttering1474184CTD
166Substance Withdrawal Syndrome2031468
6625009
6846597		CTD
167Sudden deathSIDER
168Syncope3556944CTD
169Tachycardia, Ventricular2300645
7292072		CTD
170Taste peculiarSIDER
171Testicular Diseases3335488CTD
172ThrombocytopeniaSIDER
173TinnitusCanada Vigilance: 1Canada Vigilance
SIDER
174Tooth ExtractionOFFSIDES
175Torsades de Pointes3556944
16178046
20211602		CTD
176TracheobronchitisOFFSIDES
177TremorCanada Vigilance: 26691785CTD
SIDER
Canada Vigilance
178Urinary Retention1530081
3953878
6126171		CTD
SIDER
179UrticariaSIDER
180Vascular purpuraSIDER
181Ventricular Fibrillation3556944CTD
SIDER
182VomitingCanada Vigilance: 2Canada Vigilance
SIDER
183Weight GainOFFSIDES
184Wrong technique in drug usage processOFFSIDES
185effusionOFFSIDES
186jaundiceSIDER
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