MetaADEDB 2.0 @ LMMD
Fluphenazine
(PLDUPXSUYLZYBN-UHFFFAOYSA-N)
Structure
SMILES
OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F
Type(s)
Approved
ATC code(s)
N05AB02
Molecular Formula:
C22H26F3N3OS
Molecular Weight:
437.522
Log P:
4.2489
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
55.25
CAS Number(s):
69-23-8; 146-56-5
Synonym(s)
1.
Fluphenazine
2.
Flufenazin
3.
Fluphenazine Hydrochloride
4.
Lyogen
5.
Prolixin
6.
Hydrochloride, Fluphenazine
External Link(s)
MeSHD005476
PubChem Compound3372
BindingDB78433
50017655
ChEBI5123
CHEMBLCHEMBL726
DrugBankDB00623
DrugCentral1212
IUPHAR/BPS Guide to PHARMACOLOGY204
KEGGcpd:C07010
dr:D07977
Therapeutic Target DatabaseD0P5SA
D0B7SP
ZINC19203912
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DystoniaFAERS: 4
Canada Vigilance: 2

View details

36644
589060
709286
1609046
2898212
3354100
 		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
2Neuroleptic Malignant SyndromeFAERS: 3

View details

2738187
3804828
6134661
6146918
6614876
6697897
7118846
16804507
 		CTD
OFFSIDES
SIDER
US FAERS
3AkathisiaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
4AlopeciaFAERS: 2US FAERS
5AngioedemaFAERS: 2OFFSIDES
SIDER
US FAERS
6Blood creatine phosphokinase increasedFAERS: 2OFFSIDES
SIDER
US FAERS
7DysarthriaFAERS: 2US FAERS
8HeadacheFAERS: 2SIDER
US FAERS
9Intentional product misuseFAERS: 2US FAERS
10Musculoskeletal stiffnessFAERS: 2OFFSIDES
US FAERS
11Oculogyric crisisFAERS: 2SIDER
US FAERS
12RestlessnessFAERS: 2US FAERS
13RhabdomyolysisFAERS: 2US FAERS
14SchizophreniaFAERS: 2

View details

363702
918199
1609046
2378547
2632765
4154028
4919176
6110346
6614876
6787637
7146292
7726317
8267132
8633711
16804507
20523875
 		CTD
US FAERS
15Tardive DyskinesiaFAERS: 2OFFSIDES
SIDER
US FAERS
16TremorFAERS: 2
Canada Vigilance: 1		4919176CTD
SIDER
Canada Vigilance
US FAERS
17VomitingFAERS: 2
Canada Vigilance: 1		4919176CTD
SIDER
Canada Vigilance
US FAERS
18Abdominal PainFAERS: 1US FAERS
19Accidental overdoseFAERS: 1US FAERS
20Acute kidney injuryFAERS: 1US FAERS
21AnxietyFAERS: 1US FAERS
22ArthralgiaFAERS: 1US FAERS
23AstheniaFAERS: 1OFFSIDES
US FAERS
24AtelectasisFAERS: 1US FAERS
25Atrial FibrillationFAERS: 1US FAERS
26BruxismFAERS: 1US FAERS
27Burning sensationFAERS: 1US FAERS
28Cardiac ArrestFAERS: 1SIDER
US FAERS
29CatatoniaFAERS: 1889419
3732946
6134661		CTD
OFFSIDES
SIDER
US FAERS
30Chest discomfortFAERS: 1US FAERS
31Choking sensationFAERS: 1US FAERS
32ChromaturiaFAERS: 1US FAERS
33Cogwheel RigidityFAERS: 1OFFSIDES
US FAERS
34Cold sweatFAERS: 1US FAERS
35Completed SuicideFAERS: 1US FAERS
36Disseminated Intravascular CoagulationFAERS: 1US FAERS
37Documented hypersensitivity to administered drugFAERS: 1US FAERS
38DroolingFAERS: 1US FAERS
39Drug abuseFAERS: 1US FAERS
40Drug ineffectiveFAERS: 1US FAERS
41FatigueFAERS: 1
Canada Vigilance: 4		Canada Vigilance
US FAERS
42Heat StrokeFAERS: 1US FAERS
43HypersensitivityFAERS: 1SIDER
US FAERS
44HyperthyroidismFAERS: 1US FAERS
45HypophagiaFAERS: 1US FAERS
46Incorrect storage of drugFAERS: 1US FAERS
47Intentional drug misuseFAERS: 1US FAERS
48Long QT SyndromeFAERS: 1US FAERS
49Macular degenerationFAERS: 1US FAERS
50MalnutritionFAERS: 1US FAERS
51Medication ErrorFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
52Mental status changesFAERS: 1US FAERS
53Muscle RigidityFAERS: 1
Canada Vigilance: 1		4919176
9226090
9670114		CTD
SIDER
Canada Vigilance
US FAERS
54MyalgiaFAERS: 1US FAERS
55NervousnessFAERS: 1US FAERS
56Neutrophil count decreasedFAERS: 1US FAERS
57Nipple painFAERS: 1US FAERS
58Ocular ToxicityFAERS: 1US FAERS
59Oromandibular dystoniaFAERS: 1US FAERS
60PainFAERS: 1SIDER
US FAERS
61ParanoiaFAERS: 1OFFSIDES
US FAERS
62Pharmaceutical product complaintFAERS: 1US FAERS
63PneumoniaFAERS: 1SIDER
US FAERS
64PoisoningFAERS: 1US FAERS
65PriapismFAERS: 1SIDER
US FAERS
66PruritusFAERS: 1SIDER
US FAERS
67Pulmonary EmbolismFAERS: 1SIDER
US FAERS
68Respiratory arrestFAERS: 1US FAERS
69SepsisFAERS: 1US FAERS
70Stevens-Johnson SyndromeFAERS: 1US FAERS
71SyncopeFAERS: 1SIDER
US FAERS
72TrismusFAERS: 1US FAERS
73Unresponsive to stimuliFAERS: 1US FAERS
74Urinary RetentionFAERS: 1US FAERS
75Walking aid userFAERS: 1US FAERS
76Wrong drug administeredFAERS: 1OFFSIDES
US FAERS
77AbasiaOFFSIDES
78Abdominal discomfortOFFSIDES
79AbuseOFFSIDES
80Accidental exposureOFFSIDES
81Acid refluxOFFSIDES
82Adverse eventOFFSIDES
83Affective Disorders, Psychotic2309957CTD
84AgitationCanada Vigilance: 3Canada Vigilance
SIDER
85AgranulocytosisSIDER
86Akathisia, Drug-Induced

View details

1609046
2316745
2378547
4587065
4795129
4919176
7540798
7726317
8480836
 		CTD
87AkinesiaSIDER
88Allergic skin reactionSIDER
89Altered state of consciousnessSIDER
90AmphetaminesOFFSIDES
91Anaphylactic shockSIDER
92Anaphylactoid ReactionSIDER
93Anticonvulsant drug level increasedOFFSIDES
94Application site erythemaOFFSIDES
95ArteriosclerosisOFFSIDES
96ArthritisOFFSIDES
97AsphyxiaSIDER
98AsthmaSIDER
99AutomatismOFFSIDES
100Autonomic nervous system imbalanceSIDER
101Basal Ganglia Diseases

View details

2378547
6016862
6110346
7540798
7726317
8267132
9226090
15064916
 		CTD
102Base excess decreasedOFFSIDES
103Bilirubin conjugated increasedOFFSIDES
104Bipolar Disorder3163740
7962691		CTD
OFFSIDES
105Bipolar I disorderOFFSIDES
106Bizarre dreamsSIDER
107Blepharospasm9827620CTD
OFFSIDES
108Blood GlucoseOFFSIDES
109Blood alcohol increasedOFFSIDES
110Blood chloride decreasedOFFSIDES
111Blood cholesterol abnormalOFFSIDES
112Blood cholesterolOFFSIDES
113Blood glucose decreasedOFFSIDES
114Blood sodiumOFFSIDES
115Blood triglycerides increasedOFFSIDES
116Blurred visionOFFSIDES
117Catalepsy

View details

35783
97712
945050
1033567
1168927
1172422
1687392
1827527
1977408
2111028
7912135
8616504
8811507
8868372
9137910
10499368
10651103
19644727
 		CTD
118CataractOFFSIDES
119Cell DeathOFFSIDES
120CellulitisOFFSIDES
121Cerebral disorderOFFSIDES
122Choreoathetoid movementsSIDER
123ChoreoathetosisSIDER
124Circumstance or information capable of leading to medication errorOFFSIDES
125Cocaine-Related Disorders14973230CTD
126ConfabulationOFFSIDES
127Conjunctival abrasionOFFSIDES
128ConstipationCanada Vigilance: 1Canada Vigilance
SIDER
129Corneal OpacitySIDER
130Creatine Phosphokinase IncreasedSIDER
131CystOFFSIDES
132Deep Vein ThrombosisSIDER
133Deja VuOFFSIDES
134Dental abscessOFFSIDES
135DependenceOFFSIDES
136Depressed Level of ConsciousnessSIDER
137Depression suicidalOFFSIDES
138DiabetesOFFSIDES
139Diabetes MellitusSIDER
140Diabetes mellitus inadequate controlOFFSIDES
141Diabetic RetinopathyOFFSIDES
142DiabeticSIDER
143Disorders of Excessive Somnolence6117919CTD
144Disturbance in sexual arousalSIDER
145Dizziness4919176CTD
SIDER
146DrowsinessSIDER
147Drug addictOFFSIDES
148Drug toxicityOFFSIDES
149Dyskinesia, Drug-Induced6021008
6117919		CTD
150DyspareuniaOFFSIDES
151DysphoniaCanada Vigilance: 1Canada Vigilance
152Dysthymic DisorderOFFSIDES
153Dystonic reactionSIDER
154DysuriaOFFSIDES
155EczemaSIDER
156EosinophiliaSIDER
157Epigastric discomfortSIDER
158EpistaxisOFFSIDES
159Erectile dysfunction12084416CTD
SIDER
160Erythema MultiformeSIDER
161ErythemaSIDER
162Feeling abnormalSIDER
163Fluid overloadOFFSIDES
164Gastric irritationSIDER
165General physical health deteriorationOFFSIDES
166GlaucomaSIDER
167Hepatitis COFFSIDES
168HepatitisSIDER
169Herpes Zoster OticusOFFSIDES
170HyperkeratosisOFFSIDES
171HyperkinesiaCanada Vigilance: 2Canada Vigilance
172Hyperprolactinemia9192542CTD
173HyperreflexiaSIDER
174HyperventilationOFFSIDES
175HypokinesiaCanada Vigilance: 3Canada Vigilance
176HypomaniaOFFSIDES
177Hyponatremia20672238CTD
178Hypotension4919176CTD
SIDER
179HypotensiveSIDER
180Hypothalamic Diseases5058734CTD
181Iatrogenic injuryOFFSIDES
182Ileal ulcerOFFSIDES
183Incorrect route of drug administrationOFFSIDES
184Infantile apnoeic attackOFFSIDES
185Injection site erythemaOFFSIDES
186Injection site fibrosisOFFSIDES
187Intention tremorOFFSIDES
188Intentional misuseOFFSIDES
189Intentional self-injuryOFFSIDES
190Joint stiffnessOFFSIDES
191Labile blood pressureSIDER
192Laryngeal dystoniaSIDER
193LethargyOFFSIDES
SIDER
194LeukocytosisSIDER
195LeukopeniaSIDER
196LipaseOFFSIDES
197Lupus ErythematosusSIDER
198Malignant neoplasm progressionOFFSIDES
199Memory Disorders19644727CTD
200MenorrhagiaSIDER
201Mental disorders16856516CTD
202Movement Disorders2905065CTD
203Multiple MyelomaOFFSIDES
204Musculoskeletal PainOFFSIDES
205MydriasisSIDER
206Myoglobin blood increasedOFFSIDES
207Myoglobin urine presentOFFSIDES
208Nausea4919176CTD
SIDER
209Neurocognitive Disorders438148CTD
210Nicotine DependenceOFFSIDES
211Nuchal RigidityOFFSIDES
212Nutritional condition abnormalOFFSIDES
213OpisthotonusSIDER
214Optic Disc EdemaOFFSIDES
215OverweightOFFSIDES
216PCO2 decreasedOFFSIDES
217PO2 decreasedOFFSIDES
218PancreatitisOFFSIDES
219PancytopeniaSIDER
220Paralysis of bladderSIDER
221Parkinsonian rest tremorOFFSIDES
222Physical abuseOFFSIDES
223Physical assaultOFFSIDES
224PolyuriaSIDER
225Post procedural infectionOFFSIDES
226Postmenopausal bleedingOFFSIDES
227Prenatal Exposure Delayed Effects7254089CTD
228PresbyopiaOFFSIDES
229Prescribed overdoseOFFSIDES
230Prolonged mensesSIDER
231PseudoparkinsonismSIDER
232Psychomotor Agitation453364
2962686		CTD
233Psychoses, Substance-Induced4587065CTD
234Psychotic Disorders31480
11097986		CTD
235Pulmonary InfarctionOFFSIDES
236QRS axis abnormalOFFSIDES
237Retinal Diseases16117689CTD
238RhinorrheaOFFSIDES
239Risus sardonicusOFFSIDES
240Schizoaffective DisorderOFFSIDES
241Seizures6175290
16804507		CTD
242ShockSIDER
243Skin lacerationOFFSIDES
244Sleep Wake Disorders453364CTD
245SmokerOFFSIDES
246SnoringOFFSIDES
247SomnolenceCanada Vigilance: 6Canada Vigilance
SIDER
248Stupor5058734CTD
SIDER
249Stuttering6110346CTD
250Substance Withdrawal Syndrome63037CTD
251Sudden Cardiac DeathOFFSIDES
252TachycardiaCanada Vigilance: 14919176CTD
SIDER
Canada Vigilance
253TendinitisOFFSIDES
254Tooth LossOFFSIDES
255TorticollisCanada Vigilance: 1Canada Vigilance
256Urine output increasedSIDER
257UrticariaSIDER
258Vaginal lesionOFFSIDES
259Venous ThromboembolismSIDER
260Vision Disorders4919176CTD
261Weight GainOFFSIDES
262Weight decreasedCanada Vigilance: 1Canada Vigilance
263Wheelchair userOFFSIDES
264XerosisOFFSIDES
265Xerostomia4919176CTD
266carbuncleOFFSIDES
267furuncleOFFSIDES
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