MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Trihexyphenidyl

(HWHLPVGTWGOCJO-UHFFFAOYSA-N)

Structure

SMILES: OC(c1ccccc1)(C1CCCCC1)CCN1CCCCC1
Type(s): Approved
ATC code(s): N04AA01
Molecular Formula:: C20H31NO
Molecular Weight:: 301.466
Log P:: 4.2684
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 1
TPSA:: 23.47
CAS Number(s):: 144-11-6; 40520-25-0; 58947-95-8

Synonym(s)

Trihexyphenidyl

Benzhexol

Apo-Trihex

Artane

Cyclodol

Hipokinon

Parkinane

Parkopan

Trihexane

10.

Trihexidyl Hydrochloride

11.

Trihexyphenidyl Hydrochloride

12.

Trihexyphenidyl Hydrochloride Elixir

13.

Apo Trihex

14.

ApoTrihex

External Link(s)

MeSH	D014282
PubChem Compound	5572
BindingDB	81462
ChEBI	9720
CHEMBL	CHEMBL1490
DrugBank	DB00376
DrugCentral	2745
IUPHAR/BPS Guide to PHARMACOLOGY	7315
KEGG	cpd:C07171 dr:D08638
Therapeutic Target Database	D0F5KZ D09GFL

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Anxiety	FAERS: 1		US FAERS
2	Ataxia	FAERS: 1		US FAERS
3	Chest Pain	FAERS: 1		US FAERS
4	Circumstance or information capable of leading to medication error	FAERS: 1		OFFSIDES US FAERS
5	Dizziness	FAERS: 1		SIDER US FAERS
6	Flushing	FAERS: 1		US FAERS
7	Incorrect dose administered	FAERS: 1		US FAERS
8	Memory impairment	FAERS: 1		SIDER US FAERS
9	Pharmaceutical product complaint	FAERS: 1		US FAERS
10	Poor quality drug administered	FAERS: 1		US FAERS
11	Product dispensing error	FAERS: 1		US FAERS
12	Tardive Dyskinesia	FAERS: 1		OFFSIDES US FAERS
13	Transcription medication error	FAERS: 1		US FAERS
14	White blood cell count decreased	FAERS: 1		US FAERS
15	Abdominal Compartment Syndrome			OFFSIDES
16	Accidental drug intake by child			OFFSIDES
17	Accidental overdose			OFFSIDES
18	Agitation			SIDER
19	Akathisia, Drug-Induced		1178807 3100511 7276921	CTD
20	Akinesia			OFFSIDES
21	Alanine Aminotransferase Increased			OFFSIDES
22	Alcoholic Intoxication			OFFSIDES
23	Altered state of consciousness			OFFSIDES
24	Alveolitis			OFFSIDES
25	Amaurosis Fugax			OFFSIDES
26	Ammonia increased			OFFSIDES
27	Amnesia			OFFSIDES
28	Amphetamines			OFFSIDES
29	Anger			OFFSIDES
30	Angle Closure Glaucoma			SIDER
31	Anticholinergic Syndrome			OFFSIDES
32	Anticonvulsant drug level increased			OFFSIDES
33	Antipsychotic drug level			OFFSIDES
34	Apallic syndrome			OFFSIDES
35	Apathy			OFFSIDES
36	Aphagia			OFFSIDES
37	Application site vesicles			OFFSIDES
38	Aspiration Pneumonia			OFFSIDES
39	Asterixis			OFFSIDES
40	Asthenia			SIDER
41	Asthenopia			OFFSIDES
42	Athetosis		1434066 4144147	CTD OFFSIDES
43	Aura			OFFSIDES
44	Automatism			OFFSIDES
45	Bacteria blood identified			OFFSIDES
46	Bacterial culture positive			OFFSIDES
47	Basal Ganglia Diseases		View details 4550377 4566388 6016862 9926106 11532387 15971646	CTD
48	Biliary cirrhosis			OFFSIDES
49	Bilirubinuria			OFFSIDES
50	Bipolar Disorder		View details 961932 5077102 6864584 19829091	CTD
51	Blindness		5013835	CTD SIDER
52	Blood Glucose			OFFSIDES
53	Blood albumin decreased			OFFSIDES
54	Blood cholesterol abnormal			OFFSIDES
55	Blood cholinesterase decreased			OFFSIDES
56	Blood count abnormal			OFFSIDES
57	Blood creatine phosphokinase increased			OFFSIDES
58	Blood fibrinogen			OFFSIDES
59	Blood glucose decreased			OFFSIDES
60	Blood iron increased			OFFSIDES
61	Blood prolactin increased			OFFSIDES
62	Blood sodium increased			OFFSIDES
63	Blood sodium			OFFSIDES
64	Blood thyroid stimulating hormone			OFFSIDES
65	Blood triglycerides increased			OFFSIDES
66	Bone density decreased			OFFSIDES
67	Bowel movement irregularity			OFFSIDES
68	Bradycardia		3769769	CTD
69	Brain Death			OFFSIDES
70	Brain Diseases		9005879	CTD
71	Bronchial Obstruction			OFFSIDES
72	Bruxism			OFFSIDES
73	Capgras Syndrome		2795088	CTD
74	Cardioactive drug level			OFFSIDES
75	Catalepsy		7200248 12907310	CTD
76	Catatonia		6139391	CTD
77	Cerebral atrophy			OFFSIDES
78	Chemical and Drug Induced Liver Injury		4800729	CTD
79	Chorea	Canada Vigilance: 1	470689 1434066 3504259	CTD SIDER Canada Vigilance
80	Chromatopsia			OFFSIDES
81	Chronic sinusitis			OFFSIDES
82	Chronic ulcerative colitis			OFFSIDES
83	Clostridium colitis			OFFSIDES
84	Cognition Disorders		8378414 8523038 18239197	CTD
85	Compulsive shopping			OFFSIDES
86	Confusion		3401861 3504259	CTD
87	Congenital tricuspid valve incompetence			OFFSIDES
88	Constipation			SIDER
89	Cyanosis			OFFSIDES
90	Cycloplegia			SIDER
91	Cytolytic hepatitis			OFFSIDES
92	Deep Brain Stimulation			OFFSIDES
93	Delusional disorder, persecutory type			OFFSIDES
94	Demyelination			OFFSIDES
95	Depressed Level of Consciousness			OFFSIDES
96	Depressed mood			OFFSIDES
97	Dermatitis			SIDER
98	Diabetes			OFFSIDES
99	Diabetic Retinopathy			OFFSIDES
100	Diarrhea			OFFSIDES
101	Disease Progression			OFFSIDES
102	Dopamine dysregulation syndrome			OFFSIDES
103	Drowning			OFFSIDES
104	Drowsiness			OFFSIDES SIDER
105	Drug Overdose		5506119	CTD
106	Drug abuser			OFFSIDES
107	Drug effect delayed			OFFSIDES
108	Drug level below therapeutic			OFFSIDES
109	Drug toxicity			OFFSIDES
110	Dry skin			SIDER
111	Dysarthria		4144147	CTD
112	Dysgraphia			OFFSIDES
113	Dyskinesia, Drug-Induced		View details 1434066 3698411 4155220 6017500 6114643	CTD
114	Dysmorphism			OFFSIDES
115	Dysphonia		3214980	CTD
116	Dystonia		View details 3454349 4144147 16702617 16741220	CTD
117	Echolalia			OFFSIDES
118	Economic problem			OFFSIDES
119	Electrocardiogram ST segment abnormal			OFFSIDES
120	Emotional disorder			OFFSIDES
121	Emotional distress			OFFSIDES
122	Encephalitis			OFFSIDES
123	Endocarditis			OFFSIDES
124	Enuresis		8732317	CTD
125	Epilepsy			OFFSIDES
126	Euphoric mood			SIDER
127	Extremity contracture			OFFSIDES
128	Feeding disorder neonatal			OFFSIDES
129	Feeling abnormal			SIDER
130	Flatulence			OFFSIDES
131	Food craving			OFFSIDES
132	Gambling			OFFSIDES
133	Genitourinary tract infection			OFFSIDES
134	Granulocytosis			OFFSIDES
135	Hallucinations		View details 2795088 3401861 5506119 5557919 10399867 15782612	CTD
136	Headache			SIDER
137	Heat Exhaustion			OFFSIDES
138	Heat Stroke			OFFSIDES
139	Hemothorax			OFFSIDES
140	Hormone level abnormal			OFFSIDES
141	Human herpes virus 6 serology positive			OFFSIDES
142	Hypercapnia			OFFSIDES
143	Hyperkinesia			SIDER
144	Hypertensive heart disease			OFFSIDES
145	Hypertrophic Cardiomyopathy			OFFSIDES
146	Hyperventilation			OFFSIDES
147	Hypokinesia		18495311	CTD
148	Hypoxia			OFFSIDES
149	Inappropriate affect			OFFSIDES
150	Incoherent			OFFSIDES
151	Incontinence			OFFSIDES
152	Infusion site bruising			OFFSIDES
153	Initial insomnia			OFFSIDES
154	Intention tremor			OFFSIDES
155	Intermittent Explosive Disorder			OFFSIDES
156	Intestinal Obstruction			OFFSIDES
157	Jugular vein distension			OFFSIDES
158	Leukocyte alkaline phosphatase increased			OFFSIDES
159	Leukopenia neonatal			OFFSIDES
160	Lordosis			OFFSIDES
161	Lymphocyte stimulation test			OFFSIDES
162	Megacolon			OFFSIDES
163	Memory Disorders		8378414	CTD
164	Mental disorders		5557919	CTD
165	Mental impairment			OFFSIDES
166	Mental status changes			OFFSIDES
167	Mood Disorders		852367	CTD
168	Motor retardation			OFFSIDES
169	Movement Disorders		View details 974497 9631956 10967655 15609676	CTD
170	Multiple allergies			OFFSIDES
171	Muscle Rigidity		4838913 7146292	CTD
172	Muscle Weakness			OFFSIDES
173	Muscle necrosis			OFFSIDES
174	Muscle tightness			OFFSIDES
175	Mutism			OFFSIDES
176	Myasthenia Gravis		3033545	CTD
177	Mydriasis		5506119	CTD SIDER
178	Nausea			SIDER
179	Necrosis		6632	CTD
180	Nervousness			SIDER
181	Neuroleptic Malignant Syndrome			OFFSIDES SIDER
182	Neuroma			OFFSIDES
183	Neutrophil count decreased			OFFSIDES
184	Nystagmus			OFFSIDES
185	Ocular Motility Disorders		4144147	CTD
186	Optic Disc Edema			OFFSIDES
187	Optic Neuropathy			OFFSIDES
188	Overdose			OFFSIDES
189	PCO2 increased			OFFSIDES
190	PO2 decreased			OFFSIDES
191	Pancreatitis			OFFSIDES
192	Panic Disorder			OFFSIDES
193	Paranoia			OFFSIDES SIDER
194	Parkinson Disease		View details 785578 8192765 8523038 9877318 18361473	CTD
195	Parkinsonian Disorders		4838913 15968847	CTD
196	Parotitis			SIDER
197	Pathogen resistance			OFFSIDES
198	Peripheral embolism			OFFSIDES
199	Personality Change			OFFSIDES
200	Polyneuropathy			OFFSIDES
201	Polysubstance abuse			OFFSIDES
202	Poor personal hygiene			OFFSIDES
203	Poriomania			OFFSIDES
204	Portal Hypertension			OFFSIDES
205	Product administration error	Canada Vigilance: 1		Canada Vigilance
206	Pseudomonal sepsis			OFFSIDES
207	Psychiatric symptom			OFFSIDES
208	Psychomotor Agitation		5755090 7387498	CTD
209	Psychoses, Substance-Induced		2795088 5506119	CTD
210	Respiration Disorders		3698411	CTD
211	Retrocollis			OFFSIDES
212	Rhabdomyolysis			OFFSIDES
213	Schizoaffective Disorder			OFFSIDES
214	Schizophrenia		391328 709472	CTD
215	Seizures		9877318	CTD
216	Sexual activity increased			OFFSIDES
217	Sick Sinus Syndrome			OFFSIDES
218	Sinus bradycardia			SIDER
219	Skin laceration			OFFSIDES
220	Somnolence			SIDER
221	Spasm		4144147	CTD
222	Spondylolisthesis			OFFSIDES
223	Substance Withdrawal Syndrome		View details 961932 2811895 3984771 9005879	CTD
224	Substance-Related Disorders		6741602	CTD
225	Sudden death			OFFSIDES
226	Sudden onset of sleep			OFFSIDES
227	Tachycardia			SIDER
228	Talipes			OFFSIDES
229	Temperature regulation disorder			OFFSIDES
230	Tenosynovitis			OFFSIDES
231	Tension			SIDER
232	Therapeutic product effect decreased	Canada Vigilance: 1		Canada Vigilance
233	Torsades de Pointes		9057687	CTD
234	Torticollis		2795088 9748032	CTD
235	Tremor		View details 391328 961932 3088650 9005879 9877318 9926106	CTD
236	Troponin T			OFFSIDES
237	Umbilical hernia			OFFSIDES
238	Urinary hesitation			SIDER
239	Vision Disorders		3504259	CTD
240	Vomiting			SIDER
241	Water Intoxication			OFFSIDES
242	Weight Gain			OFFSIDES
243	Weight decreased			SIDER
244	Wound Complication			OFFSIDES
245	Wound evisceration			OFFSIDES
246	Wrong drug administered			OFFSIDES
247	Xerostomia		3504259	CTD

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