Imipramine
(XZZXIYZZBJDEEP-UHFFFAOYSA-N)
Structure
- SMILES
- CN(CCCN1c2ccccc2CCc2c1cccc2)C.Cl
- Molecular Formula:
- C19H25ClN2
- Molecular Weight:
- 316.868
- Log P:
- 4.7420
- Hydrogen Bond Acceptor:
- 1
- Hydrogen Bond Donor:
- 1
- TPSA:
- 6.48
- CAS Number(s):
- 113-52-0
Synonym(s)
1.
Imipramine
2.
Imidobenzyle
3.
Imizin
4.
4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2)
5.
Imipramine Hydrochloride
6.
Imipramine Monohydrochloride
7.
Imipramine Pamoate
8.
Janimine
9.
Melipramine
10.
Norchlorimipramine
11.
Pryleugan
12.
Tofranil
External Link(s)
| MeSH | D007099 |
| PubChem Compound | 657207 15893898 8228 |
| ChEBI | 5882 |
| CHEMBL | CHEMBL1692 |
| KEGG | cpd:C07982 dr:D00815 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 7 | US FAERS | |
| 2 | Hypotension | FAERS: 6 | US FAERS | |
| 3 | Toxicity to various agents | FAERS: 6 | US FAERS | |
| 4 | Asthenia | FAERS: 4 | US FAERS | |
| 5 | Headache | FAERS: 3 | US FAERS | |
| 6 | Product taste abnormal | FAERS: 3 | US FAERS | |
| 7 | Acidosis | FAERS: 2 | US FAERS | |
| 8 | Cataract | FAERS: 2 | US FAERS | |
| 9 | Dysgeusia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 10 | Feeling abnormal | FAERS: 2 | US FAERS | |
| 11 | Floppy iris syndrome | FAERS: 2 | US FAERS | |
| 12 | Hypersensitivity | FAERS: 2 | US FAERS | |
| 13 | Lethargy | FAERS: 2 | US FAERS | |
| 14 | Neuroleptic Malignant Syndrome | FAERS: 2 | US FAERS | |
| 15 | Somnolence | FAERS: 2 | US FAERS | |
| 16 | Tachycardia | FAERS: 2 | US FAERS | |
| 17 | Vomiting | FAERS: 2 | US FAERS | |
| 18 | Abdominal discomfort | FAERS: 1 | US FAERS | |
| 19 | Accidental exposure to product by child | FAERS: 1 | US FAERS | |
| 20 | Accidental overdose | FAERS: 1 | US FAERS | |
| 21 | Akathisia | FAERS: 1 | US FAERS | |
| 22 | Antidepressant drug level increased | FAERS: 1 | US FAERS | |
| 23 | Anxiety | FAERS: 1 | US FAERS | |
| 24 | Aphagia | FAERS: 1 | US FAERS | |
| 25 | Asphyxia | FAERS: 1 | US FAERS | |
| 26 | Bedridden | FAERS: 1 | US FAERS | |
| 27 | Bradycardia | FAERS: 1 | US FAERS | |
| 28 | Burning feet syndrome | FAERS: 1 | US FAERS | |
| 29 | Completed Suicide | FAERS: 1 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 30 | Dehydration | FAERS: 1 | US FAERS | |
| 31 | Dental caries | FAERS: 1 | US FAERS | |
| 32 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 33 | Depressed mood | FAERS: 1 | US FAERS | |
| 34 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 35 | Diabetic Retinopathy | FAERS: 1 | US FAERS | |
| 36 | Dizziness | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 37 | Drowning | FAERS: 1 | US FAERS | |
| 38 | Drug ineffective for unapproved indication | FAERS: 1 | US FAERS | |
| 39 | Drug level decreased | FAERS: 1 | US FAERS | |
| 40 | Drug toxicity | FAERS: 1 | US FAERS | |
| 41 | Drug withdrawal syndrome | FAERS: 1 | US FAERS | |
| 42 | Enuresis | FAERS: 1 | US FAERS | |
| 43 | Erythema | FAERS: 1 | US FAERS | |
| 44 | Fatigue | FAERS: 1 | US FAERS | |
| 45 | Granuloma | FAERS: 1 | US FAERS | |
| 46 | Hunger | FAERS: 1 | US FAERS | |
| 47 | Hydrocephalus | FAERS: 1 | US FAERS | |
| 48 | Hyperventilation | FAERS: 1 | US FAERS | |
| 49 | Intentional product misuse | FAERS: 1 | US FAERS | |
| 50 | Intracranial Aneurysm | FAERS: 1 | US FAERS | |
| 51 | Leukopenia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 52 | Limb discomfort | FAERS: 1 | US FAERS | |
| 53 | Malaise | FAERS: 1 | US FAERS | |
| 54 | Medication Error | FAERS: 1 | US FAERS | |
| 55 | Memory impairment | FAERS: 1 | US FAERS | |
| 56 | Metabolic acidosis | FAERS: 1 | US FAERS | |
| 57 | Mood swings | FAERS: 1 | US FAERS | |
| 58 | Nausea | FAERS: 1 | US FAERS | |
| 59 | Nervousness | FAERS: 1 | US FAERS | |
| 60 | Night sweats | FAERS: 1 | US FAERS | |
| 61 | Overdose | FAERS: 1 | US FAERS | |
| 62 | Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 63 | Palpitations | FAERS: 1 | US FAERS | |
| 64 | Petechiae | FAERS: 1 | US FAERS | |
| 65 | Pharmaceutical product complaint | FAERS: 1 | US FAERS | |
| 66 | Product coating issue | FAERS: 1 | US FAERS | |
| 67 | Product quality issue | FAERS: 1 | US FAERS | |
| 68 | Product substitution issue | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 69 | Product use in unapproved indication | FAERS: 1 | US FAERS | |
| 70 | Product use issue | FAERS: 1 | US FAERS | |
| 71 | QRS axis abnormal | FAERS: 1 | US FAERS | |
| 72 | Respiratory Depression | FAERS: 1 | US FAERS | |
| 73 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 74 | Restlessness | FAERS: 1 | US FAERS | |
| 75 | Retching | FAERS: 1 | US FAERS | |
| 76 | Screaming | FAERS: 1 | US FAERS | |
| 77 | Serotonin Syndrome | FAERS: 1 | US FAERS | |
| 78 | Somnambulism | FAERS: 1 | US FAERS | |
| 79 | Spina Bifida | FAERS: 1 | US FAERS | |
| 80 | Supraventricular tachycardia | FAERS: 1 | US FAERS | |
| 81 | Talipes | FAERS: 1 | US FAERS | |
| 82 | Temperature intolerance | FAERS: 1 | US FAERS | |
| 83 | Therapeutic response unexpected with drug substitution | FAERS: 1 | US FAERS | |
| 84 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 85 | Ventricular Fibrillation | FAERS: 1 | US FAERS | |
| 86 | Ventricular arrhythmia | FAERS: 1 | US FAERS | |
| 87 | Waxy flexibility | FAERS: 1 | US FAERS | |
| 88 | Chromaturia | Canada Vigilance: 1 | Canada Vigilance | |
| 89 | Cold sweat | Canada Vigilance: 1 | Canada Vigilance | |
| 90 | Drug level increased | Canada Vigilance: 1 | Canada Vigilance | |
| 91 | Neutropenia | Canada Vigilance: 1 | Canada Vigilance | |
| 92 | Pruritus | Canada Vigilance: 1 | Canada Vigilance | |
| 93 | Tremor | Canada Vigilance: 2 | Canada Vigilance |
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