MetaADEDB 2.0 @ LMMD
nefazodone
(VRBKIVRKKCLPHA-UHFFFAOYSA-N)
Structure
SMILES
CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl
Type(s)
Approved; Withdrawn
ATC code(s)
N06AX06
Molecular Formula:
C25H32ClN5O2
Molecular Weight:
470.007
Log P:
3.5548
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
0
TPSA:
55.53
CAS Number(s):
83366-66-9
Synonym(s)
1.
nefazodone
2.
Apo-Nefazodone
3.
Dutonin
4.
Lin-Nefazodone
5.
Menfazona
6.
Nefadar
7.
Rulivan
8.
Serzone
9.
nefazodone hydrochloride
External Link(s)
MeSHC051752
PubChem Compound4449
BindingDB50069447
ChEBI7494
CHEMBLCHEMBL623
DrugBankDB01149
DrugCentral1890
IUPHAR/BPS Guide to PHARMACOLOGY7247
KEGGcpd:C07256
dr:D08257
Therapeutic Target DatabaseD0X7DE
ZINC538065
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DizzinessFAERS: 3OFFSIDES
SIDER
US FAERS
2MalaiseFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
3NauseaFAERS: 3
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
4PainFAERS: 3OFFSIDES
SIDER
US FAERS
5Visual ImpairmentFAERS: 3SIDER
US FAERS
6AnxietyFAERS: 2OFFSIDES
SIDER
US FAERS
7AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
8Drug ineffectiveFAERS: 2OFFSIDES
US FAERS
9Feeling abnormalFAERS: 2SIDER
US FAERS
10SomnolenceFAERS: 2SIDER
US FAERS
11Adverse eventFAERS: 1OFFSIDES
US FAERS
12AmnesiaFAERS: 1
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
13ArthritisFAERS: 1OFFSIDES
SIDER
US FAERS
14Autoimmune thyroiditisFAERS: 1US FAERS
15Bipolar DisorderFAERS: 18986316
15708425
CTD
OFFSIDES
US FAERS
16Blood potassium decreasedFAERS: 1US FAERS
17Diabetes MellitusFAERS: 1US FAERS
18Drug withdrawal syndromeFAERS: 1US FAERS
19DysgeusiaFAERS: 1SIDER
US FAERS
20FatigueFAERS: 1
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
US FAERS
21Food cravingFAERS: 1US FAERS
22HypersensitivityFAERS: 1SIDER
US FAERS
23Incorrect dose administeredFAERS: 1US FAERS
24InfluenzaFAERS: 1SIDER
US FAERS
25Low birth weight babyFAERS: 1US FAERS
26Muscle tightnessFAERS: 1US FAERS
27MyopathyFAERS: 1US FAERS
28PharyngitisFAERS: 1SIDER
US FAERS
29Post-Traumatic Stress DisorderFAERS: 1US FAERS
30Product use in unapproved indicationFAERS: 1US FAERS
31Sjogren's SyndromeFAERS: 1US FAERS
32SyncopeFAERS: 1SIDER
US FAERS
33TremorFAERS: 1SIDER
US FAERS
34VomitingFAERS: 1SIDER
US FAERS
35Wrong technique in drug usage processFAERS: 1US FAERS
36Abdominal PainOFFSIDES
SIDER
37Abdominal discomfortOFFSIDES
38Abnormal visionSIDER
39AbuseOFFSIDES
40Acid refluxOFFSIDES
41Acquired diaphragmatic eventrationOFFSIDES
42AcromegalyOFFSIDES
43Acute Coronary SyndromeOFFSIDES
44Acute myocardial infarctionOFFSIDES
45Acute respiratory failureOFFSIDES
46Acute sinusitisOFFSIDES
47AdenitisOFFSIDES
48AgeusiaOFFSIDES
SIDER
49AgitationSIDER
50AgoraphobiaOFFSIDES
51Akathisia, Drug-Induced11488371CTD
52Alanine Aminotransferase IncreasedCanada Vigilance: 3Canada Vigilance
OFFSIDES
SIDER
53AlopeciaOFFSIDES
SIDER
54Anal FissureOFFSIDES
55AnalgesiaOFFSIDES
56Anaphylactic shockSIDER
57Androgens decreasedOFFSIDES
58Angina PectorisSIDER
59AngioedemaSIDER
60Angle Closure GlaucomaSIDER
61AnhedoniaOFFSIDES
62AnhidrosisOFFSIDES
63Ankle FractureOFFSIDES
64AnorexiaOFFSIDES
SIDER
65AnorgasmiaSIDER
66AnosmiaOFFSIDES
67Anxiety Disorders8666573CTD
68Aortic AneurysmOFFSIDES
69ApathyOFFSIDES
SIDER
70AphagiaOFFSIDES
71ArteriosclerosisOFFSIDES
72ArthralgiaSIDER
73ArthropathyOFFSIDES
74Arthropod biteOFFSIDES
75Aspartate Aminotransferase IncreasedCanada Vigilance: 3Canada Vigilance
SIDER
76AsthmaSIDER
77AstigmatismOFFSIDES
78AtaxiaSIDER
79AtelectasisOFFSIDES
80AtherosclerosisOFFSIDES
81Atrioventricular BlockSIDER
82Atrophic vulvovaginitisOFFSIDES
83AuraOFFSIDES
84Autoimmune hepatitisOFFSIDES
85Autonomic neuropathyOFFSIDES
86Avulsion fractureOFFSIDES
87Back PainSIDER
88Bacterial sepsisOFFSIDES
89Basal Ganglia Diseases12766931CTD
90Basal cell carcinomaOFFSIDES
91Benign Prostatic HyperplasiaOFFSIDES
92Bilirubin conjugated increasedOFFSIDES
93Biopsy breast abnormalOFFSIDES
94Biopsy lymph gland abnormalOFFSIDES
95Bladder painSIDER
96Bladder spasmOFFSIDES
97Blood GlucoseOFFSIDES
98Blood alkaline phosphatase increasedOFFSIDES
99Blood cholesterol abnormalOFFSIDES
100Blood cholesterolOFFSIDES
101Blood glucose decreasedOFFSIDES
102Blood glucose fluctuationOFFSIDES
103Blood immunoglobulin A decreasedOFFSIDES
104Blood immunoglobulin G decreasedOFFSIDES
105Blood immunoglobulin G increasedOFFSIDES
106Blood lactate dehydrogenase increasedSIDER
107Blood pH increasedOFFSIDES
108Blood parathyroid hormone increasedOFFSIDES
109Blood prolactin increasedOFFSIDES
SIDER
110Blood testosterone decreasedOFFSIDES
111Blood triglycerides increasedOFFSIDES
112Blurred visionOFFSIDES
113Bone density decreasedOFFSIDES
114Bone painOFFSIDES
115Bone swellingOFFSIDES
116Bradycardia8626361CTD
SIDER
117Breast CystOFFSIDES
118Breast hyperplasiaOFFSIDES
119Breast necrosisOFFSIDES
120Breast tendernessOFFSIDES
121BronchiectasisOFFSIDES
122BronchitisOFFSIDES
SIDER
123BulimiaOFFSIDES
124Burning sensationOFFSIDES
125BursitisOFFSIDES
SIDER
126Cardiac asthmaOFFSIDES
127Cardiac stress test abnormalOFFSIDES
128Cardiac valve abscessOFFSIDES
129Cardiotoxicity26821276CTD
130Cartilage injuryOFFSIDES
131Cataract operationOFFSIDES
132CataractOFFSIDES
133CellulitisOFFSIDES
SIDER
134Cerebral AtherosclerosisOFFSIDES
135Cerebral artery stenosisOFFSIDES
136Cerebral circulatory failureOFFSIDES
137Cerebrovascular accidentSIDER
138Cervicobrachial syndromeOFFSIDES
139Chemical and Drug Induced Liver Injury

View details

CTD
140Chest PainOFFSIDES
SIDER
141Chest wall painOFFSIDES
142ChillsSIDER
143Choking sensationOFFSIDES
144CholangiolitisOFFSIDES
145CholecystitisOFFSIDES
146ChromaturiaOFFSIDES
147Chronic Fatigue SyndromeOFFSIDES
148Chronic Obstructive Airway DiseaseOFFSIDES
149Circumstance or information capable of leading to medication errorOFFSIDES
150CirrhosisOFFSIDES
151ClubbingOFFSIDES
152Cocaine-Related Disorders15730347CTD
153Cognitive deteriorationOFFSIDES
154Cold sweatOFFSIDES
155ColitisSIDER
156Completed SuicideSIDER
157Compression stockings applicationOFFSIDES
158ConfabulationOFFSIDES
159Confusion9855339CTD
160ConjunctivitisSIDER
161ConstipationSIDER
162Contact DermatitisOFFSIDES
163Coronary angioplastyOFFSIDES
164Cutis LaxaOFFSIDES
165CyanosisOFFSIDES
166CystitisSIDER
167DeafnessSIDER
168DebridementOFFSIDES
169Decreased LibidoOFFSIDES
170DehydrationSIDER
171DemyelinationOFFSIDES
172Dental FistulaOFFSIDES
173Dental cariesOFFSIDES
174Dental discomfortOFFSIDES
175Dental prosthesis placementOFFSIDES
176Dental prosthesis userOFFSIDES
177DependenceSIDER
178Depressive disorder

View details

CTD
179DermatitisSIDER
180Device FailureOFFSIDES
181DiabetesOFFSIDES
182Diabetes mellitus inadequate controlOFFSIDES
183Diabetic RetinopathyOFFSIDES
184DiarrheaOFFSIDES
185DiplopiaSIDER
186DiscomfortSIDER
187Disease ProgressionOFFSIDES
188Disease recurrenceOFFSIDES
189Disturbance in sexual arousalSIDER
190DiverticulumOFFSIDES
191Double Outlet Right VentricleOFFSIDES
192Drug DependenceSIDER
193Drug ToleranceOFFSIDES
SIDER
194Drug abuserOFFSIDES
195Drug addictOFFSIDES
196Drug dispensing errorOFFSIDES
197Drug seeking behaviorSIDER
198Drug withdrawal headacheOFFSIDES
199Dry skinOFFSIDES
SIDER
200DuodenitisOFFSIDES
201DysarthriaSIDER
202DyspepsiaOFFSIDES
SIDER
203DysphasiaOFFSIDES
204DysphoniaOFFSIDES
205Dysthymic DisorderOFFSIDES
206DysuriaOFFSIDES
SIDER
207EcchymosisSIDER
208EczemaSIDER
209Elbow operationOFFSIDES
210Electrocardiogram changeOFFSIDES
211Electromechanical dissociationOFFSIDES
212Emotional distressOFFSIDES
213Endodontic procedureOFFSIDES
214Endometrial disorderOFFSIDES
215Endometrial hypertrophyOFFSIDES
216Enlargement abdomenSIDER
217EnteritisOFFSIDES
218EpicondylitisOFFSIDES
219EpididymitisOFFSIDES
220Epidural AbscessOFFSIDES
221EpistaxisOFFSIDES
SIDER
222Erectile dysfunctionOFFSIDES
SIDER
223Erection increasedOFFSIDES
224Erosive gastritisOFFSIDES
225EructationSIDER
226Erythema MultiformeSIDER
227ErythemaOFFSIDES
228Euphoric moodCanada Vigilance: 1Canada Vigilance
SIDER
229Eustachian tube disorderOFFSIDES
230External ear cellulitisOFFSIDES
231Eye painSIDER
232Failure of implantOFFSIDES
233Failure to ThriveOFFSIDES
234Fatty LiverOFFSIDES
235FibromyalgiaOFFSIDES
236Flank PainOFFSIDES
237Flat affectOFFSIDES
SIDER
238FlatulenceSIDER
239Fluid overloadOFFSIDES
240FlushingSIDER
241Food aversionOFFSIDES
242FormicationOFFSIDES
243GamblingOFFSIDES
244Gamma-Glutamyltransferase IncreasedCanada Vigilance: 1Canada Vigilance
OFFSIDES
245Gastric hypomotilityOFFSIDES
246GastritisSIDER
247GastroenteritisSIDER
248Gastrointestinal PainSIDER
249Gastrointestinal motility disorderOFFSIDES
250General physical health deteriorationOFFSIDES
251GingivitisSIDER
252GlaucomaSIDER
253GlobulinuriaOFFSIDES
254GlossitisSIDER
255GoiterOFFSIDES
256GoutOFFSIDES
SIDER
257Granulocyte count decreasedOFFSIDES
258GranulocytosisOFFSIDES
259Headache9855339CTD
SIDER
260Heart Diseases22166485CTD
261Hepatic Encephalopathy10068386CTD
262Hepatic necrosisCanada Vigilance: 2Canada Vigilance
SIDER
263Hepatitis AOFFSIDES
264Hepatitis BOFFSIDES
265Hepatitis COFFSIDES
266Hepatitis11048561CTD
OFFSIDES
SIDER
267HerniaOFFSIDES
SIDER
268Hilar lymphadenopathyOFFSIDES
269HordeolumOFFSIDES
270HostilitySIDER
271HyperacusisSIDER
272Hyperdynamic left ventricleOFFSIDES
273HyperkinesiaSIDER
274Hypertensive cardiomyopathyOFFSIDES
275HyperventilationOFFSIDES
SIDER
276Hypoaesthesia facialOFFSIDES
277HypophagiaOFFSIDES
278HyporeflexiaOFFSIDES
279HypotensionSIDER
280Impaired driving abilityOFFSIDES
281Impaired work abilityOFFSIDES
282Incision site complicationOFFSIDES
283InfectionSIDER
284Infectious MononucleosisOFFSIDES
285Injection site burningOFFSIDES
286Injection site massOFFSIDES
287Insulin ResistanceOFFSIDES
288Insulin-requiring type 2 diabetes mellitusOFFSIDES
289Intention tremorOFFSIDES
290Intentional drug misuseOFFSIDES
291Intervertebral Disc DegenerationOFFSIDES
292Intracranial AneurysmOFFSIDES
293Joint Range of Motion DecreasedOFFSIDES
294Joint injuryOFFSIDES
295Joint sprainOFFSIDES
296KeratitisSIDER
297KeratoconjunctivitisSIDER
298Lactescent serumOFFSIDES
299Lactic dehydrogenase activity increasedSIDER
300LaryngitisSIDER
301Left atrial dilatationOFFSIDES
302Left ventricular end-diastolic pressure increasedOFFSIDES
303Left ventricular heaveOFFSIDES
304LethargyCanada Vigilance: 1Canada Vigilance
OFFSIDES
305LeukopeniaSIDER
306Life expectancy shortenedOFFSIDES
307LightheadednessSIDER
308Limb injuryOFFSIDES
309Liver AbscessOFFSIDES
310Liver Failure, Acute10894614
11048561
12873607
CTD
311Liver Failure10068386
21823597
CTD
312Liver diseases18344530CTD
313Liver transplant rejectionOFFSIDES
314Long QT Syndrome26821276CTD
315Lumbar radiculopathyOFFSIDES
316Lung consolidationOFFSIDES
317LymphadenopathySIDER
318Lysosomal Storage Diseases28551711CTD
319MacrocytosisOFFSIDES
320Malignant neoplasm progressionOFFSIDES
321Malignant syndrome NOSSIDER
322MalocclusionOFFSIDES
323MastectomyOFFSIDES
324Medical device removalOFFSIDES
325MeibomianitisOFFSIDES
326Memory impairmentSIDER
327MeningiomaOFFSIDES
328Mental status changes postoperativeOFFSIDES
329MetaplasiaOFFSIDES
330Migraine with AuraOFFSIDES
331Mood disorder due to a general medical conditionOFFSIDES
332Mood swingsSIDER
333Multi-organ disorderOFFSIDES
334Multiple SclerosisOFFSIDES
335Muscle FatigueOFFSIDES
336Muscle Rigidity9018197CTD
337Muscle relaxant therapySIDER
338Muscle strainOFFSIDES
339Musculoskeletal PainOFFSIDES
340Musculoskeletal chest painOFFSIDES
341Musculoskeletal discomfortSIDER
342Musculoskeletal stiffnessSIDER
343MyalgiaSIDER
344MydriasisSIDER
345Myoclonus12633152CTD
SIDER
346MyopiaOFFSIDES
347Myositis9002485CTD
348Nail InfectionOFFSIDES
349Neck PainSIDER
350Neck stiffnessSIDER
351Necrosis25663337CTD
352NephrolithiasisOFFSIDES
SIDER
353Nervous tensionOFFSIDES
354NeuralgiaOFFSIDES
SIDER
355Neuroleptic Malignant SyndromeSIDER
356Nicotine DependenceOFFSIDES
357NocturiaSIDER
358NoduleOFFSIDES
359Nuchal RigiditySIDER
360Ocular HypertensionOFFSIDES
361OliguriaSIDER
362Optic NeuritisOFFSIDES
363Optic NeuropathyOFFSIDES
364Oral candidiasisSIDER
365Oral infectionOFFSIDES
366Oral polypectomyOFFSIDES
367OrchitisOFFSIDES
368Oropharyngeal painOFFSIDES
369Oropharyngeal swellingOFFSIDES
370OrthopneaOFFSIDES
371OsteomyelitisOFFSIDES
372OsteopeniaOFFSIDES
373OsteoporosisOFFSIDES
374OverweightOFFSIDES
375Oxygen saturation abnormalOFFSIDES
376PRL increasedSIDER
377PallorSIDER
378PalpitationsSIDER
379PancreatitisOFFSIDES
380Panic DisorderOFFSIDES
381ParanoiaOFFSIDES
SIDER
382Paranoid reactionSIDER
383Pelvic PainSIDER
384Pelvic fluid collectionOFFSIDES
385Peptic UlcerSIDER
386PericarditisOFFSIDES
387Peripheral embolismOFFSIDES
388Pharyngolaryngeal PainOFFSIDES
389PhimosisOFFSIDES
390PhlebitisOFFSIDES
391PhonophobiaOFFSIDES
392PhotophobiaSIDER
393PingueculaOFFSIDES
394PlasmacytomaOFFSIDES
395PlatybasiaOFFSIDES
396PleurisyOFFSIDES
397PneumoniaSIDER
398PneumoperitoneumOFFSIDES
399PneumothoraxOFFSIDES
400Polysubstance abuseOFFSIDES
401PolyuriaOFFSIDES
SIDER
402Portal hypertensive gastropathyOFFSIDES
403Posterior CapsulotomyOFFSIDES
404Postmenopausal bleedingOFFSIDES
405Postoperative infectionOFFSIDES
406PresbyopiaOFFSIDES
407Prescribed overdoseOFFSIDES
408Pressure of speechOFFSIDES
409PriapismOFFSIDES
SIDER
410Primary sequestrumOFFSIDES
411ProctitisOFFSIDES
412ProctocolitisSIDER
413Productive CoughOFFSIDES
414Prostate cancer recurrentOFFSIDES
415PruritusSIDER
416PsoriasisOFFSIDES
417Psychiatric symptomOFFSIDES
418Psychomotor skills impairedOFFSIDES
419Pulmonary congestionOFFSIDES
420Pyoderma GangrenosumOFFSIDES
421PyuriaOFFSIDES
422Radicular painOFFSIDES
423Rectal polypOFFSIDES
424Reflux gastritisOFFSIDES
425Renal Insufficiency22166485CTD
426Renal cystOFFSIDES
427Renal interstitial fibrosisOFFSIDES
428Renal tubular necrosisOFFSIDES
429Restrictive pulmonary diseaseOFFSIDES
430Retinal DegenerationOFFSIDES
431Retinal VasculitisOFFSIDES
432Retroperitoneal lymphadenopathyOFFSIDES
433Rhabdomyolysis9002485CTD
SIDER
434RhinitisOFFSIDES
SIDER
435RhonchiOFFSIDES
436Schizoaffective DisorderOFFSIDES
437ScotomaSIDER
438Secretion dischargeOFFSIDES
439SeromaOFFSIDES
440Serotonin Syndrome9018197CTD
SIDER
441Serum serotonin decreasedOFFSIDES
442ShockSIDER
443SigmoiditisOFFSIDES
444Sinus bradycardiaSIDER
445SinusitisOFFSIDES
SIDER
446Skin IndurationOFFSIDES
447Skin hypertrophyOFFSIDES
448Skin lacerationOFFSIDES
449Skin lesionOFFSIDES
450Sleep Wake Disorders9184611CTD
451SnoringOFFSIDES
452Spinal column stenosisOFFSIDES
453SpondylolisthesisOFFSIDES
454Squamous cell carcinoma of skinOFFSIDES
455Stem cell transplantOFFSIDES
456Stevens-Johnson SyndromeSIDER
457StomatitisSIDER
458StressOFFSIDES
459Suicide attemptSIDER
460SuicideSIDER
461SweatingSIDER
462Synovial CystOFFSIDES
463SynovitisOFFSIDES
464TachycardiaCanada Vigilance: 1Canada Vigilance
SIDER
465Tardive DyskinesiaOFFSIDES
466Temperature intoleranceOFFSIDES
467Temporal ArteritisOFFSIDES
468TendinitisOFFSIDES
469TenosynovitisSIDER
470Tension HeadacheOFFSIDES
471Testicular massOFFSIDES
472ThirstSIDER
473ThoracotomyOFFSIDES
474Throat cancerOFFSIDES
475ThrombocytopeniaSIDER
476TinnitusSIDER
477Tobacco userOFFSIDES
478Tolerance developmentSIDER
479Tooth ExtractionOFFSIDES
480Torsades de Pointes26821276CTD
481UlcerOFFSIDES
482Upper respiratory tract inflammationOFFSIDES
483Urinary IncontinenceSIDER
484Urinary RetentionSIDER
485Urinary tract infectionSIDER
486Urine output increasedSIDER
487UrticariaSIDER
488Venous InsufficiencyOFFSIDES
489Venous thrombosis limbOFFSIDES
490Ventricular hypokinesiaOFFSIDES
491VertigoSIDER
492Vesiculobullous rashSIDER
493Viral pharyngitisOFFSIDES
494Viral upper respiratory tract infectionOFFSIDES
495Vision Disorders9855339CTD
496Visual disturbanceOFFSIDES
SIDER
497Vitamin A DeficiencyOFFSIDES
498VitrectomyOFFSIDES
499Walking aid userOFFSIDES
500Weight GainOFFSIDES
501Weight decreasedSIDER
502Wrong drug administeredOFFSIDES
503YawningSIDER
504jaundiceCanada Vigilance: 210068386
10795773
CTD
Canada Vigilance
505prostatitisOFFSIDES
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