MetaADEDB 2.0 @ LMMD
Loxapine
(XJGVXQDUIWGIRW-UHFFFAOYSA-N)
Structure
SMILES
CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Type(s)
Approved
ATC code(s)
N05AH01
Molecular Formula:
C18H18ClN3O
Molecular Weight:
327.808
Log P:
3.0828
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
28.07
CAS Number(s):
1977-10-2; 28400
Synonym(s)
1.
Loxapine
2.
Loxapinsuccinate
3.
Oxilapine
4.
2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine
5.
CL-71,563
6.
Cloxazepine
7.
Loxapine Hydrochloride
8.
Loxapine Monohydrochloride
9.
Loxapine Succinate
10.
Loxipine Maleate
11.
Loxipine Succinate
12.
Loxitane
13.
CL 71,563
14.
CL71,563
15.
Hydrochloride, Loxapine
16.
Maleate, Loxipine
17.
Succinate, Loxapine
External Link(s)
MeSHD008152
PubChem Compound3964
BindingDB22871
ChEBI50841
CHEMBLCHEMBL831
DrugBankDB00408
DrugCentral1613
IUPHAR/BPS Guide to PHARMACOLOGY205
KEGGcpd:C07104
dr:D02340
Therapeutic Target DatabaseD0U5OE
ZINC19796158
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1FatigueFAERS: 3SIDER
US FAERS
2Accidental exposure to productFAERS: 2US FAERS
3BronchospasmFAERS: 2SIDER
US FAERS
4Neuroleptic Malignant SyndromeFAERS: 2
Canada Vigilance: 1		6822486CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
5Tardive DyskinesiaFAERS: 2
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
6BlepharospasmFAERS: 110518183CTD
US FAERS
7Contraindicated drug prescribedFAERS: 1US FAERS
8Contraindicated product administeredFAERS: 1US FAERS
9CyanosisFAERS: 1OFFSIDES
US FAERS
10DizzinessFAERS: 1SIDER
US FAERS
11DroolingFAERS: 1US FAERS
12Drug toxicityFAERS: 1US FAERS
13Drug withdrawal syndromeFAERS: 1US FAERS
14DystoniaFAERS: 1
Canada Vigilance: 2		813953
3711026
16239854		CTD
SIDER
Canada Vigilance
US FAERS
15Feeling abnormalFAERS: 1SIDER
US FAERS
16Granulocyte count increasedFAERS: 1US FAERS
17HeadacheFAERS: 1SIDER
US FAERS
18HypotensionFAERS: 12738184CTD
SIDER
US FAERS
19HypoventilationFAERS: 1US FAERS
20Lymphocyte percentage decreasedFAERS: 1US FAERS
21Medication ErrorFAERS: 1US FAERS
22Mental impairmentFAERS: 1US FAERS
23Obsessive-Compulsive DisorderFAERS: 1US FAERS
24TremorFAERS: 1SIDER
US FAERS
25Urinary RetentionFAERS: 1SIDER
US FAERS
26Abdominal Compartment SyndromeOFFSIDES
27AcidosisOFFSIDES
28Acute dystoniaSIDER
29AgitationCanada Vigilance: 1Canada Vigilance
SIDER
30AgranulocytosisSIDER
31AkathisiaSIDER
32AkinesiaSIDER
33Alcoholic IntoxicationOFFSIDES
34AlopeciaSIDER
35Altered state of consciousnessOFFSIDES
36Amylase increasedCanada Vigilance: 1Canada Vigilance
37Anal fungal infectionOFFSIDES
38AngioedemaOFFSIDES
39Angle Closure GlaucomaOFFSIDES
40AnxietyCanada Vigilance: 1Canada Vigilance
41Aspiration PneumoniaOFFSIDES
42AstheniaSIDER
43Atrial Fibrillation7114310CTD
44Atrial tachycardiaOFFSIDES
45Bacterial test positiveOFFSIDES
46Basal Ganglia Diseases

View details

788001
813953
816626
7028656
 		CTD
47Bipolar I disorderOFFSIDES
48Blood albumin decreasedOFFSIDES
49Blood alkaline phosphatase decreasedOFFSIDES
50Blood creatine phosphokinase increasedOFFSIDES
51Blood fibrinogen increasedOFFSIDES
52Blood follicle stimulating hormone decreasedOFFSIDES
53Blood glucose decreasedOFFSIDES
54Blood glucose increasedCanada Vigilance: 1Canada Vigilance
55Blood sodiumOFFSIDES
56Blood thyroid stimulating hormone increasedOFFSIDES
57Body TemperatureOFFSIDES
58Brain Diseases7258388CTD
59Bronchial ObstructionOFFSIDES
60Bruxism10518183CTD
61Cardioactive drug levelOFFSIDES
62Cardiomyopathy acuteOFFSIDES
63Catalepsy9089667
9723970		CTD
64Catatonia6874654CTD
OFFSIDES
65Cerebral ThrombosisOFFSIDES
66Cerebrovascular accidentSIDER
67Chest PainCanada Vigilance: 1Canada Vigilance
SIDER
68Chest discomfortSIDER
69Chest tightnessSIDER
70CholangiolitisOFFSIDES
71Choreoathetoid movementsSIDER
72ChoreoathetosisSIDER
73Chronic Obstructive Airway DiseaseOFFSIDES
74Chronic left ventricular failureOFFSIDES
75Circumstance or information capable of leading to medication errorOFFSIDES
76ConfabulationOFFSIDES
77Congenital tricuspid valve incompetenceOFFSIDES
78ConstipationCanada Vigilance: 1Canada Vigilance
SIDER
79ContractureOFFSIDES
80CryptorchidismOFFSIDES
81Cytolytic hepatitisOFFSIDES
82DehydrationCanada Vigilance: 1Canada Vigilance
OFFSIDES
83Dementia7114310CTD
84Depressed Level of ConsciousnessOFFSIDES
85DermatitisSIDER
86DiabetesOFFSIDES
87Diabetes mellitus inadequate controlOFFSIDES
88DisorientationCanada Vigilance: 1Canada Vigilance
89DrowsinessOFFSIDES
SIDER
90Drug Overdose7258388CTD
91Drug administration errorOFFSIDES
92Drug level fluctuatingOFFSIDES
93DysarthriaSIDER
94DysgeusiaSIDER
95Electrocardiogram repolarisation abnormalityOFFSIDES
96EnterocolitisOFFSIDES
97Gastrointestinal hypomotilityOFFSIDES
98Gastrointestinal obstructionOFFSIDES
99GlaucomaSIDER
100GlobulinuriaOFFSIDES
101GranulocytosisOFFSIDES
102HemiplegiaOFFSIDES
103Hepatic necrosisOFFSIDES
104HepatitisOFFSIDES
SIDER
105HepatosplenomegalyOFFSIDES
106HyperpyrexiaSIDER
107HypersensitivitySIDER
108HypokinesiaCanada Vigilance: 1Canada Vigilance
109Hypothalamo-pituitary disorderOFFSIDES
110IncoherentOFFSIDES
111Intestinal ObstructionOFFSIDES
112IntubationOFFSIDES
113Iron OverloadOFFSIDES
114Kidney FailureOFFSIDES
115Labile blood pressureOFFSIDES
116LaryngospasmCanada Vigilance: 1Canada Vigilance
117Leukopenia neonatalOFFSIDES
118LeukopeniaSIDER
119LightheadednessSIDER
120Lipase increasedCanada Vigilance: 1Canada Vigilance
121Mastication disorderOFFSIDES
122Metabolic acidosisOFFSIDES
123MoaningOFFSIDES
124Motor restlessnessSIDER
125Motor retardationOFFSIDES
126Movement Disorders10518183CTD
127Multiple drug overdose intentionalOFFSIDES
128Muscle RigiditySIDER
129Myocardial ruptureOFFSIDES
130Myoglobinuria7258388CTD
131NauseaSIDER
132Nephrogenic Diabetes InsipidusOFFSIDES
133NumbnessSIDER
134OculogyrationSIDER
135Oculogyric crisisSIDER
136Open woundOFFSIDES
137Oral fungal infectionOFFSIDES
138Oral infectionOFFSIDES
139OverdoseOFFSIDES
140Palliative CareOFFSIDES
141ParanoiaOFFSIDES
142PhlebitisOFFSIDES
143PhototoxicitySIDER
144Pleural decorticationOFFSIDES
145PolydipsiaSIDER
146PriapismOFFSIDES
147Procedural hypotensionOFFSIDES
148Productive CoughCanada Vigilance: 1Canada Vigilance
149Propofol Infusion SyndromeOFFSIDES
150Protein C decreasedOFFSIDES
151Protein total increasedOFFSIDES
152Prothrombin level decreasedOFFSIDES
153PruritusCanada Vigilance: 1Canada Vigilance
SIDER
154Psychotic Disorders813953
3711026		CTD
155Pulmonary artery stenosisOFFSIDES
156Pulmonary function test decreasedSIDER
157Rash maculovesicularOFFSIDES
158Renal Insufficiency7258388CTD
159Respiratory DepressionSIDER
160Respiratory distressCanada Vigilance: 1Canada Vigilance
161RestlessnessCanada Vigilance: 1Canada Vigilance
162RetinitisOFFSIDES
163Rhabdomyolysis7258388CTD
OFFSIDES
164Schizophrenia

View details

39739
788001
816626
7028656
7130427
7146292
10518183
 		CTD
OFFSIDES
165Seizures7258388CTD
166Septic ShockOFFSIDES
167ShockSIDER
168Slurred speechSIDER
169SomnolenceSIDER
170Spasm7130427CTD
171Staggering gaitSIDER
172Status EpilepticusOFFSIDES
173Stupor2738184CTD
174Sudden deathOFFSIDES
175SyncopeSIDER
176Tachycardia, Paroxysmal7258388CTD
177TachycardiaCanada Vigilance: 1Canada Vigilance
SIDER
178TensionSIDER
179Thoracic cavity drainageOFFSIDES
180Throat irritationSIDER
181ThrombocytopeniaSIDER
182Transaminases increasedOFFSIDES
183TrismusCanada Vigilance: 1Canada Vigilance
184Urethral StenosisOFFSIDES
185Urine ketone body presentOFFSIDES
186VomitingCanada Vigilance: 1Canada Vigilance
SIDER
187Vulvovaginal mycotic infectionOFFSIDES
188Weight Gain816626CTD
189Weight decreasedCanada Vigilance: 1Canada Vigilance
SIDER
190WheezingSIDER
191Wound eviscerationOFFSIDES
192Wrong drug administeredOFFSIDES
193jaundiceSIDER
194nervous system disorderSIDER
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