Serotonin Syndrome
(UMLS:C0699828)
- Definition:
- An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
- UMLS ID:
- C0699828
- MeSH ID:
- D020230
Classification:
- Chemically-Induced Disorders
- MeSH Tree Number(s):
- C25.100.875
Synonym(s)
1.
Serotonin Syndrome
2.
SEROTONIN SYNDROME
3.
Serotonergic syndrome
4.
Serotonin syndrome
5.
serotonergic syndrome
6.
serotonin syndrome
7.
serotonin syndrome toxicity
8.
serotonin syndromes
9.
syndrome serotonin
Associated Drug(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Duloxetine Hydrochloride | FAERS: 146 Canada Vigilance: 16 | Canada Vigilance SIDER US FAERS | |
| 2 | Paroxetine | FAERS: 82 Canada Vigilance: 6 | CTD SIDER Canada Vigilance US FAERS | |
| 3 | Sertraline | FAERS: 81 Canada Vigilance: 10 | Canada Vigilance US FAERS | |
| 4 | Venlafaxine Hydrochloride | FAERS: 79 Canada Vigilance: 11 | CTD Canada Vigilance US FAERS | |
| 5 | Sertraline | FAERS: 77 Canada Vigilance: 4 | CTD SIDER Canada Vigilance US FAERS | |
| 6 | Fluoxetine | FAERS: 61 Canada Vigilance: 3 | CTD SIDER Canada Vigilance US FAERS | |
| 7 | Citalopram | FAERS: 58 Canada Vigilance: 4 | CTD SIDER Canada Vigilance US FAERS | |
| 8 | Linezolid | FAERS: 45 Canada Vigilance: 2 | 18624020 | CTD SIDER Canada Vigilance US FAERS |
| 9 | Vilazodone Hydrochloride | FAERS: 36 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 10 | Lamotrigine | FAERS: 34 | US FAERS | |
| 11 | Citalopram | FAERS: 31 | US FAERS | |
| 12 | Fluoxetine | FAERS: 29 | US FAERS | |
| 13 | Paroxetine | FAERS: 28 | US FAERS | |
| 14 | Ondansetron | FAERS: 26 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 15 | Venlafaxine Hydrochloride | FAERS: 26 | SIDER US FAERS | |
| 16 | 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride | FAERS: 24 | US FAERS | |
| 17 | Tramadol | FAERS: 24 | 9658268 11384912 27641627 | CTD SIDER US FAERS |
| 18 | Citalopram | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 19 | Tapentadol | FAERS: 23 | US FAERS | |
| 20 | Mirtazapine | FAERS: 22 | SIDER US FAERS | |
| 21 | Citalopram | FAERS: 21 | US FAERS | |
| 22 | Tapentadol | FAERS: 21 | SIDER US FAERS | |
| 23 | Desvenlafaxine Succinate | FAERS: 20 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 24 | Tramadol | FAERS: 17 | US FAERS | |
| 25 | Aripiprazole | FAERS: 15 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 26 | Clozapine | FAERS: 15 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 27 | Olanzapine | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 28 | Vortioxetine | FAERS: 14 | US FAERS | |
| 29 | Bupropion | FAERS: 12 | US FAERS | |
| 30 | Pregabalin | FAERS: 12 | US FAERS | |
| 31 | Vortioxetine hydrobromide | FAERS: 12 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 32 | Trazodone | FAERS: 11 | US FAERS | |
| 33 | Milnacipran | FAERS: 9 | US FAERS | |
| 34 | Atomoxetine Hydrochloride | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 35 | Fentanyl | FAERS: 8 | 18757161 | CTD US FAERS |
| 36 | Buprenorphine | FAERS: 7 | US FAERS | |
| 37 | Duloxetine Hydrochloride | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Methylene Blue | FAERS: 6 | US FAERS | |
| 39 | Trazodone | FAERS: 6 | CTD SIDER US FAERS | |
| 40 | Valproic Acid | FAERS: 6 | US FAERS | |
| 41 | lorcaserin | FAERS: 6 | SIDER US FAERS | |
| 42 | Fentanyl | FAERS: 5 | US FAERS | |
| 43 | Fluvoxamine | FAERS: 5 | US FAERS | |
| 44 | Guaifenesin | FAERS: 5 | US FAERS | |
| 45 | Levomilnacipran | FAERS: 5 | US FAERS | |
| 46 | Loperamide | FAERS: 5 | US FAERS | |
| 47 | Risperidone | FAERS: 5 | US FAERS | |
| 48 | rasagiline | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 49 | Dextromethorphan | FAERS: 4 | US FAERS | |
| 50 | Fingolimod Hydrochloride | FAERS: 4 | US FAERS | |
| 51 | Gabapentin | FAERS: 4 | US FAERS | |
| 52 | Lorazepam | FAERS: 4 | US FAERS | |
| 53 | Metoclopramide | FAERS: 4 | 11816261 | CTD US FAERS |
| 54 | Quetiapine Fumarate | FAERS: 4 | US FAERS | |
| 55 | Sumatriptan | FAERS: 4 | US FAERS | |
| 56 | Valproic Acid | FAERS: 4 | US FAERS | |
| 57 | Varenicline | FAERS: 4 | US FAERS | |
| 58 | brexpiprazole | FAERS: 4 | US FAERS | |
| 59 | eletriptan | FAERS: 4 | SIDER US FAERS | |
| 60 | Asenapine | FAERS: 3 | US FAERS | |
| 61 | Dimethyl Fumarate | FAERS: 3 | US FAERS | |
| 62 | Levetiracetam | FAERS: 3 | US FAERS | |
| 63 | Ondansetron | FAERS: 3 | US FAERS | |
| 64 | Paliperidone Palmitate | FAERS: 3 | US FAERS | |
| 65 | Quetiapine Fumarate | FAERS: 3 | US FAERS | |
| 66 | (3S,4R)-3-(1,3-Benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidin-1-ium;methanesulfonate | FAERS: 2 | US FAERS | |
| 67 | 4-hydroxybutyric acid | FAERS: 2 | US FAERS | |
| 68 | Albuterol | FAERS: 2 | US FAERS | |
| 69 | Amitriptyline | FAERS: 2 | 8869767 9031998 | CTD SIDER US FAERS |
| 70 | Clarithromycin | FAERS: 2 | US FAERS | |
| 71 | Clomipramine | FAERS: 2 | US FAERS | |
| 72 | Dextromethorphan | FAERS: 2 | 12456895 | CTD SIDER US FAERS |
| 73 | Diphenhydramine | FAERS: 2 | US FAERS | |
| 74 | Leuprolide | FAERS: 2 | US FAERS | |
| 75 | Lisdexamfetamine Dimesylate | FAERS: 2 | US FAERS | |
| 76 | Meperidine | FAERS: 2 | US FAERS | |
| 77 | Meperidine | FAERS: 2 | 7776924 | CTD US FAERS |
| 78 | Morphine | FAERS: 2 | US FAERS | |
| 79 | Pamidronate | FAERS: 2 | US FAERS | |
| 80 | Prednisone | FAERS: 2 | US FAERS | |
| 81 | Pyridostigmine Bromide | FAERS: 2 | US FAERS | |
| 82 | Selegiline | FAERS: 2 | US FAERS | |
| 83 | bupropion hydrochloride, naltrexone hydrochoride drug combination | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 84 | lanreotide | FAERS: 2 | US FAERS | |
| 85 | ramelteon | FAERS: 2 | US FAERS | |
| 86 | sumatriptan-naproxen | FAERS: 2 | US FAERS | |
| 87 | zolmitriptan | FAERS: 2 | SIDER US FAERS | |
| 88 | 4-Aminopyridine | FAERS: 1 | US FAERS | |
| 89 | 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide | FAERS: 1 | US FAERS | |
| 90 | Acetaminophen | FAERS: 1 | SIDER US FAERS | |
| 91 | Adderall | FAERS: 1 | US FAERS | |
| 92 | Alprazolam | FAERS: 1 | US FAERS | |
| 93 | Amlodipine | FAERS: 1 | US FAERS | |
| 94 | Axitinib | FAERS: 1 | US FAERS | |
| 95 | Baclofen | FAERS: 1 | US FAERS | |
| 96 | Bupivacaine | FAERS: 1 | US FAERS | |
| 97 | Buspirone | FAERS: 1 | 8681579 9179637 | CTD SIDER US FAERS |
| 98 | Carbamazepine | FAERS: 1 | US FAERS | |
| 99 | Celecoxib | FAERS: 1 | US FAERS | |
| 100 | Clomipramine | FAERS: 1 | CTD SIDER US FAERS | |
| 101 | Clonazepam | FAERS: 1 | US FAERS | |
| 102 | Cyproheptadine hydrochloride | FAERS: 1 | US FAERS | |
| 103 | Droxidopa | FAERS: 1 | US FAERS | |
| 104 | Glatiramer Acetate | FAERS: 1 | US FAERS | |
| 105 | Glipizide | FAERS: 1 | US FAERS | |
| 106 | Granisetron | FAERS: 1 | US FAERS | |
| 107 | Haloperidol lactate | FAERS: 1 | US FAERS | |
| 108 | Haloperidol | FAERS: 1 | US FAERS | |
| 109 | Hydrochlorothiazide | FAERS: 1 | US FAERS | |
| 110 | Hydroxychloroquine | FAERS: 1 | US FAERS | |
| 111 | Imipramine | FAERS: 1 | 8869767 | CTD US FAERS |
| 112 | Imipramine | FAERS: 1 | US FAERS | |
| 113 | Insulin Detemir | FAERS: 1 | US FAERS | |
| 114 | Insulin Glargine | FAERS: 1 | US FAERS | |
| 115 | Ketorolac Tromethamine | FAERS: 1 | US FAERS | |
| 116 | Levorphanol | FAERS: 1 | US FAERS | |
| 117 | Lisinopril | FAERS: 1 | US FAERS | |
| 118 | Lithium | FAERS: 1 | CTD US FAERS | |
| 119 | Lurasidone Hydrochloride | FAERS: 1 | US FAERS | |
| 120 | Lurasidone Hydrochloride | FAERS: 1 | US FAERS | |
| 121 | Metformin | FAERS: 1 | US FAERS | |
| 122 | Metformin | FAERS: 1 | US FAERS | |
| 123 | Methadone | FAERS: 1 | US FAERS | |
| 124 | Methadone | FAERS: 1 | 17187532 19996237 | CTD US FAERS |
| 125 | Methamphetamine | FAERS: 1 | US FAERS | |
| 126 | Methylphenidate | FAERS: 1 | US FAERS | |
| 127 | Metronidazole | FAERS: 1 | US FAERS | |
| 128 | Miconazole | FAERS: 1 | US FAERS | |
| 129 | Modafinil | FAERS: 1 | US FAERS | |
| 130 | Modafinil | FAERS: 1 | US FAERS | |
| 131 | Naproxen | FAERS: 1 | US FAERS | |
| 132 | NuvaRing | FAERS: 1 | US FAERS | |
| 133 | Omeprazole | FAERS: 1 | US FAERS | |
| 134 | Oxycodone | FAERS: 1 | US FAERS | |
| 135 | Paliperidone Palmitate | FAERS: 1 | US FAERS | |
| 136 | Pamidronate | FAERS: 1 | US FAERS | |
| 137 | Perphenazine | FAERS: 1 | US FAERS | |
| 138 | Phenelzine | FAERS: 1 | CTD US FAERS | |
| 139 | Prezcobix | FAERS: 1 | US FAERS | |
| 140 | Prochlorperazine | FAERS: 1 | US FAERS | |
| 141 | Propranolol | FAERS: 1 | 15707818 | CTD US FAERS |
| 142 | Rabeprazole | FAERS: 1 | US FAERS | |
| 143 | Raltegravir Potassium | FAERS: 1 | US FAERS | |
| 144 | Rivastigmine | FAERS: 1 | US FAERS | |
| 145 | Sumatriptan | FAERS: 1 | 8869767 | CTD SIDER US FAERS |
| 146 | Tacrolimus | FAERS: 1 | US FAERS | |
| 147 | Tiagabine | FAERS: 1 | US FAERS | |
| 148 | Topiramate | FAERS: 1 | US FAERS | |
| 149 | Tranylcypromine | FAERS: 1 | 8888541 | CTD US FAERS |
| 150 | Vancomycin | FAERS: 1 | US FAERS | |
| 151 | Vilazodone Hydrochloride | FAERS: 1 | SIDER US FAERS | |
| 152 | carbidopa, levodopa drug combination | FAERS: 1 | 9048728 | CTD US FAERS |
| 153 | entacapone | FAERS: 1 | US FAERS | |
| 154 | eslicarbazepine acetate | FAERS: 1 | US FAERS | |
| 155 | metaxalone | FAERS: 1 | US FAERS | |
| 156 | naloxegol | FAERS: 1 | US FAERS | |
| 157 | naratriptan | FAERS: 1 | US FAERS | |
| 158 | nefazodone | FAERS: 1 | US FAERS | |
| 159 | rizatriptan | FAERS: 1 | SIDER US FAERS | |
| 160 | sapropterin | FAERS: 1 | US FAERS | |
| 161 | sofosbuvir-velpatasvir drug combination | FAERS: 1 | US FAERS | |
| 162 | treprostinil | FAERS: 1 | US FAERS | |
| 163 | ziprasidone | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance SIDER US FAERS | |
| 164 | ziprasidone | FAERS: 1 | US FAERS | |
| 165 | 5-(2-aminopropyl)indole | 28302559 | CTD | |
| 166 | Albuterol | Canada Vigilance: 1 | Canada Vigilance | |
| 167 | Amantadine | 9048728 | CTD | |
| 168 | Bromocriptine | 3711372 | CTD | |
| 169 | Chlorpromazine | 8862337 | CTD | |
| 170 | Ciprofloxacin | 19996237 | CTD | |
| 171 | Cyclosporine | 18243426 | CTD | |
| 172 | Cyproheptadine | 17403991 18585543 20002750 | CTD | |
| 173 | Desvenlafaxine Succinate | SIDER | ||
| 174 | Diazepam | 11816261 | CTD | |
| 175 | Dihydroergotamine | 8869767 | CTD | |
| 176 | Fluconazole | 18585543 | CTD | |
| 177 | Fluvoxamine | 8127934 12456895 | CTD SIDER | |
| 178 | Isocarboxazid | 7475741 7854515 8195456 | CTD | |
| 179 | Levodopa | 3711372 | CTD | |
| 180 | Lithium Carbonate | 9031998 | CTD | |
| 181 | McN 5652 | 2905001 | CTD | |
| 182 | Methylene | SIDER | ||
| 183 | Methylphenidate | 7854515 20298736 | CTD | |
| 184 | Methysergide | 3711372 8869767 | CTD | |
| 185 | Midazolam | 15707818 | CTD | |
| 186 | Milnacipran | SIDER | ||
| 187 | Moclobemide | CTD | ||
| 188 | N-Methyl-3,4-methylenedioxyamphetamine | 1346952 12456895 19175710 | CTD | |
| 189 | Phenylpropanolamine | SIDER | ||
| 190 | Serotonin | 11812522 | CTD | |
| 191 | Tramadol | Canada Vigilance: 1 | Canada Vigilance | |
| 192 | almotriptan | SIDER | ||
| 193 | cyclobenzaprine | SIDER | ||
| 194 | drospirenone and ethinyl estradiol combination | Canada Vigilance: 1 | Canada Vigilance | |
| 195 | frovatriptan | SIDER | ||
| 196 | indopan | 28302559 | CTD | |
| 197 | naratriptan | SIDER | ||
| 198 | nefazodone | 9018197 | CTD SIDER | |
| 199 | rasagiline | SIDER | ||
| 200 | rizatriptan | SIDER | ||
| 201 | sibutramine | Canada Vigilance: 1 | Canada Vigilance | |
| 202 | sibutramine | SIDER |
Similar ADE(s)
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