MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Nitrazepam

(KJONHKAYOJNZEC-UHFFFAOYSA-N)

Structure

SMILES: O=C1CN=C(c2c(N1)ccc(c2)[N+](=O)[O-])c1ccccc1
Type(s): Approved
ATC code(s): N05CD02
Molecular Formula:: C15H11N3O3
Molecular Weight:: 281.266
Log P:: 2.4811
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 1
TPSA:: 87.28
CAS Number(s):: 146-22-5

Synonym(s)

Nitrazepam

Nitrodiazepam

Alodorm

Dormalon

Dormo-Puren

Eatan

Imadorm

Imeson

Mogadon

10.

Nitrazadon

11.

Nitrazep

12.

Nitrazepam AL

13.

Nitrazepam-Neuraxpharm

14.

Novanox

15.

Radedorm

16.

Remnos

17.

Rhoxal-Nitrazepam

18.

Serenade

19.

Somnite

20.

Nitrazepam Neuraxpharm

21.

Rhoxal Nitrazepam

External Link(s)

MeSH	D009567
PubChem Compound	4506
BindingDB	50020856
ChEBI	7581
CHEMBL	CHEMBL13209
DrugBank	DB01595
DrugCentral	1945
KEGG	cpd:C07487 dr:D00531
Therapeutic Target Database	D0T5WK
ZINC	4311748

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal discomfort			SIDER
2	Abulia			OFFSIDES
3	Abuse			OFFSIDES
4	Accidental drug intake by child			OFFSIDES
5	Acid reflux			OFFSIDES
6	Acidosis			OFFSIDES
7	Activation syndrome			OFFSIDES
8	Activities of daily living impaired			OFFSIDES
9	Acute left ventricular failure			OFFSIDES
10	Acute respiratory failure			OFFSIDES
11	Adams-Stokes Syndrome			OFFSIDES
12	Adenoidal disorder			OFFSIDES
13	Agitation	Canada Vigilance: 1		Canada Vigilance SIDER
14	Agoraphobia			OFFSIDES
15	Agranulocytosis			SIDER
16	Alanine Aminotransferase Increased			OFFSIDES
17	Alcoholic Intoxication			OFFSIDES
18	Alertness decreased			SIDER
19	Altered state of consciousness			OFFSIDES
20	Alveolitis			OFFSIDES
21	Amnesia			SIDER
22	Amphetamines			OFFSIDES
23	Anger			SIDER
24	Angle Closure Glaucoma			OFFSIDES
25	Anorexia			OFFSIDES
26	Anti-insulin antibody decreased			OFFSIDES
27	Antibody test abnormal			OFFSIDES
28	Anticholinergic Syndrome			OFFSIDES
29	Antidepressant drug level increased			OFFSIDES
30	Anuria			OFFSIDES
31	Anxiety			OFFSIDES SIDER
32	Apallic syndrome			OFFSIDES
33	Apathy			OFFSIDES
34	Apnea		7655131	CTD OFFSIDES
35	Aspiration Pneumonia			OFFSIDES
36	Asthenia			SIDER
37	Ataxia	Canada Vigilance: 1		Canada Vigilance SIDER
38	Atrioventricular Block			OFFSIDES
39	Aura			OFFSIDES
40	Autoimmune thyroiditis			OFFSIDES
41	Autonomic failure syndrome			OFFSIDES
42	Band neutrophil percentage increased			OFFSIDES
43	Bed rest			OFFSIDES
44	Bedridden			OFFSIDES
45	Bipolar I disorder			OFFSIDES
46	Blood Glucose			OFFSIDES
47	Blood alkaline phosphatase decreased			OFFSIDES
48	Blood alkaline phosphatase increased			OFFSIDES
49	Blood chloride decreased			OFFSIDES
50	Blood chloride increased			OFFSIDES
51	Blood cholinesterase decreased			OFFSIDES
52	Blood cortisol increased			OFFSIDES
53	Blood creatine phosphokinase abnormal			OFFSIDES
54	Blood creatine phosphokinase decreased			OFFSIDES
55	Blood creatine phosphokinase increased			OFFSIDES
56	Blood creatinine increased			OFFSIDES
57	Blood immunoglobulin A decreased			OFFSIDES
58	Blood immunoglobulin G decreased			OFFSIDES
59	Blood immunoglobulin M decreased			OFFSIDES
60	Blood lactate dehydrogenase decreased			OFFSIDES
61	Blood lactate dehydrogenase increased			OFFSIDES
62	Blood pH increased			OFFSIDES
63	Blood potassium increased			OFFSIDES
64	Blood sodium increased			OFFSIDES
65	Blood sodium			OFFSIDES
66	Blood triglycerides increased			OFFSIDES
67	Blood urea increased			OFFSIDES
68	Blood uric acid			OFFSIDES
69	Blunted affect			OFFSIDES
70	Body Temperature			OFFSIDES
71	Cardiac Death			OFFSIDES
72	Cardiac Hypertrophy			OFFSIDES
73	Catalepsy		33340	CTD
74	Cataplexy			OFFSIDES
75	Catheter related infection			OFFSIDES
76	Cerebellar Ataxia		4182212	CTD
77	Cerebral circulatory failure			OFFSIDES
78	Choking			OFFSIDES
79	Chromaturia			OFFSIDES
80	Chylothorax			OFFSIDES
81	Cirrhosis			OFFSIDES
82	Clubbing			OFFSIDES
83	Cognition Disorders		4653884	CTD
84	Cold sweat			OFFSIDES
85	Completed Suicide			OFFSIDES
86	Confusion		2907315 4653884	CTD
87	Congenital nystagmus			OFFSIDES
88	Constipation			SIDER
89	Conversion disorder			OFFSIDES
90	Cyanosis			OFFSIDES
91	Cytomegalovirus antibody positive			OFFSIDES
92	Dehydration			OFFSIDES
93	Delirium		2902678	CTD
94	Depressed Level of Consciousness			OFFSIDES SIDER
95	Depressed mood			OFFSIDES
96	Depression suicidal			OFFSIDES SIDER
97	Depressive disorder		7655131	CTD
98	Dermabrasion			OFFSIDES
99	Dermatitis			SIDER
100	Detachment psychological			SIDER
101	Diaphragmalgia			OFFSIDES
102	Diet refusal			OFFSIDES
103	Differential white blood cell count abnormal			OFFSIDES
104	Diplopia			SIDER
105	Disorientation			SIDER
106	Disseminated Intravascular Coagulation			OFFSIDES
107	Dissociation			SIDER
108	Dissociative disorder			OFFSIDES
109	Dizziness	Canada Vigilance: 1		Canada Vigilance SIDER
110	Dreaming excessive			SIDER
111	Drowsiness			OFFSIDES SIDER
112	Drug Overdose		88336 4182212	CTD
113	Drug exposure during pregnancy			OFFSIDES
114	Drug ineffective	Canada Vigilance: 2		Canada Vigilance
115	Drug toxicity			OFFSIDES
116	Drug withdrawal syndrome			SIDER
117	Dry skin			OFFSIDES
118	Duodenal perforation			OFFSIDES
119	Dysarthria		4653884	CTD SIDER
120	Dysgeusia	Canada Vigilance: 1		Canada Vigilance
121	Dyslalia			OFFSIDES
122	Dyspepsia			OFFSIDES SIDER
123	Dysthymic Disorder			OFFSIDES
124	Educational problem			OFFSIDES
125	Enterocolitis			OFFSIDES
126	Eosinophilic myocarditis			OFFSIDES
127	Epidermolysis			OFFSIDES
128	Epilepsy		5001124	CTD OFFSIDES
129	Erosive gastritis			OFFSIDES
130	Erythema Infectiosum			OFFSIDES
131	Erythema	Canada Vigilance: 1		Canada Vigilance
132	Erythropenia			OFFSIDES
133	Euphoric mood			OFFSIDES
134	Eyelash thickening			OFFSIDES
135	Fatigue			SIDER
136	Fecal Incontinence		4653884	CTD
137	Feeding disorder neonatal			OFFSIDES
138	Feeling abnormal			SIDER
139	Finger hypoplasia			OFFSIDES
140	Flight of ideas			OFFSIDES
141	Galactorrhea			OFFSIDES
142	Gamma-Glutamyltransferase Increased			OFFSIDES
143	Gastrectomy			OFFSIDES
144	Gastric Lavage			OFFSIDES
145	Gastrointestinal perforation			OFFSIDES
146	Gastrointestinal stoma complication			OFFSIDES
147	Gaze palsy			OFFSIDES
148	Gingival Hypertrophy			OFFSIDES
149	Glossitis			OFFSIDES
150	Granulocyte count decreased			OFFSIDES
151	Hallucinations		2902678	CTD
152	Headache			SIDER
153	Heartburn			SIDER
154	Hemiplegia			OFFSIDES
155	Hepatic congestion			OFFSIDES
156	Hiccough			OFFSIDES
157	Hostility			OFFSIDES
158	Human herpes virus 6 serology positive			OFFSIDES
159	Hyperkinesia			SIDER
160	Hypersensitivity			SIDER
161	Hypophagia			OFFSIDES
162	Hypotension			SIDER
163	Hypothermia neonatal			OFFSIDES
164	Hypoxia			OFFSIDES
165	Inappropriate schedule of drug administration			OFFSIDES
166	Incoherent			OFFSIDES
167	Incontinence			OFFSIDES
168	Infection			SIDER
169	Infusion Site Extravasation			OFFSIDES
170	Infusion site mobility decreased			OFFSIDES
171	Injection site ulcer			OFFSIDES
172	Injury asphyxiation			OFFSIDES
173	Intention tremor			OFFSIDES
174	Intubation			OFFSIDES
175	Iris hyperpigmentation			OFFSIDES
176	Jugular vein distension			OFFSIDES
177	Kidney Failure			OFFSIDES
178	Lethargy			SIDER
179	Leukopenia neonatal			OFFSIDES
180	Leukopenia			SIDER
181	Lightheadedness			SIDER
182	Lipogranuloma			OFFSIDES
183	Long QT Syndrome			OFFSIDES
184	Lordosis			OFFSIDES
185	Lung consolidation			OFFSIDES
186	Lymphatic duct rupture			OFFSIDES
187	Lymphocyte count decreased			OFFSIDES
188	Lymphocyte stimulation test positive			OFFSIDES
189	Lymphocytic infiltration			OFFSIDES
190	Macrocytosis			OFFSIDES
191	Malaise			SIDER
192	Memory Loss			SIDER
193	Memory impairment			SIDER
194	Metabolic acidosis			OFFSIDES
195	Metamyelocyte count increased			OFFSIDES
196	Metastatic pain			OFFSIDES
197	Microcephaly			OFFSIDES
198	Movement Disorders		4653884	CTD
199	Multiple drug overdose			OFFSIDES
200	Multiple drug overdose intentional			OFFSIDES
201	Murder			OFFSIDES
202	Muscle Spasticity			SIDER
203	Muscle hypotonia		72227	CTD
204	Mutism			OFFSIDES
205	Myelocyte count increased			OFFSIDES
206	Myocardial fibrosis			OFFSIDES
207	Myoglobin blood increased			OFFSIDES
208	Myoglobin urine present			OFFSIDES
209	Nasopharyngitis			OFFSIDES
210	Nausea			SIDER
211	Negativism			OFFSIDES
212	Neonatal respiratory acidosis			OFFSIDES
213	Nephrogenic Diabetes Insipidus			OFFSIDES
214	Nervousness			SIDER
215	Neuroleptic Malignant Syndrome			OFFSIDES
216	Neutrophil count decreased			OFFSIDES
217	Numbness			SIDER
218	Nystagmus			OFFSIDES
219	Obsessive thoughts			OFFSIDES
220	Oculogyration			OFFSIDES
221	Oculomucocutaneous syndrome			OFFSIDES
222	Oliguria			OFFSIDES
223	Optic Nerve Hypoplasia			OFFSIDES
224	Oral mucosal petechiae			OFFSIDES
225	Overdose			OFFSIDES
226	PCO2 increased			OFFSIDES
227	PO2 decreased			OFFSIDES
228	Pallor			OFFSIDES
229	Palpitations			SIDER
230	Panic Disorder			OFFSIDES
231	Panniculitis			OFFSIDES
232	Paresthesia		4689857	CTD
233	Perceptual disturbance			SIDER
234	Pericarditis			OFFSIDES
235	Peritonitis			OFFSIDES
236	Peritonsillar Abscess			OFFSIDES
237	Personality Change			OFFSIDES
238	Platelet Transfusion			OFFSIDES
239	Platelet aggregation			OFFSIDES
240	Pleurisy			OFFSIDES
241	Pneumonia herpes viral			OFFSIDES
242	Pneumonia			SIDER
243	Pneumothorax			OFFSIDES
244	Poor sucking reflex			OFFSIDES
245	Poriomania			OFFSIDES
246	Portal Hypertension			OFFSIDES
247	Postrenal failure			OFFSIDES
248	Potentiating drug interaction			OFFSIDES
249	Pregnancy			SIDER
250	Pressure of speech			OFFSIDES
251	Protein total decreased			OFFSIDES
252	Pruritus			SIDER
253	Psoriasis			OFFSIDES
254	Psychiatric symptom			OFFSIDES
255	Psychoses, Substance-Induced		9014234	CTD
256	Psychotic Disorders		17180133	CTD
257	Pulmonary Infarction			OFFSIDES
258	Pulmonary congestion			OFFSIDES
259	Pyloric Stenosis			OFFSIDES
260	Quadriplegia			OFFSIDES
261	Rage			SIDER
262	Rebound effect			OFFSIDES
263	Respiratory Failure			OFFSIDES
264	Reticulocyte count increased			OFFSIDES
265	Retinal Vascular Disorder			OFFSIDES
266	Retrograde amnesia			SIDER
267	Rhabdomyolysis			OFFSIDES
268	Scab			OFFSIDES
269	Schizoaffective Disorder			OFFSIDES
270	Schizophrenia			OFFSIDES
271	Screaming			OFFSIDES
272	Seizures		6774348 9844417	CTD
273	Self Mutilation			OFFSIDES
274	Sexual abuse			OFFSIDES
275	Shock			SIDER
276	Shoplifting			OFFSIDES
277	Shunt malfunction			OFFSIDES
278	Shunt occlusion			OFFSIDES
279	Sigmoidoscopy abnormal			OFFSIDES
280	Skin laceration			OFFSIDES
281	Sleep Wake Disorders		430730 4182212	CTD
282	Slurred speech			SIDER
283	Soliloquy			OFFSIDES
284	Somnolence			SIDER
285	Speech Disorders		4182212	CTD
286	Sputum culture positive			OFFSIDES
287	Staggering gait			SIDER
288	Stridor			OFFSIDES
289	Subcutaneous Abscess			OFFSIDES
290	Substance Withdrawal Syndrome		View details 430730 1737083 2877254 2902678	CTD
291	Sudden death			OFFSIDES
292	Sweating			SIDER
293	Syncope			SIDER
294	Syphilis			OFFSIDES
295	Systemic mycosis			OFFSIDES
296	Tension			SIDER
297	Thought insertion			OFFSIDES
298	Thrombophlebitis			OFFSIDES
299	Tingling of extremity			SIDER
300	Tremor			SIDER
301	Upset stomach			SIDER
302	Urinary Incontinence		4653884	CTD SIDER
303	VIIth nerve paralysis			OFFSIDES
304	Ventricular Fibrillation			OFFSIDES
305	Vertigo			SIDER
306	Victim of homicide			OFFSIDES
307	Vomiting			SIDER
308	Water Intoxication			OFFSIDES
309	Weight Gain			OFFSIDES
310	Yawning			OFFSIDES
311	apprehension			SIDER
312	jaundice			SIDER

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