MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

urapidil

(ICMGLRUYEQNHPF-UHFFFAOYSA-N)

Structure

SMILES: COc1ccccc1N1CCN(CC1)CCCNc1cc(=O)n(c(=O)n1C)C
Type(s): Investigational
ATC code(s): C02CA06
Molecular Formula:: C20H29N5O3
Molecular Weight:: 387.476
Log P:: 0.7927
Hydrogen Bond Acceptor:: 8
Hydrogen Bond Donor:: 1
TPSA:: 71.74
CAS Number(s):: 34661-75-1; 64887-14-5

Synonym(s)

urapidil

6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil

Ebrantil

urapidil monohydrochloride

urapidil, 2,3-(14)C2-labeled

urapidil, 5-(14)C-labeled

External Link(s)

MeSH	C015568
PubChem Compound	5639
BindingDB	50237617
ChEBI	32278
CHEMBL	CHEMBL279229
DrugBank	DB12661
DrugCentral	2796
KEGG	dr:D01333
Therapeutic Target Database	D0K0VO D0M8BE
ZINC	1544805

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acidosis		OFFSIDES
2	Acute Coronary Syndrome		OFFSIDES
3	Acute prerenal failure		OFFSIDES
4	Adenoma		OFFSIDES
5	Agraphia		OFFSIDES
6	Akinesia		OFFSIDES
7	Alcoholic Intoxication		OFFSIDES
8	Altered state of consciousness		OFFSIDES
9	Anal abscess		OFFSIDES
10	Analgesia		OFFSIDES
11	Anastomotic stenosis		OFFSIDES
12	Angioedema		OFFSIDES
13	Anti-thyroid antibody positive		OFFSIDES
14	Antipsychotic drug level increased		OFFSIDES
15	Anuria		OFFSIDES
16	Apathy		OFFSIDES
17	Arteriosclerosis Obliterans		OFFSIDES
18	Arteritis		OFFSIDES
19	Aspiration Pneumonia		OFFSIDES
20	Basophil count abnormal		OFFSIDES
21	Blood albumin decreased		OFFSIDES
22	Blood aldosterone increased		OFFSIDES
23	Blood amylase increased		OFFSIDES
24	Blood antidiuretic hormone decreased		OFFSIDES
25	Blood chloride decreased		OFFSIDES
26	Blood cholinesterase decreased		OFFSIDES
27	Blood creatinine increased		OFFSIDES
28	Blood iron decreased		OFFSIDES
29	Blood osmolarity increased		OFFSIDES
30	Blood pressure inadequately controlled		OFFSIDES
31	Blood sodium increased		OFFSIDES
32	Blood sodium		OFFSIDES
33	Blood triglycerides		OFFSIDES
34	Blood urea increased		OFFSIDES
35	Blood uric acid decreased		OFFSIDES
36	Bradycardia		OFFSIDES
37	Brain Death		OFFSIDES
38	Bronchial Obstruction		OFFSIDES
39	Cardioactive drug level increased		OFFSIDES
40	Cardiovascular insufficiency		OFFSIDES
41	Catheter site pain		OFFSIDES
42	Catheter site swelling		OFFSIDES
43	Chorioamnionitis		OFFSIDES
44	Chronic left ventricular failure		OFFSIDES
45	Craniotomy		OFFSIDES
46	Creatinine renal clearance decreased		OFFSIDES
47	Cytolytic hepatitis		OFFSIDES
48	Cytomegalovirus test positive		OFFSIDES
49	Dehydration		OFFSIDES
50	Depressed Level of Consciousness		OFFSIDES
51	Device related infection		OFFSIDES
52	Diabetic Nephropathy		OFFSIDES
53	Disease recurrence		OFFSIDES
54	Dyspnea	3230472	CTD
55	Electrocardiogram repolarisation abnormality		OFFSIDES
56	Epilepsy		OFFSIDES
57	Escherichia urinary tract infection		OFFSIDES
58	Essential Hypertension		OFFSIDES
59	False positive laboratory result		OFFSIDES
60	Fluid overload		OFFSIDES
61	Gamma-Glutamyltransferase Increased		OFFSIDES
62	Gastroenteritis norovirus		OFFSIDES
63	General physical condition		OFFSIDES
64	General physical health deterioration		OFFSIDES
65	Glasgow coma scale		OFFSIDES
66	Globulinuria		OFFSIDES
67	Glomerulonephritis		OFFSIDES
68	Granulocyte count increased		OFFSIDES
69	Heparin-induced thrombocytopenia		OFFSIDES
70	Hepatitis C		OFFSIDES
71	Hypotension	3023106	CTD
72	Hypoxia		OFFSIDES
73	Karnofsky scale worsened		OFFSIDES
74	Kidney Failure		OFFSIDES
75	Large intestine perforation		OFFSIDES
76	Lipase		OFFSIDES
77	Lymphocele		OFFSIDES
78	Lymphocyte count decreased		OFFSIDES
79	Lymphocyte percentage decreased		OFFSIDES
80	Lymphocyte stimulation test positive		OFFSIDES
81	Malignant Hypertension		OFFSIDES
82	Malignant ascites		OFFSIDES
83	Marasmus		OFFSIDES
84	Mechanical ventilation		OFFSIDES
85	Mental impairment		OFFSIDES
86	Muscle tightness		OFFSIDES
87	Nephroangiosclerosis		OFFSIDES
88	Neuroleptic Malignant Syndrome		OFFSIDES
89	Overdose		OFFSIDES
90	Percutaneous Coronary Intervention		OFFSIDES
91	Pericarditis		OFFSIDES
92	Peritonitis		OFFSIDES
93	Phlebitis		OFFSIDES
94	Pneumococcal sepsis		OFFSIDES
95	Pneumocystis jiroveci pneumonia		OFFSIDES
96	Postoperative Complications	9829161	CTD
97	Pre-Eclampsia	9829161	CTD
98	Procedural site reaction		OFFSIDES
99	Protein total decreased		OFFSIDES
100	Prothrombin level decreased		OFFSIDES
101	Prothrombin time abnormal		OFFSIDES
102	Prothrombin time ratio decreased		OFFSIDES
103	Psoriasis		OFFSIDES
104	Pyonephrosis		OFFSIDES
105	Renal Colic		OFFSIDES
106	Renal dysplasia		OFFSIDES
107	Renal tubular disorder		OFFSIDES
108	Renin increased		OFFSIDES
109	Rhabdomyolysis		OFFSIDES
110	Rheumatoid Nodule		OFFSIDES
111	Sarcoidosis		OFFSIDES
112	Scleroderma		OFFSIDES
113	Sclerosing encapsulating peritonitis		OFFSIDES
114	Seroma		OFFSIDES
115	Sick Sinus Syndrome		OFFSIDES
116	Sinus bradycardia		OFFSIDES
117	Superficial Thrombophlebitis		OFFSIDES
118	Suture rupture		OFFSIDES
119	Tachycardia	3007177	CTD
120	Talipes		OFFSIDES
121	Thrombophlebitis		OFFSIDES
122	Ureteral necrosis		OFFSIDES
123	Ureteral stent insertion		OFFSIDES
124	Urine output increased		OFFSIDES
125	Wound dehiscence		OFFSIDES

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