MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Ticlopidine

(PHWBOXQYWZNQIN-UHFFFAOYSA-N)

Structure

SMILES: Clc1ccccc1CN1CCc2c(C1)ccs2
Type(s): Approved
ATC code(s): B01AC05
Molecular Formula:: C14H14ClNS
Molecular Weight:: 263.786
Log P:: 3.8977
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 31.48
CAS Number(s):: 53885-35-1; 55142-85-3; 62019-75-4; 1246817-49-1

Synonym(s)

Ticlopidine

53-32C

Ticlid

Ticlodix

Ticlodone

Ticlopidine Hydrochloride

53 32C

5332C

Hydrochloride, Ticlopidine

External Link(s)

MeSH	D013988
PubChem Compound	5472
BindingDB	85509
ChEBI	9588
CHEMBL	CHEMBL833
DrugBank	DB00208
DrugCentral	2657
IUPHAR/BPS Guide to PHARMACOLOGY	7307
KEGG	cpd:C07140 dr:D08594
Therapeutic Target Database	D05LBU
ZINC	19594599

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Vomiting	FAERS: 7		SIDER US FAERS
2	Blood lactate dehydrogenase increased	FAERS: 4		OFFSIDES US FAERS
3	Red blood cell schistocytes present	FAERS: 4		US FAERS
4	Thrombocytopenia	FAERS: 4	View details 8855878 9592992 9704247 20031738	CTD SIDER US FAERS
5	Hyperpyrexia	FAERS: 2		US FAERS
6	Intraductal papillary-mucinous carcinoma of pancreas	FAERS: 2		US FAERS
7	Leukopenia	FAERS: 2		US FAERS
8	Sopor	FAERS: 2		US FAERS
9	Syncope	FAERS: 2		US FAERS
10	Urticaria	FAERS: 2	8855878	CTD SIDER US FAERS
11	Abdominal discomfort	FAERS: 1		US FAERS
12	Cholestasis	FAERS: 1	View details 1942649 7711343 7871938 8519541 8665360 9162532 9505953 9744703 9790457 10418941 10542998 10965556 10969455 11100540 11155780 11785026 11861996 12003401 12088359 12532564 12639165 14679334 15072394 18367863	CTD US FAERS
13	Drug-disease interaction	FAERS: 1		US FAERS
14	Dysarthria	FAERS: 1	9658485	CTD US FAERS
15	Epistaxis	FAERS: 1		OFFSIDES SIDER US FAERS
16	Hypotension	FAERS: 1		US FAERS
17	Influenza	FAERS: 1		US FAERS
18	Lip swelling	FAERS: 1		US FAERS
19	Monoparesis	FAERS: 1		US FAERS
20	Nausea	FAERS: 1	9658485	CTD OFFSIDES SIDER US FAERS
21	Tumour haemorrhage	FAERS: 1		US FAERS
22	Abdominal Pain		19309387	CTD OFFSIDES
23	Abdominal rigidity			OFFSIDES
24	Acute Coronary Syndrome			OFFSIDES
25	Acute bronchitis			OFFSIDES
26	Acute kidney injury		7771492	CTD
27	Acute myocardial infarction			OFFSIDES
28	Agranulocytosis		7617005 9401499 23499857	CTD
29	Alanine Aminotransferase Increased			OFFSIDES
30	Alanine aminotransferase abnormal			OFFSIDES
31	Alcoholic Intoxication			OFFSIDES
32	Altered state of consciousness			OFFSIDES
33	Anaphylactic shock			SIDER
34	Anemia		8665360	CTD
35	Angina Pectoris		19309387	CTD
36	Angioedema		9951507 20031738	CTD SIDER
37	Anorexia			OFFSIDES SIDER
38	Anti-insulin antibody positive			OFFSIDES
39	Apathy			OFFSIDES
40	Arteriosclerosis Obliterans			OFFSIDES
41	Arteriovenous graft site infection			OFFSIDES
42	Arthralgia			SIDER
43	Arthropathy			SIDER
44	Aspartate aminotransferase abnormal			OFFSIDES
45	Asthenia			OFFSIDES SIDER
46	Ataxia		9658485	CTD
47	Atherosclerosis		2651175	CTD
48	Atrial tachycardia			OFFSIDES
49	Autoimmune hepatitis			OFFSIDES
50	Bacterial Infections		12669766	CTD
51	Bilirubin conjugated increased			OFFSIDES
52	Bladder Neoplasm			OFFSIDES
53	Blood Glucose			OFFSIDES
54	Blood alkaline phosphatase abnormal			OFFSIDES
55	Blood alkaline phosphatase increased			OFFSIDES
56	Blood amylase increased			OFFSIDES
57	Blood beta-D-glucan increased			OFFSIDES
58	Blood cholesterol increased			SIDER
59	Blood cholesterol			OFFSIDES
60	Blood creatine phosphokinase increased			OFFSIDES
61	Blood creatinine increased			OFFSIDES
62	Blood glucose decreased			OFFSIDES
63	Blood lactate dehydrogenase abnormal			OFFSIDES
64	Blood phosphorus decreased			OFFSIDES
65	Blood triglycerides increased			OFFSIDES
66	Blood urea increased			OFFSIDES
67	Blood uric acid			OFFSIDES
68	Blood urine present			OFFSIDES
69	Bone marrow depression			SIDER
70	Bone pain			OFFSIDES
71	Bradycardia			OFFSIDES
72	Breast discomfort			OFFSIDES
73	Candida sepsis			OFFSIDES
74	Cerebellar Ataxia			OFFSIDES
75	Cerebellar infarction			OFFSIDES
76	Cerebral Infarction		8835608	CTD
77	Cerebrovascular Disorders		1627017 9127122	CTD
78	Chemical and Drug Induced Liver Injury		View details 8665360 9127122 9505953 9790457 10219621 10965556 11310373 11785026 12088359 12532564 15072394 18004066 20871981 21546349 22331495 23397584 24085192 25934330 26327247 26921665 27765674	CTD
79	Chemotherapeutic drug level increased			OFFSIDES
80	Chest Pain			OFFSIDES
81	Choking sensation			OFFSIDES
82	Cholangiolitis			OFFSIDES
83	Chronic Obstructive Airway Disease			OFFSIDES
84	Chronic active hepatitis			OFFSIDES
85	Circumstance or information capable of leading to medication error			OFFSIDES
86	Clonus			OFFSIDES
87	Colitis			SIDER
88	Compression fracture			OFFSIDES
89	Coronary Artery Disease		19432301	CTD
90	Coronary Restenosis		17507105	CTD
91	Coronary Thrombosis		17507105	CTD
92	Dehydration			OFFSIDES
93	Depressed Level of Consciousness			OFFSIDES
94	Dermatitis		9798669	CTD SIDER
95	Diabetes Mellitus			SIDER
96	Diabetes mellitus inadequate control			OFFSIDES
97	Diarrhea		View details 2761587 8378945 9505953 16211203	CTD OFFSIDES
98	Diplopia			OFFSIDES
99	Disseminated Intravascular Coagulation		19309387	CTD OFFSIDES
100	Dizziness			OFFSIDES SIDER
101	Drug Eruptions		View details 1923914 2761587 8378945 10533962 16211203	CTD
102	Drug withdrawal headache			OFFSIDES
103	Dyslalia			OFFSIDES
104	Dyslipidemias		1942649	CTD
105	Dyspepsia			SIDER
106	Dysphonia			OFFSIDES
107	Dysuria			OFFSIDES
108	Ecchymosis			SIDER
109	Economic problem			OFFSIDES
110	Edema		26327247	CTD
111	Eosinophilia			SIDER
112	Eosinophilic Pneumonia			OFFSIDES
113	Epilepsy			OFFSIDES
114	Erythema Multiforme			SIDER
115	Erythema			OFFSIDES
116	Esophagitis		11960063	CTD
117	Exanthema		View details 1923914 2761587 8378945 9127122 10453975 16211203 20031738	CTD
118	Exposure to toxic agent			OFFSIDES
119	Fatty Liver		10219621	CTD
120	Feeling abnormal			OFFSIDES
121	Flatulence			SIDER
122	Gamma-Glutamyltransferase Increased			OFFSIDES
123	Gamma-glutamyltransferase abnormal			OFFSIDES
124	Gangrene			OFFSIDES
125	Gastritis		11960063	CTD
126	Gastrointestinal Diseases		1923914	CTD
127	Gastrointestinal Pain			SIDER
128	Gastrointestinal fullness			SIDER
129	Globulinuria			OFFSIDES
130	Headache			SIDER
131	Hematoma		11779099 19309387	CTD
132	Hemolytic-Uremic Syndrome		11604563 16388419	CTD
133	Hemorrhage		18388341 26327247	CTD
134	Hepatic necrosis			SIDER
135	Hepatitis		View details 1942649 7711343 8519541 9744703 10965556 10969455 11155780 11310373 11861996 12003401 12088359 12639165 14679334 15072394 18004066 20440256	CTD SIDER
136	Hepatojugular reflux			OFFSIDES
137	Hepatomegaly		9790457 28108177	CTD
138	Hydronephrosis			OFFSIDES
139	Hydrothorax			OFFSIDES
140	Hypersensitivity			SIDER
141	Hypervitaminosis			OFFSIDES
142	Hypoxia			OFFSIDES
143	Infection			OFFSIDES
144	Intermittent Claudication		2661700	CTD
145	Intervertebral disc disorder			OFFSIDES
146	Jaundice, Obstructive		View details 1834400 8403812 9173469 9269384	CTD
147	Jugular vein distension			OFFSIDES
148	Kidney Diseases		8855878	CTD
149	Limb discomfort			OFFSIDES
150	Liver diseases		9798669	CTD
151	Lupus Erythematosus			SIDER
152	Lymphocyte stimulation test positive			OFFSIDES
153	Lymphocytosis		23499857	CTD
154	Mouth Breathing			OFFSIDES
155	Musculoskeletal discomfort			SIDER
156	Myalgia			SIDER
157	Myelodysplasia			OFFSIDES
158	Myocardial Infarction		1923914	CTD
159	Myocarditis		10533962	CTD
160	Myoclonus		11160978	CTD
161	Myoglobin blood increased			OFFSIDES
162	Myositis			SIDER
163	Nephritis, Interstitial		7771492	CTD
164	Nephrotic Syndrome			SIDER
165	Nerve Block			OFFSIDES
166	Neuroleptic Malignant Syndrome			OFFSIDES
167	Neutropenia		View details 1448821 1726215 1923914 2761587 8378945 9704247 16211203 20031738	CTD
168	Occult blood positive			OFFSIDES
169	Ocular icterus			OFFSIDES
170	Oliguria		19309387	CTD OFFSIDES
171	Operative bleeding			SIDER
172	Orthopnea			OFFSIDES
173	Overdose			OFFSIDES
174	PROTHROMBIN TIME			OFFSIDES
175	Pain			SIDER
176	Pancytopenia			SIDER
177	Peptic Ulcer			SIDER
178	Platelet Transfusion			OFFSIDES
179	Platelet count abnormal			OFFSIDES
180	Prothrombin time abnormal			OFFSIDES
181	Pruritus		View details 9505953 10418941 10542998 12088359 12532564	CTD SIDER
182	Purpura, Thrombotic Thrombocytopenic		View details 9704247 11604563 14687031 16388419	CTD
183	Purpura			SIDER
184	Radiculitis			OFFSIDES
185	Rales			OFFSIDES
186	Regurgitation			OFFSIDES
187	Residual urine			OFFSIDES
188	Respiratory Distress Syndrome, Adult		19309387	CTD
189	Reticulocytosis			SIDER
190	Retinal Vasculitis		10844073	CTD
191	Retinal pigment epithelial tear			OFFSIDES
192	Rhabdomyolysis			OFFSIDES
193	Scotoma			OFFSIDES
194	Sepsis			SIDER
195	Septic Shock			OFFSIDES
196	Serum Sickness			SIDER
197	Silent myocardial infarction			OFFSIDES
198	Skin tightness			OFFSIDES
199	Stevens-Johnson Syndrome		25811541	CTD OFFSIDES SIDER
200	Tachycardia		19309387	CTD
201	Thrombocytosis			SIDER
202	Thromboembolism		1884675 8659220	CTD
203	Thrombophilia		2214444	CTD
204	Thrombosis		View details 8322273 11533502 19170597 19432301	CTD
205	Tinnitus			SIDER
206	Ulcer		11960063	CTD
207	Vascular Diseases		1923914 9592992 11960063	CTD
208	Vascular purpura			SIDER
209	Vasculitis, Leukocytoclastic, Cutaneous		11141463	CTD
210	Vasculitis			SIDER
211	Ventricular Fibrillation			OFFSIDES
212	Vertigo		2651175	CTD
213	jaundice		View details 7711343 9505953 9790457 10418941 10542998 11155780 11861996 12088359 12532564 12639165	CTD
214	kyphosis			OFFSIDES

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