MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Memantine

(BUGYDGFZZOZRHP-UHFFFAOYSA-N)

Structure

SMILES: CC12CC3CC(C1)(C)CC(C2)(C3)N
Type(s): Approved; Investigational
ATC code(s): N06DA52; N06DA53; N06DX01
Molecular Formula:: C12H21N
Molecular Weight:: 179.302
Log P:: 3.3944
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 1
TPSA:: 26.02
CAS Number(s):: 19982-08-2

Synonym(s)

Memantine

1,3-Dimethyl-5-aminoadamantane

1-Amino-3,5-dimethyladamantane

Axura

D-145

D145

Ebixa

Memantin

Memantine Hydrochloride

10.

Namenda

11.

D 145

External Link(s)

MeSH	D008559
PubChem Compound	4054
BindingDB	50062599
ChEBI	64312
CHEMBL	CHEMBL807
DrugBank	DB01043
DrugCentral	1679
IUPHAR/BPS Guide to PHARMACOLOGY	4253
KEGG	cpd:C13736 dr:D08174
Therapeutic Target Database	D01JEU

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Product use issue	FAERS: 31		US FAERS
2	Somnolence	FAERS: 18		SIDER US FAERS
3	Epilepsy	FAERS: 14		US FAERS
4	Pulmonary Embolism	FAERS: 14		SIDER US FAERS
5	Accidental overdose	FAERS: 11		OFFSIDES US FAERS
6	Delirium	FAERS: 11	18303133	CTD SIDER US FAERS
7	Dizziness	FAERS: 11	12409683	CTD OFFSIDES SIDER US FAERS
8	Medication Error	FAERS: 11		US FAERS
9	Agitation	FAERS: 10		SIDER US FAERS
10	Product substitution issue	FAERS: 9		US FAERS
11	Urinary tract infection	FAERS: 9 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
12	Dementia	FAERS: 8	18413635 19155749	CTD US FAERS
13	Fatigue	FAERS: 8		OFFSIDES SIDER US FAERS
14	Syncope	FAERS: 8 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
15	Asthenia	FAERS: 7 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
16	No adverse event	FAERS: 7		US FAERS
17	Vertigo	FAERS: 7		SIDER US FAERS
18	Visual Impairment	FAERS: 7		SIDER US FAERS
19	Wrong technique in drug usage process	FAERS: 7		US FAERS
20	Constipation	FAERS: 6		SIDER US FAERS
21	Disorientation	FAERS: 5		SIDER US FAERS
22	Fracture	FAERS: 5		SIDER US FAERS
23	Hypoxia	FAERS: 5		US FAERS
24	Memory impairment	FAERS: 5		US FAERS
25	Overdose	FAERS: 5		US FAERS
26	Splenic Infarction	FAERS: 5		US FAERS
27	Unresponsive to stimuli	FAERS: 5		US FAERS
28	Anxiety	FAERS: 4		SIDER US FAERS
29	Cerebrovascular accident	FAERS: 4		SIDER US FAERS
30	Drug dispensing error	FAERS: 4		US FAERS
31	Incontinence	FAERS: 4		OFFSIDES US FAERS
32	Incorrect dose administered	FAERS: 4		US FAERS
33	Malaise	FAERS: 4		SIDER US FAERS
34	Psychomotor skills impaired	FAERS: 4		US FAERS
35	Therapy cessation	FAERS: 4		US FAERS
36	Weight decreased	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
37	Activities of daily living impaired	FAERS: 3		US FAERS
38	Amnesia	FAERS: 3	20170739	CTD SIDER US FAERS
39	Bradycardia	FAERS: 3 Canada Vigilance: 1	18500725	CTD SIDER Canada Vigilance US FAERS
40	Cerebral Infarction	FAERS: 3		SIDER US FAERS
41	Drug ineffective	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
42	Headache	FAERS: 3		SIDER US FAERS
43	Incoherent	FAERS: 3		US FAERS
44	Intentional self-injury	FAERS: 3		US FAERS
45	Mental status changes	FAERS: 3		OFFSIDES SIDER US FAERS
46	Myoclonus	FAERS: 3	17632233 18303133	CTD SIDER US FAERS
47	Ophthalmic vein thrombosis	FAERS: 3		US FAERS
48	Violence-related symptom	FAERS: 3		US FAERS
49	Alopecia	FAERS: 2		SIDER US FAERS
50	Atrioventricular Block	FAERS: 2		SIDER US FAERS
51	Blood creatine phosphokinase increased	FAERS: 2		US FAERS
52	Cholestasis	FAERS: 2	18413635	CTD US FAERS
53	Chorea	FAERS: 2		US FAERS
54	Cogwheel Rigidity	FAERS: 2		US FAERS
55	Device information output issue	FAERS: 2		US FAERS
56	Drug withdrawal syndrome	FAERS: 2		US FAERS
57	Dysarthria	FAERS: 2		US FAERS
58	Dyspepsia	FAERS: 2		SIDER US FAERS
59	Dystonia	FAERS: 2		US FAERS
60	Feeling abnormal	FAERS: 2		SIDER US FAERS
61	General physical health deterioration	FAERS: 2		US FAERS
62	Hypotension	FAERS: 2		SIDER US FAERS
63	Lethargy	FAERS: 2		OFFSIDES SIDER US FAERS
64	Lower respiratory tract infection	FAERS: 2		US FAERS
65	Marasmus	FAERS: 2		US FAERS
66	Nausea	FAERS: 2		SIDER US FAERS
67	Pneumonia	FAERS: 2		SIDER US FAERS
68	Product administration interrupted	FAERS: 2		US FAERS
69	Slow speech	FAERS: 2		US FAERS
70	Trifascicular block	FAERS: 2		US FAERS
71	Urinary Retention	FAERS: 2		SIDER US FAERS
72	Abasia	FAERS: 1		US FAERS
73	Ageusia	FAERS: 1		US FAERS
74	Akathisia	FAERS: 1		US FAERS
75	Alanine Aminotransferase Increased	FAERS: 1		SIDER US FAERS
76	Altered state of consciousness	FAERS: 1		SIDER US FAERS
77	Anger	FAERS: 1		OFFSIDES US FAERS
78	Aspartate Aminotransferase Increased	FAERS: 1		SIDER US FAERS
79	Asphyxia	FAERS: 1		US FAERS
80	Blood glucose increased	FAERS: 1		US FAERS
81	Carcinoma	FAERS: 1		US FAERS
82	Cardiac Arrest	FAERS: 1		SIDER US FAERS
83	Cardiac Death	FAERS: 1		US FAERS
84	Cell Death	FAERS: 1		US FAERS
85	Chest discomfort	FAERS: 1		US FAERS
86	Cholecystitis	FAERS: 1		US FAERS
87	Cholelithiasis	FAERS: 1		SIDER US FAERS
88	Chromaturia	FAERS: 1		OFFSIDES US FAERS
89	Colitis	FAERS: 1		SIDER US FAERS
90	Conduct Disorder	FAERS: 1		US FAERS
91	Corneal dystrophy	FAERS: 1		US FAERS
92	Corneal graft rejection	FAERS: 1		US FAERS
93	Cystitis	FAERS: 1		SIDER US FAERS
94	Delusional disorder, persecutory type	FAERS: 1		US FAERS
95	Depressed Level of Consciousness	FAERS: 1		SIDER US FAERS
96	Diplopia	FAERS: 1		OFFSIDES SIDER US FAERS
97	Disease recurrence	FAERS: 1		OFFSIDES US FAERS
98	Drug administration error	FAERS: 1		US FAERS
99	Drug prescribing error	FAERS: 1		US FAERS
100	Dysphemia	FAERS: 1		US FAERS
101	Dysphonia	FAERS: 1		US FAERS
102	Eczema	FAERS: 1		SIDER US FAERS
103	Endothelial dysfunction	FAERS: 1		US FAERS
104	Formication	FAERS: 1		US FAERS
105	Gangrene	FAERS: 1		US FAERS
106	Gastric ulcer	FAERS: 1		SIDER US FAERS
107	Genital infection fungal	FAERS: 1		US FAERS
108	Hallucinations, mixed	FAERS: 1		US FAERS
109	Hypertensive crisis	FAERS: 1		US FAERS
110	Hyperviscosity syndrome	FAERS: 1		US FAERS
111	Immobile	FAERS: 1		US FAERS
112	Impaired work ability	FAERS: 1		US FAERS
113	Infection	FAERS: 1		SIDER US FAERS
114	Intestinal Obstruction	FAERS: 1		US FAERS
115	Limb injury	FAERS: 1		US FAERS
116	Loss of personal independence in daily activities	FAERS: 1		US FAERS
117	Lymphadenopathy	FAERS: 1		US FAERS
118	Malignant neoplasm progression	FAERS: 1		US FAERS
119	Mouth swelling	FAERS: 1		US FAERS
120	Myalgia	FAERS: 1		SIDER US FAERS
121	Myocardial Infarction	FAERS: 1		SIDER US FAERS
122	Nasopharyngitis	FAERS: 1		SIDER US FAERS
123	Neutrophil count decreased	FAERS: 1		US FAERS
124	Nystagmus	FAERS: 1		US FAERS
125	Pancreatitis	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
126	Peripheral swelling	FAERS: 1		US FAERS
127	Peripheral venous disease	FAERS: 1		US FAERS
128	Phlebitis	FAERS: 1		SIDER US FAERS
129	Physical assault	FAERS: 1		US FAERS
130	Poor peripheral circulation	FAERS: 1		US FAERS
131	Pregnancy	FAERS: 1		US FAERS
132	Product label confusion	FAERS: 1		US FAERS
133	Psychiatric symptom	FAERS: 1		US FAERS
134	Quality of life decreased	FAERS: 1		US FAERS
135	Restlessness	FAERS: 1		US FAERS
136	Sinoatrial Block	FAERS: 1		US FAERS
137	Sleep Talking	FAERS: 1		US FAERS
138	Soft tissue necrosis	FAERS: 1		US FAERS
139	Suicide attempt	FAERS: 1		SIDER US FAERS
140	T-Cell Lymphoma	FAERS: 1		US FAERS
141	Tachycardia	FAERS: 1		SIDER US FAERS
142	Therapy partial responder	FAERS: 1		US FAERS
143	Thrombocytopenia	FAERS: 1		SIDER US FAERS
144	Tooth Loss	FAERS: 1		US FAERS
145	Toxicity to various agents	FAERS: 1		US FAERS
146	Urinary Incontinence	FAERS: 1		SIDER US FAERS
147	Ventricular arrhythmia	FAERS: 1		SIDER US FAERS
148	Vomiting	FAERS: 1		SIDER US FAERS
149	White blood cell count decreased	FAERS: 1		US FAERS
150	Wrong technique in product usage process	FAERS: 1		US FAERS
151	Abdominal Pain			SIDER
152	Abdominal adhesions			OFFSIDES
153	Abnormal vision			SIDER
154	Abscess			SIDER
155	Abuse			OFFSIDES
156	Acid reflux			OFFSIDES
157	Acute Coronary Syndrome			SIDER
158	Adnexitis			OFFSIDES
159	Adrenal mass			OFFSIDES
160	Aggressive reaction			SIDER
161	Agranulocytosis			SIDER
162	Alcohol interaction			OFFSIDES
163	Alcohol-Induced Disorders		29800586	CTD
164	Anal cancer metastatic			OFFSIDES
165	Angina Pectoris			SIDER
166	Angiogram abnormal			OFFSIDES
167	Anhedonia			OFFSIDES
168	Anorexia			OFFSIDES SIDER
169	Anticoagulation drug level above therapeutic			OFFSIDES
170	Anuria	Canada Vigilance: 1		Canada Vigilance
171	Aortic Valve Stenosis			SIDER
172	Apathy			SIDER
173	Aphasia			SIDER
174	Application site ulcer			OFFSIDES
175	Arteriosclerosis			SIDER
176	Arthralgia			SIDER
177	Arthritis aggravated			SIDER
178	Arthritis			SIDER
179	Arthropathy			SIDER
180	Arthropod bite			OFFSIDES
181	Asthma			SIDER
182	Ataxia		10215643 30682440	CTD SIDER
183	Atelectasis			OFFSIDES SIDER
184	Atrial Fibrillation			SIDER
185	Atrial arrhythmia			SIDER
186	Aura			OFFSIDES
187	Auricular swelling			OFFSIDES
188	Autistic Disorder		17690064	CTD
189	Autonomic neuropathy			OFFSIDES
190	Back Pain			SIDER
191	Bacterial sepsis			OFFSIDES
192	Band neutrophil count increased			OFFSIDES
193	Basal cell carcinoma			SIDER
194	Belligerence			OFFSIDES
195	Bilirubin conjugated increased			OFFSIDES
196	Bladder adenocarcinoma stage unspecified			OFFSIDES
197	Bladder discomfort			OFFSIDES
198	Bladder pain			SIDER
199	Bladder prolapse			OFFSIDES
200	Blepharitis			SIDER
201	Blood 1,25-dihydroxycholecalciferol decreased			OFFSIDES
202	Blood alkaline phosphatase increased			SIDER
203	Blood and lymphatic system disorders			SIDER
204	Blood cortisol decreased			OFFSIDES
205	Blood creatinine increased			SIDER
206	Blood glucose decreased			OFFSIDES
207	Blood iron decreased			OFFSIDES
208	Blood thyroid stimulating hormone increased			SIDER
209	Blood urea increased			SIDER
210	Blurred vision			OFFSIDES
211	Body fat disorder			OFFSIDES
212	Bone erosion			OFFSIDES
213	Bone pain			OFFSIDES SIDER
214	Bowel movement irregularity			OFFSIDES
215	Brain Injuries		27655295	CTD
216	Brain natriuretic peptide decreased			OFFSIDES
217	Breast discomfort			OFFSIDES
218	Breast necrosis			OFFSIDES
219	Bronchial Hyperreactivity			SIDER
220	Bronchitis			SIDER
221	Bronchospasm			SIDER
222	Bullous eruption			SIDER
223	Bursitis			SIDER
224	CD4 lymphocytes increased			OFFSIDES
225	Cardiac Hypertrophy			OFFSIDES
226	Cardiac enzymes increased			OFFSIDES
227	Cardioactive drug level above therapeutic			OFFSIDES
228	Cardioactive drug level increased			OFFSIDES
229	Cardiomegaly			SIDER
230	Carpal Tunnel Syndrome			SIDER
231	Catalepsy		12762595	CTD
232	Cataract			SIDER
233	Cellulitis			OFFSIDES SIDER
234	Chemical and Drug Induced Liver Injury		18413635	CTD
235	Chest Pain			SIDER
236	Chills			SIDER
237	Chronic Obstructive Airway Disease			OFFSIDES
238	Cognition Disorders		21741993	CTD
239	Cognitive deterioration			OFFSIDES
240	Completed Suicide			SIDER
241	Complication of device insertion			OFFSIDES
242	Confabulation			OFFSIDES
243	Confusion		15889961	CTD
244	Conjunctivitis			SIDER
245	Corneal Opacity			SIDER
246	Coronary Artery Disease			SIDER
247	Creatinine increased			SIDER
248	Crying			OFFSIDES SIDER
249	Cystocele			OFFSIDES
250	Deafness			OFFSIDES SIDER
251	Decreased Libido			OFFSIDES
252	Deep Vein Thrombosis			SIDER
253	Dehydration			SIDER
254	Dementia, Vascular		12409683	CTD
255	Dental abscess			OFFSIDES
256	Dental caries			OFFSIDES SIDER
257	Dermatitis			SIDER
258	Developmental Disabilities		17016714	CTD
259	Device malfunction			OFFSIDES
260	Diabetes Mellitus			SIDER
261	Diabetes mellitus exacerbated			SIDER
262	Diabetic Retinopathy			OFFSIDES
263	Discomfort			SIDER
264	Disease complication			OFFSIDES
265	Disturbance in sexual arousal			SIDER
266	Diverticulitis			SIDER
267	Diverticulum			SIDER
268	Drowsiness			OFFSIDES
269	Drug withdrawal headache			OFFSIDES
270	Dry skin			SIDER
271	Dysgeusia			SIDER
272	Dyskinesia, Drug-Induced		14642644 20014061	CTD
273	Dyslexia			OFFSIDES
274	Dyspnoea exacerbated			OFFSIDES
275	Dysthymic Disorder			OFFSIDES
276	Dysuria			OFFSIDES SIDER
277	Economic problem			OFFSIDES
278	Ectropion			SIDER
279	Electrocardiogram abnormal specific			SIDER
280	Electrocardiogram abnormal			SIDER
281	Electrocardiogram change			SIDER
282	Embolism			SIDER
283	Endarterectomy			OFFSIDES
284	Endotracheal intubation complication			OFFSIDES
285	Enuresis			OFFSIDES
286	Eosinophil percentage increased			OFFSIDES
287	Epistaxis			SIDER
288	Erectile dysfunction			SIDER
289	Eructation			SIDER
290	Erythema Multiforme			SIDER
291	Escherichia infection	Canada Vigilance: 1		Canada Vigilance
292	Essential Hypertension			OFFSIDES
293	Excoriation			SIDER
294	Eye pain			SIDER
295	Failure of implant			OFFSIDES
296	Failure to Thrive			OFFSIDES
297	Feeling of body temperature change			SIDER
298	Fibromyalgia			OFFSIDES
299	Flat affect			SIDER
300	Flatulence			SIDER
301	Flushing			SIDER
302	Foaming at mouth			OFFSIDES
303	Food Poisoning			SIDER
304	Food craving			OFFSIDES
305	Full blood count decreased			OFFSIDES
306	Gamma-Glutamyltransferase Increased			SIDER
307	Gastritis			SIDER
308	Gastroenteritis			SIDER
309	Gastrointestinal Pain			SIDER
310	General nutrition disorder			OFFSIDES
311	Gingivitis			SIDER
312	Glaucoma			SIDER
313	Gout			OFFSIDES SIDER
314	Granulocyte count increased			OFFSIDES
315	Hallucinations		16087923 17030587 18294023	CTD
316	Hemiplegia			SIDER
317	Hepatic calcification			OFFSIDES
318	Hepatitis A			OFFSIDES
319	Hepatitis			SIDER
320	Hepatotoxicity			OFFSIDES
321	Hernia			SIDER
322	Hidradenitis			OFFSIDES
323	Hydrocephalus	Canada Vigilance: 1		Canada Vigilance
324	Hyperalgesia		20830263	CTD
325	Hyperkeratosis			SIDER
326	Hyperkinesia			SIDER
327	Hypersensitivity			SIDER
328	Hypersomnia	Canada Vigilance: 1		Canada Vigilance
329	Hypertension worsened			SIDER
330	Hyperthyroidism			SIDER
331	Hypokinesia			SIDER
332	Hyporeflexia			SIDER
333	Hypothyroidism			SIDER
334	Hysterectomy			OFFSIDES
335	Ileus			SIDER
336	Infestation			SIDER
337	Inflicted injury			SIDER
338	Influenza-like symptoms			SIDER
339	Influenza			SIDER
340	Injection site cellulitis			OFFSIDES
341	Injection site scab			OFFSIDES
342	Intermittent Claudication			SIDER
343	Ischial neuralgia			SIDER
344	Laceration			OFFSIDES
345	Lack of spontaneous speech			OFFSIDES
346	Lacrimation abnormal NOS			SIDER
347	Laryngitis			SIDER
348	Leukocytosis			SIDER
349	Leukopenia			SIDER
350	Lewy Body Disease		16087923 16340086	CTD
351	Lyme Disease			OFFSIDES
352	Lymphoma			SIDER
353	Macular degeneration			SIDER
354	Malnutrition			SIDER
355	Mastication disorder			OFFSIDES
356	Melanosis			SIDER
357	Memory Disorders		View details 18582864 20553881 24333387 29800586	CTD
358	Meningioma surgery			OFFSIDES
359	Mental impairment			OFFSIDES
360	Mercury Poisoning, Nervous System		18597911	CTD
361	Migraine Disorders		18194287	CTD
362	Monocyte percentage decreased			OFFSIDES
363	Monocyte percentage increased			OFFSIDES
364	Mood swings			SIDER
365	Motor Skills Disorders		30682440	CTD
366	Movement Disorders		8904651	CTD
367	Multiple Sclerosis			OFFSIDES
368	Multiple drug overdose intentional			OFFSIDES
369	Muscle Spasticity		6891227	CTD
370	Muscle strain			OFFSIDES
371	Musculoskeletal chest pain			OFFSIDES
372	Musculoskeletal discomfort			SIDER
373	Myopia			SIDER
374	Necrosis		18597911	CTD SIDER
375	Nephrolithiasis			OFFSIDES SIDER
376	Nerve Degeneration		18418360	CTD
377	Nervousness			SIDER
378	Neuralgia			SIDER
379	Neuroleptic Malignant Syndrome			SIDER
380	Neuropathy			SIDER
381	Neurosensory hypoacusis			OFFSIDES
382	Neutropenia			SIDER
383	Nevus			SIDER
384	No adverse effect			OFFSIDES
385	Numbness			SIDER
386	Onychomycosis			SIDER
387	Oral fungal infection			OFFSIDES
388	Organophosphate poisoning		30682440	CTD
389	Osteitis Deformans			OFFSIDES
390	Osteopenia			OFFSIDES
391	Osteoporosis			SIDER
392	Osteosclerosis			OFFSIDES
393	Otitis Externa			SIDER
394	Otitis Media			SIDER
395	Pain		18806054	CTD SIDER
396	Pallor			SIDER
397	Palpitations			SIDER
398	Pancytopenia			SIDER
399	Paradoxical drug reaction			OFFSIDES
400	Paranoia			SIDER
401	Paranoid reaction			SIDER
402	Patellofemoral Pain Syndrome			OFFSIDES
403	Personality Change			OFFSIDES
404	Pharmaceutical product complaint			OFFSIDES
405	Pharyngitis			SIDER
406	Pneumothorax			SIDER
407	Poisoning		15824473	CTD
408	Polydipsia			SIDER
409	Polyuria			SIDER
410	Portal vein pressure increased			OFFSIDES
411	Postoperative wound complication			OFFSIDES
412	Product dose omission	Canada Vigilance: 1		Canada Vigilance
413	Product tampering			OFFSIDES
414	Pruritus		18413635	CTD SIDER
415	Psychomotor Agitation		17030587 18294023	CTD
416	Psychoses, Substance-Induced		1681331 15889961	CTD
417	Pulmonary arterial hypertension			OFFSIDES
418	Pulmonary thrombosis			OFFSIDES
419	Purpura			SIDER
420	Pyuria			SIDER
421	Rash erythematous			SIDER
422	Rectocele			OFFSIDES
423	Renal Artery Stenosis			OFFSIDES
424	Renal cyst			SIDER
425	Respiratory Failure			SIDER
426	Respiratory Insufficiency			SIDER
427	Retinal Detachment			SIDER
428	Rhinitis			SIDER
429	Rhinorrhea			OFFSIDES
430	Sacroiliitis			OFFSIDES
431	Sarcoidosis		19512963	CTD
432	Sciatica			SIDER
433	Scotoma			OFFSIDES
434	Seizures		View details 10087439 10215643 10698007 10834088 12679146 27108687	CTD
435	Senile dementia			OFFSIDES
436	Sepsis			SIDER
437	Sexual activity increased			OFFSIDES
438	Shock			SIDER
439	Sinusitis			SIDER
440	Skin Ulcer			SIDER
441	Skin laceration			OFFSIDES
442	Skin neoplasm excision			OFFSIDES
443	Sleep Wake Disorders		19305123	CTD
444	Spasm		30682440	CTD
445	Splenic cyst			OFFSIDES
446	Spondylitis			OFFSIDES
447	Squamous cell carcinoma			SIDER
448	Staring			OFFSIDES
449	Stevens-Johnson Syndrome			SIDER
450	Stupor			SIDER
451	Substance Withdrawal Syndrome		10867961	CTD
452	Sudden death			SIDER
453	Suicide			SIDER
454	Superficial Thrombophlebitis			OFFSIDES
455	Supraventricular tachycardia			SIDER
456	Tardive Dyskinesia			SIDER
457	Tension			SIDER
458	Therapeutic response unexpected			OFFSIDES
459	Thromboembolism			SIDER
460	Thrombophlebitis			SIDER
461	Tinnitus			OFFSIDES SIDER
462	Toothache			SIDER
463	Tremor		30682440	CTD SIDER
464	Trousseau's syndrome			OFFSIDES
465	Ulcerative stomatitis			SIDER
466	Umbilical hernia			OFFSIDES
467	Underweight			OFFSIDES
468	Urinary tract infection pseudomonal			OFFSIDES
469	Urine flow decreased			OFFSIDES
470	Urine output increased			SIDER
471	Urticaria			SIDER
472	Vascular purpura			SIDER
473	Venous Thrombosis			SIDER
474	Vibration test abnormal			OFFSIDES
475	Vulvovaginal mycotic infection			OFFSIDES
476	Xerophthalmia			SIDER
477	effusion			OFFSIDES
478	jaundice		18413635	CTD
479	muscle injury			OFFSIDES
480	nervous system disorder			SIDER

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