MetaADEDB 2.0 @ LMMD
Thiothixene
(GFBKORZTTCHDGY-UWVJOHFNSA-N)
Structure
SMILES
CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C
Type(s)
Approved
ATC code(s)
N05AF04
Molecular Formula:
C23H29N3O2S2
Molecular Weight:
443.625
Log P:
4.4273
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
0
TPSA:
77.54
CAS Number(s):
3313-26-6; 5591-45-7
Synonym(s)
1.
Thiothixene
2.
Tiotixene
3.
Navane
External Link(s)
MeSHD013888
PubChem Compound941651
BindingDB78576
ChEBI9571
CHEMBLCHEMBL1201
DrugBankDB01623
DrugCentral2639
IUPHAR/BPS Guide to PHARMACOLOGY212
KEGGdr:D00374
Therapeutic Target DatabaseD0E0LQ
ZINC30690433
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 14OFFSIDES
US FAERS
2Pharmaceutical product complaintFAERS: 6OFFSIDES
US FAERS
3Tardive DyskinesiaFAERS: 6OFFSIDES
SIDER
US FAERS
4TremorFAERS: 54604854CTD
US FAERS
5AgitationFAERS: 4SIDER
US FAERS
6MalaiseFAERS: 4US FAERS
7Product availability issueFAERS: 4US FAERS
8SomnolenceFAERS: 4SIDER
US FAERS
9AnxietyFAERS: 3OFFSIDES
US FAERS
10AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
11DizzinessFAERS: 3SIDER
US FAERS
12Feeling abnormalFAERS: 3US FAERS
13Activities of daily living impairedFAERS: 2US FAERS
14AmnesiaFAERS: 2US FAERS
15ArthralgiaFAERS: 2US FAERS
16Back PainFAERS: 2US FAERS
17Blood prolactin increasedFAERS: 2US FAERS
18Chest PainFAERS: 2OFFSIDES
US FAERS
19ConstipationFAERS: 2SIDER
US FAERS
20Drug DependenceFAERS: 2US FAERS
21Drug dose omissionFAERS: 2US FAERS
22Drug effect incompleteFAERS: 2US FAERS
23Erectile dysfunctionFAERS: 2OFFSIDES
SIDER
US FAERS
24HeadacheFAERS: 2US FAERS
25LeukopeniaFAERS: 2SIDER
US FAERS
26Medication ErrorFAERS: 2US FAERS
27Muscle RigidityFAERS: 2
Canada Vigilance: 1		4604854CTD
Canada Vigilance
US FAERS
28NauseaFAERS: 2OFFSIDES
SIDER
US FAERS
29PainFAERS: 2OFFSIDES
US FAERS
30PruritusFAERS: 2SIDER
US FAERS
31RestlessnessFAERS: 2US FAERS
32Therapeutic response unexpected with drug substitutionFAERS: 2OFFSIDES
US FAERS
33ThirstFAERS: 2US FAERS
34Weight decreasedFAERS: 2US FAERS
35Adverse eventFAERS: 1US FAERS
36AkathisiaFAERS: 1SIDER
US FAERS
37AkinesiaFAERS: 1US FAERS
38ApathyFAERS: 1US FAERS
39Blood triglycerides increasedFAERS: 1OFFSIDES
US FAERS
40Cardiac ArrestFAERS: 1SIDER
US FAERS
41CataractFAERS: 1OFFSIDES
US FAERS
42Chest discomfortFAERS: 1US FAERS
43ChillsFAERS: 1US FAERS
44ChromaturiaFAERS: 1US FAERS
45CyanosisFAERS: 1US FAERS
46DehydrationFAERS: 1US FAERS
47Diabetes MellitusFAERS: 1US FAERS
48Disease recurrenceFAERS: 1US FAERS
49DissociationFAERS: 1US FAERS
50Drug dispensing errorFAERS: 1US FAERS
51Drug ineffective for unapproved indicationFAERS: 1US FAERS
52Drug screen positiveFAERS: 1OFFSIDES
US FAERS
53DysuriaFAERS: 1OFFSIDES
US FAERS
54Eye painFAERS: 1US FAERS
55Feeling jitteryFAERS: 1US FAERS
56HypersomniaFAERS: 1US FAERS
57HypotensionFAERS: 1SIDER
US FAERS
58InfertilityFAERS: 1US FAERS
59Intentional product misuseFAERS: 1US FAERS
60Lung InjuryFAERS: 1US FAERS
61Memory impairmentFAERS: 1US FAERS
62Mental impairmentFAERS: 1US FAERS
63Middle insomniaFAERS: 1US FAERS
64Mood swingsFAERS: 1US FAERS
65Motion SicknessFAERS: 1US FAERS
66Muscle CrampFAERS: 1US FAERS
67Muscle tightnessFAERS: 1OFFSIDES
US FAERS
68Musculoskeletal stiffnessFAERS: 1US FAERS
69MyoclonusFAERS: 1US FAERS
70Neck PainFAERS: 1US FAERS
71Neuroleptic Malignant SyndromeFAERS: 16130277CTD
OFFSIDES
SIDER
US FAERS
72OculogyrationFAERS: 1US FAERS
73Oromandibular dystoniaFAERS: 1US FAERS
74OverweightFAERS: 1OFFSIDES
US FAERS
75ParanoiaFAERS: 1OFFSIDES
US FAERS
76Personality ChangeFAERS: 1US FAERS
77Pharyngeal dyskinesiaFAERS: 1US FAERS
78PovertyFAERS: 1US FAERS
79Product dose omissionFAERS: 1US FAERS
80Product substitution issueFAERS: 1US FAERS
81Restless Legs SyndromeFAERS: 1US FAERS
82SchizophreniaFAERS: 1

View details

666482
4604854
6123407
7037757
7212946
 		CTD
OFFSIDES
US FAERS
83SluggishnessFAERS: 1US FAERS
84TachyphreniaFAERS: 1OFFSIDES
US FAERS
85Teeth brittleFAERS: 1US FAERS
86TorticollisFAERS: 1US FAERS
87Visual ImpairmentFAERS: 1US FAERS
88Wrong drug administeredFAERS: 1OFFSIDES
US FAERS
89Abdominal PainOFFSIDES
90Abdominal tendernessOFFSIDES
91Abnormal cervical smearOFFSIDES
92Acid refluxOFFSIDES
93Acute Coronary SyndromeOFFSIDES
94Acute sinusitisOFFSIDES
95AdnexitisOFFSIDES
96AgoraphobiaOFFSIDES
97AgranulocytosisSIDER
98Akathisia, Drug-Induced6497564CTD
99Aldolase increasedOFFSIDES
100AlopeciaCanada Vigilance: 2Canada Vigilance
101AmphetaminesOFFSIDES
102Anaphylactic shockSIDER
103AngerOFFSIDES
104AnhidrosisOFFSIDES
105Anorectal discomfortOFFSIDES
106AnorexiaSIDER
107Anticoagulation drug level above therapeuticOFFSIDES
108Antiphospholipid AntibodiesOFFSIDES
109Aortic valve sclerosisOFFSIDES
110ArthritisOFFSIDES
111Arthropod biteOFFSIDES
112Aseptic MeningitisOFFSIDES
113AsphyxiaSIDER
114AuraOFFSIDES
115Autonomic neuropathyOFFSIDES
116Basal Ganglia Diseases7212946
8214193		CTD
117Basal cell carcinomaOFFSIDES
118Biliary DyskinesiaOFFSIDES
119Bipolar Disorder3163740
8214193		CTD
OFFSIDES
120Bipolar I disorderOFFSIDES
121Blood GlucoseOFFSIDES
122Blood cholesterol abnormalOFFSIDES
123Blood cholesterolOFFSIDES
124Blood glucose abnormalOFFSIDES
125Blood glucose decreasedOFFSIDES
126Blood sodiumOFFSIDES
127Blurred visionOFFSIDES
128Bone density decreasedOFFSIDES
129Bone density increasedOFFSIDES
130Bone painOFFSIDES
131Borderline Personality DisorderOFFSIDES
132BradycardiaOFFSIDES
133Brain ConcussionOFFSIDES
134BronchitisOFFSIDES
135BruxismOFFSIDES
136Burning sensationOFFSIDES
137BursitisOFFSIDES
138Cardiac stress test abnormalOFFSIDES
139Cardioactive drug levelOFFSIDES
140Catalepsy1827527CTD
141Cataract operationOFFSIDES
142Catatonia6470193CTD
143CellulitisOFFSIDES
144Cerebral atrophyOFFSIDES
145Chemical and Drug Induced Liver Injury6886037CTD
146Chemotherapeutic drug level increasedOFFSIDES
147Choking sensationOFFSIDES
148Circumstance or information capable of leading to medication errorOFFSIDES
149ConfabulationOFFSIDES
150Congenital tricuspid valve incompetenceOFFSIDES
151CystOFFSIDES
152DebridementOFFSIDES
153Decreased LibidoOFFSIDES
154Deglutition Disorders6470193CTD
155Delusional perceptionOFFSIDES
156DemyelinationOFFSIDES
157Dental abscessOFFSIDES
158DependenceOFFSIDES
159Depressive disorder6470193CTD
160DermatitisSIDER
161DiabetesOFFSIDES
162Diabetes mellitus inadequate controlOFFSIDES
163Diabetic Autonomic NeuropathyOFFSIDES
164Diabetic FootOFFSIDES
165Diabetic RetinopathyOFFSIDES
166Diabetic foot infectionOFFSIDES
167Diabetic ulcerOFFSIDES
168DiarrheaOFFSIDES
169DiplopiaOFFSIDES
170Dissociative Identity DisorderOFFSIDES
171DiverticulumOFFSIDES
172DrowsinessSIDER
173Drug abuserOFFSIDES
174Drug addictOFFSIDES
175Drug toxicityOFFSIDES
176Drug withdrawal headacheOFFSIDES
177DysgeusiaOFFSIDES
178DysmenorrheaOFFSIDES
179DyspepsiaOFFSIDES
180DysphoniaOFFSIDES
181Dysthymic DisorderOFFSIDES
182Dystonia

View details

36644
1119613
2898212
3711026
 		CTD
183Emotional distressOFFSIDES
184EndometriosisOFFSIDES
185EndophthalmitisOFFSIDES
186EosinophiliaSIDER
187Escherichia infectionOFFSIDES
188Esophageal motility disorders8354511CTD
189ExcoriationOFFSIDES
190Facial NeuralgiaOFFSIDES
191FatigueOFFSIDES
SIDER
192Fever666482CTD
193FibromyalgiaOFFSIDES
194Flank PainOFFSIDES
195Food cravingOFFSIDES
196FormicationOFFSIDES
197Gait Ataxia6470193CTD
198GastroenteritisOFFSIDES
199Gestational DiabetesOFFSIDES
200GlycosuriaSIDER
201GranulocytosisOFFSIDES
202Hallucinations8562668CTD
203Hormone level abnormalOFFSIDES
204HostilityOFFSIDES
205HydrocephalusOFFSIDES
206HyperpyrexiaSIDER
207HyperreflexiaSIDER
208HypersensitivitySIDER
209HyperventilationOFFSIDES
210Impaired gastric emptyingOFFSIDES
211Implantable defibrillator insertionOFFSIDES
212IncontinenceOFFSIDES
213Incorrect route of drug administrationOFFSIDES
214Infusion site bruisingOFFSIDES
215Injection site discomfortOFFSIDES
216Insulin ResistanceOFFSIDES
217Insulin-requiring type 2 diabetes mellitusOFFSIDES
218Intention tremorOFFSIDES
219Intermittent ClaudicationOFFSIDES
220Intermittent Explosive DisorderOFFSIDES
221Intervertebral disc disorderOFFSIDES
222Intracranial AneurysmOFFSIDES
223Kidney FailureOFFSIDES
224LacerationOFFSIDES
225Lethargy6470193CTD
226LeukocytosisSIDER
227LightheadednessSIDER
228Limb discomfortOFFSIDES
229LipaseOFFSIDES
230Low turnover osteopathyOFFSIDES
231Mental disorders6470193CTD
232Mental status changesOFFSIDES
233Mood Disorders7212946CTD
234Morbid thoughtsOFFSIDES
235Movement Disorders2230752CTD
236Multiple drug overdoseOFFSIDES
237Muscle necrosisOFFSIDES
238MydriasisSIDER
239NephrolithiasisOFFSIDES
240Nervous tensionOFFSIDES
241NeuralgiaOFFSIDES
242Optic NeuropathyOFFSIDES
243Oropharyngeal painOFFSIDES
244OrthopneaOFFSIDES
245OsteoporosisOFFSIDES
246OverdoseOFFSIDES
247Pancreatic CystOFFSIDES
248PancreatitisOFFSIDES
249PancytopeniaSIDER
250Panic DisorderOFFSIDES
251Panic disorder with agoraphobiaOFFSIDES
252Parkinsonian Disorders7247630CTD
253Periumbilical abscessOFFSIDES
254PhimosisOFFSIDES
255PleurisyOFFSIDES
256PolydipsiaSIDER
257PolyneuropathyOFFSIDES
258Portal HypertensionOFFSIDES
259Postoperative infectionOFFSIDES
260Pregnancy test false positiveSIDER
261PresbyopiaOFFSIDES
262Prescribed overdoseOFFSIDES
263Productive CoughOFFSIDES
264PseudoparkinsonismSIDER
265Psychotic Disorders3711026CTD
266Pulmonary HypertensionOFFSIDES
267QRS axis abnormalOFFSIDES
268Radicular painOFFSIDES
269RadiculitisOFFSIDES
270Renal ColicOFFSIDES
271RhinitisOFFSIDES
272Schizoaffective DisorderOFFSIDES
273ShockSIDER
274Sinus bradycardiaOFFSIDES
275SinusitisOFFSIDES
276Skin lacerationOFFSIDES
277SnoringOFFSIDES
278Speech Disorders6470193CTD
279Spinal column stenosisOFFSIDES
280StarvationOFFSIDES
281Stomach scan abnormalOFFSIDES
282Suprapubic painOFFSIDES
283SyncopeSIDER
284Tachycardia666482CTD
SIDER
285Temperature intoleranceOFFSIDES
286TendinitisOFFSIDES
287ThrombocytopeniaSIDER
288Thromboembolic strokeOFFSIDES
289Umbilical herniaOFFSIDES
290Urinary Incontinence6470193CTD
291UrticariaSIDER
292Vaginal burning sensationOFFSIDES
293Visual disturbanceOFFSIDES
294Vitamin B 12 DeficiencyOFFSIDES
295VomitingSIDER
296Vulvovaginal discomfortOFFSIDES
297Weight GainOFFSIDES
298Wound infection bacterialOFFSIDES
299jaundiceSIDER
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