MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Trifluoperazine

(ZEWQUBUPAILYHI-UHFFFAOYSA-N)

Structure

SMILES: CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F
Type(s): Approved; Investigational
ATC code(s): N05AB06
Molecular Formula:: C21H24F3N3S
Molecular Weight:: 407.496
Log P:: 4.8864
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 0
TPSA:: 35.02
CAS Number(s):: 117-89-5; 440-17-5

Synonym(s)

Trifluoperazine

Trifluoroperazine

Triftazin

Apo-Trifluoperazine

Eskazine

Flupazine

Stelazine

Terfluzine

Trifluoperazine HCL

10.

Trifluoperazine Hydrochloride

11.

Trifluperazine

12.

Apo Trifluoperazine

13.

ApoTrifluoperazine

External Link(s)

MeSH	D014268
PubChem Compound	5566
BindingDB	79181 50001886
ChEBI	45951
CHEMBL	CHEMBL422
DrugBank	DB00831
DrugCentral	2740
IUPHAR/BPS Guide to PHARMACOLOGY	214
KEGG	cpd:C07168 dr:D08636
Therapeutic Target Database	D0R4OM
ZINC	19418959

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Anxiety	FAERS: 7		US FAERS
2	Drug ineffective	FAERS: 4		US FAERS
3	Feeling abnormal	FAERS: 3		OFFSIDES US FAERS
4	Headache	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
5	Malaise	FAERS: 3		US FAERS
6	Somnolence	FAERS: 3 Canada Vigilance: 4		Canada Vigilance SIDER US FAERS
7	Asthenia	FAERS: 2		SIDER US FAERS
8	Restlessness	FAERS: 2		US FAERS
9	Tardive Dyskinesia	FAERS: 2		OFFSIDES US FAERS
10	Wrong technique in product usage process	FAERS: 2		US FAERS
11	Asthma	FAERS: 1		SIDER US FAERS
12	Discomfort	FAERS: 1		US FAERS
13	Dizziness	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
14	Muscle tightness	FAERS: 1		OFFSIDES US FAERS
15	Musculoskeletal Pain	FAERS: 1		US FAERS
16	Myocardial Infarction	FAERS: 1		US FAERS
17	Nausea	FAERS: 1		SIDER US FAERS
18	Nerve injury	FAERS: 1		US FAERS
19	No adverse reaction	FAERS: 1		US FAERS
20	Palpitations	FAERS: 1		US FAERS
21	Paranoia	FAERS: 1		OFFSIDES US FAERS
22	Product quality issue	FAERS: 1		US FAERS
23	Product substitution issue	FAERS: 1		US FAERS
24	Product use issue	FAERS: 1		US FAERS
25	Tachycardia	FAERS: 1		US FAERS
26	Therapeutic product effect decreased	FAERS: 1		US FAERS
27	Thrombocytopenia	FAERS: 1		US FAERS
28	Tremor	FAERS: 1 Canada Vigilance: 8	View details 872557 961932 1147074 4557435 4759422 15232633	CTD SIDER Canada Vigilance US FAERS
29	Activities of daily living impaired			OFFSIDES
30	Acute Coronary Syndrome			OFFSIDES
31	Acute respiratory failure			OFFSIDES
32	Adams-Stokes Syndrome		4647552	CTD
33	Agitation			SIDER
34	Agranulocytosis			SIDER
35	Agraphia			OFFSIDES
36	Akathisia, Drug-Induced		View details 1147074 4557435 4587065 7146292 7540798 9827620 17308236	CTD
37	Akathisia	Canada Vigilance: 5		Canada Vigilance SIDER
38	Alcohol interaction			OFFSIDES
39	Allergic sinusitis			OFFSIDES
40	Anaphylactic shock			SIDER
41	Anaphylactoid Reaction			SIDER
42	Angioedema		4468604	CTD SIDER
43	Anhidrosis			OFFSIDES
44	Anorexia			SIDER
45	Anxiety Disorders		4816841 9827620 10675082	CTD
46	Apnea			OFFSIDES
47	Appendicitis			OFFSIDES
48	Asphyxia			SIDER
49	Astigmatism			OFFSIDES
50	Aura			OFFSIDES
51	Basal Ganglia Diseases		View details 619844 4144552 4759422 4944664 5249511 5781950 6016862 7540798 9226090	CTD
52	Bipolar Disorder		961932 5077102	CTD
53	Blepharospasm		2716647 9827620	CTD
54	Blood Glucose			OFFSIDES
55	Blood cholesterol			OFFSIDES
56	Blood glucose decreased			OFFSIDES
57	Blood triglycerides increased			OFFSIDES
58	Body temperature fluctuation			OFFSIDES
59	Bronchitis			OFFSIDES
60	Bronchospasm			SIDER
61	Bunion operation			OFFSIDES
62	Cardiac Arrest			SIDER
63	Carotid artery occlusion			OFFSIDES
64	Catalepsy		1827527 9142555 15232633	CTD
65	Cataract			OFFSIDES
66	Catatonia		1429421 6139391	CTD SIDER
67	Cellulitis			OFFSIDES
68	Cerebral atrophy			OFFSIDES
69	Chemotherapeutic drug level increased			OFFSIDES
70	Chest Pain			OFFSIDES
71	Chest wall cyst			OFFSIDES
72	Cholestasis			SIDER
73	Chorea		122926 4557435	CTD
74	Chronic Obstructive Airway Disease			OFFSIDES
75	Cogwheel Rigidity			SIDER
76	Constipation	Canada Vigilance: 1		Canada Vigilance SIDER
77	Cyst			OFFSIDES
78	Decreased Libido			OFFSIDES
79	Deglutition Disorders		8873877	CTD
80	Demyelination			OFFSIDES
81	Dental abscess			OFFSIDES
82	Depressed mood			OFFSIDES
83	Depressive disorder		6124134 9827620	CTD
84	Dermatitis			SIDER
85	Diabetes			OFFSIDES
86	Diabetes Mellitus		5634402	CTD
87	Diabetes mellitus inadequate control			OFFSIDES
88	Diabetic Foot			OFFSIDES
89	Diabetic Retinopathy			OFFSIDES
90	Diabetic ulcer			OFFSIDES
91	Disseminated Intravascular Coagulation			OFFSIDES
92	Drooling			SIDER
93	Drowsiness			SIDER
94	Drug Overdose		6050800	CTD
95	Drug resistance			OFFSIDES
96	Dysarthria		9161771	CTD
97	Dyskinesia, Drug-Induced		View details 1147074 4405372 4414178 4414187 4557435 4816841 4902773 4938245 5781950 6021008 9161771	CTD
98	Dysmenorrhea			OFFSIDES
99	Dysthymic Disorder			OFFSIDES
100	Dystonia	Canada Vigilance: 2	View details 36644 589060 1119613 2036543 2278124 2903183 4405372 5249511 8573063	CTD Canada Vigilance
101	Echolalia			OFFSIDES
102	Eczema			SIDER
103	Elevated mood			OFFSIDES
104	Emotional disorder			OFFSIDES
105	Eosinophilia			SIDER
106	Erectile dysfunction			OFFSIDES SIDER
107	Erythema			SIDER
108	Escherichia infection			OFFSIDES
109	Excoriation			OFFSIDES
110	Facial Neuralgia			OFFSIDES
111	Fatigue			SIDER
112	Feeling jittery			SIDER
113	Fever		6050800	CTD
114	Flank Pain			OFFSIDES
115	Formication			OFFSIDES
116	Gastric ulcer			OFFSIDES
117	Gestational Diabetes			OFFSIDES
118	Glaucoma			OFFSIDES
119	Glycosuria			SIDER
120	Granulocytosis			OFFSIDES
121	Granuloma			OFFSIDES
122	Heparin-induced thrombocytopenia			OFFSIDES
123	Hepatitis C			OFFSIDES
124	Hostility			OFFSIDES
125	Hyperkeratosis			OFFSIDES
126	Hyperpyrexia			SIDER
127	Hyperreflexia			SIDER
128	Hypersensitivity			SIDER
129	Hypervigilance			OFFSIDES
130	Hypokinesia		4557435 15232633	CTD
131	Hypotension, Orthostatic		3559152 5042830	CTD
132	Hypotension	Canada Vigilance: 2		Canada Vigilance SIDER
133	Ileus			SIDER
134	Impaired self-care			OFFSIDES
135	Implantable defibrillator insertion			OFFSIDES
136	Incorrect drug administration duration			OFFSIDES
137	Infantile apnoeic attack			OFFSIDES
138	Infective exacerbation of chronic obstructive airways disease			OFFSIDES
139	Insulin Resistance			OFFSIDES
140	Insulin-requiring type 2 diabetes mellitus			OFFSIDES
141	Intentional self-injury			OFFSIDES
142	Intermittent Explosive Disorder			OFFSIDES
143	Keratopathy			SIDER
144	Lethargy			OFFSIDES
145	Leukopenia			SIDER
146	Lupus-like syndrome			SIDER
147	Lymphocyte count decreased			OFFSIDES
148	Megacolon			SIDER
149	Metabolic acidosis			OFFSIDES
150	Motor restlessness			SIDER
151	Movement Disorders		7871054	CTD
152	Multiple drug overdose			OFFSIDES
153	Muscle Rigidity	Canada Vigilance: 5	View details 4557435 4759422 7146292 9226090 15232633	CTD SIDER Canada Vigilance
154	Musculoskeletal chest pain			OFFSIDES
155	Mutism		4405372	CTD
156	Mydriasis			SIDER
157	Myopia			OFFSIDES
158	Nasal mucosal disorder			OFFSIDES
159	Necrosis		25445804	CTD
160	Nephrolithiasis			OFFSIDES
161	Nervousness			SIDER
162	Neuroleptic Malignant Syndrome		2036482 10197221 10675082	CTD OFFSIDES SIDER
163	Obstipation			SIDER
164	Oculogyric crisis			SIDER
165	Opisthotonus			SIDER
166	Oropharyngeal pain			OFFSIDES
167	Overdose			OFFSIDES
168	Overweight			OFFSIDES
169	Pancreatitis			OFFSIDES
170	Pancytopenia			SIDER
171	Parkinsonian Disorders		1275103 4405372 12724469	CTD
172	Parkinsonian rest tremor			SIDER
173	Patellofemoral Pain Syndrome			OFFSIDES
174	Periumbilical abscess			OFFSIDES
175	Polyneuropathy			OFFSIDES
176	Polyuria			OFFSIDES
177	Pregnancy test false positive			SIDER
178	Presbyopia			OFFSIDES
179	Priapism			SIDER
180	Productive Cough			OFFSIDES
181	Pruritus			SIDER
182	Pseudodementia			OFFSIDES
183	Pseudoparkinsonism			SIDER
184	Psychomotor Agitation		12724469	CTD
185	Psychoses, Substance-Induced		4587065	CTD
186	Psychotic Disorders		View details 2036482 3559152 9161771 17308236	CTD
187	Puerperal Disorders		3559152	CTD
188	Radicular pain			OFFSIDES
189	Respiratory dyskinesia			OFFSIDES
190	Rhinitis			OFFSIDES
191	Rhinorrhea			OFFSIDES
192	Schizoaffective Disorder			OFFSIDES
193	Schizophrenia		View details 709472 872557 2036543 3063660 4944664 6110346 7146292	CTD OFFSIDES
194	Seizures		1803	CTD
195	Sinus bradycardia			OFFSIDES
196	Sinusitis			OFFSIDES
197	Skin laceration			OFFSIDES
198	Sleep Initiation and Maintenance Disorders		2903183	CTD
199	Sleep inertia			OFFSIDES
200	Somatoform disorder pregnancy			OFFSIDES
201	Spinal column stenosis			OFFSIDES
202	Starvation			OFFSIDES
203	Status Epilepticus		6050800	CTD
204	Stuttering		6110346	CTD
205	Substance Withdrawal Syndrome		View details 961932 1147074 2560590 5781950	CTD
206	Sudden death			SIDER
207	Suprapubic pain			OFFSIDES
208	Tendinitis			OFFSIDES
209	Tetany			SIDER
210	Theft			OFFSIDES
211	Thrombocytopenic purpura			SIDER
212	Tinea Pedis			OFFSIDES
213	Torsades de Pointes		2416504	CTD
214	Torticollis			SIDER
215	Trigonitis			OFFSIDES
216	Trismus			SIDER
217	Ulcer			OFFSIDES
218	Urethral Stenosis			OFFSIDES
219	Urinary Retention			SIDER
220	Urticaria	Canada Vigilance: 1		Canada Vigilance SIDER
221	Ventricular arrhythmia			SIDER
222	Vulvovaginal mycotic infection			OFFSIDES
223	Weight Gain			OFFSIDES
224	Wrong drug administered			OFFSIDES
225	diagnostic procedure			OFFSIDES
226	jaundice			SIDER

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