MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Thioridazine

(KLBQZWRITKRQQV-UHFFFAOYSA-N)

Structure

SMILES: CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1
Type(s): Approved; Withdrawn
ATC code(s): N05AC02
Molecular Formula:: C21H26N2S2
Molecular Weight:: 370.575
Log P:: 5.8885
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 0
TPSA:: 57.08
CAS Number(s):: 50-52-2

Synonym(s)

Thioridazine

Aldazine

Apo-Thioridazine

Meleril

Mellaril

Melleretten

Melleril

Melleryl

Melzine

10.

Rideril

11.

Sonapax

12.

Thioridazine HCL

13.

Thioridazine Hydrochloride

14.

Thioridazine-Neurazpharm

15.

Thiozine

16.

Apo Thioridazine

17.

ApoThioridazine

18.

Thioridazine Neurazpharm

19.

ThioridazineNeurazpharm

External Link(s)

MeSH	D013881
PubChem Compound	5452
BindingDB	50002338
ChEBI	9566
CHEMBL	CHEMBL479
DrugBank	DB00679
DrugCentral	2637
IUPHAR/BPS Guide to PHARMACOLOGY	100
KEGG	dr:D00373
Therapeutic Target Database	D0U1OE

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Depressed Level of Consciousness	FAERS: 6		OFFSIDES US FAERS
2	Somnolence	FAERS: 4 Canada Vigilance: 74		Canada Vigilance SIDER US FAERS
3	Tardive Dyskinesia	FAERS: 4 Canada Vigilance: 4		Canada Vigilance OFFSIDES SIDER US FAERS
4	Sudden death	FAERS: 3		OFFSIDES SIDER US FAERS
5	Adverse event	FAERS: 2		OFFSIDES US FAERS
6	Crying	FAERS: 2		US FAERS
7	Diabetes Mellitus	FAERS: 2	5634402	CTD US FAERS
8	Disability	FAERS: 2		US FAERS
9	Drug level increased	FAERS: 2		US FAERS
10	Drug prescribing error	FAERS: 2		US FAERS
11	Feeling abnormal	FAERS: 2		OFFSIDES SIDER US FAERS
12	Mental status changes	FAERS: 2		OFFSIDES US FAERS
13	Overdose	FAERS: 2		OFFSIDES US FAERS
14	Pain	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
15	Palpitations	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
16	Periodontitis	FAERS: 2		US FAERS
17	Priapism	FAERS: 2		SIDER US FAERS
18	Schizophrenia	FAERS: 2	View details 707646 709472 2773973 4065553 5237376 6123407 7435691 7446763 15285957 18634530	CTD OFFSIDES US FAERS
19	Syncope	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
20	Tremor	FAERS: 2 Canada Vigilance: 30	2925349 5237376 7396317	CTD SIDER Canada Vigilance US FAERS
21	Unevaluable event	FAERS: 2		OFFSIDES US FAERS
22	Accidental death	FAERS: 1		US FAERS
23	Accidental overdose	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
24	Agitation	FAERS: 1 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
25	Amnesia	FAERS: 1		US FAERS
26	Anuria	FAERS: 1		US FAERS
27	Apathy	FAERS: 1		OFFSIDES US FAERS
28	Arteriosclerosis	FAERS: 1		US FAERS
29	Arthralgia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
30	Asthenia	FAERS: 1 Canada Vigilance: 5		Canada Vigilance OFFSIDES US FAERS
31	Asthma	FAERS: 1		OFFSIDES SIDER US FAERS
32	Bipolar Disorder	FAERS: 1	5066616 7104553	CTD OFFSIDES US FAERS
33	Blindness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
34	Blood creatine phosphokinase increased	FAERS: 1		US FAERS
35	Cardiac Arrest	FAERS: 1		SIDER US FAERS
36	Catatonia	FAERS: 1	6134661	CTD US FAERS
37	Cerebrovascular accident	FAERS: 1		US FAERS
38	Choking	FAERS: 1		US FAERS
39	Dehydration	FAERS: 1		OFFSIDES US FAERS
40	Depressed mood	FAERS: 1		OFFSIDES US FAERS
41	Detachment of retinal pigment epithelium	FAERS: 1		US FAERS
42	Disorientation	FAERS: 1		US FAERS
43	Drug dispensing error	FAERS: 1		US FAERS
44	Drug ineffective	FAERS: 1		US FAERS
45	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
46	Drug toxicity	FAERS: 1		US FAERS
47	Dysarthria	FAERS: 1 Canada Vigilance: 2	7396317	CTD Canada Vigilance US FAERS
48	Erythema	FAERS: 1 Canada Vigilance: 2	2602249	CTD OFFSIDES SIDER Canada Vigilance US FAERS
49	Expired product administered	FAERS: 1		US FAERS
50	Eyelid Function Disorder	FAERS: 1		US FAERS
51	Feeling jittery	FAERS: 1		US FAERS
52	Glaucoma	FAERS: 1		US FAERS
53	Incontinence	FAERS: 1		OFFSIDES SIDER US FAERS
54	Medication residue	FAERS: 1		US FAERS
55	Mental Retardation	FAERS: 1		US FAERS
56	Mental impairment	FAERS: 1		OFFSIDES US FAERS
57	Myocardial Infarction	FAERS: 1		US FAERS
58	Nausea	FAERS: 1 Canada Vigilance: 3	7396317	CTD SIDER Canada Vigilance US FAERS
59	Nervousness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
60	Neuroleptic Malignant Syndrome	FAERS: 1	View details 2738187 6134661 7118846 8555725	CTD SIDER US FAERS
61	Pharmaceutical product complaint	FAERS: 1		US FAERS
62	Poisoning	FAERS: 1		US FAERS
63	Product quality issue	FAERS: 1		US FAERS
64	Product substitution issue	FAERS: 1		US FAERS
65	Rhabdomyolysis	FAERS: 1		US FAERS
66	Sexual activity increased	FAERS: 1		US FAERS
67	Sudden Cardiac Death	FAERS: 1		US FAERS
68	Unresponsive to stimuli	FAERS: 1		US FAERS
69	Upper airway obstruction	FAERS: 1		US FAERS
70	Urinary Incontinence	FAERS: 1 Canada Vigilance: 4		Canada Vigilance US FAERS
71	Urinary tract infection	FAERS: 1		US FAERS
72	Urticaria	FAERS: 1 Canada Vigilance: 4		Canada Vigilance US FAERS
73	Wrong drug administered	FAERS: 1		US FAERS
74	Abdominal Pain			OFFSIDES
75	Abdominal discomfort			OFFSIDES
76	Abuse			OFFSIDES
77	Acholia			OFFSIDES
78	Acid reflux			OFFSIDES
79	Acquired night blindness			OFFSIDES
80	Acute bronchitis			OFFSIDES
81	Acute myocardial infarction			OFFSIDES
82	Acute sinusitis			OFFSIDES
83	Agranulocytosis	Canada Vigilance: 1	4739612	CTD SIDER Canada Vigilance
84	Akathisia, Drug-Induced		4795129 5237376 6132118	CTD
85	Akathisia	Canada Vigilance: 14		Canada Vigilance SIDER
86	Akinesia	Canada Vigilance: 1		Canada Vigilance SIDER
87	Albuminuria	Canada Vigilance: 1		Canada Vigilance
88	Alcohol problem			OFFSIDES
89	Alcohol withdrawal syndrome			OFFSIDES
90	Alopecia			OFFSIDES
91	Alveolitis			OFFSIDES
92	Amblyopia			OFFSIDES
93	Amphetamines			OFFSIDES
94	Analgesia			OFFSIDES
95	Angioedema			SIDER
96	Anhidrosis			OFFSIDES
97	Anorexia		2602249	CTD OFFSIDES SIDER
98	Anorgasmia	Canada Vigilance: 1		Canada Vigilance
99	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis		12452885	CTD
100	Anticholinergic Syndrome			OFFSIDES
101	Anticonvulsant drug level decreased			OFFSIDES
102	Anticonvulsant drug level increased			OFFSIDES
103	Anxiety Disorders		4816841	CTD
104	Anxiety	Canada Vigilance: 2		Canada Vigilance OFFSIDES
105	Aortic Aneurysm			OFFSIDES
106	Arthritis			OFFSIDES
107	Arthropathy			OFFSIDES
108	Ascites			OFFSIDES
109	Ataxia	Canada Vigilance: 2		Canada Vigilance
110	Athetosis		6132118 7396317 12739384	CTD
111	Atrioventricular Block		1304415	CTD
112	Aura			OFFSIDES
113	Autonomic nervous system imbalance			SIDER
114	Band neutrophil count increased			OFFSIDES
115	Basal Ganglia Diseases		6016862 11549212	CTD
116	Basal cell carcinoma			OFFSIDES
117	Bipolar I disorder			OFFSIDES
118	Bizarre dreams			SIDER
119	Bladder prolapse			OFFSIDES
120	Blood Glucose			OFFSIDES
121	Blood alkaline phosphatase increased			OFFSIDES
122	Blood cholesterol			OFFSIDES
123	Blood glucose decreased			OFFSIDES
124	Blood lactate dehydrogenase increased			OFFSIDES
125	Blood prolactin increased			OFFSIDES
126	Blood triglycerides increased			OFFSIDES
127	Blood urea increased	Canada Vigilance: 2		Canada Vigilance
128	Body Temperature			OFFSIDES
129	Borderline Personality Disorder		6517994	CTD
130	Bradycardia			OFFSIDES
131	Breast engorgement			SIDER
132	Bronchitis			OFFSIDES
133	Bruxism		6132118	CTD
134	Bundle-Branch Block		1304415	CTD
135	Burning sensation	Canada Vigilance: 1		Canada Vigilance
136	Cardiovascular Diseases		2863351	CTD
137	Catalepsy		97712	CTD
138	Cataract	Canada Vigilance: 1		Canada Vigilance OFFSIDES
139	Central Nervous System Infection			OFFSIDES
140	Chemical and Drug Induced Liver Injury		2602249 4739612 23397584	CTD
141	Chemical burn of skin			OFFSIDES
142	Chemotherapeutic drug level increased			OFFSIDES
143	Chest Pain	Canada Vigilance: 2		Canada Vigilance OFFSIDES
144	Child Behavior Disorders		3894338	CTD
145	Choking sensation			OFFSIDES
146	Cholestasis		5178723	CTD SIDER
147	Chorea		6132118 7396317 12739384	CTD
148	Choreoathetoid movements			SIDER
149	Choreoathetosis			SIDER
150	Chromaturia			OFFSIDES
151	Chronic Fatigue Syndrome			OFFSIDES
152	Chronic Obstructive Airway Disease			OFFSIDES
153	Circumstance or information capable of leading to medication error			OFFSIDES
154	Clostridium difficile colitis			OFFSIDES
155	Cognition Disorders		3089336 7435691	CTD
156	Cogwheel Rigidity	Canada Vigilance: 1		Canada Vigilance
157	Color blindness			OFFSIDES
158	Completed Suicide	Canada Vigilance: 4		Canada Vigilance OFFSIDES
159	Compression fracture			OFFSIDES
160	Conduct Disorder		9031564	CTD
161	Confabulation			OFFSIDES
162	Confusion		7396317	CTD
163	Congenital tricuspid valve incompetence			OFFSIDES
164	Conjunctival abrasion			OFFSIDES
165	Conjunctival deposit			OFFSIDES
166	Conjunctivitis	Canada Vigilance: 1		Canada Vigilance
167	Constipation	Canada Vigilance: 12		Canada Vigilance SIDER
168	Cyanosis	Canada Vigilance: 1		Canada Vigilance
169	Delirium		106047 3805341	CTD
170	Delusional disorder, persecutory type			OFFSIDES
171	Dementia		7114310 11575062	CTD
172	Dengue Fever			OFFSIDES
173	Dependence			OFFSIDES
174	Depressive disorder		2247245	CTD
175	Dermatitis	Canada Vigilance: 1		Canada Vigilance SIDER
176	Diabetes			OFFSIDES
177	Diabetes Insipidus		5743036	CTD
178	Diabetes mellitus inadequate control			OFFSIDES
179	Diabetic Nephropathy			OFFSIDES
180	Diarrhea			OFFSIDES
181	Diplopia		7396317	CTD
182	Disorders of Excessive Somnolence		5237376 6117919	CTD
183	Disruptive, Impulse Control, and Conduct Disorders		6458665	CTD
184	Dizziness	Canada Vigilance: 22		Canada Vigilance OFFSIDES
185	Drowsiness			OFFSIDES SIDER
186	Drug abuser			OFFSIDES
187	Drug addict			OFFSIDES
188	Drug withdrawal headache			OFFSIDES
189	Duodenal Ulcer			OFFSIDES
190	Duodenitis			OFFSIDES
191	Dyskinesia, Drug-Induced		View details 4816841 6132118 7396317 7446763	CTD
192	Dyspepsia			OFFSIDES
193	Dysthymic Disorder			OFFSIDES
194	Dystonia	Canada Vigilance: 14	View details 1119613 3508694 5237376 8496127	CTD SIDER Canada Vigilance
195	Dystonic reaction			SIDER
196	Dysuria			OFFSIDES
197	Eczema	Canada Vigilance: 1		Canada Vigilance
198	Electrocardiogram ST segment abnormal			OFFSIDES
199	Electrocardiogram U wave present			SIDER
200	Electrocardiogram U-wave abnormality			SIDER
201	Electrocardiogram abnormal	Canada Vigilance: 14		Canada Vigilance
202	Enuresis		5066616	CTD
203	Eosinophilia			SIDER
204	Epistaxis	Canada Vigilance: 2		Canada Vigilance
205	Erectile dysfunction	Canada Vigilance: 2	5557274	CTD OFFSIDES Canada Vigilance
206	Erosive gastritis			OFFSIDES
207	Erythema Multiforme	Canada Vigilance: 1		Canada Vigilance
208	Excoriation			OFFSIDES
209	Eye irritation	Canada Vigilance: 1		Canada Vigilance
210	Fatigue	Canada Vigilance: 1		Canada Vigilance
211	Fever		3390252	CTD
212	Flatulence			OFFSIDES
213	Flight of ideas			OFFSIDES
214	Flushing	Canada Vigilance: 1		Canada Vigilance
215	Gait Ataxia		7396317	CTD
216	Galactorrhea			OFFSIDES
217	Gastric Lavage			OFFSIDES
218	Gastric ulcer			OFFSIDES
219	Gastrointestinal hypermotility			OFFSIDES
220	General physical health deterioration			OFFSIDES
221	General symptom			OFFSIDES
222	Granulocytosis			OFFSIDES
223	Hallucinations		3089336	CTD
224	Headache	Canada Vigilance: 10		Canada Vigilance SIDER
225	Heart Block		6665117	CTD
226	Heart Diseases		5426834 8632504	CTD
227	Hepatic Encephalopathy		4739612	CTD
228	Hepatotoxicity			SIDER
229	Hyperkeratosis			OFFSIDES
230	Hyperkinesia	Canada Vigilance: 4		Canada Vigilance SIDER
231	Hyperprolactinemia		View details 564936 4047382 4065553 9192542	CTD
232	Hyperpyrexia			SIDER
233	Hypersensitivity			SIDER
234	Hypertensive heart disease			OFFSIDES
235	Hypokinesia	Canada Vigilance: 1		Canada Vigilance
236	Hypomania			OFFSIDES
237	Hypotension, Orthostatic		3559152 8561216 14870961	CTD
238	Hypotension	Canada Vigilance: 11	View details 1242767 5237376 6044072 7114310 7849693	CTD SIDER Canada Vigilance
239	Hypothermia neonatal			OFFSIDES
240	Hypoxia			OFFSIDES
241	Impaired self-care			OFFSIDES
242	Inappropriate affect			OFFSIDES
243	Infusion site mobility decreased			OFFSIDES
244	Intentional misuse			OFFSIDES
245	Intentional self-injury			OFFSIDES
246	Intestinal Perforation			OFFSIDES
247	Jaundice, Obstructive		6071857	CTD
248	Joint stiffness			OFFSIDES
249	Kidney Failure			OFFSIDES
250	Lethargy	Canada Vigilance: 8	7396317	CTD OFFSIDES SIDER Canada Vigilance
251	Leukopenia	Canada Vigilance: 5		Canada Vigilance SIDER
252	Lipase			OFFSIDES
253	Livedo Reticularis			OFFSIDES
254	Long QT Syndrome		View details 15285957 16178046 20210726 20636881 24052561 25822712	CTD OFFSIDES
255	Malaria, Falciparum		16882315	CTD
256	Meige Syndrome		2894781	CTD
257	Memory Disorders		7396317	CTD
258	Mental disorders		1094544 7849693 16856516	CTD
259	Mental retardation severity unspecified			OFFSIDES
260	Motor restlessness			SIDER
261	Movement Disorders		1971459	CTD
262	Multiple drug overdose			OFFSIDES
263	Muscle Hypertonia		3390252	CTD
264	Muscle Rigidity	Canada Vigilance: 5	3089336 5237376	CTD SIDER Canada Vigilance
265	Musculoskeletal chest pain			OFFSIDES
266	Musculoskeletal discomfort			OFFSIDES
267	Musculoskeletal stiffness	Canada Vigilance: 1		Canada Vigilance
268	Nasopharyngitis			OFFSIDES
269	Nervous tension			OFFSIDES
270	Neurotoxicity Syndromes		106047	CTD
271	Nicotine Dependence			OFFSIDES
272	Night Terrors		3255460	CTD
273	Nocturnal confusion			SIDER
274	Nodule on extremity			OFFSIDES
275	Non-cardiac chest pain			OFFSIDES
276	Obstipation			SIDER
277	Oculogyric crisis	Canada Vigilance: 4		Canada Vigilance SIDER
278	Open wound			OFFSIDES
279	Opisthotonus	Canada Vigilance: 1		Canada Vigilance SIDER
280	Osteomyelitis			OFFSIDES
281	Overweight			OFFSIDES
282	Pallor	Canada Vigilance: 6		Canada Vigilance SIDER
283	Pancreatitis			OFFSIDES
284	Pancytopenia			SIDER
285	Paranoia			OFFSIDES
286	Parkinsonian Disorders		7247630	CTD
287	Parkinsonian rest tremor			OFFSIDES
288	Parotid swelling			SIDER
289	Pedal pulse decreased			OFFSIDES
290	Peritonitis			OFFSIDES
291	Personality Change			OFFSIDES
292	Personality Disorders		575199	CTD
293	Polyneuropathy			OFFSIDES
294	Poor peripheral circulation			OFFSIDES
295	Pregnancy test false positive			SIDER
296	Presbyopia			OFFSIDES
297	Procedural site reaction			OFFSIDES
298	Prolactinoma		4065553	CTD
299	Protein total decreased			OFFSIDES
300	Pruritus	Canada Vigilance: 3		Canada Vigilance
301	Pseudoparkinsonism			SIDER
302	Psychiatric symptom			OFFSIDES
303	Psychomotor Agitation		3340705	CTD
304	Psychotic Disorders		View details 2773973 3508694 3559152 14961937 16882315	CTD
305	Puerperal Disorders		3559152	CTD
306	Pulmonary Edema		709472	CTD
307	Pulmonary Embolism		14762980	CTD
308	Pulmonary congestion			OFFSIDES
309	Pulse irregular			SIDER
310	Purpura	Canada Vigilance: 1		Canada Vigilance
311	Rash erythematous	Canada Vigilance: 5		Canada Vigilance
312	Rectal Prolapse			OFFSIDES
313	Reduced facial expression	Canada Vigilance: 3		Canada Vigilance
314	Regurgitation of food			OFFSIDES
315	Renal Insufficiency		2602249	CTD
316	Respiratory Insufficiency		709472	CTD
317	Respiratory tract congestion			OFFSIDES
318	Restlessness	Canada Vigilance: 2		Canada Vigilance
319	Retinal Degeneration		8780438	CTD
320	Retinal Diseases		3337876 16117689	CTD
321	Rhinitis	Canada Vigilance: 1		Canada Vigilance
322	Schizoaffective Disorder			OFFSIDES
323	Schizophrenia, Catatonic		5574054	CTD
324	Schizotypal Personality Disorder		4671919	CTD
325	Seizures		View details 1803 106047 1977176 6175290	CTD
326	Sinusitis	Canada Vigilance: 1		Canada Vigilance OFFSIDES
327	Skin laceration			OFFSIDES
328	Skin lesion			OFFSIDES
329	Sleep Initiation and Maintenance Disorders		3340705 8555725	CTD
330	Somnambulism		453369 707646 3255460	CTD
331	Spondylolisthesis			OFFSIDES
332	Stomatitis	Canada Vigilance: 1		Canada Vigilance
333	Substance Withdrawal Syndrome		4758451 7565144	CTD
334	Tachycardia, Ventricular		View details 2004 1304415 2300645 4758451 5765133 5923090 7224396 20210726	CTD
335	Tachycardia	Canada Vigilance: 6	5237376 6665117	CTD SIDER Canada Vigilance
336	Temperature regulation disorder			OFFSIDES
337	Tendinitis			OFFSIDES
338	Thirst	Canada Vigilance: 1		Canada Vigilance
339	Thrombocytopenia			SIDER
340	Tobacco user			OFFSIDES
341	Torsades de Pointes		View details 1304415 1407620 2053762 2416504 3744606 3790644 6145728 6842807 9057687 9659329 16178046 18634530	CTD
342	Torticollis	Canada Vigilance: 1		Canada Vigilance SIDER
343	Transposition of Great Vessels		5763432	CTD
344	Trismus			SIDER
345	Ulcer			OFFSIDES
346	Urge Incontinence			OFFSIDES
347	Urinary Retention	Canada Vigilance: 2		Canada Vigilance
348	Uterine Prolapse			OFFSIDES
349	Venous Thrombosis		6665117	CTD
350	Ventricular Dysfunction, Left		11308123	CTD
351	Ventricular Fibrillation		View details 709472 1304415 4758451 6462991 7452506	CTD OFFSIDES
352	Ventricular Flutter		7177942	CTD
353	Ventricular arrhythmia			SIDER
354	Vertigo	Canada Vigilance: 5	7396317	CTD Canada Vigilance
355	Vision Disorders		2221706	CTD
356	Visual Impairment	Canada Vigilance: 2		Canada Vigilance
357	Visual disturbance			OFFSIDES
358	Vomiting	Canada Vigilance: 4	7396317	CTD SIDER Canada Vigilance
359	Weight Gain		3255460	CTD OFFSIDES
360	furuncle			OFFSIDES
361	jaundice	Canada Vigilance: 1	2602249	CTD SIDER Canada Vigilance

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