MetaADEDB 2.0 @ LMMD
Vortioxetine
(YQNWZWMKLDQSAC-UHFFFAOYSA-N)
Structure
SMILES
Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1
Type(s)
Approved; Investigational
ATC code(s)
N06AX26
Molecular Formula:
C18H22N2S
Molecular Weight:
298.446
Log P:
4.2580
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
40.57
CAS Number(s):
508233-74-7
Synonym(s)
1.
Vortioxetine
2.
1-(2-(2,4-Dimethylphenylsulfanyl)phenyl)piperazine
3.
Brintellix
4.
Lu AA21004
5.
Lu-AA21004
6.
LuAA21004
7.
Vortioxetine Hydrobromide
External Link(s)
MeSHD000078784
PubChem Compound9966051
71768094
BindingDB50400902
ChEBI76016
CHEMBLCHEMBL2104993
DrugBankDB09068
DrugCentral4806
IUPHAR/BPS Guide to PHARMACOLOGY7351
KEGGdr:D10184
Therapeutic Target DatabaseD03WEX
ZINC34051848
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 399US FAERS
2PruritusFAERS: 159US FAERS
3VomitingFAERS: 138US FAERS
4HeadacheFAERS: 98US FAERS
5Drug ineffectiveFAERS: 95US FAERS
6AnxietyFAERS: 89US FAERS
7Feeling abnormalFAERS: 73US FAERS
8DizzinessFAERS: 71US FAERS
9AgitationFAERS: 58US FAERS
10FatigueFAERS: 46US FAERS
11No adverse eventFAERS: 44US FAERS
12ConstipationFAERS: 43US FAERS
13AngerFAERS: 39US FAERS
14MalaiseFAERS: 39US FAERS
15SomnolenceFAERS: 35US FAERS
16Completed SuicideFAERS: 32US FAERS
17Suicide attemptFAERS: 30US FAERS
18UrticariaFAERS: 29US FAERS
19TremorFAERS: 26US FAERS
20PalpitationsFAERS: 25US FAERS
21Abdominal discomfortFAERS: 23US FAERS
22Sexual DysfunctionFAERS: 23US FAERS
23CryingFAERS: 22US FAERS
24AstheniaFAERS: 20US FAERS
25Product use issueFAERS: 18US FAERS
26Wrong technique in product usage processFAERS: 17US FAERS
27Depressed moodFAERS: 16US FAERS
28PainFAERS: 16US FAERS
29VertigoFAERS: 16US FAERS
30Abdominal PainFAERS: 15US FAERS
31Adverse eventFAERS: 15US FAERS
32Feeling jitteryFAERS: 15US FAERS
33Prescribed overdoseFAERS: 15US FAERS
34Cerebrovascular accidentFAERS: 14US FAERS
35Chest PainFAERS: 14US FAERS
36Memory impairmentFAERS: 14US FAERS
37Serotonin SyndromeFAERS: 14US FAERS
38TinnitusFAERS: 14US FAERS
39Drug prescribing errorFAERS: 13US FAERS
40PregnancyFAERS: 13US FAERS
41MyalgiaFAERS: 12US FAERS
42OverdoseFAERS: 12US FAERS
43Weight decreasedFAERS: 12US FAERS
44FlatulenceFAERS: 11US FAERS
45SyncopeFAERS: 11US FAERS
46NervousnessFAERS: 10US FAERS
47Product use in unapproved indicationFAERS: 9US FAERS
48AmnesiaFAERS: 8US FAERS
49ArthralgiaFAERS: 8US FAERS
50DehydrationFAERS: 8US FAERS
51Drug dose omissionFAERS: 8US FAERS
52EpistaxisFAERS: 8US FAERS
53Myocardial InfarctionFAERS: 8US FAERS
54Night sweatsFAERS: 8US FAERS
55PneumoniaFAERS: 8US FAERS
56AlopeciaFAERS: 7US FAERS
57BruxismFAERS: 7US FAERS
58DysgeusiaFAERS: 7US FAERS
59Euphoric moodFAERS: 7US FAERS
60HypersensitivityFAERS: 7US FAERS
61Intentional self-injuryFAERS: 7US FAERS
62Peripheral swellingFAERS: 7US FAERS
63RestlessnessFAERS: 7US FAERS
64Urinary RetentionFAERS: 7US FAERS
65ApathyFAERS: 6US FAERS
66Chest discomfortFAERS: 6US FAERS
67DyspepsiaFAERS: 6US FAERS
68EpilepsyFAERS: 6US FAERS
69Negative thoughtsFAERS: 6US FAERS
70TachycardiaFAERS: 6US FAERS
71Atrial FibrillationFAERS: 5US FAERS
72Blood glucose decreasedFAERS: 5US FAERS
73BradyphreniaFAERS: 5US FAERS
74Burning sensationFAERS: 5US FAERS
75Drug administered to patient of inappropriate ageFAERS: 5US FAERS
76Erectile dysfunctionFAERS: 5US FAERS
77Eye painFAERS: 5US FAERS
78FlushingFAERS: 5US FAERS
79GastritisFAERS: 5US FAERS
80Muscle tightnessFAERS: 5US FAERS
81Pulmonary EmbolismFAERS: 5US FAERS
82RetchingFAERS: 5US FAERS
83Unevaluable eventFAERS: 5US FAERS
84Urinary tract infectionFAERS: 5US FAERS
85ChillsFAERS: 4US FAERS
86DissociationFAERS: 4US FAERS
87Emotional disorderFAERS: 4US FAERS
88Feelings of worthlessnessFAERS: 4US FAERS
89Gastric ulcerFAERS: 4US FAERS
90HypersomniaFAERS: 4US FAERS
91HypotensionFAERS: 4US FAERS
92InfluenzaFAERS: 4US FAERS
93Lip swellingFAERS: 4US FAERS
94Musculoskeletal PainFAERS: 4US FAERS
95Rash erythematousFAERS: 4US FAERS
96SomnambulismFAERS: 4US FAERS
97SwellingFAERS: 4US FAERS
98TachyphreniaFAERS: 4US FAERS
99ThrombosisFAERS: 4US FAERS
100Urinary IncontinenceFAERS: 4US FAERS
101AbuliaFAERS: 3US FAERS
102AcneFAERS: 3US FAERS
103AkathisiaFAERS: 3US FAERS
104AngioedemaFAERS: 3US FAERS
105ArthropathyFAERS: 3US FAERS
106Back PainFAERS: 3US FAERS
107Blood glucose increasedFAERS: 3US FAERS
108Breast tendernessFAERS: 3US FAERS
109BronchitisFAERS: 3US FAERS
110CellulitisFAERS: 3US FAERS
111Dermatitis acneiformFAERS: 3US FAERS
112DisorientationFAERS: 3US FAERS
113Drug screen positiveFAERS: 3US FAERS
114DystoniaFAERS: 3US FAERS
115DysuriaFAERS: 3US FAERS
116ErythemaFAERS: 3US FAERS
117Feeling ColdFAERS: 3US FAERS
118FormicationFAERS: 3US FAERS
119Gastric BypassFAERS: 3US FAERS
120Gastrointestinal PainFAERS: 3US FAERS
121HepatitisFAERS: 3US FAERS
122HungerFAERS: 3US FAERS
123Impaired work abilityFAERS: 3US FAERS
124Mood swingsFAERS: 3US FAERS
125Mouth swellingFAERS: 3US FAERS
126Ocular discomfortFAERS: 3US FAERS
127Poor quality sleepFAERS: 3US FAERS
128Post-Traumatic Stress DisorderFAERS: 3US FAERS
129Product name confusionFAERS: 3US FAERS
130Violence-related symptomFAERS: 3US FAERS
131Visual ImpairmentFAERS: 3US FAERS
132Accidental overdoseFAERS: 2US FAERS
133Alanine Aminotransferase IncreasedFAERS: 2US FAERS
134Ankle FractureFAERS: 2US FAERS
135AnorgasmiaFAERS: 2US FAERS
136AphasiaFAERS: 2US FAERS
137AuraFAERS: 2US FAERS
138Back disorderFAERS: 2US FAERS
139Bipolar DisorderFAERS: 2US FAERS
140Blood prolactin increasedFAERS: 2US FAERS
141Blood urine presentFAERS: 2US FAERS
142ChokingFAERS: 2US FAERS
143Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
144DeafnessFAERS: 2US FAERS
145DeliriumFAERS: 2US FAERS
146DementiaFAERS: 2US FAERS
147DisabilityFAERS: 2US FAERS
148DiscomfortFAERS: 2US FAERS
149Disturbance in sexual arousalFAERS: 2US FAERS
150DiverticulitisFAERS: 2US FAERS
151Drug dispensing errorFAERS: 2US FAERS
152Drug effect incompleteFAERS: 2US FAERS
153Drug screen false positiveFAERS: 2US FAERS
154Drug withdrawal syndromeFAERS: 2US FAERS
155EcchymosisFAERS: 2US FAERS
156Emotional distressFAERS: 2US FAERS
157EncephalitisFAERS: 2US FAERS
158EnuresisFAERS: 2US FAERS
159Erythema MultiformeFAERS: 2US FAERS
160Eye irritationFAERS: 2US FAERS
161Feeling of body temperature changeFAERS: 2US FAERS
162General physical health deteriorationFAERS: 2US FAERS
163GlaucomaFAERS: 2US FAERS
164HypomaniaFAERS: 2US FAERS
165Inappropriate schedule of drug administrationFAERS: 2US FAERS
166Incorrect dose administeredFAERS: 2US FAERS
167Initial insomniaFAERS: 2US FAERS
168Intestinal ObstructionFAERS: 2US FAERS
169Joint swellingFAERS: 2US FAERS
170LethargyFAERS: 2US FAERS
171Limb discomfortFAERS: 2US FAERS
172MeningitisFAERS: 2US FAERS
173Middle insomniaFAERS: 2US FAERS
174Muscle RigidityFAERS: 2US FAERS
175Neck PainFAERS: 2US FAERS
176NephrolithiasisFAERS: 2US FAERS
177Neuroleptic Malignant SyndromeFAERS: 2US FAERS
178PancreatitisFAERS: 2US FAERS
179Panic DisorderFAERS: 2US FAERS
180ParanoiaFAERS: 2US FAERS
181Personality ChangeFAERS: 2US FAERS
182PetechiaeFAERS: 2US FAERS
183PhotophobiaFAERS: 2US FAERS
184Psychotic symptomFAERS: 2US FAERS
185Pulmonary InfarctionFAERS: 2US FAERS
186Respiratory FailureFAERS: 2US FAERS
187Restless Legs SyndromeFAERS: 2US FAERS
188Retinitis PigmentosaFAERS: 2US FAERS
189Schizoaffective DisorderFAERS: 2US FAERS
190ScreamingFAERS: 2US FAERS
191Sinus bradycardiaFAERS: 2US FAERS
192SinusitisFAERS: 2US FAERS
193SluggishnessFAERS: 2US FAERS
194Stevens-Johnson SyndromeFAERS: 2US FAERS
195StressFAERS: 2US FAERS
196Tardive DyskinesiaFAERS: 2US FAERS
197Thalamic infarctionFAERS: 2US FAERS
198Therapeutic response unexpectedFAERS: 2US FAERS
199Throat irritationFAERS: 2US FAERS
200ThrombocytopeniaFAERS: 2US FAERS
201Toxicity to various agentsFAERS: 2US FAERS
202TrichotillomaniaFAERS: 2US FAERS
203Unresponsive to stimuliFAERS: 2US FAERS
204VasculitisFAERS: 2US FAERS
205YawningFAERS: 2US FAERS
206Abnormal sleep-related eventFAERS: 1US FAERS
207Acute sinusitisFAERS: 1US FAERS
208Alcohol poisoningFAERS: 1US FAERS
209Alcohol withdrawal syndromeFAERS: 1US FAERS
210Altered state of consciousnessFAERS: 1US FAERS
211Amylase increasedFAERS: 1US FAERS
212Angle Closure GlaucomaFAERS: 1US FAERS
213AphagiaFAERS: 1US FAERS
214Aphthous StomatitisFAERS: 1US FAERS
215Apparent deathFAERS: 1US FAERS
216Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
217BRCA1 gene mutationFAERS: 1US FAERS
218BlindnessFAERS: 1US FAERS
219Blood alkaline phosphatase increasedFAERS: 1US FAERS
220Blood growth hormone increasedFAERS: 1US FAERS
221Blood sodium abnormalFAERS: 1US FAERS
222Blood sodium decreasedFAERS: 1US FAERS
223BradycardiaFAERS: 1US FAERS
224Bulimia NervosaFAERS: 1US FAERS
225Cardiac FlutterFAERS: 1US FAERS
226Carpal Tunnel SyndromeFAERS: 1US FAERS
227CataractFAERS: 1US FAERS
228CatarrhFAERS: 1US FAERS
229Cerebral InfarctionFAERS: 1US FAERS
230Cerebral ThrombosisFAERS: 1US FAERS
231Cerebral cystFAERS: 1US FAERS
232Cerebral disorderFAERS: 1US FAERS
233CheilitisFAERS: 1US FAERS
234Choking sensationFAERS: 1US FAERS
235ChorioretinitisFAERS: 1US FAERS
236Chronic sinusitisFAERS: 1US FAERS
237Contraindicated drug administeredFAERS: 1US FAERS
238Corneal OpacityFAERS: 1US FAERS
239DermatitisFAERS: 1US FAERS
240Device malfunctionFAERS: 1US FAERS
241Disease recurrenceFAERS: 1US FAERS
242Drug abuseFAERS: 1US FAERS
243Drug administration errorFAERS: 1US FAERS
244Drug dose titration not performedFAERS: 1US FAERS
245Drug ineffective for unapproved indicationFAERS: 1US FAERS
246Dry skinFAERS: 1US FAERS
247DysarthriaFAERS: 1US FAERS
248DysphemiaFAERS: 1US FAERS
249Electroencephalogram abnormalFAERS: 1US FAERS
250Epigastric discomfortFAERS: 1US FAERS
251EructationFAERS: 1US FAERS
252Erythema NodosumFAERS: 1US FAERS
253Exfoliative rashFAERS: 1US FAERS
254Exposure during breast feedingFAERS: 1US FAERS
255Exposure via fatherFAERS: 1US FAERS
256Eyelid exfoliationFAERS: 1US FAERS
257Eyelid rashFAERS: 1US FAERS
258Eyelids pruritusFAERS: 1US FAERS
259Flank PainFAERS: 1US FAERS
260FolliculitisFAERS: 1US FAERS
261Frustration tolerance decreasedFAERS: 1US FAERS
262Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
263Gastrointestinal motility disorderFAERS: 1US FAERS
264Gastrointestinal sounds abnormalFAERS: 1US FAERS
265GoutFAERS: 1US FAERS
266Head discomfortFAERS: 1US FAERS
267Head titubationFAERS: 1US FAERS
268HepatomegalyFAERS: 1US FAERS
269HerniaFAERS: 1US FAERS
270HomicideFAERS: 1US FAERS
271HostilityFAERS: 1US FAERS
272Hypertensive crisisFAERS: 1US FAERS
273HyperthyroidismFAERS: 1US FAERS
274HysterectomyFAERS: 1US FAERS
275Impaired driving abilityFAERS: 1US FAERS
276Impaired gastric emptyingFAERS: 1US FAERS
277Impaired quality of lifeFAERS: 1US FAERS
278Inability to afford medicationFAERS: 1US FAERS
279Incision site complicationFAERS: 1US FAERS
280IncontinenceFAERS: 1US FAERS
281Increased viscosity of bronchial secretionFAERS: 1US FAERS
282InfarctionFAERS: 1US FAERS
283Intentional product use issueFAERS: 1US FAERS
284Iodine uptake increasedFAERS: 1US FAERS
285Irritable Bowel SyndromeFAERS: 1US FAERS
286LacerationFAERS: 1US FAERS
287Libido disorderFAERS: 1US FAERS
288Limb injuryFAERS: 1US FAERS
289Limb operationFAERS: 1US FAERS
290Lip pruritusFAERS: 1US FAERS
291Lipase increasedFAERS: 1US FAERS
292Liver AbscessFAERS: 1US FAERS
293Long QT SyndromeFAERS: 1US FAERS
294Loss of dreamingFAERS: 1US FAERS
295Lower respiratory tract infectionFAERS: 1US FAERS
296MastectomyFAERS: 1US FAERS
297Mental impairmentFAERS: 1US FAERS
298Morbid thoughtsFAERS: 1US FAERS
299Motion SicknessFAERS: 1US FAERS
300Muscle strainFAERS: 1US FAERS
301Musculoskeletal discomfortFAERS: 1US FAERS
302Musculoskeletal stiffnessFAERS: 1US FAERS
303Mycobacterium tuberculosis complex test positiveFAERS: 1US FAERS
304Myoclonic EpilepsyFAERS: 1US FAERS
305Nerve injuryFAERS: 1US FAERS
306NeuralgiaFAERS: 1US FAERS
307NeutropeniaFAERS: 1US FAERS
308Nipple painFAERS: 1US FAERS
309Nuchal RigidityFAERS: 1US FAERS
310NystagmusFAERS: 1US FAERS
311Obsessive thoughtsFAERS: 1US FAERS
312Obsessive-Compulsive DisorderFAERS: 1US FAERS
313Opiates positiveFAERS: 1US FAERS
314OpisthotonusFAERS: 1US FAERS
315Oromandibular dystoniaFAERS: 1US FAERS
316Oropharyngeal painFAERS: 1US FAERS
317Pain of skinFAERS: 1US FAERS
318PallorFAERS: 1US FAERS
319Pancreatic CystFAERS: 1US FAERS
320Pancreatic carcinomaFAERS: 1US FAERS
321Paternal exposure during pregnancyFAERS: 1US FAERS
322PneumoconiosisFAERS: 1US FAERS
323PoisoningFAERS: 1US FAERS
324Post procedural swellingFAERS: 1US FAERS
325PresyncopeFAERS: 1US FAERS
326Product dose omissionFAERS: 1US FAERS
327PseudoanginaFAERS: 1US FAERS
328PsoriasisFAERS: 1US FAERS
329Pulmonary FibrosisFAERS: 1US FAERS
330Radiation skin injuryFAERS: 1US FAERS
331Rheumatoid ArthritisFAERS: 1US FAERS
332Seizure like phenomenaFAERS: 1US FAERS
333SepsisFAERS: 1US FAERS
334Sinus TachycardiaFAERS: 1US FAERS
335Skin test negativeFAERS: 1US FAERS
336Sleep ParalysisFAERS: 1US FAERS
337SoliloquyFAERS: 1US FAERS
338SplenomegalyFAERS: 1US FAERS
339Spontaneous penile erectionFAERS: 1US FAERS
340Subcutaneous AbscessFAERS: 1US FAERS
341Temperature intoleranceFAERS: 1US FAERS
342Tension HeadacheFAERS: 1US FAERS
343TensionFAERS: 1US FAERS
344Terminal stateFAERS: 1US FAERS
345Therapeutic product effect decreasedFAERS: 1US FAERS
346ThirstFAERS: 1US FAERS
347Tobacco userFAERS: 1US FAERS
348Toe operationFAERS: 1US FAERS
349ToothacheFAERS: 1US FAERS
350TrichorrhexisFAERS: 1US FAERS
351TrismusFAERS: 1US FAERS
352Upper-airway cough syndromeFAERS: 1US FAERS
353Urinary Tract PainFAERS: 1US FAERS
354Urinary sediment presentFAERS: 1US FAERS
355Urinary tract obstructionFAERS: 1US FAERS
356Urine amphetamine positiveFAERS: 1US FAERS
357VIIth nerve paralysisFAERS: 1US FAERS
358Victim of homicideFAERS: 1US FAERS
359Vitreous floatersFAERS: 1US FAERS
360Wound InfectionFAERS: 1US FAERS
361XerophthalmiaFAERS: 1US FAERS
362jaundiceFAERS: 1US FAERS
363Depressive disorder21486038CTD
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