MetaADEDB 2.0 @ LMMD
entacapone
(JRURYQJSLYLRLN-BJMVGYQFSA-N)
Structure
SMILES
CCN(C(=O)/C(=C/c1cc(O)c(c(c1)[N+](=O)[O-])O)/C#N)CC
Type(s)
Approved; Investigational
ATC code(s)
N04BX02
Molecular Formula:
C14H15N3O5
Molecular Weight:
305.286
Log P:
2.3046
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
130.38
CAS Number(s):
116314-67-1; 130929-57-6
Synonym(s)
1.
entacapone
2.
2-cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide
3.
Comtan
4.
Comtess
5.
OR 611
6.
OR-611
External Link(s)
MeSHC071192
PubChem Compound5281081
BindingDB50108879
ChEBI4798
CHEMBLCHEMBL953
DrugBankDB00494
DrugCentral1018
IUPHAR/BPS Guide to PHARMACOLOGY6647
KEGGcpd:C07943
dr:D00781
Therapeutic Target DatabaseD0J1VY
ZINC35342787
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 15
Canada Vigilance: 5
Canada Vigilance
US FAERS
2MalaiseFAERS: 14
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
3Feeling abnormalFAERS: 13SIDER
US FAERS
4Wrong technique in drug usage processFAERS: 13US FAERS
5PneumoniaFAERS: 10SIDER
US FAERS
6Product quality issueFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
7Muscle RigidityFAERS: 9
Canada Vigilance: 4
Canada Vigilance
US FAERS
8Neuroleptic Malignant SyndromeFAERS: 9OFFSIDES
SIDER
US FAERS
9SomnolenceFAERS: 9SIDER
US FAERS
10Blood creatine phosphokinase increasedFAERS: 8OFFSIDES
US FAERS
11Blood pressure fluctuationFAERS: 8OFFSIDES
US FAERS
12DeliriumFAERS: 8US FAERS
13DizzinessFAERS: 7
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
14Gastric FistulaFAERS: 7US FAERS
15Weight decreasedFAERS: 7SIDER
US FAERS
16AstheniaFAERS: 6
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
17Cerebrovascular accidentFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
18ChokingFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
19ChromaturiaFAERS: 6OFFSIDES
SIDER
US FAERS
20DehydrationFAERS: 6OFFSIDES
US FAERS
21TremorFAERS: 6
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
22Wrong technique in product usage processFAERS: 6US FAERS
23Abdominal PainFAERS: 5
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
SIDER
US FAERS
24General physical health deteriorationFAERS: 5OFFSIDES
US FAERS
25NauseaFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
26ThrombocytopeniaFAERS: 5SIDER
US FAERS
27Cerebral InfarctionFAERS: 4US FAERS
28CystitisFAERS: 4US FAERS
29DementiaFAERS: 4US FAERS
30Diet refusalFAERS: 4US FAERS
31Drug DependenceFAERS: 4US FAERS
32Gait inabilityFAERS: 4US FAERS
33ImmobileFAERS: 4OFFSIDES
US FAERS
34Incorrect route of drug administrationFAERS: 4US FAERS
35Medication residue presentFAERS: 4US FAERS
36Pharmaceutical product complaintFAERS: 4US FAERS
37Psychiatric symptomFAERS: 4OFFSIDES
US FAERS
38TachycardiaFAERS: 4US FAERS
39AkinesiaFAERS: 3OFFSIDES
US FAERS
40Angina PectorisFAERS: 3SIDER
US FAERS
41Back PainFAERS: 3SIDER
US FAERS
42Disease ProgressionFAERS: 3OFFSIDES
US FAERS
43DroolingFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
44Drug dose omissionFAERS: 3US FAERS
45DysgeusiaFAERS: 3SIDER
US FAERS
46IleusFAERS: 3US FAERS
47Joint swellingFAERS: 3US FAERS
48LethargyFAERS: 3US FAERS
49Musculoskeletal stiffnessFAERS: 3
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
50PalpitationsFAERS: 3US FAERS
51Pancreatic CystFAERS: 3OFFSIDES
US FAERS
52RhabdomyolysisFAERS: 3SIDER
US FAERS
53SepsisFAERS: 3US FAERS
54Sudden onset of sleepFAERS: 3OFFSIDES
US FAERS
55Suicide attemptFAERS: 3US FAERS
56AbasiaFAERS: 2OFFSIDES
US FAERS
57AgitationFAERS: 2SIDER
US FAERS
58Altered state of consciousnessFAERS: 2SIDER
US FAERS
59AnuriaFAERS: 2US FAERS
60AnxietyFAERS: 2
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
61AphagiaFAERS: 2US FAERS
62AscitesFAERS: 2US FAERS
63Benign neoplasm of adrenal glandFAERS: 2US FAERS
64Blood creatine increasedFAERS: 2US FAERS
65Blood sodium decreasedFAERS: 2US FAERS
66CellulitisFAERS: 2OFFSIDES
US FAERS
67Chest PainFAERS: 2OFFSIDES
SIDER
US FAERS
68ChillsFAERS: 2US FAERS
69Completed SuicideFAERS: 2US FAERS
70Depressed Level of ConsciousnessFAERS: 2US FAERS
71Disease recurrenceFAERS: 2US FAERS
72Drug prescribing errorFAERS: 2US FAERS
73DysphoniaFAERS: 2OFFSIDES
US FAERS
74EructationFAERS: 2US FAERS
75ErythemaFAERS: 2US FAERS
76FatigueFAERS: 2SIDER
US FAERS
77Foreign body traumaFAERS: 2US FAERS
78FractureFAERS: 2US FAERS
79Freezing phenomenonFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
80Gamma-Glutamyltransferase IncreasedFAERS: 2OFFSIDES
SIDER
US FAERS
81Gastric ulcerFAERS: 2US FAERS
82General physical condition abnormalFAERS: 2US FAERS
83Heat illnessFAERS: 2OFFSIDES
US FAERS
84IleitisFAERS: 2OFFSIDES
US FAERS
85InflammationFAERS: 2SIDER
US FAERS
86Joint sprainFAERS: 2US FAERS
87Joint stiffnessFAERS: 2US FAERS
88Loss of personal independence in daily activitiesFAERS: 2US FAERS
89Mental status changesFAERS: 2US FAERS
90MyalgiaFAERS: 2SIDER
US FAERS
91NervousnessFAERS: 2SIDER
US FAERS
92No adverse eventFAERS: 2US FAERS
93OsteoporosisFAERS: 2US FAERS
94OverdoseFAERS: 2OFFSIDES
US FAERS
95Product availability issueFAERS: 2US FAERS
96PruritusFAERS: 2SIDER
US FAERS
97Respiratory DepressionFAERS: 2US FAERS
98RetchingFAERS: 2US FAERS
99Rheumatoid ArthritisFAERS: 2US FAERS
100SplenomegalyFAERS: 2US FAERS
101Sudden deathFAERS: 2OFFSIDES
US FAERS
102SyncopeFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
103Temperature intoleranceFAERS: 2US FAERS
104Urinary IncontinenceFAERS: 2SIDER
US FAERS
105Uterine ProlapseFAERS: 2US FAERS
106White blood cell count decreasedFAERS: 2US FAERS
107Abdominal rigidityFAERS: 1US FAERS
108Adverse eventFAERS: 1US FAERS
109AnorexiaFAERS: 1SIDER
US FAERS
110Apparent deathFAERS: 1US FAERS
111Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
112Atrial FibrillationFAERS: 1SIDER
US FAERS
113BedriddenFAERS: 1OFFSIDES
US FAERS
114Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
SIDER
US FAERS
115BradykinesiaFAERS: 1US FAERS
116CataractFAERS: 1SIDER
US FAERS
117CholestasisFAERS: 1US FAERS
118Cold sweatFAERS: 1SIDER
US FAERS
119ConstipationFAERS: 1SIDER
US FAERS
120Contraindicated product administeredFAERS: 1US FAERS
121Device breakageFAERS: 1US FAERS
122Diabetes MellitusFAERS: 1US FAERS
123DiscomfortFAERS: 1SIDER
US FAERS
124DisorientationFAERS: 1US FAERS
125Drug level increasedFAERS: 1US FAERS
126DysarthriaFAERS: 1US FAERS
127Economic problemFAERS: 1US FAERS
128EosinophiliaFAERS: 1US FAERS
129Erectile dysfunctionFAERS: 1OFFSIDES
SIDER
US FAERS
130FlatulenceFAERS: 1OFFSIDES
SIDER
US FAERS
131Gastrointestinal perforationFAERS: 1OFFSIDES
US FAERS
132Gastrooesophageal sphincter insufficiencyFAERS: 1US FAERS
133GastrostomyFAERS: 1US FAERS
134GlaucomaFAERS: 1US FAERS
135HemiparesisFAERS: 1US FAERS
136HepatitisFAERS: 1OFFSIDES
SIDER
US FAERS
137HypophagiaFAERS: 1US FAERS
138Impaired self-careFAERS: 1US FAERS
139IncoherentFAERS: 1OFFSIDES
US FAERS
140Incorrect dose administeredFAERS: 1US FAERS
141InfectionFAERS: 1OFFSIDES
US FAERS
142Intentional product misuseFAERS: 1US FAERS
143Intestinal ObstructionFAERS: 1OFFSIDES
US FAERS
144Libido disorderFAERS: 1OFFSIDES
US FAERS
145Multiple drug overdose intentionalFAERS: 1US FAERS
146MydriasisFAERS: 1US FAERS
147Myocardial InfarctionFAERS: 1SIDER
US FAERS
148Myoglobin blood increasedFAERS: 1US FAERS
149Neck PainFAERS: 1US FAERS
150Oral administration complicationFAERS: 1US FAERS
151PallorFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
152Pancreatic carcinomaFAERS: 1US FAERS
153ParanoiaFAERS: 1OFFSIDES
SIDER
US FAERS
154Product difficult to swallowFAERS: 1US FAERS
155Product physical issueFAERS: 1US FAERS
156Productive CoughFAERS: 1OFFSIDES
US FAERS
157ProteinuriaFAERS: 1US FAERS
158Prothrombin level decreasedFAERS: 1US FAERS
159QuadriparesisFAERS: 1US FAERS
160Restless Legs SyndromeFAERS: 1US FAERS
161RestlessnessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
162Secondary hypertensionFAERS: 1OFFSIDES
US FAERS
163Serotonin SyndromeFAERS: 1US FAERS
164ShockFAERS: 1SIDER
US FAERS
165Skin reactionFAERS: 1
Canada Vigilance: 2
Canada Vigilance
US FAERS
166Slow response to stimuliFAERS: 1US FAERS
167Therapy cessationFAERS: 1OFFSIDES
US FAERS
168Unevaluable eventFAERS: 1US FAERS
169Urinary RetentionFAERS: 1US FAERS
170Urinary tract infectionFAERS: 1US FAERS
171UrticariaFAERS: 1SIDER
US FAERS
172VomitingFAERS: 1SIDER
US FAERS
173Wrong drug administeredFAERS: 1US FAERS
174jaundiceFAERS: 1US FAERS
175AbscessOFFSIDES
176AbuseOFFSIDES
177Acute Coronary SyndromeSIDER
178Adjustment disorder with depressed moodOFFSIDES
179AgeusiaSIDER
180Alanine Aminotransferase IncreasedOFFSIDES
181AlbuminuriaOFFSIDES
SIDER
182AmnesiaOFFSIDES
183AmphetaminesOFFSIDES
184AnhedoniaOFFSIDES
185AnisocoriaOFFSIDES
186AnosmiaOFFSIDES
187Anticholinergic SyndromeOFFSIDES
188ApathyOFFSIDES
189AphasiaCanada Vigilance: 1Canada Vigilance
190ApneaOFFSIDES
191ArteriosclerosisOFFSIDES
192ArthralgiaCanada Vigilance: 1Canada Vigilance
193ArthritisSIDER
194ArthropathyOFFSIDES
195Aspiration PneumoniaOFFSIDES
196AtaxiaSIDER
197AthetosisOFFSIDES
198AuraOFFSIDES
199B-lymphocyte count decreasedOFFSIDES
200BlepharospasmOFFSIDES
201Blood alkaline phosphatase decreasedOFFSIDES
202Blood blisterOFFSIDES
203Blood creatinine decreasedOFFSIDES
204Blood creatinine increasedOFFSIDES
205Blood glucose decreasedOFFSIDES
206Blood lactate dehydrogenase increasedOFFSIDES
207Blood urea increasedOFFSIDES
208Body temperature fluctuationOFFSIDES
209Bowel movement irregularityOFFSIDES
210BradycardiaSIDER
211BruxismOFFSIDES
212BursitisSIDER
213Carpal Tunnel SyndromeSIDER
214CataplexyOFFSIDES
215CatatoniaOFFSIDES
216Catheter related complicationOFFSIDES
217Cerebral atrophyOFFSIDES
218Chemical and Drug Induced Liver Injury19783845CTD
219CholangitisSIDER
220CholecystitisSIDER
221CholelithiasisSIDER
222Cogwheel RigidityOFFSIDES
223ColitisOFFSIDES
SIDER
224Colon adenomaOFFSIDES
225Compulsive shoppingOFFSIDES
226Concomitant disease progressionOFFSIDES
227ConjunctivitisSIDER
228Consciousness fluctuatingOFFSIDES
229Cramps of lower extremitiesSIDER
230Creatinine renal clearance decreasedOFFSIDES
231Deep Brain StimulationOFFSIDES
232Delusional disorder, persecutory typeOFFSIDES
233Depressive disorder7768276CTD
234DermatitisSIDER
235DiarrheaOFFSIDES
236DiplopiaOFFSIDES
SIDER
237Disorders of Excessive Somnolence12588639CTD
238Disseminated Intravascular CoagulationOFFSIDES
239Disturbance in sexual arousalSIDER
240DiverticulitisSIDER
241DiverticulosisOFFSIDES
242Dopamine dysregulation syndromeOFFSIDES
243DrowsinessOFFSIDES
244Drug dispensing errorOFFSIDES
245Drug resistanceOFFSIDES
246Dyskinesia, Drug-Induced

View details

CTD
247DyspepsiaSIDER
248Dysthymic DisorderOFFSIDES
249Dystonia18814889CTD
OFFSIDES
250DysuriaSIDER
251EczemaSIDER
252EncephalomalaciaOFFSIDES
253Endocardial diseaseOFFSIDES
254EndocarditisOFFSIDES
255Endocrine test abnormalOFFSIDES
256EnterocolitisOFFSIDES
257Eosinophilic PneumoniaOFFSIDES
258EpistaxisSIDER
259Erosive gastritisOFFSIDES
260Erythema MultiformeSIDER
261Esophageal StenosisOFFSIDES
262Essential TremorOFFSIDES
263Excessive daytime sleepinessSIDER
264Excessive masturbationOFFSIDES
265Extensively Drug-Resistant Tuberculosis19578428CTD
266Eye painOFFSIDES
267Eyelid DiseasesOFFSIDES
268Facial paralysisCanada Vigilance: 1Canada Vigilance
269Failure to ThriveOFFSIDES
270Feeling of body temperature changeSIDER
271Fibroadenoma of breastSIDER
272Fibroadenosis of breastSIDER
273Flight of ideasOFFSIDES
274Foaming at mouthOFFSIDES
275GamblingOFFSIDES
276GastritisSIDER
277GastroenteritisSIDER
278Gastrointestinal PainSIDER
279Gastrointestinal sounds abnormalOFFSIDES
280Glasgow coma scaleOFFSIDES
281GlobulinuriaOFFSIDES
282GranulocytosisOFFSIDES
283Hallucinations, mixedOFFSIDES
284Hallucinations12815666CTD
285HeadacheSIDER
286Hepatic calcificationOFFSIDES
287Hepatitis B antibody positiveOFFSIDES
288Hilar lymphadenopathyOFFSIDES
289HoarsenessOFFSIDES
290HyperkinesiaSIDER
291HypersensitivitySIDER
292HyperthyroidismSIDER
293HypokinesiaCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
294HypomaniaOFFSIDES
295HyporeflexiaOFFSIDES
296HypotensionCanada Vigilance: 1Canada Vigilance
SIDER
297Immediate post-injection reactionOFFSIDES
298Implantable defibrillator malfunctionOFFSIDES
299Incision site painOFFSIDES
300Infective tenosynovitisOFFSIDES
301Inflicted injurySIDER
302Infusion site mobility decreasedOFFSIDES
303Infusion site reactionOFFSIDES
304Initial insomniaOFFSIDES
305Injection site erythemaOFFSIDES
306Injection site infectionOFFSIDES
307Injection site inflammationOFFSIDES
308Intermittent ClaudicationSIDER
309Intervertebral disc disorderOFFSIDES
310Intestinal PerforationOFFSIDES
311IntubationOFFSIDES
312LeukopeniaSIDER
313Limb injuryOFFSIDES
314Lower respiratory tract infectionCanada Vigilance: 1Canada Vigilance
315Lumbar vertebra injuryOFFSIDES
316Lung consolidationOFFSIDES
317MalnutritionSIDER
318MenorrhagiaSIDER
319Mental impairmentOFFSIDES
320Middle insomniaOFFSIDES
321Mood disorder due to a general medical conditionOFFSIDES
322Muscle necrosisOFFSIDES
323Muscle relaxant therapySIDER
324Musculoskeletal PainOFFSIDES
325Musculoskeletal discomfortSIDER
326MyelodysplasiaOFFSIDES
327Narcissistic Personality DisorderOFFSIDES
328NephrolithiasisOFFSIDES
329Nervous tensionOFFSIDES
330Neutrophil count abnormalOFFSIDES
331Neutrophil count decreasedOFFSIDES
332NocturiaSIDER
333OliguriaOFFSIDES
334Oral fungal infectionOFFSIDES
335Pain managementOFFSIDES
336PainSIDER
337PanniculitisOFFSIDES
338Paranoid reactionSIDER
339Parkinson Disease

View details

CTD
340Parkinsonian Disorders18722529CTD
341Parkinsonism aggravatedSIDER
342Partner stressOFFSIDES
343Performance status decreasedOFFSIDES
344Perivascular dermatitisOFFSIDES
345PharyngitisSIDER
346PiloerectionSIDER
347PoriomaniaOFFSIDES
348Product substitution issueCanada Vigilance: 2Canada Vigilance
349Progressive supranuclear palsyOFFSIDES
350Prolonged mensesSIDER
351Pupillary light reflex tests abnormalOFFSIDES
352PurpuraSIDER
353RegurgitationOFFSIDES
354Renal cystOFFSIDES
355Renal painSIDER
356Rheumatic Heart DiseaseOFFSIDES
357RhinalgiaOFFSIDES
358RhinorrheaOFFSIDES
359ScotomaOFFSIDES
360Severe Acute Respiratory SyndromeOFFSIDES
361Sexual DysfunctionSIDER
362SilicosisOFFSIDES
363SinusitisSIDER
364Skin cold clammySIDER
365Sputum retentionOFFSIDES
366Stasis dermatitisOFFSIDES
367Stent occlusionOFFSIDES
368StiffnessSIDER
369StressOFFSIDES
370SubileusOFFSIDES
371SweatingSIDER
372TensionSIDER
373TetanyOFFSIDES
374Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
375Tooth LossOFFSIDES
376Toxic Epidermal NecrolysisSIDER
377Tuberculosis, Multidrug-Resistant19578428CTD
378Unresponsive to stimuliOFFSIDES
379Vascular purpuraSIDER
380Vasculitic rashOFFSIDES
381Venous InsufficiencyOFFSIDES
382Venous stasisOFFSIDES
383VertigoSIDER
384Visual ImpairmentCanada Vigilance: 1Canada Vigilance
SIDER
385Vulvovaginal mycotic infectionOFFSIDES
386Wound ComplicationOFFSIDES
387nervous system disorderSIDER
388treatment failureOFFSIDES
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