MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Amisulpride

(NTJOBXMMWNYJFB-UHFFFAOYSA-N)

Structure

SMILES: CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC
Type(s): Approved; Investigational
ATC code(s): N05AL05
Molecular Formula:: C17H27N3O4S
Molecular Weight:: 369.479
Log P:: 3.2759
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 2
TPSA:: 110.11
CAS Number(s):: 71675-85-9

Synonym(s)

Amisulpride

4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide

Barnetil

DAN 2163

DAN-2163

LIN 1418

LIN-1418

N-(Ethyl-1-pyrrolidinyl- 2-methyl)methoxy-2-ethylsulfonyl-5-benzamide

Solian

10.

Sultopride

11.

Sultopride Hydrochloride

External Link(s)

MeSH	D000077582
PubChem Compound	2159
BindingDB	81790
ChEBI	64045
CHEMBL	CHEMBL243712
DrugBank	DB06288
DrugCentral	179
IUPHAR/BPS Guide to PHARMACOLOGY	963
KEGG	dr:D07310
Therapeutic Target Database	D03ELL

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug withdrawal syndrome	FAERS: 1		SIDER US FAERS
2	Stress	FAERS: 1		US FAERS
3	Tension	FAERS: 1		SIDER US FAERS
4	Abdominal Pain			SIDER
5	Acute dystonia			SIDER
6	Acute glomerulonephritis			OFFSIDES
7	Acute prerenal failure			OFFSIDES
8	Aggressive reaction			SIDER
9	Agitation			SIDER
10	Agranulocytosis			SIDER
11	Akathisia, Drug-Induced		6147865	CTD
12	Akathisia			SIDER
13	Alanine Aminotransferase Increased			OFFSIDES
14	Aldolase increased			OFFSIDES
15	Amenorrhea		View details 14966260 15467977 17414262 18950388	CTD OFFSIDES
16	Amphetamines			OFFSIDES
17	Angioedema			SIDER
18	Anisocoria			OFFSIDES
19	Antibiotic Prophylaxis			OFFSIDES
20	Anticholinergic Syndrome			OFFSIDES
21	Antipsychotic drug level above therapeutic			OFFSIDES
22	Antipsychotic drug level below therapeutic			OFFSIDES
23	Antipsychotic drug level increased			OFFSIDES
24	Antiviral drug level above therapeutic			OFFSIDES
25	Anxiety			SIDER
26	Apathy			OFFSIDES
27	Asterixis			OFFSIDES
28	Asthenia			SIDER
29	Ataxia			OFFSIDES
30	Atrial Flutter			OFFSIDES
31	Atrial tachycardia			OFFSIDES
32	Autoimmune thrombocytopenia			OFFSIDES
33	Basal Ganglia Diseases		View details 10468313 12107616 16220421 19673087	CTD
34	Benign Prostatic Hyperplasia			OFFSIDES
35	Benign neoplasm of thyroid gland			OFFSIDES
36	Bipolar Disorder		12066449 12893676 19766159	CTD OFFSIDES
37	Blood alkaline phosphatase increased			OFFSIDES
38	Blood and lymphatic system disorders			SIDER
39	Blood creatine phosphokinase increased			OFFSIDES
40	Blood creatinine decreased			OFFSIDES
41	Blood creatinine increased			OFFSIDES
42	Blood immunoglobulin A decreased			OFFSIDES
43	Blood lactate dehydrogenase increased			OFFSIDES
44	Blood phosphorus decreased			OFFSIDES
45	Blood potassium increased			OFFSIDES
46	Blood pressure fluctuation			OFFSIDES
47	Blood prolactin increased			OFFSIDES
48	Blood sodium increased			OFFSIDES
49	Blood sodium			OFFSIDES
50	Blood triglycerides			OFFSIDES
51	Blood urea increased			OFFSIDES
52	Blood uric acid			OFFSIDES
53	Blunted affect			OFFSIDES
54	Body temperature fluctuation			OFFSIDES
55	Bradycardia		11778148	CTD SIDER
56	Bronchial secretion retention			OFFSIDES
57	Cardiac Arrest			SIDER
58	Cardiac Hypertrophy			OFFSIDES
59	Cardiovascular insufficiency			OFFSIDES
60	Catalepsy		12191584	CTD
61	Cataplexy			OFFSIDES
62	Catatonia		18562406	CTD
63	Cerebellar infarction			OFFSIDES
64	Chemotherapeutic drug level increased			OFFSIDES
65	Chest Pain			OFFSIDES
66	Cholecystitis			OFFSIDES
67	Chronic Obstructive Airway Disease			OFFSIDES
68	Cognition Disorders		10350027	CTD
69	Cold sweat			OFFSIDES
70	Coma acidotic			OFFSIDES
71	Concomitant disease progression			OFFSIDES
72	Confabulation			OFFSIDES
73	Congenital cystic kidney disease			OFFSIDES
74	Constipation			SIDER
75	Cytolytic hepatitis			OFFSIDES
76	Deafness			OFFSIDES
77	Deep Vein Thrombosis			SIDER
78	Dehydration			OFFSIDES
79	Delirium		15225684	CTD
80	Delusional perception			OFFSIDES
81	Depressed Level of Consciousness			OFFSIDES
82	Depressive disorder		7586996	CTD
83	Dizziness			SIDER
84	Drowsiness			OFFSIDES
85	Drug abuser			OFFSIDES
86	Drug toxicity			OFFSIDES
87	Dyskinesia, Drug-Induced		6117919 18794659	CTD
88	Dyspepsia			SIDER
89	Dystonia		View details 18504810 18597910 18603743 18794659 19482053 19944732 20686163 20935407	CTD SIDER
90	Electrocardiogram QT interval abnormal			OFFSIDES
91	Elevated mood			OFFSIDES
92	Encephalitis			OFFSIDES
93	Endocrine System Diseases		10468313	CTD
94	Enuresis			OFFSIDES
95	Epididymitis			OFFSIDES
96	Erectile dysfunction			SIDER
97	Escherichia infection			OFFSIDES
98	Fatigue			SIDER
99	Fatty Liver			OFFSIDES
100	Fever		15641884	CTD
101	Full blood count decreased			OFFSIDES
102	Galactorrhea		14966260 15467977 18950388	CTD OFFSIDES
103	Gamma-Glutamyltransferase Increased			OFFSIDES
104	Gastrointestinal Pain			SIDER
105	Gastrointestinal obstruction			OFFSIDES
106	General physical condition			OFFSIDES
107	General physical health deterioration			OFFSIDES
108	Globulinuria			OFFSIDES
109	Granulocytosis			OFFSIDES
110	Hallucinations, mixed			OFFSIDES
111	Headache		15811908	CTD SIDER
112	Heat Stroke			OFFSIDES
113	Hemiparesis			OFFSIDES
114	Hernia			OFFSIDES
115	Hyperprolactinemia		View details 12106810 12144950 14509051 14966260 15225684 15467977 15665803 16938372 16942633 17414262 17606473 18063941 18585544 18950385 18950388 19265646 20732372	CTD
116	Hypersensitivity			SIDER
117	Hypertensive heart disease			OFFSIDES
118	Hypertriglyceridemia		18950385	CTD
119	Hypocalcemia		15953230	CTD
120	Hypokinesia		2880435	CTD OFFSIDES SIDER
121	Hypotension			SIDER
122	Ileectomy			OFFSIDES
123	Implantable defibrillator insertion			OFFSIDES
124	Inappropriate affect			OFFSIDES
125	Infusion site mobility decreased			OFFSIDES
126	Injection site infection			OFFSIDES
127	Intestinal infarction			OFFSIDES
128	Joint stiffness			OFFSIDES
129	Kidney Failure			OFFSIDES
130	Lethargy			OFFSIDES
131	Leukocytosis		15641884	CTD
132	Leukopenia neonatal			OFFSIDES
133	Leukopenia			SIDER
134	Locked-In Syndrome			OFFSIDES
135	Long QT Syndrome		15953230	CTD OFFSIDES
136	Lumbar puncture abnormal			OFFSIDES
137	Lung infection pseudomonal			OFFSIDES
138	Lymphocyte count decreased			OFFSIDES
139	Lymphocytosis			OFFSIDES
140	Lymphoma			OFFSIDES
141	Mallory-Weiss Syndrome			OFFSIDES
142	Malnutrition			SIDER
143	Meningorrhagia			OFFSIDES
144	Menstruation Disturbances		18950385	CTD
145	Mental disorders		16856516	CTD
146	Mental impairment			OFFSIDES
147	Motor retardation			OFFSIDES
148	Movement Disorders		16963229 17700005	CTD
149	Multiple drug overdose			OFFSIDES
150	Multiple drug overdose intentional			OFFSIDES
151	Muscle Rigidity			SIDER
152	Myasthenia Gravis			OFFSIDES
153	Myocardial Infarction		17645196	CTD
154	Nausea			SIDER
155	Nephrolithiasis			OFFSIDES
156	Nervousness			SIDER
157	Neuroleptic Malignant Syndrome		18562406 18774435	CTD OFFSIDES SIDER
158	Neutropenia			SIDER
159	Neutrophil count decreased			OFFSIDES
160	Ocular Motility Disorders		18603743 20935407	CTD
161	Oculogyric crisis			SIDER
162	Orchitis			OFFSIDES
163	Oropharyngeal pain			OFFSIDES
164	Overdose			OFFSIDES
165	Overweight			OFFSIDES
166	Pancreatitis			OFFSIDES
167	Pericarditis			OFFSIDES
168	Peritonitis			OFFSIDES
169	Pleocytosis			OFFSIDES
170	Poor personal hygiene			OFFSIDES
171	Poverty			OFFSIDES
172	Pregnancy			SIDER
173	Protein C decreased			OFFSIDES
174	Protein total decreased			OFFSIDES
175	Pruritus			SIDER
176	Psychomotor skills impaired			OFFSIDES
177	Psychoses, Alcoholic		19482053	CTD
178	Psychoses, Substance-Induced		11000703	CTD
179	Psychotic Disorders		15467977 16220421 19766159	CTD
180	Pulmonary Embolism			SIDER
181	Pulmonary congestion			OFFSIDES
182	Rebound effect			OFFSIDES
183	Renal Colic			OFFSIDES
184	Renal abscess			OFFSIDES
185	Renal cancer metastatic			OFFSIDES
186	Respiratory Failure			OFFSIDES
187	Rhabdomyolysis		15641884	CTD OFFSIDES
188	Schizophrenia		View details 6147865 8996184 10221135 11829208 12893676 14966260 16225977 16942633 16963229 18308817 18504810 18774435 19673087 20050717 25085534	CTD
189	Sleep Initiation and Maintenance Disorders		20050717	CTD
190	Somnolence			SIDER
191	Sopor			OFFSIDES
192	Spermatozoa progressive motility decreased			OFFSIDES
193	Staring			OFFSIDES
194	Status Epilepticus			OFFSIDES
195	Subacute endocarditis			OFFSIDES
196	Subcutaneous Abscess			OFFSIDES
197	Subileus			OFFSIDES
198	Sudden death			OFFSIDES SIDER
199	Suicide attempt			SIDER
200	Tardive Dyskinesia			OFFSIDES SIDER
201	Terminal state			OFFSIDES
202	Therapy cessation			OFFSIDES
203	Thrombotic stroke			OFFSIDES
204	Tobacco user			OFFSIDES
205	Tongue biting			OFFSIDES
206	Torsades de Pointes		1363741 18957479	CTD
207	Transaminases increased			OFFSIDES
208	Tremor		20050717	CTD SIDER
209	Trismus		18603743	CTD SIDER
210	Troponin I increased			OFFSIDES
211	Troponin T			OFFSIDES
212	Urinary Incontinence		18609424	CTD
213	Urticaria			SIDER
214	Venous Thromboembolism			SIDER
215	Ventricular Fibrillation			SIDER
216	Ventricular arrhythmia			SIDER
217	Vomiting		15811908	CTD SIDER
218	Weight Gain		14966260 18950385	CTD
219	Weight decreased			SIDER
220	Wound Infection			OFFSIDES
221	nervous system disorder			SIDER

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