MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Vitamin A

(FPIPGXGPPPQFEQ-OVSJKPMPSA-N)

Structure

SMILES: OC/C=C(/C=C/C=C(/C=C/C1=C(C)CCCC1(C)C)\C)\C
Type(s): Approved; Nutraceutical; Vet_approved
ATC code(s): A11CA01; D10AD02; R01AX02; S01XA02; V04CB01
Molecular Formula:: C20H30O
Molecular Weight:: 286.452
Log P:: 5.5103
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 1
TPSA:: 20.23
CAS Number(s):: 68-26-8; 11103-57-4

Synonym(s)

Vitamin A

Retinol

11-cis-Retinol

3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer

All-Trans-Retinol

Aquasol A

Vitamin A1

All Trans Retinol

External Link(s)

MeSH	D014801
PubChem Compound	445354
BindingDB	50092056
ChEBI	17336
CHEMBL	CHEMBL986
DrugBank	DB00162
DrugCentral	2831
IUPHAR/BPS Guide to PHARMACOLOGY	4053
KEGG	cpd:C00473 cpd:C17276 dr:D00069 dr:D06543
Therapeutic Target Database	D0S7WX D0AO6P
ZINC	3831417

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Accidental exposure	FAERS: 2		OFFSIDES US FAERS
2	Product label issue	FAERS: 2		US FAERS
3	Pruritus	FAERS: 2		US FAERS
4	Urticaria	FAERS: 2	11792017	CTD US FAERS
5	Vitreous floaters	FAERS: 2		US FAERS
6	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
7	Application site pain	FAERS: 1		US FAERS
8	Application site swelling	FAERS: 1		US FAERS
9	Arthralgia	FAERS: 1		US FAERS
10	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
11	Blood alkaline phosphatase increased	FAERS: 1		US FAERS
12	Chemical burn of skin	FAERS: 1		US FAERS
13	Chemical injury	FAERS: 1		OFFSIDES US FAERS
14	Cholestatic liver injury	FAERS: 1		US FAERS
15	Depressed Level of Consciousness	FAERS: 1		US FAERS
16	Drug ineffective	FAERS: 1		US FAERS
17	Excessive dietary supplement intake	FAERS: 1		US FAERS
18	Eye irritation	FAERS: 1		US FAERS
19	Hepatotoxicity	FAERS: 1		OFFSIDES US FAERS
20	Hydrocephalus	FAERS: 1	7477116 13410607	CTD US FAERS
21	Hyperreflexia	FAERS: 1		OFFSIDES US FAERS
22	Hypersensitivity	FAERS: 1		SIDER US FAERS
23	Hypervitaminosis A	FAERS: 1	View details 2324882 4641958 4810330 4843409 6071832 6500549 8963427 11824142 16054864 19619235 19944093	CTD OFFSIDES US FAERS
24	Hypotension	FAERS: 1		US FAERS
25	Incorrect dose administered	FAERS: 1		US FAERS
26	Incorrect route of drug administration	FAERS: 1		US FAERS
27	Leukocytosis	FAERS: 1		US FAERS
28	Metabolic acidosis	FAERS: 1		US FAERS
29	Pain	FAERS: 1	4473880 6071832	CTD OFFSIDES US FAERS
30	Presyncope	FAERS: 1		US FAERS
31	Respiratory Depression	FAERS: 1		US FAERS
32	Skeletal survey abnormal	FAERS: 1		US FAERS
33	Splenomegaly	FAERS: 1		US FAERS
34	Sunburn	FAERS: 1		US FAERS
35	Tachycardia	FAERS: 1		US FAERS
36	Thrombocytopenia	FAERS: 1		US FAERS
37	Toxicity to various agents	FAERS: 1		US FAERS
38	Visual Impairment	FAERS: 1		US FAERS
39	Abasia			OFFSIDES
40	Abdominal Pain			OFFSIDES
41	Abdominal discomfort			OFFSIDES
42	Abdominal rigidity			OFFSIDES
43	Abnormal vision			OFFSIDES
44	Abnormalities, Drug-Induced		4810330 7477116 8602193	CTD
45	Abscess			OFFSIDES
46	Accidental overdose	Canada Vigilance: 1		Canada Vigilance
47	Acid reflux			OFFSIDES
48	Acne Vulgaris		View details 151668 5467368 6455256 6780129 7769163 8239326 11824142	CTD
49	Acne			OFFSIDES
50	Actinic keratosis			OFFSIDES
51	Acute bronchitis			OFFSIDES
52	Acute kidney injury		1248399	CTD
53	Acute respiratory failure			OFFSIDES
54	Acute sinusitis			OFFSIDES
55	Adenoma			OFFSIDES
56	Ageusia			OFFSIDES
57	Agraphia			OFFSIDES
58	Alcoholic Intoxication			OFFSIDES
59	Aldolase increased			OFFSIDES
60	Alopecia			OFFSIDES
61	Amblyopia		7460169	CTD
62	Anaphylactic shock			SIDER
63	Anemia, Hemolytic		4684742	CTD
64	Anemia		1248399 11965502 16960172	CTD
65	Anhedonia			OFFSIDES
66	Anorexia			OFFSIDES
67	Anticholinergic Syndrome			OFFSIDES
68	Antinuclear antibody increased			OFFSIDES
69	Anxiety			OFFSIDES
70	Apathy			OFFSIDES
71	Aphagia			OFFSIDES
72	Aphonia			OFFSIDES
73	Aphthous Stomatitis			OFFSIDES
74	Arthritis			OFFSIDES
75	Ascites		636413 4045180	CTD OFFSIDES
76	Aspergillosis			OFFSIDES
77	Asthenia			OFFSIDES
78	Asthma		16732791	CTD
79	Atrial tachycardia			OFFSIDES
80	Autoimmune thyroiditis			OFFSIDES
81	Benign neoplasm of thyroid gland			OFFSIDES
82	Biopsy			OFFSIDES
83	Blindness		7763066 12290005	CTD
84	Blood Glucose			OFFSIDES
85	Blood cholesterol			OFFSIDES
86	Blood creatine phosphokinase increased			OFFSIDES
87	Blood creatinine increased			OFFSIDES
88	Blood lactate dehydrogenase abnormal			OFFSIDES
89	Blood potassium increased			OFFSIDES
90	Blood pressure fluctuation			OFFSIDES
91	Blood prolactin increased			OFFSIDES
92	Blood testosterone decreased			OFFSIDES
93	Blood uric acid			OFFSIDES
94	Blood urine present			OFFSIDES
95	Blurred vision			OFFSIDES
96	Body Temperature			OFFSIDES
97	Bone Diseases, Developmental		7229658	CTD
98	Bone Diseases		946392	CTD
99	Bone lesion			OFFSIDES
100	Bone pain			OFFSIDES
101	Bone scan abnormal			OFFSIDES
102	Bradycardia			OFFSIDES
103	Brain Diseases		4810330	CTD
104	Brain Edema		4593602	CTD
105	Breast tenderness			OFFSIDES
106	Bronchitis			OFFSIDES
107	Bronchopulmonary Dysplasia		15713907 17377406 17426644	CTD
108	Bruxism			OFFSIDES
109	Bunion			OFFSIDES
110	Burning sensation			OFFSIDES
111	CD4 Lymphocytes Decreased			OFFSIDES
112	Cardiomyopathies		8169849	CTD
113	Cataract operation			OFFSIDES
114	Cataract		11438049	CTD OFFSIDES
115	Catheter site infection			OFFSIDES
116	Cellulitis			OFFSIDES
117	Central venous catheter removal			OFFSIDES
118	Cervicobrachial syndrome			OFFSIDES
119	Chemical and Drug Induced Liver Injury		View details 4684742 4843409 6500549 6668507 6681608 7985711 16448456 17151585 17924304	CTD
120	Chemotherapeutic drug level increased			OFFSIDES
121	Chest Pain			OFFSIDES
122	Child Nutrition Disorders		16153327	CTD
123	Choking sensation			OFFSIDES
124	Cholangiolitis			OFFSIDES
125	Cholestasis		16175620 19944093	CTD
126	Chromatopsia			OFFSIDES
127	Chromaturia	Canada Vigilance: 1		Canada Vigilance OFFSIDES
128	Chronic Obstructive Airway Disease			OFFSIDES
129	Cleft Palate		16054864	CTD
130	Collagen-vascular disease			OFFSIDES
131	Colonic Neoplasms		16267017 17219422	CTD
132	Complex partial seizures			OFFSIDES
133	Compression fracture			OFFSIDES
134	Congenital tricuspid valve incompetence			OFFSIDES
135	Conjunctival deposit			OFFSIDES
136	Corneal Diseases		6716538	CTD
137	Coronary artery insufficiency			OFFSIDES
138	Craniofacial Abnormalities		10992263	CTD
139	Crystalluria			OFFSIDES
140	Cyanopsia			OFFSIDES
141	Decreased Libido			OFFSIDES
142	Delusional disorder, unspecified type			OFFSIDES
143	Demyelination			OFFSIDES
144	Denture wearer			OFFSIDES
145	Depressed mood			OFFSIDES
146	Depressive disorder		4810330 6071832	CTD
147	Dermatomyositis			OFFSIDES
148	Diabetic ulcer			OFFSIDES
149	Diarrhea			OFFSIDES
150	Diastolic dysfunction			OFFSIDES
151	Diplopia		View details 4473880 5467368 6780129 8239326	CTD OFFSIDES
152	Disturbance in sexual arousal			OFFSIDES
153	Dizziness		4473880	CTD OFFSIDES
154	Drowsiness			OFFSIDES
155	Drug Eruptions		11792017	CTD
156	Drug Overdose		844241 4045180	CTD
157	Drug addict			OFFSIDES
158	Drug administration error			OFFSIDES
159	Drug prescribing error			OFFSIDES
160	Drug toxicity			OFFSIDES
161	Drug withdrawal headache			OFFSIDES
162	Dry Eye Syndromes		16146918	CTD
163	Dry skin			OFFSIDES
164	Dysgeusia			OFFSIDES
165	Eales disease		9068938	CTD
166	Ear discomfort			OFFSIDES
167	Ectromelia		16054864	CTD
168	Edema		6071832	CTD
169	Electrocardiogram ST segment abnormal			OFFSIDES
170	Electrocardiogram ST-T segment abnormal			OFFSIDES
171	Electromechanical dissociation			OFFSIDES
172	Endometrial Hyperplasia			OFFSIDES
173	Enterococcal infection			OFFSIDES
174	Erectile dysfunction			OFFSIDES
175	Erythema			OFFSIDES
176	Escherichia sepsis			OFFSIDES
177	Escherichia urinary tract infection			OFFSIDES
178	Esophageal and Gastric Varices		303561	CTD
179	Euphoric mood			OFFSIDES
180	Eye Infection			OFFSIDES
181	Eye pain			OFFSIDES
182	Eyelid Diseases			OFFSIDES
183	Facial wasting			OFFSIDES
184	Fatigue		6071832	CTD OFFSIDES
185	Fatty Liver		6681608	CTD
186	Feeling Cold			OFFSIDES
187	Fetal Death		16028844	CTD
188	Fetal Resorption		16054864	CTD
189	Fibromyalgia		7610649	CTD OFFSIDES
190	Fibrosis		6681608 10681193 16448456	CTD
191	Flatulence			OFFSIDES
192	Fluid overload			OFFSIDES
193	Foreign body sensation in eyes			OFFSIDES
194	Gamma-glutamyltransferase abnormal			OFFSIDES
195	Gastrointestinal toxicity			OFFSIDES
196	General physical health deterioration			OFFSIDES
197	Glaucoma			OFFSIDES
198	Glossitis			OFFSIDES
199	Granuloma			OFFSIDES
200	HIV Infections		16960176	CTD
201	HIV Seropositivity		17209195	CTD
202	Headache	Canada Vigilance: 1	View details 4473880 5467368 6138537 6780129 8239326 8963427	CTD Canada Vigilance
203	Heart sounds abnormal			OFFSIDES
204	Hepatitis B			OFFSIDES
205	Hepatitis C, Chronic		11012474	CTD
206	Hepatitis C			OFFSIDES
207	Hepatitis			OFFSIDES
208	Hepatomegaly		6071832 6668507	CTD
209	Hypercalcemia		View details 1248399 3237276 4273771 4473880 4641958 4684742 6788164 7179960 7292640 11225264 15496578	CTD
210	Hypereosinophilic syndrome			OFFSIDES
211	Hyperkeratosis			OFFSIDES
212	Hyperoxaluria			OFFSIDES
213	Hyperplasia		10681193 12555267	CTD
214	Hypertriglyceridemia		4045180	CTD
215	Hypesthesia		6701590	CTD
216	Hypoaesthesia facial			OFFSIDES
217	Hypochondriasis			OFFSIDES
218	Hypokinesia		17673185 17698304 17727954	CTD
219	Hypotrichosis		6071832	CTD
220	Hysterectomy			OFFSIDES
221	Idiopathic intracranial hypertension with papilledema		7769163	CTD
222	Impetigo			OFFSIDES
223	Incontinence			OFFSIDES
224	Infection			OFFSIDES
225	Inflammation		6681608	CTD
226	Initial insomnia			OFFSIDES
227	Injection site dermatitis			OFFSIDES
228	Injection site pallor			OFFSIDES
229	Injection site stinging			OFFSIDES
230	Injury asphyxiation			OFFSIDES
231	Intertrigo			OFFSIDES
232	Intestinal Neoplasms		4703115	CTD
233	Intracranial Hypertension		3993456 15955940	CTD
234	Joint injury			OFFSIDES
235	Joint warmth			OFFSIDES
236	Keratitis sicca			OFFSIDES
237	Keratorhexis			OFFSIDES
238	Lactose Intolerance			OFFSIDES
239	Leukopenia neonatal			OFFSIDES
240	Lichen Planus			OFFSIDES
241	Ligament injury			OFFSIDES
242	Limb Deformities, Congenital		16054864	CTD
243	Limb discomfort			OFFSIDES
244	Limb injury			OFFSIDES
245	Livedo Reticularis			OFFSIDES
246	Liver Cirrhosis, Experimental		16248980	CTD
247	Liver Cirrhosis		View details 303561 636413 1470008 2324882 4810330 4843409 10750659 11012474 16256175 17151585 18755329	CTD
248	Liver Neoplasms, Experimental		17113696	CTD
249	Liver diseases		10424294 16175620	CTD
250	Liver neoplasms		2055368	CTD
251	Lung Neoplasms		27506545	CTD
252	Lung diseases		16863852	CTD
253	Lung hyperinflation			OFFSIDES
254	Malformations of Cortical Development		8180004	CTD
255	Malignant neoplasm progression			OFFSIDES
256	Meningioma			OFFSIDES
257	Metastatic Renal Cell Carcinoma			OFFSIDES
258	Microcephaly		665178	CTD
259	Middle insomnia			OFFSIDES
260	Migraine with Aura			OFFSIDES
261	Multiple Myeloma		16374440	CTD
262	Multiple drug overdose			OFFSIDES
263	Multiple sclerosis relapse			OFFSIDES
264	Muscle Weakness			OFFSIDES
265	Musculoskeletal Diseases		4473880	CTD
266	Musculoskeletal Pain			OFFSIDES
267	Musculoskeletal chest pain			OFFSIDES
268	Nasal mucosal disorder			OFFSIDES
269	Nasopharyngitis			OFFSIDES
270	Nausea	Canada Vigilance: 1	2403062 8963427	CTD OFFSIDES Canada Vigilance
271	Necrosis		6681608 7519440 18676402	CTD
272	Negative thoughts			OFFSIDES
273	Neonatal hypotension			OFFSIDES
274	Neoplasms		6668507	CTD
275	Nephrogenic Fibrosing Dermopathy			OFFSIDES
276	Nephrolithiasis			OFFSIDES
277	Nephrosis		12660332	CTD
278	Neural Tube Defects		View details 6635991 7477116 8180004 8602193 16028844 17400914	CTD
279	Neurobehavioral Manifestations		6668507	CTD
280	Neurodermatitis			OFFSIDES
281	Neuroleptic Malignant Syndrome			OFFSIDES
282	Neurotoxicity Syndromes		12652617	CTD
283	Nodule			OFFSIDES
284	Occult blood positive			OFFSIDES
285	Ocular icterus			OFFSIDES
286	Open wound			OFFSIDES
287	Optic Disc Edema			OFFSIDES
288	Oral infection			OFFSIDES
289	Oral mucosal exfoliation			OFFSIDES
290	Oropharyngeal pain			OFFSIDES
291	Oropharyngeal spasm			OFFSIDES
292	Osteopenia			OFFSIDES
293	Osteoporosis			OFFSIDES
294	Oxygen saturation abnormal			OFFSIDES
295	Pallor	Canada Vigilance: 1		Canada Vigilance
296	Pancreatic Pseudocyst			OFFSIDES
297	Pancytopenia		6701590	CTD
298	Papilledema		View details 151668 4037599 4473880 5467368 6780129	CTD
299	Papilloma			OFFSIDES
300	Paranoia			OFFSIDES
301	Pericarditis			OFFSIDES
302	Peripheral arterial occlusive disease			OFFSIDES
303	Peritonitis			OFFSIDES
304	Peritonsillar Abscess			OFFSIDES
305	Pigmentation Disorders		19648781 19852122	CTD
306	Pleurodesis			OFFSIDES
307	Pneumoconiosis			OFFSIDES
308	Pneumocystis jiroveci pneumonia			OFFSIDES
309	Pneumothorax			OFFSIDES
310	Poisoning		19145591	CTD
311	Polymenorrhea			OFFSIDES
312	Posturing			OFFSIDES
313	Pre-existing condition improved			OFFSIDES
314	Precancerous Conditions		2055368	CTD
315	Pregnancy Complications		4810330	CTD
316	Prenatal Exposure Delayed Effects		665178 7229658	CTD
317	Productive Cough			OFFSIDES
318	Pseudotumor Cerebri		View details 130200 151668 844241 1463588 5467368 6780129 6890166 7289761 8239326 11824142 15818308 19619235	CTD
319	Psoriasis		View details 267312 303561 4473880 14746632	CTD
320	Pulmonary Hypertension			OFFSIDES
321	Pulmonary congestion			OFFSIDES
322	Pyelonephritis			OFFSIDES
323	QRS axis abnormal			OFFSIDES
324	Rectal Prolapse			OFFSIDES
325	Rectal polyp			OFFSIDES
326	Reflex, Abnormal		4473880	CTD
327	Renal cyst			OFFSIDES
328	Renal tubular necrosis			OFFSIDES
329	Respiratory Distress Syndrome, Newborn		16877224	CTD
330	Respiratory Failure			OFFSIDES
331	Retinal Vein Occlusion			OFFSIDES
332	Retinal vascular occlusion			OFFSIDES
333	Rheumatoid Nodule			OFFSIDES
334	Rhinorrhea			OFFSIDES
335	Salpingectomy			OFFSIDES
336	Schizophrenia		4810330	CTD
337	Scleroderma			OFFSIDES
338	Scotoma			OFFSIDES
339	Semen volume decreased			OFFSIDES
340	Septic Shock			OFFSIDES
341	Sinus bradycardia			OFFSIDES
342	Sinusitis			OFFSIDES
343	Skin lesion			OFFSIDES
344	Spina Bifida Cystica		8422324	CTD
345	Stevens-Johnson Syndrome			OFFSIDES
346	Synovitis			OFFSIDES
347	Tendinitis			OFFSIDES
348	Tenosynovitis			OFFSIDES
349	Tension Headache			OFFSIDES
350	Teratozoospermia		30944279	CTD
351	Testicular Diseases		30944279	CTD
352	Thalamic infarction			OFFSIDES
353	Tinnitus			OFFSIDES
354	Tobacco user			OFFSIDES
355	Tooth Extraction			OFFSIDES
356	Tracheobronchitis			OFFSIDES
357	Urinary tract infection pseudomonal			OFFSIDES
358	Urine output increased			OFFSIDES
359	Vertebral column mass			OFFSIDES
360	Vision Disorders		4037599	CTD
361	Visual disturbance			OFFSIDES
362	Vitamin A Deficiency		16146918 16175781 16960172	CTD OFFSIDES
363	Vomiting		2403062 6780129	CTD
364	Waxy flexibility			OFFSIDES
365	Wound infection staphylococcal			OFFSIDES
366	colonoscopy			OFFSIDES
367	effusion			OFFSIDES
368	jaundice		19944093	CTD
369	keratoacanthoma			OFFSIDES
370	kyphosis			OFFSIDES

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