MetaADEDB 2.0 @ LMMD
Methotrimeprazine
(VRQVVMDWGGWHTJ-CQSZACIVSA-N)
Structure
SMILES
COc1ccc2c(c1)N(C[C@@H](CN(C)C)C)c1c(S2)cccc1
Type(s)
Approved; Investigational
ATC code(s)
N05AA02
Molecular Formula:
C19H24N2OS
Molecular Weight:
328.472
Log P:
4.5606
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
41.01
CAS Number(s):
60-99-1; 7104-38-3
Synonym(s)
1.
Methotrimeprazine
2.
Levomeprazin
3.
Levomepromazine
4.
Levopromazine
5.
Tisercin
6.
Tizercine
7.
Tizertsin
External Link(s)
MeSHD008728
PubChem Compound72287
BindingDB50418049
ChEBI6838
CHEMBLCHEMBL1764
DrugBankDB01403
DrugCentral1752
IUPHAR/BPS Guide to PHARMACOLOGY7603
KEGGcpd:C07192
dr:D00403
Therapeutic Target DatabaseD0W2BW
D09LZT
ZINC20246
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AbuseOFFSIDES
2Activated partial thromboplastin time shortenedOFFSIDES
3Activation syndromeOFFSIDES
4Acute bronchitisOFFSIDES
5AgranulocytosisSIDER
6Akathisia, Drug-Induced12381501CTD
7AkinesiaOFFSIDES
8Alanine Aminotransferase IncreasedOFFSIDES
9Alcoholic IntoxicationOFFSIDES
10Altered state of consciousnessOFFSIDES
11AlveolitisOFFSIDES
12AmenorrheaOFFSIDES
13AmphetaminesOFFSIDES
14AnorexiaOFFSIDES
15Antibody test abnormalOFFSIDES
16Anticholinergic SyndromeOFFSIDES
17Antipsychotic drug level below therapeuticOFFSIDES
18Antiviral drug level above therapeuticOFFSIDES
19AnuriaOFFSIDES
20AnxietyOFFSIDES
21Apallic syndromeOFFSIDES
22ApathyOFFSIDES
23ApneaOFFSIDES
24ArteriosclerosisOFFSIDES
25AsphyxiaOFFSIDES
26Aspiration PneumoniaOFFSIDES
27AuraOFFSIDES
28B-lymphocyte count decreasedOFFSIDES
29B-lymphocyte count increasedOFFSIDES
30Benign Prostatic HyperplasiaOFFSIDES
31Blast cells presentOFFSIDES
32BlepharoptosisOFFSIDES
33BlepharospasmOFFSIDES
34Blood albumin decreasedOFFSIDES
35Blood alcohol increasedOFFSIDES
36Blood alkaline phosphatase decreasedOFFSIDES
37Blood amylase increasedOFFSIDES
38Blood cholinesterase decreasedOFFSIDES
39Blood creatine phosphokinase increasedOFFSIDES
40Blood creatinine increasedOFFSIDES
41Blood lactate dehydrogenase increasedOFFSIDES
42Blood magnesium increasedOFFSIDES
43Blood osmolarity decreasedOFFSIDES
44Blood sodiumOFFSIDES
45Blood triglycerides increasedOFFSIDES
46Blood urea increasedOFFSIDES
47Body TemperatureOFFSIDES
48Bone marrow toxicityOFFSIDES
49Bradycardia10464538CTD
50Cardiac HypertrophyOFFSIDES
51Cardio-respiratory distressOFFSIDES
52Cardioactive drug levelOFFSIDES
53CatatoniaOFFSIDES
54Cerebral circulatory failureOFFSIDES
55Cerebral disorderOFFSIDES
56Ceruloplasmin decreasedOFFSIDES
57Chemotherapeutic drug level increasedOFFSIDES
58ChokingOFFSIDES
59Chronic Fatigue SyndromeOFFSIDES
60Chronic left ventricular failureOFFSIDES
61Citrobacter infectionOFFSIDES
62Cogwheel RigidityOFFSIDES
63Completed SuicideCanada Vigilance: 1Canada Vigilance
OFFSIDES
64ConfabulationOFFSIDES
65Confusion8876855CTD
66Congenital HydrocephalusOFFSIDES
67Congenital acrochordonOFFSIDES
68Congenital hearing disorderOFFSIDES
69Congenital vaginal cystOFFSIDES
70Consciousness fluctuatingOFFSIDES
71ConstipationSIDER
72ContractureOFFSIDES
73Creatinine renal clearance decreasedOFFSIDES
74CystOFFSIDES
75Cytomegalovirus myocarditisOFFSIDES
76DactylitisOFFSIDES
77Delusional disorder, persecutory typeOFFSIDES
78Depressed Level of ConsciousnessOFFSIDES
79Depressed moodOFFSIDES
80Depressive disorder8238650CTD
81DextrocardiaOFFSIDES
82Diabetes InsipidusOFFSIDES
83Diet refusalOFFSIDES
84Disruptive, Impulse Control, and Conduct Disorders6458665CTD
85Disseminated Intravascular Coagulation10464538CTD
86Disturbance in sexual arousalOFFSIDES
87DrowsinessOFFSIDES
SIDER
88Drug exposure during pregnancyOFFSIDES
89Drug ineffectiveCanada Vigilance: 1Canada Vigilance
90Drug toxicityOFFSIDES
91Dyskinesia, Drug-Induced3978350CTD
92Dyspnea10653217CTD
93Dysthymic DisorderOFFSIDES
94Dystonia8876855CTD
95Educational problemOFFSIDES
96Endotoxic shockOFFSIDES
97Enterococcal infectionOFFSIDES
98Eosinophil percentage decreasedOFFSIDES
99Eosinophilic PneumoniaOFFSIDES
100Eosinophilic myocarditisOFFSIDES
101EpilepsyOFFSIDES
102Erectile dysfunctionOFFSIDES
103ExcoriationOFFSIDES
104Feeding disorder neonatalOFFSIDES
105Fibrosis17631667CTD
106Food AllergyOFFSIDES
107GalactorrheaOFFSIDES
108Gamma-Glutamyltransferase IncreasedOFFSIDES
109GangreneOFFSIDES
110Gastrointestinal hypomotilityOFFSIDES
111Gastrointestinal motility disorderOFFSIDES
112Gastrointestinal obstructionOFFSIDES
113General physical health deteriorationOFFSIDES
114Gingival HyperplasiaOFFSIDES
115Gingival erythemaOFFSIDES
116GlossoptosisOFFSIDES
117Granulocyte count decreasedOFFSIDES
118GranulocytosisOFFSIDES
119Grip strengthOFFSIDES
120Hallucinations, mixedOFFSIDES
121Hallucinations10362445CTD
122Heart Diseases17631667CTD
123Heart sounds abnormalOFFSIDES
124Hepatic congestionOFFSIDES
125HepatitisOFFSIDES
126Histrionic Personality DisorderOFFSIDES
127HomicideOFFSIDES
128Human herpes virus 6 serology positiveOFFSIDES
129HypercreatininaemiaOFFSIDES
130HypersensitivitySIDER
131HypokinesiaOFFSIDES
132HypomaniaOFFSIDES
133HypophagiaOFFSIDES
134ImmobileOFFSIDES
135IncontinenceOFFSIDES
136Infantile apnoeic attackOFFSIDES
137Infection in an immunocompromised hostOFFSIDES
138Injection site dermatitisOFFSIDES
139Injection site fibrosisOFFSIDES
140Intention tremorOFFSIDES
141Intentional self-injuryOFFSIDES
142Internal injuryOFFSIDES
143Intestinal ObstructionOFFSIDES
144Intestinal PerforationOFFSIDES
145Intestinal hypomotilityOFFSIDES
146IntubationOFFSIDES
147LaparotomyOFFSIDES
148Large intestine perforationOFFSIDES
149LethargyOFFSIDES
150Leukopenia neonatalOFFSIDES
151Life expectancy shortenedOFFSIDES
152Locked-In SyndromeOFFSIDES
153LordosisOFFSIDES
154Low Back Pain7090846CTD
155Lymphocyte count decreasedOFFSIDES
156Lymphocyte percentage decreasedOFFSIDES
157Lymphocyte stimulation test positiveOFFSIDES
158Lymphocytic infiltrationOFFSIDES
159Mallory-Weiss SyndromeOFFSIDES
160MegacolonOFFSIDES
161Mental disorders2568639
16856516		CTD
162MesotheliomaOFFSIDES
163MoaningOFFSIDES
164Motor retardationOFFSIDES
165Mouth BreathingOFFSIDES
166Multiple drug overdoseOFFSIDES
167Multiple drug overdose intentionalOFFSIDES
168Muscle necrosisOFFSIDES
169Musculoskeletal stiffnessOFFSIDES
170MutismOFFSIDES
171Myocardial fibrosisOFFSIDES
172Myoclonus2860211CTD
173Myoglobin blood increasedOFFSIDES
174Myoglobin urine presentOFFSIDES
175NasopharyngitisOFFSIDES
176Necrosis17631667CTD
177Necrotizing EnterocolitisSIDER
178Nephrotic SyndromeOFFSIDES
179Neuroleptic Malignant Syndrome1891487
12452552		CTD
OFFSIDES
180NystagmusOFFSIDES
181ObesityCanada Vigilance: 1Canada Vigilance
182OculogyrationOFFSIDES
183OphthalmoplegiaOFFSIDES
184Oropharyngeal candidiasisOFFSIDES
185Ovarian InfectionOFFSIDES
186OverdoseOFFSIDES
187Pain, Postoperative7048838CTD
188Pain5694544CTD
189Pancreatic PseudocystOFFSIDES
190Panic DisorderOFFSIDES
191Patient restraintOFFSIDES
192Perceptual Disorders14638603CTD
193PeritonitisOFFSIDES
194Personality Disorders3978350CTD
195PleurisyOFFSIDES
196Pneumatosis Cystoides IntestinalisOFFSIDES
197Poor personal hygieneOFFSIDES
198Poor quality drug administeredOFFSIDES
199PoriomaniaOFFSIDES
200Portal HypertensionOFFSIDES
201Post procedural bile leakOFFSIDES
202Postoperative Complications7048838CTD
203Preauricular cystOFFSIDES
204Prescribed overdoseOFFSIDES
205PriapismSIDER
206Productive CoughOFFSIDES
207Psychiatric decompensationOFFSIDES
208Psychiatric symptomOFFSIDES
209Psychomotor Agitation8876855CTD
210Psychomotor skills impairedOFFSIDES
211Psychoses, Substance-Induced10362445CTD
212Psychotic Disorders14670884CTD
213Pulmonary InfarctionOFFSIDES
214Pulmonary congestionOFFSIDES
215QuadriplegiaOFFSIDES
216Quality of life decreasedOFFSIDES
217Rectal ProlapseOFFSIDES
218Refusal of treatment by relativeOFFSIDES
219RegurgitationOFFSIDES
220Respiratory FailureOFFSIDES
221Respiratory dyskinesiaOFFSIDES
222Restless Legs Syndrome1777530CTD
223Retinopathy of PrematurityOFFSIDES
224RetrocollisOFFSIDES
225RetrognathiaOFFSIDES
226RhabdomyolysisOFFSIDES
227Schizophrenia709472
1561898
10464538		CTD
OFFSIDES
228Sciatica7090846CTD
229Secondary hypothyroidismOFFSIDES
230Seizures8473723CTD
231Self MutilationOFFSIDES
232ShopliftingOFFSIDES
233Sick Sinus SyndromeOFFSIDES
234Sleep Initiation and Maintenance Disorders10954064CTD
235SnoringOFFSIDES
236SoliloquyOFFSIDES
237SomnolenceCanada Vigilance: 1Canada Vigilance
SIDER
238SoporOFFSIDES
239Speech Disorders8876855CTD
240Status EpilepticusOFFSIDES
241Stress ulcerOFFSIDES
242Stupor2860211CTD
243Sudden deathOFFSIDES
SIDER
244SyndactylyOFFSIDES
245Tachycardia, Ventricular7878614CTD
246TachycardiaSIDER
247Therapeutic product ineffectiveOFFSIDES
248TinnitusOFFSIDES
249Tooth ResorptionOFFSIDES
250Torsades de Pointes8256055CTD
251TracheobronchitisOFFSIDES
252Transaminases increasedOFFSIDES
253Tryptase increasedOFFSIDES
254Urinary RetentionSIDER
255Vascular Diseases10464538CTD
256Ventricular FibrillationOFFSIDES
257Water IntoxicationOFFSIDES
258Waxy flexibilityOFFSIDES
259Weight GainOFFSIDES
260jaundiceSIDER
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