MetaADEDB 2.0 @ LMMD
Dantrolene
(OZOMQRBLCMDCEG-VIZOYTHASA-N)
Structure
SMILES
O=C1CN(C(=O)N1)/N=C/c1ccc(o1)c1ccc(cc1)[N+](=O)[O-]
Type(s)
Approved; Investigational
ATC code(s)
M03CA01
Molecular Formula:
C14H10N4O5
Molecular Weight:
314.253
Log P:
2.5304
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
1
TPSA:
120.73
CAS Number(s):
7261-97-4; 85008-71-5; 833480-90-3
Synonym(s)
1.
Dantrolene
2.
Dantrium
3.
Dantrolene Sodium
4.
Sodium, Dantrolene
External Link(s)
MeSHD003620
PubChem Compound6914273
BindingDB50198767
ChEBI4317
CHEMBLCHEMBL1201288
DrugBankDB01219
DrugCentral780
KEGGcpd:C06939
dr:D02347
Therapeutic Target DatabaseD0I8DD
ZINC7997966
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Respiratory FailureFAERS: 7OFFSIDES
SIDER
US FAERS
2Infusion site irritationFAERS: 6US FAERS
3Medication ErrorFAERS: 6US FAERS
4VomitingFAERS: 5SIDER
US FAERS
5NauseaFAERS: 4946274CTD
SIDER
US FAERS
6PneumoniaFAERS: 46736987CTD
US FAERS
7Urinary tract infectionFAERS: 4US FAERS
8Acute myocardial infarctionFAERS: 3US FAERS
9Acute respiratory failureFAERS: 3OFFSIDES
US FAERS
10Blood creatine phosphokinase increasedFAERS: 3OFFSIDES
US FAERS
11DysuriaFAERS: 3US FAERS
12HydronephrosisFAERS: 3US FAERS
13PleurisyFAERS: 3OFFSIDES
US FAERS
14Cerebrovascular accidentFAERS: 2US FAERS
15Drug ineffectiveFAERS: 2US FAERS
16Drug level increasedFAERS: 2US FAERS
17FatigueFAERS: 27861811CTD
SIDER
US FAERS
18HydrothoraxFAERS: 2OFFSIDES
US FAERS
19No adverse eventFAERS: 2US FAERS
20SomnolenceFAERS: 2SIDER
US FAERS
21Accidental exposureFAERS: 1US FAERS
22AgitationFAERS: 1US FAERS
23Altered state of consciousnessFAERS: 1OFFSIDES
US FAERS
24AstheniaFAERS: 1SIDER
US FAERS
25Chest discomfortFAERS: 1US FAERS
26CholecystitisFAERS: 1US FAERS
27Depressed Level of ConsciousnessFAERS: 1OFFSIDES
US FAERS
28Disease ProgressionFAERS: 1OFFSIDES
US FAERS
29Drug effect incompleteFAERS: 1US FAERS
30Drug exposure during pregnancyFAERS: 1US FAERS
31EpilepsyFAERS: 1OFFSIDES
US FAERS
32Feeding tube complicationFAERS: 1US FAERS
33GlossoptosisFAERS: 1US FAERS
34Hepatitis AFAERS: 1OFFSIDES
US FAERS
35HypercapniaFAERS: 1US FAERS
36HypoxiaFAERS: 1US FAERS
37IleusFAERS: 1US FAERS
38Inappropriate schedule of drug administrationFAERS: 1US FAERS
39Incorrect drug administration rateFAERS: 1US FAERS
40InflammationFAERS: 1US FAERS
41Infusion Site ExtravasationFAERS: 1US FAERS
42Infusion site necrosisFAERS: 1US FAERS
43Infusion site thrombosisFAERS: 1US FAERS
44Injection site extravasationFAERS: 1US FAERS
45Intestinal ObstructionFAERS: 1SIDER
US FAERS
46MalaiseFAERS: 1SIDER
US FAERS
47MeningitisFAERS: 1US FAERS
48Muscle SpasticityFAERS: 1US FAERS
49PainFAERS: 1375768CTD
SIDER
US FAERS
50PetechiaeFAERS: 1US FAERS
51Pharmaceutical product complaintFAERS: 1US FAERS
52PneumothoraxFAERS: 1US FAERS
53Product substitution issueFAERS: 1US FAERS
54Pulmonary EosinophiliaFAERS: 1US FAERS
55Respiratory arrestFAERS: 1US FAERS
56Retinal DetachmentFAERS: 1US FAERS
57Sputum retentionFAERS: 1US FAERS
58Status EpilepticusFAERS: 1OFFSIDES
US FAERS
59ThrombophlebitisFAERS: 1SIDER
US FAERS
60Unevaluable eventFAERS: 1US FAERS
61WheezingFAERS: 1US FAERS
62nervous system disorderFAERS: 1US FAERS
63Abdominal CrampsSIDER
64Abdominal PainSIDER
65AbuliaOFFSIDES
66AcidosisOFFSIDES
67AcneSIDER
68AdenocarcinomaOFFSIDES
69Alanine Aminotransferase IncreasedOFFSIDES
70Alcoholic IntoxicationOFFSIDES
71AminoaciduriaOFFSIDES
72Anal FissureOFFSIDES
73Anaphylactic shockSIDER
74AneurysmOFFSIDES
75Angle Closure GlaucomaOFFSIDES
76AnisocytosisOFFSIDES
77Anorexia946274CTD
SIDER
78Antithrombin III decreasedOFFSIDES
79ApathyOFFSIDES
80AtelectasisOFFSIDES
81Atrioventricular Block6711841CTD
OFFSIDES
SIDER
82AuraOFFSIDES
83AutomatismOFFSIDES
84Back PainSIDER
85Band neutrophil percentage increasedOFFSIDES
86Benign neoplasm of thyroid glandOFFSIDES
87Blood acid phosphatase increasedOFFSIDES
88Blood albumin decreasedOFFSIDES
89Blood alkaline phosphatase increasedOFFSIDES
90Blood amylase increasedOFFSIDES
91Blood creatine phosphokinase decreasedOFFSIDES
92Blood creatinine decreasedOFFSIDES
93Blood erythropoietin increasedOFFSIDES
94Blood immunoglobulin A decreasedOFFSIDES
95Blood insulinOFFSIDES
96Blood lactate dehydrogenase increasedOFFSIDES
97Blood parathyroid hormone increasedOFFSIDES
98Blood sodium increasedOFFSIDES
99Blood sodiumOFFSIDES
100Body TemperatureOFFSIDES
101Brain DeathOFFSIDES
102Carcinoma, Transitional Cell17924939CTD
103Cardioactive drug levelOFFSIDES
104Cardiomyopathies15222403CTD
105Carotid artery aneurysmOFFSIDES
106Catatonia2399829CTD
107Catheter related infectionOFFSIDES
108Cerebral Palsy1107103CTD
109Chemical and Drug Induced Liver Injury

View details

761834
838213
946274
15674093
17868276
18524759
 		CTD
110Chemotherapeutic drug level increasedOFFSIDES
111ChillsSIDER
112Choking sensationSIDER
113CholangiolitisOFFSIDES
114Cholestasis946274CTD
115ChromaturiaSIDER
116Compression fractureOFFSIDES
117ConfabulationOFFSIDES
118Consciousness fluctuatingOFFSIDES
119ConstipationSIDER
120CrystalluriaSIDER
121CyanosisOFFSIDES
122Cytolytic hepatitisOFFSIDES
123Depression suicidalOFFSIDES
124DermatitisSIDER
125Device related infectionOFFSIDES
126DiplopiaSIDER
127DiscomfortSIDER
128Disease recurrenceOFFSIDES
129Disseminated Intravascular CoagulationOFFSIDES
130Dizziness7861811
16192781		CTD
SIDER
131DroolingSIDER
132DrowsinessOFFSIDES
SIDER
133Drug toxicityOFFSIDES
134DuodenitisOFFSIDES
135DysgeusiaSIDER
136DyspepsiaSIDER
137DysphoniaSIDER
138Eating disorder symptomOFFSIDES
139End-tidal CO2 increasedOFFSIDES
140Enzyme InhibitionOFFSIDES
141EosinophiliaSIDER
142Epigastric discomfortSIDER
143Erectile dysfunctionOFFSIDES
144Erythema MultiformeOFFSIDES
145ErythemaSIDER
146Escherichia infectionOFFSIDES
147ExtravasationSIDER
148Fanconi SyndromeOFFSIDES
149Feeling abnormalSIDER
150Fever7079122
15859445
16931708		CTD
151FlatulenceOFFSIDES
152FlushingSIDER
153Gamma-Glutamyltransferase IncreasedOFFSIDES
154Gastric irritationSIDER
155Gastrointestinal PainSIDER
156Gastrointestinal motility disorderOFFSIDES
157Gingival HypertrophyOFFSIDES
158GingivectomyOFFSIDES
159Hallucinations1111870CTD
160HeadacheSIDER
161Hearing Loss, Bilateral3343565CTD
162Hearing Loss, Sudden3343565CTD
163Heart failure3826797CTD
164Heat StrokeOFFSIDES
165Hematuria17924939CTD
166Hepatitis BOFFSIDES
167Hepatitis, Chronic14986274CTD
168Hepatitis761834CTD
SIDER
169Hepatomegaly28108177CTD
170HepatotoxicitySIDER
171Hyperkalemia375768
6711841		CTD
172HypersensitivitySIDER
173Hypertrophic CardiomyopathyOFFSIDES
174IncontinenceOFFSIDES
175InfectionOFFSIDES
176Infusion site painSIDER
177Injection Site ReactionSIDER
178Injection site infectionOFFSIDES
179Injection site ulcerOFFSIDES
180Injury asphyxiationOFFSIDES
181Intracranial AneurysmOFFSIDES
182Kidney FailureOFFSIDES
183Labile blood pressureOFFSIDES
184Laboratory test interferenceOFFSIDES
185LeukopeniaSIDER
186Light chain diseaseOFFSIDES
187LightheadednessSIDER
188Liver neoplasms25058030CTD
189LymphomaSIDER
190MacrocytosisOFFSIDES
191MalabsorptionOFFSIDES
192Metabolic acidosisOFFSIDES
193Miyoshi myopathy17868276CTD
194Multi-organ disorderOFFSIDES
195Multiple SclerosisOFFSIDES
196Multiple sclerosis relapseOFFSIDES
197Muscle Cramp23164761CTD
198Muscle Hypertonia7079122CTD
199Muscle Rigidity3729640
8059048
9017254		CTD
200Muscle Weakness7486124
7861811
16192781		CTD
201Muscle necrosisOFFSIDES
202Muscle tightnessOFFSIDES
203Musculoskeletal discomfortSIDER
204Musculoskeletal stiffnessOFFSIDES
205MutismOFFSIDES
206MyalgiaSIDER
207MyelodysplasiaOFFSIDES
208Myoclonus7486124
14652121		CTD
209NecrosisSIDER
210NephrolithiasisOFFSIDES
211Nephrotic SyndromeOFFSIDES
212NervousnessSIDER
213Neuroleptic Malignant Syndrome

View details

1295627
1587202
2044308
2925603
6123782
6614876
6682201
6824251
7999444
9128030
10675082
12397878
15362259
16669738
17119106
 		CTD
OFFSIDES
214NocturiaSIDER
215NystagmusOFFSIDES
216OliguriaOFFSIDES
217Pancreatic duct dilatationOFFSIDES
218Pancreatitis22517774CTD
219Paraplegia6893628CTD
220Pericarditis501885
6736987		CTD
SIDER
221PhlebitisOFFSIDES
SIDER
222Physical disabilityOFFSIDES
223PoikilocytosisOFFSIDES
224Post procedural complicationOFFSIDES
225Protein total decreasedOFFSIDES
226PruritusSIDER
227Psychiatric decompensationOFFSIDES
228Psychomotor skills impairedOFFSIDES
229Pulmonary Edema3826797CTD
230Pulmonary function test decreasedSIDER
231Renal tubular disorderOFFSIDES
232Respiratory DepressionSIDER
233RhabdomyolysisOFFSIDES
234Right Ventricular DysfunctionOFFSIDES
235Risus sardonicusOFFSIDES
236Seizures1107103
8532155		CTD
237Spasm1107103CTD
238Sputum culture positiveOFFSIDES
239Subcutaneous AbscessOFFSIDES
240SweatingSIDER
241SwellingSIDER
242Tachycardia, Ventricular20944434CTD
243TachycardiaSIDER
244TensionSIDER
245Therapeutic response unexpected with drug substitutionOFFSIDES
246ThrombocytopeniaSIDER
247Upper respiratory tract inflammationOFFSIDES
248Urinary IncontinenceSIDER
249Urinary Retention16263650CTD
SIDER
250Urine ketone body presentOFFSIDES
251Urine output increasedOFFSIDES
252UrticariaSIDER
253VIIth nerve paralysisOFFSIDES
254Vision Disorders7861811CTD
255Visual ImpairmentSIDER
256Visual disturbanceSIDER
257furuncleOFFSIDES
258jaundice946274CTD
259muscle injuryOFFSIDES
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