Salmeterol Xinafoate
(GIIZNNXWQWCKIB-UHFFFAOYSA-N)
Structure
- SMILES
- OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O
- Type(s)
- Approved
- ATC code(s)
- R03AC12; R03AK06; R03AK12
- Molecular Formula:
- C25H37NO4
- Molecular Weight:
- 415.566
- Log P:
- 4.4983
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 4
- TPSA:
- 81.95
- CAS Number(s):
- 89365-50-4; 136112-01-1
Synonym(s)
1.
Salmeterol Xinafoate
2.
Salmeterol
3.
Serevent
4.
Xinafoate, Salmeterol
External Link(s)
| MeSH | D000068299 |
| PubChem Compound | 5152 |
| BindingDB | 25771 |
| ChEBI | 64064 |
| CHEMBL | CHEMBL1263 |
| DrugBank | DB00938 |
| DrugCentral | 2419 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 559 |
| KEGG | cpd:C07241 dr:D05792 |
| Therapeutic Target Database | D0L5YV |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 196 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 2 | Pharmaceutical product complaint | FAERS: 86 | US FAERS | |
| 3 | Asthma | FAERS: 49 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 4 | Adverse event | FAERS: 28 | US FAERS | |
| 5 | Product quality issue | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 6 | Pharyngolaryngeal Pain | FAERS: 18 | US FAERS | |
| 7 | Wheezing | FAERS: 15 | US FAERS | |
| 8 | Headache | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 9 | Malaise | FAERS: 13 | SIDER US FAERS | |
| 10 | Chest discomfort | FAERS: 11 | SIDER US FAERS | |
| 11 | Dysgeusia | FAERS: 11 | OFFSIDES US FAERS | |
| 12 | Hypersensitivity | FAERS: 11 | SIDER US FAERS | |
| 13 | Palpitations | FAERS: 11 | SIDER US FAERS | |
| 14 | Chest Pain | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 15 | Dizziness | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 16 | Overdose | FAERS: 9 | US FAERS | |
| 17 | Candidiasis | FAERS: 7 | US FAERS | |
| 18 | Nausea | FAERS: 7 Canada Vigilance: 3 | Canada Vigilance SIDER US FAERS | |
| 19 | Asthenia | FAERS: 6 | SIDER US FAERS | |
| 20 | Choking sensation | FAERS: 6 | OFFSIDES US FAERS | |
| 21 | Choking | FAERS: 6 | SIDER US FAERS | |
| 22 | Fatigue | FAERS: 6 | SIDER US FAERS | |
| 23 | Nervousness | FAERS: 6 | SIDER US FAERS | |
| 24 | Pain | FAERS: 6 | SIDER US FAERS | |
| 25 | Throat irritation | FAERS: 6 | SIDER US FAERS | |
| 26 | Tremor | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 27 | Urticaria | FAERS: 6 | SIDER US FAERS | |
| 28 | Anxiety | FAERS: 5 | OFFSIDES SIDER US FAERS | |
| 29 | Lung hyperinflation | FAERS: 5 | US FAERS | |
| 30 | Medication Error | FAERS: 5 | US FAERS | |
| 31 | Medication residue | FAERS: 5 | US FAERS | |
| 32 | Oral candidiasis | FAERS: 5 | SIDER US FAERS | |
| 33 | Alopecia | FAERS: 4 | US FAERS | |
| 34 | Angioedema | FAERS: 4 | SIDER US FAERS | |
| 35 | Dyspepsia | FAERS: 4 | SIDER US FAERS | |
| 36 | Feeling jittery | FAERS: 4 | US FAERS | |
| 37 | General physical health deterioration | FAERS: 4 | US FAERS | |
| 38 | Hoarseness | FAERS: 4 | US FAERS | |
| 39 | Pruritus | FAERS: 4 | US FAERS | |
| 40 | Somnolence | FAERS: 4 | US FAERS | |
| 41 | Status Asthmaticus | FAERS: 4 | US FAERS | |
| 42 | Syncope | FAERS: 4 | US FAERS | |
| 43 | Tachycardia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 44 | Abdominal Pain | FAERS: 3 | SIDER US FAERS | |
| 45 | Accidental overdose | FAERS: 3 | US FAERS | |
| 46 | Ageusia | FAERS: 3 | US FAERS | |
| 47 | Anosmia | FAERS: 3 | OFFSIDES US FAERS | |
| 48 | Aphonia | FAERS: 3 | US FAERS | |
| 49 | Atrial Fibrillation | FAERS: 3 | SIDER US FAERS | |
| 50 | Bronchitis | FAERS: 3 | OFFSIDES SIDER US FAERS | |
| 51 | Bronchospasm | FAERS: 3 | SIDER US FAERS | |
| 52 | Dysphonia | FAERS: 3 | OFFSIDES US FAERS | |
| 53 | Feeling abnormal | FAERS: 3 | SIDER US FAERS | |
| 54 | Food Allergy | FAERS: 3 | SIDER US FAERS | |
| 55 | Myalgia | FAERS: 3 | SIDER US FAERS | |
| 56 | Oropharyngeal swelling | FAERS: 3 | US FAERS | |
| 57 | Pneumonia | FAERS: 3 | SIDER US FAERS | |
| 58 | Respiratory arrest | FAERS: 3 | US FAERS | |
| 59 | Respiratory tract congestion | FAERS: 3 | SIDER US FAERS | |
| 60 | Anoxic Encephalopathy | FAERS: 2 | OFFSIDES US FAERS | |
| 61 | Arthralgia | FAERS: 2 | SIDER US FAERS | |
| 62 | Atherosclerosis | FAERS: 2 | OFFSIDES US FAERS | |
| 63 | Cardiac Arrest | FAERS: 2 | US FAERS | |
| 64 | Device malfunction | FAERS: 2 | US FAERS | |
| 65 | Discomfort | FAERS: 2 | SIDER US FAERS | |
| 66 | Drug dose omission | FAERS: 2 | US FAERS | |
| 67 | Drug exposure during pregnancy | FAERS: 2 | US FAERS | |
| 68 | Dyspnoea exacerbated | FAERS: 2 | US FAERS | |
| 69 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 70 | Increased viscosity of bronchial secretion | FAERS: 2 | US FAERS | |
| 71 | Injury asphyxiation | FAERS: 2 | US FAERS | |
| 72 | Lactose Intolerance | FAERS: 2 | OFFSIDES US FAERS | |
| 73 | Leukocytosis | FAERS: 2 | US FAERS | |
| 74 | Lung Injury | FAERS: 2 | US FAERS | |
| 75 | Muscle hypertrophy | FAERS: 2 | US FAERS | |
| 76 | Myocardial Infarction | FAERS: 2 | US FAERS | |
| 77 | Nasopharyngitis | FAERS: 2 | SIDER US FAERS | |
| 78 | Nonspecific reaction | FAERS: 2 | OFFSIDES US FAERS | |
| 79 | Oral fungal infection | FAERS: 2 | US FAERS | |
| 80 | Oral infection | FAERS: 2 | OFFSIDES US FAERS | |
| 81 | Oral pain | FAERS: 2 | US FAERS | |
| 82 | Productive Cough | FAERS: 2 | OFFSIDES US FAERS | |
| 83 | Secretion discharge | FAERS: 2 | US FAERS | |
| 84 | Sinusitis | FAERS: 2 | SIDER US FAERS | |
| 85 | Tracheobronchitis | FAERS: 2 | SIDER US FAERS | |
| 86 | Abdominal discomfort | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 87 | Acute Coronary Syndrome | FAERS: 1 | US FAERS | |
| 88 | Acute respiratory failure | FAERS: 1 | US FAERS | |
| 89 | Agitation | FAERS: 1 | US FAERS | |
| 90 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 91 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 92 | Apparent death | FAERS: 1 | US FAERS | |
| 93 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 94 | Aspergillosis | FAERS: 1 | US FAERS | |
| 95 | Atelectasis | FAERS: 1 | US FAERS | |
| 96 | Back Pain | FAERS: 1 | SIDER US FAERS | |
| 97 | Burning sensation | FAERS: 1 | US FAERS | |
| 98 | Coronary Artery Disease | FAERS: 1 | US FAERS | |
| 99 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 100 | Device Failure | FAERS: 1 | US FAERS | |
| 101 | Disorientation | FAERS: 1 | US FAERS | |
| 102 | Drug abuse | FAERS: 1 | US FAERS | |
| 103 | Drug administration error | FAERS: 1 | OFFSIDES US FAERS | |
| 104 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 105 | Drug toxicity | FAERS: 1 | US FAERS | |
| 106 | Eczema | FAERS: 1 | SIDER US FAERS | |
| 107 | Emphysematous bulla | FAERS: 1 | US FAERS | |
| 108 | Erythema Multiforme | FAERS: 1 | US FAERS | |
| 109 | Erythema | FAERS: 1 | OFFSIDES US FAERS | |
| 110 | Eye Redness | FAERS: 1 | US FAERS | |
| 111 | Gamma-Glutamyltransferase Increased | FAERS: 1 | US FAERS | |
| 112 | Hypercapnia | FAERS: 1 | US FAERS | |
| 113 | Hypertrophy of tongue papillae | FAERS: 1 | US FAERS | |
| 114 | Infection | FAERS: 1 | SIDER US FAERS | |
| 115 | Intentional product misuse | FAERS: 1 | US FAERS | |
| 116 | Intubation complication | FAERS: 1 | US FAERS | |
| 117 | Laryngitis | FAERS: 1 | SIDER US FAERS | |
| 118 | Left Ventricular Hypertrophy | FAERS: 1 | US FAERS | |
| 119 | Lethargy | FAERS: 1 | US FAERS | |
| 120 | Lip swelling | FAERS: 1 | US FAERS | |
| 121 | Live Birth | FAERS: 1 | US FAERS | |
| 122 | Lower respiratory tract infection | FAERS: 1 | SIDER US FAERS | |
| 123 | Metrorrhagia | FAERS: 1 | US FAERS | |
| 124 | Middle insomnia | FAERS: 1 | US FAERS | |
| 125 | Mood swings | FAERS: 1 | US FAERS | |
| 126 | Muscle Cramp | FAERS: 1 | US FAERS | |
| 127 | Musculoskeletal stiffness | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 128 | Onychoclasis | FAERS: 1 | US FAERS | |
| 129 | Oral administration complication | FAERS: 1 | US FAERS | |
| 130 | Oral discharge | FAERS: 1 | US FAERS | |
| 131 | Oropharyngeal pain | FAERS: 1 | SIDER US FAERS | |
| 132 | Osteolysis | FAERS: 1 | US FAERS | |
| 133 | Oxygen supplementation | FAERS: 1 | US FAERS | |
| 134 | Personality Change | FAERS: 1 | US FAERS | |
| 135 | Pharyngeal leukoplakia | FAERS: 1 | US FAERS | |
| 136 | Pneumothorax | FAERS: 1 | US FAERS | |
| 137 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 138 | Product counterfeit | FAERS: 1 | US FAERS | |
| 139 | Product packaging confusion | FAERS: 1 | US FAERS | |
| 140 | Product taste abnormal | FAERS: 1 | US FAERS | |
| 141 | Product use in unapproved indication | FAERS: 1 | US FAERS | |
| 142 | Rash erythematous | FAERS: 1 | US FAERS | |
| 143 | Respiratory Failure | FAERS: 1 | OFFSIDES US FAERS | |
| 144 | Respiratory distress | FAERS: 1 | US FAERS | |
| 145 | Retching | FAERS: 1 | US FAERS | |
| 146 | Sluggishness | FAERS: 1 | US FAERS | |
| 147 | Stomatitis | FAERS: 1 | US FAERS | |
| 148 | Suppressed lactation | FAERS: 1 | US FAERS | |
| 149 | Suspected counterfeit product | FAERS: 1 | US FAERS | |
| 150 | Therapeutic response changed | FAERS: 1 | US FAERS | |
| 151 | Tinnitus | FAERS: 1 | US FAERS | |
| 152 | Tongue blistering | FAERS: 1 | US FAERS | |
| 153 | Toxic Epidermal Necrolysis | FAERS: 1 | US FAERS | |
| 154 | Unevaluable event | FAERS: 1 | US FAERS | |
| 155 | Urinary Retention | FAERS: 1 | US FAERS | |
| 156 | Vocal Cord Paralysis | FAERS: 1 | US FAERS | |
| 157 | Vomiting | FAERS: 1 | SIDER US FAERS | |
| 158 | Abdominal tenderness | OFFSIDES | ||
| 159 | Abscess | OFFSIDES | ||
| 160 | Acidosis | OFFSIDES | ||
| 161 | Acne | OFFSIDES | ||
| 162 | Acute bronchitis | OFFSIDES SIDER | ||
| 163 | Acute prerenal failure | OFFSIDES | ||
| 164 | Agoraphobia | OFFSIDES | ||
| 165 | Ammonia increased | OFFSIDES | ||
| 166 | Amnesia | OFFSIDES | ||
| 167 | Anaphylactic shock | SIDER | ||
| 168 | Aortic valve calcification | OFFSIDES | ||
| 169 | Arthropathy | OFFSIDES | ||
| 170 | Arthroscopy | OFFSIDES | ||
| 171 | Automatism | OFFSIDES | ||
| 172 | Axillary vein thrombosis | OFFSIDES | ||
| 173 | Bilirubin conjugated increased | OFFSIDES | ||
| 174 | Bladder spasm | OFFSIDES | ||
| 175 | Blood cholesterol | OFFSIDES | ||
| 176 | Blood cortisol decreased | OFFSIDES | ||
| 177 | Blood creatine phosphokinase increased | OFFSIDES | ||
| 178 | Blood glucose decreased | OFFSIDES | ||
| 179 | Blood phosphorus increased | OFFSIDES | ||
| 180 | Blood potassium decreased | OFFSIDES | ||
| 181 | Blood potassium increased | OFFSIDES | ||
| 182 | Blood pressure immeasurable | OFFSIDES | ||
| 183 | Blood uric acid | OFFSIDES | ||
| 184 | Blurred vision | OFFSIDES | ||
| 185 | Bone pain | SIDER | ||
| 186 | Bulbar palsy | OFFSIDES | ||
| 187 | Bursitis | OFFSIDES | ||
| 188 | Cardiac Death | OFFSIDES | ||
| 189 | Cardiac asthma | OFFSIDES | ||
| 190 | Carotid artery occlusion | OFFSIDES | ||
| 191 | Cerebral Arteriosclerosis | OFFSIDES | ||
| 192 | Cervicobrachial syndrome | OFFSIDES | ||
| 193 | Cheilitis | OFFSIDES | ||
| 194 | Chemotherapeutic drug level increased | OFFSIDES | ||
| 195 | Chronic Obstructive Airway Disease | OFFSIDES | ||
| 196 | Chronic respiratory failure | OFFSIDES | ||
| 197 | Chronic sinusitis | OFFSIDES | ||
| 198 | Claustrophobia | OFFSIDES | ||
| 199 | Cold symptoms | SIDER | ||
| 200 | Common Cold | SIDER | ||
| 201 | Congenital tricuspid valve incompetence | OFFSIDES | ||
| 202 | Conjunctivitis | SIDER | ||
| 203 | Constipation | SIDER | ||
| 204 | Cramps of lower extremities | SIDER | ||
| 205 | Creatinine renal clearance decreased | OFFSIDES | ||
| 206 | Cyanosis | OFFSIDES | ||
| 207 | Cystocele | OFFSIDES | ||
| 208 | Decreased Libido | OFFSIDES | ||
| 209 | Dental discomfort | SIDER | ||
| 210 | Depressed mood | OFFSIDES | ||
| 211 | Dermatitis | SIDER | ||
| 212 | Diabetes | OFFSIDES | ||
| 213 | Diabetes mellitus inadequate control | OFFSIDES | ||
| 214 | Diffuse alveolar damage | OFFSIDES | ||
| 215 | Disseminated Intravascular Coagulation | OFFSIDES | ||
| 216 | Diverticulitis | OFFSIDES | ||
| 217 | Diverticulosis | OFFSIDES | ||
| 218 | Drowsiness | OFFSIDES | ||
| 219 | Drug withdrawal headache | OFFSIDES | ||
| 220 | Dry skin | OFFSIDES | ||
| 221 | Duodenal ulcer perforation | OFFSIDES | ||
| 222 | Dyspeptic signs and symptoms | SIDER | ||
| 223 | Dystonia | OFFSIDES | ||
| 224 | Electromechanical dissociation | OFFSIDES | ||
| 225 | Embolic stroke | OFFSIDES | ||
| 226 | Emotional distress | OFFSIDES | ||
| 227 | Epistaxis | SIDER | ||
| 228 | Erectile dysfunction | OFFSIDES | ||
| 229 | Eye Infection | SIDER | ||
| 230 | Fever of Unknown Origin | SIDER | ||
| 231 | Flatulence | OFFSIDES | ||
| 232 | Formication | OFFSIDES | ||
| 233 | Galactorrhea | OFFSIDES | ||
| 234 | Gambling | OFFSIDES | ||
| 235 | Gastric outlet obstruction | OFFSIDES | ||
| 236 | Gastroenteritis | SIDER | ||
| 237 | Gastrointestinal Pain | SIDER | ||
| 238 | Gastrointestinal erosion | OFFSIDES | ||
| 239 | Gastrointestinal infection | SIDER | ||
| 240 | Genital erosion | OFFSIDES | ||
| 241 | Gout | OFFSIDES | ||
| 242 | Granulocytosis | OFFSIDES | ||
| 243 | Heartburn | SIDER | ||
| 244 | Hemiparesis | OFFSIDES | ||
| 245 | Hypophonesis | OFFSIDES | ||
| 246 | Incontinence | OFFSIDES | ||
| 247 | Inflammation | SIDER | ||
| 248 | Influenza | SIDER | ||
| 249 | Intestinal Perforation | OFFSIDES | ||
| 250 | Joint injury | OFFSIDES | ||
| 251 | Joint sprain | OFFSIDES | ||
| 252 | Keratitis | SIDER | ||
| 253 | Kidney Failure | OFFSIDES | ||
| 254 | Laryngospasm | SIDER | ||
| 255 | Lip erosion | OFFSIDES | ||
| 256 | Lipase | OFFSIDES | ||
| 257 | Listeria sepsis | OFFSIDES | ||
| 258 | Lyme Disease | OFFSIDES | ||
| 259 | Malnutrition | SIDER | ||
| 260 | Mineral supplementation | OFFSIDES | ||
| 261 | Morphea | OFFSIDES | ||
| 262 | Mucosal erosion | OFFSIDES | ||
| 263 | Muscle Rigidity | SIDER | ||
| 264 | Muscle necrosis | OFFSIDES | ||
| 265 | Musculoskeletal Pain | SIDER | ||
| 266 | Musculoskeletal discomfort | SIDER | ||
| 267 | Myositis | SIDER | ||
| 268 | Neck Pain | SIDER | ||
| 269 | Nephrolithiasis | OFFSIDES | ||
| 270 | Neuroleptic Malignant Syndrome | OFFSIDES | ||
| 271 | Nodal osteoarthritis | OFFSIDES | ||
| 272 | Nodule | OFFSIDES | ||
| 273 | Optic Disc Edema | OFFSIDES | ||
| 274 | Oropharyngeal discomfort | SIDER | ||
| 275 | Osteopenia | OFFSIDES | ||
| 276 | Pain of skin | OFFSIDES | ||
| 277 | Pallor | SIDER | ||
| 278 | Panic Disorder | OFFSIDES | ||
| 279 | Periodontitis | OFFSIDES | ||
| 280 | Peritonitis | OFFSIDES | ||
| 281 | Pharyngitis | SIDER | ||
| 282 | Product complaint | Canada Vigilance: 2 | Canada Vigilance | |
| 283 | Protein allergy | SIDER | ||
| 284 | Pulmonary Infarction | OFFSIDES | ||
| 285 | Pulmonary congestion | SIDER | ||
| 286 | Rectal polyp | OFFSIDES | ||
| 287 | Renal cyst | OFFSIDES | ||
| 288 | Retrocollis | OFFSIDES | ||
| 289 | Rheumatic disorder | SIDER | ||
| 290 | Rheumatism | SIDER | ||
| 291 | Rhinitis | SIDER | ||
| 292 | Rhonchi | OFFSIDES | ||
| 293 | Scleroderma | OFFSIDES | ||
| 294 | Sensory level abnormal | OFFSIDES | ||
| 295 | Septic Shock | OFFSIDES | ||
| 296 | Shoulder Pain | SIDER | ||
| 297 | Sinus bradycardia | OFFSIDES | ||
| 298 | Sinus headache | SIDER | ||
| 299 | Skin lesion | OFFSIDES | ||
| 300 | Sneezing | SIDER | ||
| 301 | Sputum culture positive | OFFSIDES | ||
| 302 | Sputum retention | OFFSIDES | ||
| 303 | Status Migrainosus | OFFSIDES | ||
| 304 | Stevens-Johnson Syndrome | OFFSIDES | ||
| 305 | Stomach ache | SIDER | ||
| 306 | Stress | OFFSIDES | ||
| 307 | Stridor | SIDER | ||
| 308 | Sudden death | OFFSIDES | ||
| 309 | Supraventricular tachycardia | SIDER | ||
| 310 | Sustained ventricular tachycardia | SIDER | ||
| 311 | Swelling | SIDER | ||
| 312 | Syndactyly | OFFSIDES | ||
| 313 | T-Cell Lymphoma | OFFSIDES | ||
| 314 | Tension | SIDER | ||
| 315 | Thrombosis in device | OFFSIDES | ||
| 316 | Toothache | SIDER | ||
| 317 | Tracheitis | SIDER | ||
| 318 | Ulcer | OFFSIDES | ||
| 319 | Ultrasound abdomen abnormal | OFFSIDES | ||
| 320 | Upset stomach | SIDER | ||
| 321 | Urge Incontinence | OFFSIDES | ||
| 322 | Urinary tract infection | SIDER | ||
| 323 | Vasodilation procedure | SIDER | ||
| 324 | Vasodilation | SIDER | ||
| 325 | Ventricular Fibrillation | OFFSIDES | ||
| 326 | Ventricular hypokinesia | OFFSIDES | ||
| 327 | Violence-related symptom | OFFSIDES | ||
| 328 | Visual disturbance | OFFSIDES | ||
| 329 | Weight Gain | OFFSIDES | ||
| 330 | muscle injury | SIDER | ||
| 331 | nervous system disorder | SIDER |
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