MetaADEDB 2.0 @ LMMD
pimavanserin
(RGSULKHNAKTFIZ-CEAXSRTFSA-N)
Structure
SMILES
O[C@H]([C@H](C(=O)O)O)C(=O)O.CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C.CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C
Molecular Formula:
C54H74F2N6O10
Molecular Weight:
1005.200
Log P:
7.8680
Hydrogen Bond Acceptor:
16
Hydrogen Bond Donor:
6
TPSA:
204.68
CAS Number(s):
706782-28-7
Synonym(s)
1.
pimavanserin
2.
ACP 103
3.
ACP-103
4.
ACP103
5.
N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide
6.
Nuplazid
7.
bis(1-(4-fluorobenzyl)-1-(1-methylpiperidin-4-yl)-3-(4-(2-methylpropoxy)benzyl)urea) (2R,3R)-2,3-dihydroxybutanedioate
8.
pimavanserin tartrate
9.
urea, n-((4-fluorophenyl)methyl)-n-(1-methyl-4-piperidinyl)-n'-((4-(2-methylpropoxy)phenyl)methyl)-, (2R,3R)-2,3-dihydroxybutanedioate (2:1)
External Link(s)
MeSHC510793
PubChem Compound11672491
ChEBI133014
KEGGdr:D08969
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 752US FAERS
2Prescribed underdoseFAERS: 691US FAERS
3Nonspecific reactionFAERS: 283US FAERS
4SomnolenceFAERS: 280US FAERS
5Peripheral swellingFAERS: 241US FAERS
6NauseaFAERS: 210US FAERS
7Inappropriate schedule of drug administrationFAERS: 203US FAERS
8Drug dose omissionFAERS: 183US FAERS
9DizzinessFAERS: 171US FAERS
10FatigueFAERS: 156US FAERS
11AstheniaFAERS: 146US FAERS
12Product dose omissionFAERS: 146US FAERS
13Feeling abnormalFAERS: 140US FAERS
14ConstipationFAERS: 136US FAERS
15Urinary tract infectionFAERS: 135US FAERS
16Therapeutic response unexpectedFAERS: 134US FAERS
17AgitationFAERS: 115US FAERS
18MalaiseFAERS: 113US FAERS
19TremorFAERS: 111US FAERS
20HypersomniaFAERS: 99US FAERS
21PneumoniaFAERS: 98US FAERS
22AnxietyFAERS: 95US FAERS
23LethargyFAERS: 91US FAERS
24HeadacheFAERS: 81US FAERS
25ParanoiaFAERS: 75US FAERS
26Memory impairmentFAERS: 69US FAERS
27Inappropriate schedule of product administrationFAERS: 65US FAERS
28General physical health deteriorationFAERS: 59US FAERS
29RestlessnessFAERS: 58US FAERS
30DisorientationFAERS: 54US FAERS
31DementiaFAERS: 52US FAERS
32Gait inabilityFAERS: 51US FAERS
33Abdominal discomfortFAERS: 46US FAERS
34Adverse eventFAERS: 46US FAERS
35Unresponsive to stimuliFAERS: 42US FAERS
36Weight decreasedFAERS: 42US FAERS
37Loss of personal independence in daily activitiesFAERS: 38US FAERS
38Disease ProgressionFAERS: 35US FAERS
39AmnesiaFAERS: 33US FAERS
40AngerFAERS: 33US FAERS
41OverdoseFAERS: 33US FAERS
42AbasiaFAERS: 32US FAERS
43Joint swellingFAERS: 32US FAERS
44DehydrationFAERS: 31US FAERS
45VomitingFAERS: 31US FAERS
46Drug prescribing errorFAERS: 30US FAERS
47Incorrect dose administeredFAERS: 29US FAERS
48HypokinesiaFAERS: 28US FAERS
49PainFAERS: 28US FAERS
50Prescribed overdoseFAERS: 28US FAERS
51Cerebrovascular accidentFAERS: 27US FAERS
52Musculoskeletal stiffnessFAERS: 27US FAERS
53HypotensionFAERS: 26US FAERS
54DysarthriaFAERS: 25US FAERS
55DroolingFAERS: 24US FAERS
56ScreamingFAERS: 24US FAERS
57SwellingFAERS: 24US FAERS
58Chest PainFAERS: 23US FAERS
59Poor quality sleepFAERS: 23US FAERS
60SluggishnessFAERS: 23US FAERS
61CryingFAERS: 21US FAERS
62NervousnessFAERS: 21US FAERS
63PalpitationsFAERS: 21US FAERS
64Wrong technique in product usage processFAERS: 21US FAERS
65Back PainFAERS: 20US FAERS
66CystitisFAERS: 20US FAERS
67Myocardial InfarctionFAERS: 20US FAERS
68HypersensitivityFAERS: 19US FAERS
69IncoherentFAERS: 19US FAERS
70Accidental underdoseFAERS: 18US FAERS
71SepsisFAERS: 18US FAERS
72Visual ImpairmentFAERS: 18US FAERS
73BedriddenFAERS: 17US FAERS
74InfectionFAERS: 17US FAERS
75Drug ineffective for unapproved indicationFAERS: 16US FAERS
76DyspepsiaFAERS: 16US FAERS
77Freezing phenomenonFAERS: 16US FAERS
78ImmobileFAERS: 16US FAERS
79Personality ChangeFAERS: 16US FAERS
80AphasiaFAERS: 15US FAERS
81Mental impairmentFAERS: 15US FAERS
82Middle insomniaFAERS: 15US FAERS
83Productive CoughFAERS: 15US FAERS
84Urinary IncontinenceFAERS: 15US FAERS
85DeliriumFAERS: 14US FAERS
86Limb discomfortFAERS: 14US FAERS
87NasopharyngitisFAERS: 14US FAERS
88StaringFAERS: 14US FAERS
89SyncopeFAERS: 14US FAERS
90IncontinenceFAERS: 13US FAERS
91InfluenzaFAERS: 13US FAERS
92Product prescribing errorFAERS: 13US FAERS
93Respiratory FailureFAERS: 13US FAERS
94Urinary RetentionFAERS: 13US FAERS
95ArthralgiaFAERS: 12US FAERS
96Electrocardiogram abnormalFAERS: 12US FAERS
97Hospice CareFAERS: 12US FAERS
98Lip swellingFAERS: 12US FAERS
99Psychotic symptomFAERS: 12US FAERS
100Blood glucose increasedFAERS: 11US FAERS
101Cardiac ArrestFAERS: 11US FAERS
102Depressed Level of ConsciousnessFAERS: 11US FAERS
103Drug effect incompleteFAERS: 11US FAERS
104PruritusFAERS: 11US FAERS
105Pulmonary EmbolismFAERS: 11US FAERS
106Sleep TalkingFAERS: 11US FAERS
107Atrial FibrillationFAERS: 10US FAERS
108Depressed moodFAERS: 10US FAERS
109ErythemaFAERS: 10US FAERS
110ThrombosisFAERS: 10US FAERS
111Activities of daily living impairedFAERS: 9US FAERS
112Feeling jitteryFAERS: 9US FAERS
113Hallucinations, mixedFAERS: 9US FAERS
114HypophagiaFAERS: 9US FAERS
115StressFAERS: 9US FAERS
116UrticariaFAERS: 9US FAERS
117Abnormal sleep-related eventFAERS: 8US FAERS
118Accidental overdoseFAERS: 8US FAERS
119Blood pressure fluctuationFAERS: 8US FAERS
120ChillsFAERS: 8US FAERS
121ChokingFAERS: 8US FAERS
122DysgeusiaFAERS: 8US FAERS
123FlushingFAERS: 8US FAERS
124Mental status changesFAERS: 8US FAERS
125Walking aid userFAERS: 8US FAERS
126Altered state of consciousnessFAERS: 7US FAERS
127CatatoniaFAERS: 7US FAERS
128Emotional disorderFAERS: 7US FAERS
129Feeding tube userFAERS: 7US FAERS
130Initial insomniaFAERS: 7US FAERS
131Night sweatsFAERS: 7US FAERS
132Oropharyngeal painFAERS: 7US FAERS
133Terminal stateFAERS: 7US FAERS
134Unevaluable eventFAERS: 7US FAERS
135BradycardiaFAERS: 6US FAERS
136BronchitisFAERS: 6US FAERS
137Chest discomfortFAERS: 6US FAERS
138EpistaxisFAERS: 6US FAERS
139Joint injuryFAERS: 6US FAERS
140LacerationFAERS: 6US FAERS
141Mood swingsFAERS: 6US FAERS
142Muscle RigidityFAERS: 6US FAERS
143PallorFAERS: 6US FAERS
144RetchingFAERS: 6US FAERS
145SoliloquyFAERS: 6US FAERS
146AlopeciaFAERS: 5US FAERS
147AsthmaFAERS: 5US FAERS
148Delusional perceptionFAERS: 5US FAERS
149DysphoniaFAERS: 5US FAERS
150GastrostomyFAERS: 5US FAERS
151HostilityFAERS: 5US FAERS
152Intentional dose omissionFAERS: 5US FAERS
153NocturiaFAERS: 5US FAERS
154Patient uncooperativeFAERS: 5US FAERS
155Secretion dischargeFAERS: 5US FAERS
156SomnambulismFAERS: 5US FAERS
157VertigoFAERS: 5US FAERS
158AkathisiaFAERS: 4US FAERS
159AkinesiaFAERS: 4US FAERS
160Back disorderFAERS: 4US FAERS
161BelligerenceFAERS: 4US FAERS
162Blood glucose decreasedFAERS: 4US FAERS
163Blood potassium decreasedFAERS: 4US FAERS
164Cold sweatFAERS: 4US FAERS
165Diet refusalFAERS: 4US FAERS
166DiverticulitisFAERS: 4US FAERS
167Dry skinFAERS: 4US FAERS
168HypervigilanceFAERS: 4US FAERS
169Intestinal ObstructionFAERS: 4US FAERS
170Joint stiffnessFAERS: 4US FAERS
171MyalgiaFAERS: 4US FAERS
172Obsessive-Compulsive DisorderFAERS: 4US FAERS
173Respiratory distressFAERS: 4US FAERS
174SciaticaFAERS: 4US FAERS
175Slow speechFAERS: 4US FAERS
176Therapeutic product effect decreasedFAERS: 4US FAERS
177Throat clearingFAERS: 4US FAERS
178Throat irritationFAERS: 4US FAERS
179Tongue movement disturbanceFAERS: 4US FAERS
180Upper-airway cough syndromeFAERS: 4US FAERS
181Abdominal PainFAERS: 3US FAERS
182ArthritisFAERS: 3US FAERS
183Blood cholesterol increasedFAERS: 3US FAERS
184Blood sodium decreasedFAERS: 3US FAERS
185CellulitisFAERS: 3US FAERS
186Completed SuicideFAERS: 3US FAERS
187Deep Vein ThrombosisFAERS: 3US FAERS
188DiplopiaFAERS: 3US FAERS
189DiscomfortFAERS: 3US FAERS
190Drug administration errorFAERS: 3US FAERS
191Drug dispensing errorFAERS: 3US FAERS
192Drug effect delayedFAERS: 3US FAERS
193DysuriaFAERS: 3US FAERS
194Escherichia infectionFAERS: 3US FAERS
195Euphoric moodFAERS: 3US FAERS
196Eye irritationFAERS: 3US FAERS
197Eye painFAERS: 3US FAERS
198FolliculitisFAERS: 3US FAERS
199Frustration tolerance decreasedFAERS: 3US FAERS
200General physical condition abnormalFAERS: 3US FAERS
201Head discomfortFAERS: 3US FAERS
202LazinessFAERS: 3US FAERS
203Limb injuryFAERS: 3US FAERS
204NephrolithiasisFAERS: 3US FAERS
205OsteitisFAERS: 3US FAERS
206Pancreatic carcinomaFAERS: 3US FAERS
207Parkinson's disease psychosisFAERS: 3US FAERS
208Psychiatric symptomFAERS: 3US FAERS
209Respiratory arrestFAERS: 3US FAERS
210RhabdomyolysisFAERS: 3US FAERS
211Suicide attemptFAERS: 3US FAERS
212Wheelchair userFAERS: 3US FAERS
213WheezingFAERS: 3US FAERS
214furuncleFAERS: 3US FAERS
215Acute myocardial infarctionFAERS: 2US FAERS
216ArthropathyFAERS: 2US FAERS
217Bowel movement irregularityFAERS: 2US FAERS
218BradykinesiaFAERS: 2US FAERS
219BradyphreniaFAERS: 2US FAERS
220Cataract operationFAERS: 2US FAERS
221ChromaturiaFAERS: 2US FAERS
222Clostridium difficile infectionFAERS: 2US FAERS
223ClumsinessFAERS: 2US FAERS
224Coronary Artery DiseaseFAERS: 2US FAERS
225CyanosisFAERS: 2US FAERS
226Diabetes MellitusFAERS: 2US FAERS
227Dose calculation errorFAERS: 2US FAERS
228Drug effective for unapproved indicationFAERS: 2US FAERS
229Drug withdrawal syndromeFAERS: 2US FAERS
230Ear discomfortFAERS: 2US FAERS
231Emotional distressFAERS: 2US FAERS
232EnuresisFAERS: 2US FAERS
233Expired product administeredFAERS: 2US FAERS
234Facial paralysisFAERS: 2US FAERS
235Failure to ThriveFAERS: 2US FAERS
236Feeling ColdFAERS: 2US FAERS
237Female Orgasmic DisorderFAERS: 2US FAERS
238Flat affectFAERS: 2US FAERS
239FlatulenceFAERS: 2US FAERS
240GastritisFAERS: 2US FAERS
241GlaucomaFAERS: 2US FAERS
242GoutFAERS: 2US FAERS
243Impaired quality of lifeFAERS: 2US FAERS
244Increased viscosity of upper respiratory secretionFAERS: 2US FAERS
245Intentional product use issueFAERS: 2US FAERS
246Intentional self-injuryFAERS: 2US FAERS
247Laryngeal cancer stage IIIFAERS: 2US FAERS
248Mechanical ventilationFAERS: 2US FAERS
249Muscle tightnessFAERS: 2US FAERS
250Myocardial necrosis marker increasedFAERS: 2US FAERS
251No adverse eventFAERS: 2US FAERS
252Obsessive thoughtsFAERS: 2US FAERS
253Oral painFAERS: 2US FAERS
254Pain of skinFAERS: 2US FAERS
255ParesisFAERS: 2US FAERS
256PhotophobiaFAERS: 2US FAERS
257PresyncopeFAERS: 2US FAERS
258Product prescribing issueFAERS: 2US FAERS
259Product storage errorFAERS: 2US FAERS
260Product supply issueFAERS: 2US FAERS
261Product use complaintFAERS: 2US FAERS
262Progressive supranuclear palsyFAERS: 2US FAERS
263Pupillary deformityFAERS: 2US FAERS
264Renal painFAERS: 2US FAERS
265Restless Legs SyndromeFAERS: 2US FAERS
266ScabFAERS: 2US FAERS
267Sexual activity increasedFAERS: 2US FAERS
268SinusitisFAERS: 2US FAERS
269Skin UlcerFAERS: 2US FAERS
270Skin irritationFAERS: 2US FAERS
271Slow response to stimuliFAERS: 2US FAERS
272SnoringFAERS: 2US FAERS
273Suprapubic painFAERS: 2US FAERS
274Tardive DyskinesiaFAERS: 2US FAERS
275Therapy cessationFAERS: 2US FAERS
276Therapy non-responderFAERS: 2US FAERS
277ThirstFAERS: 2US FAERS
278Urine output increasedFAERS: 2US FAERS
279Viral upper respiratory tract infectionFAERS: 2US FAERS
280Wrong doseFAERS: 2US FAERS
281Accidental exposure to productFAERS: 1US FAERS
282Acute kidney injuryFAERS: 1US FAERS
283Acute respiratory failureFAERS: 1US FAERS
284AgeusiaFAERS: 1US FAERS
285Altered visual depth perceptionFAERS: 1US FAERS
286AneurysmFAERS: 1US FAERS
287AngioedemaFAERS: 1US FAERS
288Ankle FractureFAERS: 1US FAERS
289Arthropod biteFAERS: 1US FAERS
290Bacterial sepsisFAERS: 1US FAERS
291Bed restFAERS: 1US FAERS
292Bipolar DisorderFAERS: 1US FAERS
293Bladder catheter temporaryFAERS: 1US FAERS
294Blood catecholamines increasedFAERS: 1US FAERS
295Blood count abnormalFAERS: 1US FAERS
296Blood creatinine increasedFAERS: 1US FAERS
297Blood glucose abnormalFAERS: 1US FAERS
298Blood magnesium decreasedFAERS: 1US FAERS
299Blood urea increasedFAERS: 1US FAERS
300Blood urine presentFAERS: 1US FAERS
301Body temperature fluctuationFAERS: 1US FAERS
302Bone painFAERS: 1US FAERS
303BronchospasmFAERS: 1US FAERS
304BruxismFAERS: 1US FAERS
305Burning sensationFAERS: 1US FAERS
306Capillary FragilityFAERS: 1US FAERS
307Carbon dioxide abnormalFAERS: 1US FAERS
308Carotid artery calcificationFAERS: 1US FAERS
309Catheter managementFAERS: 1US FAERS
310Cerebral disorderFAERS: 1US FAERS
311Change in sustained attentionFAERS: 1US FAERS
312Chronic diseaseFAERS: 1US FAERS
313Clostridial sepsisFAERS: 1US FAERS
314Compulsive sexual behaviourFAERS: 1US FAERS
315Contraindicated product administeredFAERS: 1US FAERS
316Conversion disorderFAERS: 1US FAERS
317CystoscopyFAERS: 1US FAERS
318CystFAERS: 1US FAERS
319DeafnessFAERS: 1US FAERS
320Deep Brain StimulationFAERS: 1US FAERS
321Delusion of replacementFAERS: 1US FAERS
322DiplegiaFAERS: 1US FAERS
323Disease complicationFAERS: 1US FAERS
324Disturbance in sexual arousalFAERS: 1US FAERS
325DyscheziaFAERS: 1US FAERS
326DysgraphiaFAERS: 1US FAERS
327DystoniaFAERS: 1US FAERS
328Economic problemFAERS: 1US FAERS
329Electrocardiogram ST-T segment abnormalFAERS: 1US FAERS
330EndocarditisFAERS: 1US FAERS
331Erectile dysfunctionFAERS: 1US FAERS
332EructationFAERS: 1US FAERS
333ExhibitionismFAERS: 1US FAERS
334Extra dose administeredFAERS: 1US FAERS
335Eyelid rashFAERS: 1US FAERS
336Feeling of body temperature changeFAERS: 1US FAERS
337Flank PainFAERS: 1US FAERS
338Flight of ideasFAERS: 1US FAERS
339Food cravingFAERS: 1US FAERS
340FormicationFAERS: 1US FAERS
341Frontotemporal dementiaFAERS: 1US FAERS
342Gait deviationFAERS: 1US FAERS
343Gastrointestinal perforationFAERS: 1US FAERS
344Gaze palsyFAERS: 1US FAERS
345Grip strength decreasedFAERS: 1US FAERS
346Head titubationFAERS: 1US FAERS
347HungerFAERS: 1US FAERS
348HyperchlorhydriaFAERS: 1US FAERS
349HyperphagiaFAERS: 1US FAERS
350Hypertensive heart diseaseFAERS: 1US FAERS
351HypoxiaFAERS: 1US FAERS
352Ideas of referenceFAERS: 1US FAERS
353Impaired driving abilityFAERS: 1US FAERS
354Impaired work abilityFAERS: 1US FAERS
355Implantable defibrillator insertionFAERS: 1US FAERS
356Incorrect drug administration durationFAERS: 1US FAERS
357InflammationFAERS: 1US FAERS
358Insurance issueFAERS: 1US FAERS
359Joint InstabilityFAERS: 1US FAERS
360Lack of spontaneous speechFAERS: 1US FAERS
361LeukocytosisFAERS: 1US FAERS
362Libido disorderFAERS: 1US FAERS
363Life expectancy shortenedFAERS: 1US FAERS
364Living in residential institutionFAERS: 1US FAERS
365Locked-In SyndromeFAERS: 1US FAERS
366Long QT SyndromeFAERS: 1US FAERS
367LymphadenopathyFAERS: 1US FAERS
368MalnutritionFAERS: 1US FAERS
369Medical device battery replacementFAERS: 1US FAERS
370Medical observationFAERS: 1US FAERS
371Medication ErrorFAERS: 1US FAERS
372Metastatic NeoplasmFAERS: 1US FAERS
373MoaningFAERS: 1US FAERS
374Morbid thoughtsFAERS: 1US FAERS
375Multiple SclerosisFAERS: 1US FAERS
376Muscle SpasticityFAERS: 1US FAERS
377Muscle tone disorderFAERS: 1US FAERS
378Musculoskeletal PainFAERS: 1US FAERS
379Musculoskeletal chest painFAERS: 1US FAERS
380Musculoskeletal discomfortFAERS: 1US FAERS
381MyoclonusFAERS: 1US FAERS
382MyopathyFAERS: 1US FAERS
383Neck PainFAERS: 1US FAERS
384Negative thoughtsFAERS: 1US FAERS
385NegativismFAERS: 1US FAERS
386NephrectomyFAERS: 1US FAERS
387NeuralgiaFAERS: 1US FAERS
388Neuroleptic Malignant SyndromeFAERS: 1US FAERS
389Nipple painFAERS: 1US FAERS
390Ocular discomfortFAERS: 1US FAERS
391Oromandibular dystoniaFAERS: 1US FAERS
392Orthostatic hypertensionFAERS: 1US FAERS
393Paradoxical drug reactionFAERS: 1US FAERS
394ParaplegiaFAERS: 1US FAERS
395Performance status decreasedFAERS: 1US FAERS
396Peripheral embolismFAERS: 1US FAERS
397Peripheral venous diseaseFAERS: 1US FAERS
398Pharyngeal swellingFAERS: 1US FAERS
399PhlebitisFAERS: 1US FAERS
400PleurothotonusFAERS: 1US FAERS
401PneumothoraxFAERS: 1US FAERS
402Post procedural complicationFAERS: 1US FAERS
403Product label issueFAERS: 1US FAERS
404Product physical issueFAERS: 1US FAERS
405Product used for unknown indicationFAERS: 1US FAERS
406PseudostrokeFAERS: 1US FAERS
407Psychiatric evaluationFAERS: 1US FAERS
408Rash erythematousFAERS: 1US FAERS
409Reduced facial expressionFAERS: 1US FAERS
410Refractory cytopenia with unilineage dysplasiaFAERS: 1US FAERS
411Rehabilitation therapyFAERS: 1US FAERS
412Respiratory muscle weaknessFAERS: 1US FAERS
413Respiratory tract congestionFAERS: 1US FAERS
414SchizophreniaFAERS: 1US FAERS
415Scrotal erythemaFAERS: 1US FAERS
416Skin reactionFAERS: 1US FAERS
417StrabismusFAERS: 1US FAERS
418StubbornnessFAERS: 1US FAERS
419Sudden deathFAERS: 1US FAERS
420Supraventricular tachycardiaFAERS: 1US FAERS
421TachycardiaFAERS: 1US FAERS
422TachyphreniaFAERS: 1US FAERS
423Tension HeadacheFAERS: 1US FAERS
424TensionFAERS: 1US FAERS
425Terminal agitationFAERS: 1US FAERS
426Therapeutic product effective for unapproved indicationFAERS: 1US FAERS
427Therapeutic response changedFAERS: 1US FAERS
428Therapy changeFAERS: 1US FAERS
429Time perception alteredFAERS: 1US FAERS
430TinnitusFAERS: 1US FAERS
431Toe operationFAERS: 1US FAERS
432Tongue bitingFAERS: 1US FAERS
433Tooth InfectionFAERS: 1US FAERS
434ToothacheFAERS: 1US FAERS
435Transient aphasiaFAERS: 1US FAERS
436TrismusFAERS: 1US FAERS
437Troponin increasedFAERS: 1US FAERS
438Tympanic Membrane PerforationFAERS: 1US FAERS
439Urine flow decreasedFAERS: 1US FAERS
440Uterine ProlapseFAERS: 1US FAERS
441White blood cell count decreasedFAERS: 1US FAERS
442nervous system disorderFAERS: 1US FAERS
443skin abrasionFAERS: 1US FAERS
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