Carbidopa, levodopa, and entacapone
(OTVUCEMFRGJEMR-FTXVUGNJSA-N)
Structure
- SMILES
- OC(=O)[C@H](Cc1ccc(c(c1)O)O)N.NN[C@](C(=O)O)(Cc1ccc(c(c1)O)O)C.CCN(C(=O)/C(=C/c1cc(O)c(c(c1)[N+](=O)[O-])O)/C#N)CC
- Molecular Formula:
- C33H40N6O13
- Molecular Weight:
- 728.703
- Log P:
- 4.0952
- Hydrogen Bond Acceptor:
- 16
- Hydrogen Bond Donor:
- 11
- TPSA:
- 349.97
- CAS Number(s):
- 745835-09-0
Synonym(s)
1.
Carbidopa, levodopa, and entacapone
External Link(s)
| PubChem Compound | 9831783 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Pneumonia | FAERS: 43 | US FAERS | |
| 2 | Tremor | FAERS: 32 | US FAERS | |
| 3 | Respiratory arrest | FAERS: 21 | US FAERS | |
| 4 | Dizziness | FAERS: 20 | US FAERS | |
| 5 | Nausea | FAERS: 18 | US FAERS | |
| 6 | Cerebrovascular accident | FAERS: 17 | US FAERS | |
| 7 | Drug ineffective | FAERS: 17 | US FAERS | |
| 8 | Cardiac Arrest | FAERS: 16 | US FAERS | |
| 9 | Chromaturia | FAERS: 16 | US FAERS | |
| 10 | Myocardial Infarction | FAERS: 15 | US FAERS | |
| 11 | Urinary tract infection | FAERS: 15 | US FAERS | |
| 12 | Weight decreased | FAERS: 15 | US FAERS | |
| 13 | Fatigue | FAERS: 14 | US FAERS | |
| 14 | Musculoskeletal stiffness | FAERS: 14 | US FAERS | |
| 15 | Vomiting | FAERS: 13 | US FAERS | |
| 16 | Wrong technique in drug usage process | FAERS: 13 | US FAERS | |
| 17 | Asthenia | FAERS: 12 | US FAERS | |
| 18 | General physical health deterioration | FAERS: 11 | US FAERS | |
| 19 | Abasia | FAERS: 10 | US FAERS | |
| 20 | Choking | FAERS: 10 | US FAERS | |
| 21 | Constipation | FAERS: 10 | US FAERS | |
| 22 | Incorrect dose administered | FAERS: 10 | US FAERS | |
| 23 | Infection | FAERS: 10 | US FAERS | |
| 24 | Delirium | FAERS: 9 | US FAERS | |
| 25 | Disease Progression | FAERS: 9 | US FAERS | |
| 26 | Freezing phenomenon | FAERS: 9 | US FAERS | |
| 27 | Intestinal Obstruction | FAERS: 9 | US FAERS | |
| 28 | Muscle Rigidity | FAERS: 9 | US FAERS | |
| 29 | Respiratory Failure | FAERS: 9 | US FAERS | |
| 30 | Agitation | FAERS: 8 | US FAERS | |
| 31 | Aphasia | FAERS: 8 | US FAERS | |
| 32 | Feeling abnormal | FAERS: 8 | US FAERS | |
| 33 | Malaise | FAERS: 8 | US FAERS | |
| 34 | Anxiety | FAERS: 7 | US FAERS | |
| 35 | Overdose | FAERS: 7 | US FAERS | |
| 36 | Sepsis | FAERS: 7 | US FAERS | |
| 37 | jaundice | FAERS: 7 | US FAERS | |
| 38 | Anuria | FAERS: 6 | US FAERS | |
| 39 | Calcinosis | FAERS: 6 | US FAERS | |
| 40 | Chest Pain | FAERS: 6 | US FAERS | |
| 41 | Disorientation | FAERS: 6 | US FAERS | |
| 42 | Foreign body trauma | FAERS: 6 | US FAERS | |
| 43 | Hypersensitivity | FAERS: 6 | US FAERS | |
| 44 | Hypotension | FAERS: 6 | US FAERS | |
| 45 | Incontinence | FAERS: 6 | US FAERS | |
| 46 | Increased upper airway secretion | FAERS: 6 | US FAERS | |
| 47 | Restless Legs Syndrome | FAERS: 6 | US FAERS | |
| 48 | Syncope | FAERS: 6 | US FAERS | |
| 49 | Asthma | FAERS: 5 | US FAERS | |
| 50 | Colitis | FAERS: 5 | US FAERS | |
| 51 | Drug dispensing error | FAERS: 5 | US FAERS | |
| 52 | Gastroenteritis | FAERS: 5 | US FAERS | |
| 53 | Groin infection | FAERS: 5 | US FAERS | |
| 54 | Headache | FAERS: 5 | US FAERS | |
| 55 | Infarction | FAERS: 5 | US FAERS | |
| 56 | Pharmaceutical product complaint | FAERS: 5 | US FAERS | |
| 57 | Somnolence | FAERS: 5 | US FAERS | |
| 58 | Ulcer | FAERS: 5 | US FAERS | |
| 59 | Abdominal Pain | FAERS: 4 | US FAERS | |
| 60 | Cerebral Infarction | FAERS: 4 | US FAERS | |
| 61 | Cholelithiasis | FAERS: 4 | US FAERS | |
| 62 | Dysuria | FAERS: 4 | US FAERS | |
| 63 | Erythema | FAERS: 4 | US FAERS | |
| 64 | Hypertensive crisis | FAERS: 4 | US FAERS | |
| 65 | Hypokinesia | FAERS: 4 | US FAERS | |
| 66 | Limb injury | FAERS: 4 | US FAERS | |
| 67 | MYELODYSPLASTIC SYNDROME | FAERS: 4 | US FAERS | |
| 68 | Medication Error | FAERS: 4 | US FAERS | |
| 69 | Nervousness | FAERS: 4 | US FAERS | |
| 70 | Pain | FAERS: 4 | US FAERS | |
| 71 | Palpitations | FAERS: 4 | US FAERS | |
| 72 | Post procedural complication | FAERS: 4 | US FAERS | |
| 73 | Pruritus | FAERS: 4 | US FAERS | |
| 74 | Senile dementia | FAERS: 4 | US FAERS | |
| 75 | Swelling | FAERS: 4 | US FAERS | |
| 76 | Akinesia | FAERS: 3 | US FAERS | |
| 77 | Angioedema | FAERS: 3 | US FAERS | |
| 78 | Anorexia | FAERS: 3 | US FAERS | |
| 79 | Anoxia | FAERS: 3 | US FAERS | |
| 80 | Back Pain | FAERS: 3 | US FAERS | |
| 81 | Bacterial food poisoning | FAERS: 3 | US FAERS | |
| 82 | Blood urine present | FAERS: 3 | US FAERS | |
| 83 | Brain Hypoxia | FAERS: 3 | US FAERS | |
| 84 | Cataract | FAERS: 3 | US FAERS | |
| 85 | Completed Suicide | FAERS: 3 | US FAERS | |
| 86 | Deep Brain Stimulation | FAERS: 3 | US FAERS | |
| 87 | Dehydration | FAERS: 3 | US FAERS | |
| 88 | Diabetes mellitus inadequate control | FAERS: 3 | US FAERS | |
| 89 | Diplopia | FAERS: 3 | US FAERS | |
| 90 | Discomfort | FAERS: 3 | US FAERS | |
| 91 | Drooling | FAERS: 3 | US FAERS | |
| 92 | Drug exposure during pregnancy | FAERS: 3 | US FAERS | |
| 93 | Gamma-Glutamyltransferase Increased | FAERS: 3 | US FAERS | |
| 94 | Gastritis | FAERS: 3 | US FAERS | |
| 95 | Gastrostomy | FAERS: 3 | US FAERS | |
| 96 | Incoherent | FAERS: 3 | US FAERS | |
| 97 | Incorrect route of drug administration | FAERS: 3 | US FAERS | |
| 98 | Joint injury | FAERS: 3 | US FAERS | |
| 99 | Joint stiffness | FAERS: 3 | US FAERS | |
| 100 | Paranoia | FAERS: 3 | US FAERS | |
| 101 | Product quality issue | FAERS: 3 | US FAERS | |
| 102 | Suicide attempt | FAERS: 3 | US FAERS | |
| 103 | Vasculitis | FAERS: 3 | US FAERS | |
| 104 | Visual Impairment | FAERS: 3 | US FAERS | |
| 105 | Vocal Cord Paralysis | FAERS: 3 | US FAERS | |
| 106 | Abdominal discomfort | FAERS: 2 | US FAERS | |
| 107 | Abscess | FAERS: 2 | US FAERS | |
| 108 | Acne | FAERS: 2 | US FAERS | |
| 109 | Acute myocardial infarction | FAERS: 2 | US FAERS | |
| 110 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 111 | Angina Pectoris | FAERS: 2 | US FAERS | |
| 112 | Arthritis | FAERS: 2 | US FAERS | |
| 113 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 114 | Autonomic nervous system imbalance | FAERS: 2 | US FAERS | |
| 115 | Benign neoplasm of prostate | FAERS: 2 | US FAERS | |
| 116 | Blindness | FAERS: 2 | US FAERS | |
| 117 | Blood creatine phosphokinase increased | FAERS: 2 | US FAERS | |
| 118 | Bradycardia | FAERS: 2 | US FAERS | |
| 119 | Bradykinesia | FAERS: 2 | US FAERS | |
| 120 | Bronchial Obstruction | FAERS: 2 | US FAERS | |
| 121 | Bronchitis | FAERS: 2 | US FAERS | |
| 122 | Bronchospasm | FAERS: 2 | US FAERS | |
| 123 | Burning sensation | FAERS: 2 | US FAERS | |
| 124 | Cataract operation | FAERS: 2 | US FAERS | |
| 125 | Chills | FAERS: 2 | US FAERS | |
| 126 | Compulsive sexual behaviour | FAERS: 2 | US FAERS | |
| 127 | Drug Dependence | FAERS: 2 | US FAERS | |
| 128 | Drug administration error | FAERS: 2 | US FAERS | |
| 129 | Drug prescribing error | FAERS: 2 | US FAERS | |
| 130 | Drug toxicity | FAERS: 2 | US FAERS | |
| 131 | Dysarthria | FAERS: 2 | US FAERS | |
| 132 | Dysgeusia | FAERS: 2 | US FAERS | |
| 133 | Eczema | FAERS: 2 | US FAERS | |
| 134 | Embolism | FAERS: 2 | US FAERS | |
| 135 | Expired drug administered | FAERS: 2 | US FAERS | |
| 136 | Gastrointestinal angiodysplasia | FAERS: 2 | US FAERS | |
| 137 | Gastrointestinal carcinoma | FAERS: 2 | US FAERS | |
| 138 | Gastrointestinal infection | FAERS: 2 | US FAERS | |
| 139 | Glaucoma | FAERS: 2 | US FAERS | |
| 140 | Glutamate dehydrogenase increased | FAERS: 2 | US FAERS | |
| 141 | Hepatotoxicity | FAERS: 2 | US FAERS | |
| 142 | Hernia | FAERS: 2 | US FAERS | |
| 143 | Hip surgery | FAERS: 2 | US FAERS | |
| 144 | Hyperpyrexia | FAERS: 2 | US FAERS | |
| 145 | Ileitis | FAERS: 2 | US FAERS | |
| 146 | Immobile | FAERS: 2 | US FAERS | |
| 147 | Inappropriate schedule of drug administration | FAERS: 2 | US FAERS | |
| 148 | Induration | FAERS: 2 | US FAERS | |
| 149 | Inflammation | FAERS: 2 | US FAERS | |
| 150 | Medical device implantation | FAERS: 2 | US FAERS | |
| 151 | Mental impairment | FAERS: 2 | US FAERS | |
| 152 | Neonatal disorder | FAERS: 2 | US FAERS | |
| 153 | Neonatal pneumonia | FAERS: 2 | US FAERS | |
| 154 | Neuralgia | FAERS: 2 | US FAERS | |
| 155 | Neuroleptic Malignant Syndrome | FAERS: 2 | US FAERS | |
| 156 | Oral administration complication | FAERS: 2 | US FAERS | |
| 157 | Oxygen supplementation | FAERS: 2 | US FAERS | |
| 158 | Pallor | FAERS: 2 | US FAERS | |
| 159 | Pancreatic carcinoma | FAERS: 2 | US FAERS | |
| 160 | Pancreatitis | FAERS: 2 | US FAERS | |
| 161 | Pancytopenia | FAERS: 2 | US FAERS | |
| 162 | Peritonitis | FAERS: 2 | US FAERS | |
| 163 | Pneumothorax | FAERS: 2 | US FAERS | |
| 164 | Polyuria | FAERS: 2 | US FAERS | |
| 165 | Postoperative abscess | FAERS: 2 | US FAERS | |
| 166 | Product substitution issue | FAERS: 2 | US FAERS | |
| 167 | Protein urine present | FAERS: 2 | US FAERS | |
| 168 | Pulmonary Embolism | FAERS: 2 | US FAERS | |
| 169 | Pulmonary Fibrosis | FAERS: 2 | US FAERS | |
| 170 | Pulmonary congestion | FAERS: 2 | US FAERS | |
| 171 | Pulmonary sepsis | FAERS: 2 | US FAERS | |
| 172 | Renal pain | FAERS: 2 | US FAERS | |
| 173 | Septic Shock | FAERS: 2 | US FAERS | |
| 174 | Tooth Loss | FAERS: 2 | US FAERS | |
| 175 | Traumatic Brain Injury | FAERS: 2 | US FAERS | |
| 176 | Urticaria | FAERS: 2 | US FAERS | |
| 177 | nervous system disorder | FAERS: 2 | US FAERS | |
| 178 | Accidental drug intake by child | FAERS: 1 | US FAERS | |
| 179 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 180 | Ageusia | FAERS: 1 | US FAERS | |
| 181 | Allergic respiratory symptom | FAERS: 1 | US FAERS | |
| 182 | Anaphylactic shock | FAERS: 1 | US FAERS | |
| 183 | Anger | FAERS: 1 | US FAERS | |
| 184 | Angiogram retina | FAERS: 1 | US FAERS | |
| 185 | Apallic syndrome | FAERS: 1 | US FAERS | |
| 186 | Aphagia | FAERS: 1 | US FAERS | |
| 187 | Appendicitis | FAERS: 1 | US FAERS | |
| 188 | Arthralgia | FAERS: 1 | US FAERS | |
| 189 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 190 | Bed rest | FAERS: 1 | US FAERS | |
| 191 | Blood cholesterol increased | FAERS: 1 | US FAERS | |
| 192 | Blood creatinine decreased | FAERS: 1 | US FAERS | |
| 193 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 194 | Blood glucose increased | FAERS: 1 | US FAERS | |
| 195 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 196 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 197 | Bone density abnormal | FAERS: 1 | US FAERS | |
| 198 | Bruxism | FAERS: 1 | US FAERS | |
| 199 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 200 | Catheter related complication | FAERS: 1 | US FAERS | |
| 201 | Cerebral artery occlusion | FAERS: 1 | US FAERS | |
| 202 | Cold sweat | FAERS: 1 | US FAERS | |
| 203 | Colonic Pseudo-Obstruction | FAERS: 1 | US FAERS | |
| 204 | Crying | FAERS: 1 | US FAERS | |
| 205 | Cystitis | FAERS: 1 | US FAERS | |
| 206 | Diabetes Mellitus | FAERS: 1 | US FAERS | |
| 207 | Diplegia | FAERS: 1 | US FAERS | |
| 208 | Disease complication | FAERS: 1 | US FAERS | |
| 209 | Diverticulum | FAERS: 1 | US FAERS | |
| 210 | Drug abuse | FAERS: 1 | US FAERS | |
| 211 | Drug exposure via breast milk | FAERS: 1 | US FAERS | |
| 212 | Drug level below therapeutic | FAERS: 1 | US FAERS | |
| 213 | Drug resistance | FAERS: 1 | US FAERS | |
| 214 | Dysphonia | FAERS: 1 | US FAERS | |
| 215 | Dysplasia | FAERS: 1 | US FAERS | |
| 216 | Electroencephalogram abnormal | FAERS: 1 | US FAERS | |
| 217 | Exophthalmos | FAERS: 1 | US FAERS | |
| 218 | Feeling Cold | FAERS: 1 | US FAERS | |
| 219 | Foreign body aspiration | FAERS: 1 | US FAERS | |
| 220 | Frontotemporal dementia | FAERS: 1 | US FAERS | |
| 221 | Gallbladder pain | FAERS: 1 | US FAERS | |
| 222 | Hyperkinesia | FAERS: 1 | US FAERS | |
| 223 | Hypophagia | FAERS: 1 | US FAERS | |
| 224 | Hypoxia | FAERS: 1 | US FAERS | |
| 225 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 226 | Intentional misuse | FAERS: 1 | US FAERS | |
| 227 | Intestinal resection | FAERS: 1 | US FAERS | |
| 228 | Intestinal stoma | FAERS: 1 | US FAERS | |
| 229 | Leukocytoclastic vasculitis | FAERS: 1 | US FAERS | |
| 230 | Limb operation | FAERS: 1 | US FAERS | |
| 231 | Malabsorption | FAERS: 1 | US FAERS | |
| 232 | Meningioma | FAERS: 1 | US FAERS | |
| 233 | Meningitis | FAERS: 1 | US FAERS | |
| 234 | Multiple System Atrophy | FAERS: 1 | US FAERS | |
| 235 | Myalgia | FAERS: 1 | US FAERS | |
| 236 | Myeloid Metaplasia | FAERS: 1 | US FAERS | |
| 237 | Myocardial fibrosis | FAERS: 1 | US FAERS | |
| 238 | Myoglobin blood increased | FAERS: 1 | US FAERS | |
| 239 | Neurological decompensation | FAERS: 1 | US FAERS | |
| 240 | No adverse effect | FAERS: 1 | US FAERS | |
| 241 | Nocturia | FAERS: 1 | US FAERS | |
| 242 | Oncologic complication | FAERS: 1 | US FAERS | |
| 243 | Oropharyngitis fungal | FAERS: 1 | US FAERS | |
| 244 | Pallidotomy | FAERS: 1 | US FAERS | |
| 245 | Pancreatic Insufficiency | FAERS: 1 | US FAERS | |
| 246 | Personality Change | FAERS: 1 | US FAERS | |
| 247 | Poisoning | FAERS: 1 | US FAERS | |
| 248 | Polydipsia | FAERS: 1 | US FAERS | |
| 249 | Poor quality drug administered | FAERS: 1 | US FAERS | |
| 250 | Postoperative fever | FAERS: 1 | US FAERS | |
| 251 | Postoperative wound complication | FAERS: 1 | US FAERS | |
| 252 | Pregnancy | FAERS: 1 | US FAERS | |
| 253 | Procedural complication | FAERS: 1 | US FAERS | |
| 254 | Product counterfeit | FAERS: 1 | US FAERS | |
| 255 | Product measured potency issue | FAERS: 1 | US FAERS | |
| 256 | Product packaging issue | FAERS: 1 | US FAERS | |
| 257 | Prosthesis Implantation | FAERS: 1 | US FAERS | |
| 258 | Pyuria | FAERS: 1 | US FAERS | |
| 259 | Rash erythematous | FAERS: 1 | US FAERS | |
| 260 | Renal mass | FAERS: 1 | US FAERS | |
| 261 | Rhabdomyolysis | FAERS: 1 | US FAERS | |
| 262 | Shock | FAERS: 1 | US FAERS | |
| 263 | Sinus bradycardia | FAERS: 1 | US FAERS | |
| 264 | Sinusitis | FAERS: 1 | US FAERS | |
| 265 | Spinal column injury | FAERS: 1 | US FAERS | |
| 266 | Staring | FAERS: 1 | US FAERS | |
| 267 | Stool analysis abnormal | FAERS: 1 | US FAERS | |
| 268 | Tachycardia | FAERS: 1 | US FAERS | |
| 269 | Terminal state | FAERS: 1 | US FAERS | |
| 270 | Therapeutic response delayed | FAERS: 1 | US FAERS | |
| 271 | Throat irritation | FAERS: 1 | US FAERS | |
| 272 | Trismus | FAERS: 1 | US FAERS | |
| 273 | Unevaluable event | FAERS: 1 | US FAERS | |
| 274 | Upper airway obstruction | FAERS: 1 | US FAERS | |
| 275 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 276 | Urinary tract obstruction | FAERS: 1 | US FAERS | |
| 277 | Visual disturbance | FAERS: 1 | US FAERS | |
| 278 | Walking aid user | FAERS: 1 | US FAERS | |
| 279 | Wheelchair user | FAERS: 1 | US FAERS |
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