MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Didanosine

(BXZVVICBKDXVGW-NKWVEPMBSA-N)

Structure

SMILES: OC[C@@H]1CC[C@@H](O1)n1cnc2c1nc[nH]c2=O
Type(s): Approved
ATC code(s): J05AF02
Molecular Formula:: C10H12N4O3
Molecular Weight:: 236.227
Log P:: -0.2105
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 2
TPSA:: 93.03
CAS Number(s):: 69655-05-6

Synonym(s)

Didanosine

2',3'-Dideoxyinosine

Dideoxyinosine

ddI (Antiviral)

NSC-612049

Videx

2',3' Dideoxyinosine

NSC 612049

NSC612049

External Link(s)

MeSH	D016049
PubChem Compound	135398739 50599
BindingDB	50404252
ChEBI	490877
CHEMBL	CHEMBL1460
DrugBank	DB00900
DrugCentral	869
IUPHAR/BPS Guide to PHARMACOLOGY	4833
KEGG	cpd:C06953 dr:D00296
Therapeutic Target Database	D0P6OM D06FDR
ZINC	13597823

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Portal Hypertension	FAERS: 36		OFFSIDES SIDER US FAERS
2	Nodular regenerative hyperplasia	FAERS: 11		OFFSIDES US FAERS
3	Pancreatitis	FAERS: 8 Canada Vigilance: 4	View details 1362093 1659189 1671969 1974724 1974725 1974726 1974727 2166965 7915361 8387218 9028860 9665308 15040545	CTD OFFSIDES SIDER Canada Vigilance US FAERS
4	Splenomegaly	FAERS: 7		US FAERS
5	Retinal toxicity	FAERS: 6		US FAERS
6	Portal Vein Thrombosis	FAERS: 5		OFFSIDES US FAERS
7	Retinal Degeneration	FAERS: 5		SIDER US FAERS
8	Ascites	FAERS: 4		OFFSIDES US FAERS
9	Retinal Detachment	FAERS: 4		US FAERS
10	Adverse event	FAERS: 3		US FAERS
11	Medication Error	FAERS: 3		US FAERS
12	Non-cirrhotic portal hypertension	FAERS: 3		US FAERS
13	Drug dose omission	FAERS: 2		US FAERS
14	Enamel anomaly	FAERS: 2		US FAERS
15	Fanconi Syndrome	FAERS: 2	18260800 19334328	CTD OFFSIDES US FAERS
16	Lipoatrophy	FAERS: 2		US FAERS
17	Mitochondrial toxicity	FAERS: 2		OFFSIDES US FAERS
18	Myopathy	FAERS: 2		SIDER US FAERS
19	Nausea	FAERS: 2	9089033 10950090 11061656	CTD OFFSIDES SIDER US FAERS
20	Osteomalacia	FAERS: 2		US FAERS
21	Overdose	FAERS: 2		US FAERS
22	Pregnancy	FAERS: 2		US FAERS
23	Stillbirth	FAERS: 2		US FAERS
24	Thrombocytopenia	FAERS: 2	1974726	CTD SIDER US FAERS
25	Weight decreased	FAERS: 2		US FAERS
26	Abdominal discomfort	FAERS: 1		US FAERS
27	Accidental exposure	FAERS: 1		US FAERS
28	Accidental overdose	FAERS: 1		US FAERS
29	Acidosis	FAERS: 1		OFFSIDES US FAERS
30	Acute Coronary Syndrome	FAERS: 1		US FAERS
31	Arthralgia	FAERS: 1		SIDER US FAERS
32	Basal cell carcinoma	FAERS: 1		US FAERS
33	Biopsy liver abnormal	FAERS: 1		US FAERS
34	Blood alkaline phosphatase increased	FAERS: 1		SIDER US FAERS
35	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
36	Blood potassium decreased	FAERS: 1		US FAERS
37	Blood sodium increased	FAERS: 1		US FAERS
38	Central Nervous System Infection	FAERS: 1		US FAERS
39	Chest Pain	FAERS: 1		OFFSIDES US FAERS
40	Chorioretinal atrophy	FAERS: 1		US FAERS
41	Congenital hydronephrosis	FAERS: 1		OFFSIDES US FAERS
42	Disease Progression	FAERS: 1		US FAERS
43	Fatigue	FAERS: 1	11061656	CTD OFFSIDES US FAERS
44	Fibrosis	FAERS: 1		US FAERS
45	Hepatitis	FAERS: 1		OFFSIDES SIDER US FAERS
46	Hepatosplenomegaly	FAERS: 1		OFFSIDES US FAERS
47	Hypersplenism	FAERS: 1		US FAERS
48	Hypospadias	FAERS: 1		OFFSIDES US FAERS
49	Impaired gastric emptying	FAERS: 1		OFFSIDES US FAERS
50	Intercepted medication error	FAERS: 1		OFFSIDES US FAERS
51	Live Birth	FAERS: 1		US FAERS
52	Low birth weight baby	FAERS: 1		US FAERS
53	Memory impairment	FAERS: 1		US FAERS
54	Osteolysis	FAERS: 1		OFFSIDES US FAERS
55	Osteomyelitis	FAERS: 1		US FAERS
56	Pancreatic Insufficiency	FAERS: 1		US FAERS
57	Pancytopenia	FAERS: 1		US FAERS
58	Peritoneal Fibrosis	FAERS: 1		OFFSIDES US FAERS
59	Pharmaceutical product complaint	FAERS: 1		US FAERS
60	Pneumonia	FAERS: 1		US FAERS
61	Polydipsia	FAERS: 1		US FAERS
62	Polyneuropathy	FAERS: 1		OFFSIDES US FAERS
63	Polyuria	FAERS: 1		OFFSIDES US FAERS
64	Portal shunt procedure	FAERS: 1		US FAERS
65	Product container issue	FAERS: 1		US FAERS
66	Product preparation error	FAERS: 1		US FAERS
67	Renal cyst	FAERS: 1		US FAERS
68	Respiratory distress	FAERS: 1		US FAERS
69	Retinitis	FAERS: 1		US FAERS
70	Transaminases increased	FAERS: 1		OFFSIDES US FAERS
71	Trisomy 21	FAERS: 1		OFFSIDES US FAERS
72	Vomiting	FAERS: 1	8151270 9089033 11061656	CTD SIDER US FAERS
73	jaundice	FAERS: 1		US FAERS
74	AIDS-Related Opportunistic Infections		8093846	CTD
75	Abdominal Compartment Syndrome			OFFSIDES
76	Abdominal Pain		18261327	CTD OFFSIDES SIDER
77	Acanthosis			OFFSIDES
78	Acid fast stain positive			OFFSIDES
79	Acidosis, Lactic		View details 8151270 11356442 11450788 15040545 16176639 23782481	CTD
80	Acquired Immunodeficiency Syndrome		View details 1659189 1974724 1974725 1974727 2166965 8093846	CTD SIDER
81	Acquired Protein S Deficiency			OFFSIDES
82	Acquired macrocephaly			OFFSIDES
83	Acute kidney injury		12684925	CTD
84	Acute myocardial infarction			OFFSIDES
85	Acute prerenal failure			OFFSIDES
86	Adenoma			OFFSIDES
87	Agitation	Canada Vigilance: 1		Canada Vigilance
88	Agranulocytosis			SIDER
89	Agraphia			OFFSIDES
90	Alanine Aminotransferase Increased			OFFSIDES
91	Albinism			OFFSIDES
92	Alkaline phosphatase serum increased			SIDER
93	Alopecia		18261327	CTD SIDER
94	Aminoaciduria			OFFSIDES
95	Amphetamines			OFFSIDES
96	Amylase increased	Canada Vigilance: 1		Canada Vigilance SIDER
97	Anal Fissure			OFFSIDES
98	Anal abscess			OFFSIDES
99	Anal fistula infection			OFFSIDES
100	Anaphylactic shock			SIDER
101	Anaphylactoid Reaction			SIDER
102	Anogenital dysplasia			OFFSIDES
103	Anorexia			OFFSIDES SIDER
104	Anticonvulsant drug level decreased			OFFSIDES
105	Aplasia Cutis Congenita			OFFSIDES
106	Appendectomy			OFFSIDES
107	Appendicitis			OFFSIDES
108	Arterial Injury			OFFSIDES
109	Asterixis			OFFSIDES
110	Asthenia			OFFSIDES SIDER
111	Atrial tachycardia			OFFSIDES
112	Atrioventricular extrasystoles			OFFSIDES
113	B-cell lymphoma recurrent			OFFSIDES
114	Biopsy bone marrow abnormal			OFFSIDES
115	Blepharoptosis			OFFSIDES
116	Blood Glucose			OFFSIDES
117	Blood HIV RNA			OFFSIDES
118	Blood albumin abnormal			OFFSIDES
119	Blood alkaline phosphatase abnormal			OFFSIDES
120	Blood amylase increased			OFFSIDES
121	Blood and lymphatic system disorders			SIDER
122	Blood antidiuretic hormone increased			OFFSIDES
123	Blood bicarbonate			OFFSIDES
124	Blood bilirubin unconjugated increased			OFFSIDES
125	Blood cholesterol			OFFSIDES
126	Blood creatine increased			OFFSIDES
127	Blood creatinine increased			OFFSIDES
128	Blood immunoglobulin A increased			OFFSIDES
129	Blood immunoglobulin E			OFFSIDES
130	Blood immunoglobulin G increased			OFFSIDES
131	Blood immunoglobulin M			OFFSIDES
132	Blood ketone body decreased			OFFSIDES
133	Blood lactate dehydrogenase increased			OFFSIDES
134	Blood osmolarity increased			OFFSIDES
135	Blood pH abnormal			OFFSIDES
136	Blood pH decreased			OFFSIDES
137	Blood phosphorus decreased			OFFSIDES
138	Blood phosphorus increased			OFFSIDES
139	Blood potassium increased			OFFSIDES
140	Blood pyruvic acid decreased			OFFSIDES
141	Blood testosterone decreased			OFFSIDES
142	Blood triglycerides increased			OFFSIDES
143	Blood urea increased			OFFSIDES
144	Blood uric acid			OFFSIDES
145	Body Temperature			OFFSIDES
146	Body fat disorder			OFFSIDES
147	Bone infarction			OFFSIDES
148	Bone marrow depression			OFFSIDES
149	Bone marrow necrosis			OFFSIDES
150	Bradycardia			OFFSIDES
151	Brain natriuretic peptide abnormal			OFFSIDES
152	Brain stem syndrome			OFFSIDES
153	Breast Feeding			SIDER
154	Buffalo hump			SIDER
155	CD4 Lymphocytes Decreased			OFFSIDES
156	CD8 lymphocytes decreased			OFFSIDES
157	CYTOMEGALOVIRUS ANTIGEN			OFFSIDES
158	Campylobacter infection			OFFSIDES
159	Cardiac Tamponade			OFFSIDES
160	Cardiac enzymes increased			OFFSIDES
161	Cataract			OFFSIDES
162	Catheter sepsis			OFFSIDES
163	Catheter site infection			OFFSIDES
164	Cerebellar Hypoplasia			OFFSIDES
165	Cerebral disorder			OFFSIDES
166	Chemical and Drug Induced Liver Injury		View details 1974725 10950090 11356442 22331495 28437613	CTD
167	Chills			SIDER
168	Cholangiolitis			OFFSIDES
169	Cholecystitis			OFFSIDES
170	Chordee			OFFSIDES
171	Circumstance or information capable of leading to medication error			OFFSIDES
172	Cirrhosis			OFFSIDES
173	Clubbing			OFFSIDES
174	Complications of maternal exposure to therapeutic drugs			OFFSIDES
175	Congenital cystic kidney disease			OFFSIDES
176	Congenital heart disease			OFFSIDES
177	Congenital mitochondrial cytopathy			OFFSIDES
178	Congenital neurological disorder			OFFSIDES
179	Congenital teratoma			OFFSIDES
180	Corneal abscess			OFFSIDES
181	Cryptosporidiosis			OFFSIDES
182	Cubital Tunnel Syndrome			OFFSIDES
183	Cyst			OFFSIDES
184	Cytolytic hepatitis			OFFSIDES
185	Demyelination			OFFSIDES
186	Depressed mood			OFFSIDES
187	Dermatitis			SIDER
188	Diabetes			OFFSIDES
189	Diabetes Insipidus			OFFSIDES
190	Diabetes Mellitus			SIDER
191	Diarrhea		8151270 8387218 10950090	CTD
192	Diplopia			OFFSIDES
193	Discomfort			SIDER
194	Disease recurrence			OFFSIDES
195	Drowsiness			OFFSIDES
196	Drug Eruptions		18837731	CTD
197	Drug ineffective			OFFSIDES
198	Drug resistance			OFFSIDES
199	Drug toxicity			OFFSIDES
200	Duodenal Obstruction			OFFSIDES
201	Dyspepsia			SIDER
202	Dysphasia			OFFSIDES
203	Dyspnea		8151270	CTD
204	Dysthymic Disorder			OFFSIDES
205	Ear discomfort			OFFSIDES
206	Electrocardiogram R on T phenomenon			OFFSIDES
207	Enterocolitis			OFFSIDES
208	Epstein-Barr virus antibody positive			OFFSIDES
209	Erythema Infectiosum			OFFSIDES
210	Erythema Nodosum			OFFSIDES
211	Erythema		18261327	CTD
212	Escherichia infection			OFFSIDES
213	Eustachian tube disorder			OFFSIDES
214	Exanthema		1974727	CTD
215	Eyelid Diseases			OFFSIDES
216	Facial wasting			OFFSIDES
217	Factor V Leiden mutation			OFFSIDES
218	Factor VIII Deficiency			OFFSIDES
219	Failure to Thrive			OFFSIDES
220	Fanconi like syndrome		16773419	CTD
221	Fat redistribution			SIDER
222	Fatty Liver		8151270 11450788	CTD OFFSIDES
223	Fever		18261327	CTD
224	Flank Pain			OFFSIDES
225	Flatulence			OFFSIDES SIDER
226	Focal Nodular Hyperplasia			OFFSIDES
227	Focal glomerulosclerosis			OFFSIDES
228	Folliculitis			OFFSIDES
229	Food aversion			OFFSIDES
230	Gamma-Glutamyltransferase Increased			OFFSIDES
231	Gamma-glutamyltransferase abnormal			OFFSIDES
232	Gastric Dilatation			OFFSIDES
233	Gastric ulcer			OFFSIDES
234	Gastrointestinal Pain			SIDER
235	Gastrointestinal motility disorder			OFFSIDES
236	Gaze palsy			OFFSIDES
237	General physical health deterioration			OFFSIDES
238	Globulinuria			OFFSIDES
239	Glomerulonephritis			OFFSIDES
240	Glossitis			OFFSIDES
241	Glycosuria		8442906	CTD
242	Graft dysfunction			OFFSIDES
243	Granulocytosis			OFFSIDES
244	Granuloma			OFFSIDES
245	HIV Infections		View details 1671969 8387218 10465092 10534145 10534154 11061656 11356442 11442229 11556343 15259896 16288408 18261327 20009143 21057809	CTD
246	HIV Wasting Syndrome			OFFSIDES
247	Haptoglobin Decreased			OFFSIDES
248	Headache			SIDER
249	Hearing Loss		9665308	CTD
250	Heart Diseases		18348343	CTD
251	Helicobacter pylori identification test positive			OFFSIDES
252	Hepatic necrosis			OFFSIDES
253	Hepatitis A			OFFSIDES
254	Hepatitis B Virus			OFFSIDES
255	Hepatitis B positive			OFFSIDES
256	Hepatitis B			OFFSIDES
257	Hepatitis C			OFFSIDES
258	Hepatomegaly		10950090	CTD SIDER
259	Hepatotoxicity			SIDER
260	Hyperaldosteronism			OFFSIDES
261	Hyperamylasemia		15040545	CTD
262	Hyperphosphaturia			OFFSIDES
263	Hyperreflexia			OFFSIDES
264	Hypersensitivity			SIDER
265	Hypertensive hydrocephalus			OFFSIDES
266	Hyperuricemia		1974726 1974727 2166965	CTD
267	Hypocalcemia		1659189	CTD
268	Hypogonadism			OFFSIDES
269	Hypokalemia		1670826	CTD
270	Hyporeflexia			OFFSIDES
271	Ileal ulcer			OFFSIDES
272	Impaired driving ability			OFFSIDES
273	Impaired work ability			OFFSIDES
274	Infection			SIDER
275	Inflammation			SIDER
276	Infusion site mobility decreased			OFFSIDES
277	Injection site discomfort			OFFSIDES
278	Injection site mass			OFFSIDES
279	Injection site pruritus			OFFSIDES
280	Insulin Resistance			OFFSIDES
281	Insulin-requiring type 2 diabetes mellitus			OFFSIDES
282	Intracranial Aneurysm			OFFSIDES
283	Kidney Diseases		15097160 18261327	CTD
284	Kidney Failure			OFFSIDES
285	Lactate pyruvate ratio increased			OFFSIDES
286	Late developer			OFFSIDES
287	Legionella			OFFSIDES
288	Leukoderma			SIDER
289	Leukopenia neonatal			OFFSIDES
290	Leukopenia			SIDER
291	Light chain analysis increased			OFFSIDES
292	Lipase abnormal			OFFSIDES
293	Lipase			OFFSIDES
294	Lipodystrophy acquired			OFFSIDES
295	Lipodystrophy		23782481	CTD
296	Lipohypertrophy			OFFSIDES SIDER
297	Livedo Reticularis			OFFSIDES
298	Liver Failure, Acute		View details 1906693 8151270 11450788 16176639	CTD
299	Liver Failure		11556343 16288408	CTD
300	Liver diseases		18261327	CTD
301	Liver transplant rejection			OFFSIDES
302	Lymphadenitis bacterial			OFFSIDES
303	Lymphocytosis			OFFSIDES
304	Macrocytosis			OFFSIDES
305	Malabsorption from injection site			OFFSIDES
306	Malaise			SIDER
307	Mallory-Weiss Syndrome			OFFSIDES
308	Markedly reduced dietary intake			OFFSIDES
309	Medical device pain			OFFSIDES
310	Medical observation			OFFSIDES
311	Meningitis herpes			OFFSIDES
312	Mental retardation severity unspecified			OFFSIDES
313	Metabolic acidosis			OFFSIDES
314	Metastatic Neoplasm			OFFSIDES
315	Microcytosis			OFFSIDES
316	Microphthalmos			OFFSIDES
317	Mitochondrial Diseases		20702595	CTD
318	Mitochondrial Myopathies		17545213	CTD
319	Molluscum Contagiosum			OFFSIDES
320	Monoparesis			OFFSIDES
321	Multi-organ disorder			OFFSIDES
322	Muscle necrosis			OFFSIDES
323	Musculoskeletal discomfort			SIDER
324	Myalgia			SIDER
325	Myocardial Infarction		18387667 18434947	CTD
326	Myoglobin blood increased			OFFSIDES
327	Nephrogenic Diabetes Insipidus			OFFSIDES
328	Neuritis		9665308	CTD SIDER
329	Neuroleptic Malignant Syndrome			OFFSIDES
330	Neurologic Manifestations		10465092	CTD
331	Neuropathy			SIDER
332	Neurosyphilis			OFFSIDES
333	No adverse effect			OFFSIDES
334	Nodule			OFFSIDES
335	Numbness			SIDER
336	Nystagmus			OFFSIDES
337	Ocular icterus			OFFSIDES
338	Oliguria		12684925	CTD
339	Ophthalmoplegia			OFFSIDES
340	Optic Atrophy		1671969	CTD
341	Optic Neuritis		1671969	CTD SIDER
342	Optic Neuropathy			OFFSIDES
343	Oropharyngeal candidiasis			OFFSIDES
344	Oropharyngitis fungal			OFFSIDES
345	Orthopnea			OFFSIDES
346	Osteopenia			OFFSIDES
347	Oxygen consumption decreased			OFFSIDES
348	Pain of skin			OFFSIDES
349	Pain			SIDER
350	Pancreatic Pseudocyst		9028860	CTD
351	Parasite DNA test positive			OFFSIDES
352	Parotitis			OFFSIDES
353	Partner stress			OFFSIDES
354	Patellofemoral Pain Syndrome			OFFSIDES
355	Pathogen resistance			OFFSIDES
356	Periarthritis			OFFSIDES
357	Pericarditis			OFFSIDES
358	Peripheral Nervous System Diseases		View details 1346633 1362093 1659189 1671969 1849990 1974724 1974726 1974727 2166965 7915361 8387218 9030365 10463516 10534154 10716503 10716516 10840187 18261327 18505180	CTD
359	Placental Insufficiency			OFFSIDES
360	Plagiocephaly			OFFSIDES
361	Pneumococcal sepsis			OFFSIDES
362	Portal hypertensive gastropathy			OFFSIDES
363	Postoperative respiratory distress			OFFSIDES
364	Predisposition to disease			OFFSIDES
365	Prenatal Exposure Delayed Effects		20702595	CTD
366	Pressure of speech			OFFSIDES
367	Protein total increased			OFFSIDES
368	Proteinuria		8442906	CTD
369	Prothrombin time abnormal			OFFSIDES
370	Prothrombin time ratio decreased			OFFSIDES
371	Pruritus			SIDER
372	Psoriasis			OFFSIDES
373	Psychiatric symptom			OFFSIDES
374	Psychomotor skills impaired			OFFSIDES
375	Pulmonary Hypertension			OFFSIDES
376	Pulmonary artery stenosis			OFFSIDES
377	Pyelonephritis			OFFSIDES
378	Pyonephrosis			OFFSIDES
379	Renal Insufficiency		16773419	CTD
380	Renal interstitial fibrosis			OFFSIDES
381	Renal tubular acidosis			OFFSIDES
382	Renal tubular disorder			OFFSIDES
383	Renal tubular necrosis			OFFSIDES
384	Retinal Vein Occlusion			OFFSIDES
385	Retinal depigmentation			SIDER
386	Retinoblastoma unilateral			OFFSIDES
387	Retinoblastoma			OFFSIDES
388	Rhabdomyolysis			SIDER
389	Rhinitis			OFFSIDES
390	Rhonchi			OFFSIDES
391	Sclerosis		21057809	CTD
392	Septic Shock			OFFSIDES
393	Serositis			OFFSIDES
394	Serum Amylase Increased			SIDER
395	Sex hormone binding globulin decreased			OFFSIDES
396	Sick Sinus Syndrome			OFFSIDES
397	Sinusitis			OFFSIDES
398	Situs ambiguous			OFFSIDES
399	Skin Diseases, Vesiculobullous		18837731	CTD
400	Spina Bifida			OFFSIDES
401	Sporotrichosis			OFFSIDES
402	Stent occlusion			OFFSIDES
403	Stevens-Johnson Syndrome		7915361	CTD
404	Stomach ache			SIDER
405	Supraventricular tachycardia			OFFSIDES
406	Symptomatic hyperlactatemia			SIDER
407	Tetany			OFFSIDES
408	Therapy non-responder			OFFSIDES
409	Tongue biting			OFFSIDES
410	Tonsillitis			OFFSIDES
411	Transmission of drug via semen			OFFSIDES
412	Ulcer			OFFSIDES
413	Umbilical hernia			OFFSIDES
414	Upper respiratory tract infection bacterial			OFFSIDES
415	Urethral discharge			OFFSIDES
416	Urine electrolytes increased			OFFSIDES
417	Vasculitis, Leukocytoclastic, Cutaneous		7915361	CTD
418	Ventricular hypoplasia			OFFSIDES
419	Vestibular Neuronitis			OFFSIDES
420	Viral mutation identified			OFFSIDES
421	Visual disturbance			OFFSIDES
422	Xerophthalmia			OFFSIDES
423	muscle injury			OFFSIDES
424	prostatitis			OFFSIDES
425	treatment failure			OFFSIDES

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