MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Pergolide

(YEHCICAEULNIGD-MZMPZRCHSA-N)

Structure

SMILES: CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3
Type(s): Approved; Investigational; Vet_approved; Withdrawn
ATC code(s): N04BC02
Molecular Formula:: C19H26N2S
Molecular Weight:: 314.488
Log P:: 4.2090
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 1
TPSA:: 44.33
CAS Number(s):: 66104-22-1

Synonym(s)

Pergolide

Celance

LY-127,809

LY-127809

Parkotil

Pergolide Mesylate

Permax

Pharken

LY127,809

10.

LY127809

11.

Mesylate, Pergolide

External Link(s)

MeSH	D010479
PubChem Compound	47811
BindingDB	50017543 50028421
ChEBI	63617
CHEMBL	CHEMBL531
DrugBank	DB01186
DrugCentral	2105
IUPHAR/BPS Guide to PHARMACOLOGY	48
KEGG	cpd:C07425 dr:D08339
Therapeutic Target Database	D04JCN
ZINC	3786466

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Chest Pain	FAERS: 4		OFFSIDES SIDER US FAERS
2	Pleurisy	FAERS: 4	19170199	CTD OFFSIDES US FAERS
3	Retroperitoneal fibrosis	FAERS: 4	10600093 19170199 19912629	CTD OFFSIDES US FAERS
4	Pneumonitis	FAERS: 3		US FAERS
5	Accidental drug intake by child	FAERS: 2		OFFSIDES US FAERS
6	Disseminated Intravascular Coagulation	FAERS: 2		OFFSIDES US FAERS
7	Inflammation	FAERS: 2		US FAERS
8	Myocardial fibrosis	FAERS: 2		OFFSIDES US FAERS
9	Pericardial effusion	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
10	Pulmonary Hypertension	FAERS: 2		OFFSIDES SIDER US FAERS
11	Sinus Arrhythmia	FAERS: 2		US FAERS
12	Somnolence	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
13	Tachycardia	FAERS: 2		SIDER US FAERS
14	Vomiting	FAERS: 2	9779521	CTD SIDER US FAERS
15	Acute psychosis	FAERS: 1		US FAERS
16	Anorexia	FAERS: 1		SIDER US FAERS
17	Anxiety	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
18	Aortic Valve Stenosis	FAERS: 1		US FAERS
19	Asthenia	FAERS: 1		SIDER US FAERS
20	Atherosclerosis	FAERS: 1		OFFSIDES US FAERS
21	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
22	Bradycardia	FAERS: 1	6707926	CTD OFFSIDES SIDER US FAERS
23	Cardiomegaly	FAERS: 1		US FAERS
24	Coronary Artery Disease	FAERS: 1		US FAERS
25	Drug ineffective	FAERS: 1		US FAERS
26	Economic problem	FAERS: 1		US FAERS
27	Electrocardiogram abnormal	FAERS: 1		SIDER US FAERS
28	Fatigue	FAERS: 1		OFFSIDES US FAERS
29	Feeling abnormal	FAERS: 1		SIDER US FAERS
30	Fibrosis	FAERS: 1		US FAERS
31	Heart valve calcification	FAERS: 1		OFFSIDES US FAERS
32	Intestinal Obstruction	FAERS: 1		OFFSIDES SIDER US FAERS
33	Left Ventricular Hypertrophy	FAERS: 1		US FAERS
34	Low density lipoprotein increased	FAERS: 1		US FAERS
35	Medication Error	FAERS: 1		US FAERS
36	Mitral Valve Stenosis	FAERS: 1		OFFSIDES US FAERS
37	Obsessive-Compulsive Disorder	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
38	Pain	FAERS: 1		SIDER US FAERS
39	Pericarditis	FAERS: 1	19170199	CTD OFFSIDES SIDER US FAERS
40	Peritoneal Fibrosis	FAERS: 1		US FAERS
41	Post procedural complication	FAERS: 1		OFFSIDES US FAERS
42	Prescribed overdose	FAERS: 1		OFFSIDES US FAERS
43	Rheumatic Heart Disease	FAERS: 1		OFFSIDES US FAERS
44	Stress	FAERS: 1		US FAERS
45	Sudden death	FAERS: 1		US FAERS
46	Tinnitus	FAERS: 1		SIDER US FAERS
47	Triple vessel bypass graft	FAERS: 1		US FAERS
48	Tuberculosis	FAERS: 1		US FAERS
49	Urethral Stenosis	FAERS: 1		US FAERS
50	Venous stasis	FAERS: 1		OFFSIDES US FAERS
51	Ventricular hypertrophy	FAERS: 1		US FAERS
52	Abdominal Pain			SIDER
53	Abnormal vision			SIDER
54	Abscess			SIDER
55	Abuse			OFFSIDES
56	Acanthoma			OFFSIDES
57	Acidosis			SIDER
58	Activities of daily living impaired			OFFSIDES
59	Acute Coronary Syndrome			SIDER
60	Acute bronchitis			OFFSIDES
61	Adjustment disorder with depressed mood			OFFSIDES
62	Agitation	Canada Vigilance: 1		Canada Vigilance SIDER
63	Akathisia			SIDER
64	Akinesia			OFFSIDES SIDER
65	Alanine Aminotransferase Increased			OFFSIDES
66	Alopecia			SIDER
67	Alveolitis			OFFSIDES
68	Amnesia			SIDER
69	Amphetamines			OFFSIDES
70	Amyloidosis			OFFSIDES
71	Angina Pectoris			SIDER
72	Anosmia			OFFSIDES
73	Aortic Diseases		19912629	CTD
74	Aortic Valve Insufficiency		View details 12934784 15277624 15868996 16092580 17202454 17307289 17353380 17636306 18560792 18579494 18989898 19346455 19912629	CTD
75	Aortic valve calcification			OFFSIDES
76	Aortic valve sclerosis			OFFSIDES
77	Apathy			OFFSIDES SIDER
78	Aphthous Stomatitis			SIDER
79	Apnea			OFFSIDES
80	Arthralgia			SIDER
81	Arthritis			SIDER
82	Aspiration Pneumonia			OFFSIDES
83	Asthma			SIDER
84	Ataxia			OFFSIDES SIDER
85	Atrial Fibrillation			SIDER
86	Atrioventricular Block			SIDER
87	Autonomic failure syndrome			OFFSIDES
88	Autonomic neuropathy			OFFSIDES
89	Back Pain			SIDER
90	Band neutrophil percentage decreased			OFFSIDES
91	Basal ganglion degeneration			OFFSIDES
92	Bedridden			OFFSIDES
93	Benign Prostatic Hyperplasia			OFFSIDES
94	Benign neoplasm of skin			SIDER
95	Biliary cirrhosis			OFFSIDES
96	Bladder pain			SIDER
97	Blindness			SIDER
98	Blood alkaline phosphatase decreased			OFFSIDES
99	Blood alkaline phosphatase increased			OFFSIDES
100	Blood chloride decreased			OFFSIDES
101	Blood chloride increased			OFFSIDES
102	Blood creatine phosphokinase MB increased			OFFSIDES
103	Blood fibrinogen			OFFSIDES
104	Blood iron increased			OFFSIDES
105	Blood lactate dehydrogenase increased			OFFSIDES
106	Blood osmolarity decreased			OFFSIDES
107	Blood pH increased			OFFSIDES
108	Blood sodium			OFFSIDES
109	Bone Sarcoma			SIDER
110	Bone pain			SIDER
111	Brain scan abnormal			OFFSIDES
112	Breast Cyst			OFFSIDES
113	Breast engorgement			SIDER
114	Breast hyperplasia			OFFSIDES
115	Bronchitis			SIDER
116	Bulbar palsy			OFFSIDES
117	Bursitis			SIDER
118	Cachexia			SIDER
119	Carcinoma of lung			SIDER
120	Cardiac Arrest			SIDER
121	Cardiac Hypertrophy			OFFSIDES
122	Cardiac enzymes increased			OFFSIDES
123	Cardiac valve replacement complication			OFFSIDES
124	Cardiac valve sclerosis			OFFSIDES
125	Cardiovascular Diseases		4050844	CTD
126	Carotid bruit			OFFSIDES
127	Cataract			SIDER
128	Cellulitis			OFFSIDES SIDER
129	Cerebral disorder			OFFSIDES
130	Cerebrovascular accident			SIDER
131	Cervix carcinoma			SIDER
132	Chest wall pain			OFFSIDES
133	Chills			SIDER
134	Choking sensation			OFFSIDES
135	Cholecystitis			SIDER
136	Cholelithiasis			SIDER
137	Chondroplasty			OFFSIDES
138	Choreoathetosis			SIDER
139	Chronic left ventricular failure			OFFSIDES
140	Cogwheel Rigidity			OFFSIDES
141	Colitis			SIDER
142	Compulsive shopping	Canada Vigilance: 1		Canada Vigilance
143	Confusion		4050844 6860883	CTD
144	Congenital tricuspid valve incompetence			OFFSIDES
145	Conjunctivitis			SIDER
146	Constipation			SIDER
147	Cor pulmonale			OFFSIDES
148	Cyanosis			SIDER
149	Cystitis			SIDER
150	Deafness			OFFSIDES SIDER
151	Dehydration			SIDER
152	Delirium			SIDER
153	Dental caries			SIDER
154	Dependence	Canada Vigilance: 1		Canada Vigilance
155	Depressed Level of Consciousness			OFFSIDES SIDER
156	Depressed mood			OFFSIDES
157	Dermatitis	Canada Vigilance: 1		Canada Vigilance SIDER
158	Diabetes Mellitus			SIDER
159	Diastolic dysfunction			OFFSIDES
160	Diplopia	Canada Vigilance: 1		Canada Vigilance SIDER
161	Discomfort			SIDER
162	Disease recurrence			OFFSIDES
163	Disorders of Excessive Somnolence		10776749 10776750 11839851	CTD
164	Disruptive, Impulse Control, and Conduct Disorders		9613761	CTD
165	Disturbance in sexual arousal			SIDER
166	Dizziness			SIDER
167	Dopamine dysregulation syndrome			OFFSIDES
168	Drug chemical incompatibility			OFFSIDES
169	Dry skin			SIDER
170	Duodenitis			SIDER
171	Dysgeusia			SIDER
172	Dyskinesia, Drug-Induced		View details 8552122 8749992 11261747 12504871	CTD
173	Dyslalia			OFFSIDES
174	Dyspepsia			SIDER
175	Dysthymic Disorder			OFFSIDES
176	Dystonia		7651452 19319462	CTD OFFSIDES
177	Dysuria			OFFSIDES SIDER
178	Echocardiogram abnormal			OFFSIDES
179	Eczema	Canada Vigilance: 1		Canada Vigilance SIDER
180	Ejection Fraction Decreased			OFFSIDES
181	Electrolyte imbalance			SIDER
182	Embolic cerebral infarction			OFFSIDES
183	Endocarditis			OFFSIDES
184	Endomyocardial Fibrosis		19170199	CTD
185	Enlargement abdomen			SIDER
186	Eosinophil percentage increased			OFFSIDES
187	Eosinophilia			SIDER
188	Epicondylitis			OFFSIDES
189	Epididymitis			SIDER
190	Epistaxis			SIDER
191	Erectile dysfunction		11954860 15994112	CTD OFFSIDES SIDER
192	Eructation			SIDER
193	Erythromelalgia		6743541	CTD OFFSIDES
194	Euphoric mood			SIDER
195	Exanthema		12601100	CTD
196	Eye pain			SIDER
197	Eyelid Diseases			OFFSIDES
198	Facial Neuralgia			OFFSIDES
199	Facial paralysis			SIDER
200	Flat affect			SIDER
201	Flatulence			SIDER
202	Food craving			OFFSIDES
203	Gambling		16941457 17356338 18855926	CTD
204	Gamma-Glutamyltransferase Increased			OFFSIDES
205	Gastric ulcer			OFFSIDES SIDER
206	Gastritis			SIDER
207	Gastroenteritis			SIDER
208	Gastrointestinal Diseases		12601100	CTD
209	Gastrointestinal Pain			SIDER
210	General physical health deterioration			OFFSIDES
211	Gingivitis			SIDER
212	Glaucoma			SIDER
213	Gliosis			OFFSIDES
214	Glossitis			SIDER
215	Gout			SIDER
216	Hallucinations		12588639 12815666	CTD
217	Headache	Canada Vigilance: 1	12601100 15111679	CTD SIDER Canada Vigilance
218	Heart failure		14504342 18574930	CTD
219	Hemiplegia			SIDER
220	Hepaplastin abnormal			OFFSIDES
221	Hepatic congestion			OFFSIDES
222	Hepatic necrosis			OFFSIDES
223	Hepatitis			SIDER
224	Hepatomegaly			SIDER
225	Hepatosplenomegaly			OFFSIDES
226	Hernia			SIDER
227	Hirsutism			SIDER
228	Hoarseness			OFFSIDES
229	Hostility			SIDER
230	Hydronephrosis			OFFSIDES
231	Hypercapnia			OFFSIDES
232	Hyperkeratosis			OFFSIDES
233	Hyperkinesia			SIDER
234	Hyperventilation			OFFSIDES SIDER
235	Hypogonadism			SIDER
236	Hypokinesia		3670563	CTD OFFSIDES SIDER
237	Hypotension			SIDER
238	Hypothyroidism			SIDER
239	Hypoventilation			SIDER
240	Hypoxia			SIDER
241	Hysterectomy			OFFSIDES
242	Infection			SIDER
243	Influenza			SIDER
244	Intervertebral disc disorder			OFFSIDES
245	Jugular vein distension			OFFSIDES
246	Laryngitis			SIDER
247	Leukocytosis			SIDER
248	Leukopenia			SIDER
249	Leukorrhea			SIDER
250	Lymphadenopathy			SIDER
251	Lymphedema			OFFSIDES
252	Lymphocyte count decreased			OFFSIDES
253	Lymphocytosis			SIDER
254	Malaise			SIDER
255	Manic psychosis			SIDER
256	Meningitis			SIDER
257	Menopause			SIDER
258	Menorrhagia			SIDER
259	Mental disorders		11487183	CTD
260	Mental impairment			OFFSIDES
261	Metrorrhagia			SIDER
262	Migraine Disorders		16614540	CTD
263	Mitral Valve Insufficiency		View details 12934784 15277624 15868996 17202454 17307289 17353380 17636306 18560792 18579494 18989898 19912629	CTD
264	Mitral valve sclerosis			OFFSIDES
265	Monocyte percentage decreased			OFFSIDES
266	Monocytosis			OFFSIDES
267	Mood swings			SIDER
268	Movement Disorders		10967655	CTD
269	Muscle Rigidity		3670563 12191819	CTD
270	Muscle Weakness			OFFSIDES
271	Muscle necrosis			OFFSIDES
272	Muscle relaxant therapy			SIDER
273	Musculoskeletal Pain			OFFSIDES
274	Musculoskeletal discomfort			SIDER
275	Myalgia			SIDER
276	Myelitis			SIDER
277	Myocardial Infarction			SIDER
278	Myoclonus			SIDER
279	Myositis			SIDER
280	Myotonia			OFFSIDES
281	Narcissistic Personality Disorder			OFFSIDES
282	Nausea		9779521 11261747 15111679	CTD SIDER
283	Neck Pain			SIDER
284	Nephrolithiasis			SIDER
285	Nephrosis			SIDER
286	Nephrotic Syndrome			SIDER
287	Nervousness			SIDER
288	Neuralgia			SIDER
289	Neuritis			SIDER
290	Neurogenic Bowel			OFFSIDES
291	Neuroleptic Malignant Syndrome			OFFSIDES SIDER
292	Neuroma			OFFSIDES
293	Neuropathy			SIDER
294	Nocturia			OFFSIDES
295	Nocturnal Myoclonus Syndrome		9295178 10947026 14592347	CTD
296	Obstruction			OFFSIDES
297	Occult blood positive			OFFSIDES
298	Orthopnea			OFFSIDES
299	Osteitis Deformans			OFFSIDES
300	Osteomyelitis			SIDER
301	Osteoporosis			SIDER
302	Otitis Media			SIDER
303	Overdose			OFFSIDES
304	PCO2 increased			OFFSIDES
305	PO2 decreased			OFFSIDES
306	Pallor	Canada Vigilance: 1		Canada Vigilance
307	Palpitations			SIDER
308	Pancreatitis			SIDER
309	Panic Disorder			OFFSIDES
310	Paranoia			SIDER
311	Paranoid reaction			SIDER
312	Parkinson Disease		View details 3233591 3990974 4050844 7159813 8552122 9221983 9613761 9921882 10600093 10776749 10776750 11194495 11261747 11487183 11746615 11954860 12134281 12486908 15197703 15851743 15994112 16129789 16258207 16534128 16614540 16845152 16904253 16941457 18361473	CTD
313	Parkinsonian Disorders		12504871 17356338	CTD
314	Pelvic Pain			SIDER
315	Peptic Ulcer			SIDER
316	Perceptual Disorders		7159813	CTD
317	Performance status decreased			OFFSIDES
318	Pericarditis, Constrictive		11796875	CTD
319	Petechiae			SIDER
320	Pharyngitis			SIDER
321	Phimosis			OFFSIDES
322	Phlebitis			OFFSIDES
323	Photophobia			SIDER
324	Pneumonia			SIDER
325	Pneumothorax			SIDER
326	Portal Hypertension			OFFSIDES
327	Postrenal failure			OFFSIDES
328	Poverty			OFFSIDES
329	Priapism			SIDER
330	Prolactinoma		12131469	CTD
331	Pruritus			SIDER
332	Pulmonary Embolism			SIDER
333	Pulmonary Fibrosis	Canada Vigilance: 6	19170199	CTD SIDER Canada Vigilance
334	Pulmonary Valve Insufficiency		17636306	CTD
335	Pulmonary arterial pressure increased			OFFSIDES
336	Purpura			SIDER
337	Pyelonephritis			SIDER
338	Pyuria			SIDER
339	Residual urine			OFFSIDES
340	Respiratory Failure			SIDER
341	Restless Legs Syndrome		View details 9295178 9779521 10947026 14592347 15111679 16845152 18579494 18855926	CTD
342	Restrictive cardiomyopathy			OFFSIDES
343	Restrictive pulmonary disease			OFFSIDES
344	Retinal Detachment			SIDER
345	Retinal Vascular Disorder			SIDER
346	Retrocollis			OFFSIDES
347	Rhinitis			SIDER
348	Right ventricular systolic pressure increased			OFFSIDES
349	Salpingitis			SIDER
350	Scotoma			SIDER
351	Seizures		1924492	CTD
352	Sepsis			SIDER
353	Shock			SIDER
354	Sick Sinus Syndrome			OFFSIDES
355	Sinusitis			SIDER
356	Skin Ulcer			SIDER
357	Skin carcinoma			SIDER
358	Skin nodule			SIDER
359	Sleep Initiation and Maintenance Disorders		12601100	CTD
360	Sleep Wake Disorders		11839851 15851743	CTD
361	Soliloquy			OFFSIDES
362	Splenomegaly			SIDER
363	Sputum retention			OFFSIDES
364	Status Epilepticus			OFFSIDES
365	Stupor			SIDER
366	Subcutaneous nodule			SIDER
367	Substance Withdrawal Syndrome		3233591	CTD
368	Sweating			SIDER
369	Syncope			SIDER
370	Temperature regulation disorder			OFFSIDES
371	Tenosynovitis			SIDER
372	Tension			SIDER
373	Therapeutic product ineffective			OFFSIDES
374	Therapy regimen changed			OFFSIDES
375	Thirst			SIDER
376	Thrombocytopenia			SIDER
377	Thrombocytosis			SIDER
378	Thrombophlebitis			SIDER
379	Torticollis			SIDER
380	Tremor	Canada Vigilance: 1	3670563 9779521	CTD SIDER Canada Vigilance
381	Tricuspid Valve Insufficiency		View details 12934784 15277624 15868996 17307289 17353380	CTD
382	Troponin T			OFFSIDES
383	Upper respiratory tract inflammation			OFFSIDES
384	Ureteral obstruction		19912629	CTD
385	Urinary Incontinence			SIDER
386	Urinary Retention			SIDER
387	Urinary tract infection			SIDER
388	Urolithiasis			SIDER
389	VIIth nerve paralysis			SIDER
390	Vaginal Discharge			SIDER
391	Vascular purpura			SIDER
392	Vasculitis			SIDER
393	Venous Insufficiency			OFFSIDES
394	Ventricular hypokinesia			OFFSIDES
395	Vertigo			SIDER
396	Vesiculobullous rash			SIDER
397	Vestibular Neuronitis			OFFSIDES
398	Viral upper respiratory tract infection			OFFSIDES
399	Vision Disorders		12131469	CTD
400	Visual Impairment			SIDER
401	Weight Gain			OFFSIDES
402	Weight decreased			SIDER
403	Wound Complication			OFFSIDES
404	jaundice			SIDER

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