MetaADEDB 2.0 @ LMMD
Maprotiline
(QSLMDECMDJKHMQ-UHFFFAOYSA-N)
Structure
SMILES
CNCCCC12CCC(c3c1cccc3)c1c2cccc1
Type(s)
Approved; Investigational
ATC code(s)
N06AA21
Molecular Formula:
C20H23N
Molecular Weight:
277.403
Log P:
4.6023
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
1
TPSA:
12.03
CAS Number(s):
10262-69-8; 10347-81-6
Synonym(s)
1.
Maprotiline
2.
Ba-34,276
3.
Deprilept
4.
Dibencycladine
5.
Ludiomil
6.
Maprolu
7.
Maprotilin
8.
Maprotilin Holsten
9.
Maprotilin-TEVA
10.
Maprotilin-neuraxpharm
11.
Maprotilin-ratiopharm
12.
Maprotiline Hydrochloride
13.
Maprotiline Mesylate
14.
Mirpan
15.
N-Methyl-9,10-ethanoanthracene-9(10H)-propylamine
16.
Novo-Maprotiline
17.
Psymion
18.
maprotilin von ct
19.
Ba34,276
20.
Hydrochloride, Maprotiline
21.
Maprotilin TEVA
22.
Maprotilin neuraxpharm
23.
Maprotilin ratiopharm
24.
Mesylate, Maprotiline
25.
Novo Maprotiline
External Link(s)
MeSHD008376
PubChem Compound4011
BindingDB35228
50378025
50101973
ChEBI6690
CHEMBLCHEMBL21731
CHEMBL1201257
DrugBankDB00934
DrugCentral1634
IUPHAR/BPS Guide to PHARMACOLOGY2402
KEGGcpd:C07107
dr:D02566
Therapeutic Target DatabaseD03KQF
ZINC1530688
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Accidental exposure to product by childFAERS: 1US FAERS
2AnxietyFAERS: 1SIDER
US FAERS
3DementiaFAERS: 1US FAERS
4Drug ineffectiveFAERS: 1US FAERS
5DysphoniaFAERS: 1US FAERS
6Feeling abnormalFAERS: 1SIDER
US FAERS
7HeadacheFAERS: 17885518CTD
SIDER
US FAERS
8Migraine with AuraFAERS: 1US FAERS
9MydriasisFAERS: 1SIDER
US FAERS
10Neck PainFAERS: 1US FAERS
11Oropharyngeal painFAERS: 1US FAERS
12OverdoseFAERS: 1OFFSIDES
US FAERS
13RestlessnessFAERS: 1US FAERS
14StaringFAERS: 1OFFSIDES
US FAERS
15Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
16Unevaluable eventFAERS: 1US FAERS
17Abdominal CrampsSIDER
18Abdominal PainSIDER
19AbuliaOFFSIDES
20Accidental drug intake by childOFFSIDES
21Activation syndromeOFFSIDES
22Acute Coronary SyndromeSIDER
23Acute myocardial infarctionOFFSIDES
24AdenitisSIDER
25AgitationSIDER
26AgoraphobiaOFFSIDES
27AgranulocytosisSIDER
28AkathisiaSIDER
29AkinesiaOFFSIDES
30Alanine Aminotransferase IncreasedOFFSIDES
31Alcohol abuseOFFSIDES
32Alcohol poisoningOFFSIDES
33Alcoholic IntoxicationOFFSIDES
34AlopeciaSIDER
35AmphetaminesOFFSIDES
36AngioedemaOFFSIDES
37Angle Closure GlaucomaOFFSIDES
38Anticholinergic SyndromeOFFSIDES
39Antidepressant drug level above therapeuticOFFSIDES
40Antidepressant drug level increasedOFFSIDES
41AnuriaOFFSIDES
42Anxiety Disorders537962
1664617
3351011		CTD
43ApathyOFFSIDES
44Aphthous StomatitisOFFSIDES
45AstheniaSIDER
46AtaxiaSIDER
47Atrial Flutter6693361CTD
48Atrioventricular BlockSIDER
49Bipolar Disorder3420461
6837798
8043101		CTD
50Bipolar II disorderOFFSIDES
51Black hairy tongueSIDER
52Blepharoptosis1240830CTD
53Blood GlucoseOFFSIDES
54Blood and lymphatic system disordersSIDER
55Blood cortisol increasedOFFSIDES
56Blood creatine phosphokinase MB increasedOFFSIDES
57Blood creatine phosphokinase increasedOFFSIDES
58Blood creatinine increasedOFFSIDES
59Blood lactate dehydrogenase increasedOFFSIDES
60Blood pressure fluctuationOFFSIDES
61Blood sodiumOFFSIDES
62Blood thyroid stimulating hormone increasedOFFSIDES
63Blood urea increasedOFFSIDES
64Blood urine presentOFFSIDES
65Blunted affectOFFSIDES
66Bone fissureOFFSIDES
67Bone marrow depressionSIDER
68Bronchoalveolar lavage abnormalOFFSIDES
69BronchospasmSIDER
70Burning sensationOFFSIDES
71CardiotoxicityOFFSIDES
72Catalepsy1240830
9567763		CTD
73Catatonia6470193CTD
OFFSIDES
74Cell marker increasedOFFSIDES
75Cerebellar Ataxia3805338CTD
76Cerebral atrophyOFFSIDES
77Cerebrovascular accidentSIDER
78Chemical and Drug Induced Liver Injury3350260
22331495
27765674		CTD
79Chemotherapeutic drug level increasedOFFSIDES
80ChromaturiaOFFSIDES
81Circumstance or information capable of leading to medication errorOFFSIDES
82Congenital vitreous anomalyOFFSIDES
83Constipation3805338
6805342		CTD
SIDER
84Conversion disorderOFFSIDES
85Deglutition Disorders6470193CTD
86DehydrationOFFSIDES
87Delirium3351011CTD
SIDER
88Dental cariesSIDER
89Depressed Level of ConsciousnessOFFSIDES
90Depressed moodSIDER
91Depressive disorder

View details

101269
418842
537962
791194
1530086
1664617
2957608
3750010
3805338
3942475
3953878
3994566
4073318
6470193
6798885
6803598
6805342
6829452
9663805
10965252
11740632
12645397
20066059
23219590
 		CTD
92DermatitisSIDER
93Disorders of Excessive Somnolence2966613
9663805		CTD
94DisorientationSIDER
95Disruptive, Impulse Control, and Conduct Disorders6458665CTD
96Disturbance in sexual arousalSIDER
97Dizziness3805338CTD
SIDER
98DrowsinessOFFSIDES
SIDER
99Drug Overdose6421394
6428280		CTD
100Drug abuserOFFSIDES
101Drug dispensing errorOFFSIDES
102Drug level below therapeuticOFFSIDES
103Drug screen positiveOFFSIDES
104Drug toxicityOFFSIDES
105Drug withdrawal syndromeSIDER
106Duodenal UlcerOFFSIDES
107DysarthriaSIDER
108DysgeusiaSIDER
109DyslaliaOFFSIDES
110DyspepsiaSIDER
111Ear and labyrinth disordersSIDER
112Echocardiogram abnormalOFFSIDES
113Electrocardiogram QRS complexSIDER
114Electroconvulsive TherapyOFFSIDES
115Electroencephalogram abnormalSIDER
116EosinophiliaSIDER
117Eosinophilic PneumoniaOFFSIDES
118Epigastric distressSIDER
119Epilepsy537962CTD
120Erectile dysfunctionSIDER
121Erythema MultiformeOFFSIDES
SIDER
122Exanthema791194
3805338		CTD
123Eye painOFFSIDES
124Eyelid Function DisorderOFFSIDES
125FatigueSIDER
126Fatty LiverOFFSIDES
127Female sexual arousal disorderOFFSIDES
128Fever3805338CTD
129FlushingSIDER
130Gait Ataxia6470193CTD
131Gamma-Glutamyltransferase IncreasedOFFSIDES
132Gastric ulcerOFFSIDES
133Gastrointestinal PainSIDER
134General physical health deteriorationOFFSIDES
135Genital discomfortOFFSIDES
136Genital painOFFSIDES
137GlossoptosisOFFSIDES
138GranulocytosisOFFSIDES
139Hallucinations3351011
6833203		CTD
140Hepatic necrosisOFFSIDES
141HepatitisSIDER
142HerniaOFFSIDES
143HypercreatininaemiaOFFSIDES
144HyperkinesiaSIDER
145HyperreflexiaOFFSIDES
146Hypertrophy of BreastSIDER
147HypomaniaSIDER
148HypophagiaOFFSIDES
149HyporeflexiaOFFSIDES
150HypotensionSIDER
151InfectionSIDER
152InfestationSIDER
153Intention tremorOFFSIDES
154Intentional misuseOFFSIDES
155IntubationOFFSIDES
156Labile blood pressureOFFSIDES
157Lethargy6470193CTD
158LeukopeniaSIDER
159Libido disorderSIDER
160Lip erosionOFFSIDES
161LissencephalyOFFSIDES
162Long QT Syndrome11740632CTD
163LymphadenitisSIDER
164MalnutritionSIDER
165Memory impairmentSIDER
166Mental disorders3805338
6470193
16856516		CTD
167Mental impairmentOFFSIDES
168Movement Disorders3805338CTD
169Multiple drug overdoseOFFSIDES
170Muscle WeaknessOFFSIDES
171Muscular DystrophyOFFSIDES
172MutismOFFSIDES
173Myocardial InfarctionSIDER
174Myoclonus

View details

1530086
3827519
4008453
6886043
 		CTD
SIDER
175Myoglobin blood increasedOFFSIDES
176Myoglobin urine presentOFFSIDES
177NauseaSIDER
178NegativismOFFSIDES
179NervousnessSIDER
180Neuralgia12734762CTD
181Neuroleptic Malignant Syndrome12654986CTD
OFFSIDES
182NumbnessSIDER
183OliguriaOFFSIDES
184Optic AtrophyOFFSIDES
185Oral dischargeOFFSIDES
186PCO2 decreasedOFFSIDES
187PO2 decreasedOFFSIDES
188PallorOFFSIDES
189PalpitationsSIDER
190PancytopeniaSIDER
191Panic DisorderOFFSIDES
192PetechiaeSIDER
193PleurisyOFFSIDES
194Poor sucking reflexOFFSIDES
195Postoperative infectionOFFSIDES
196Prothrombin level decreasedOFFSIDES
197Prothrombin time ratio increasedOFFSIDES
198PruritusSIDER
199Psychomotor Agitation3351011CTD
200Pulmonary arterial pressure increasedOFFSIDES
201Pulmonary congestionOFFSIDES
202Pulmonary function test increasedOFFSIDES
203PurpuraSIDER
204QRS axis abnormalOFFSIDES
205QuadriplegiaOFFSIDES
206RalesOFFSIDES
207Respiratory Insufficiency6421394CTD
208RhabdomyolysisOFFSIDES
209Seizures

View details

1240830
3750010
3805338
3942475
3994566
6421394
6428280
6442931
6801027
6833527
6837798
6921934
8043101
12573515
12645397
 		CTD
210Septic ShockOFFSIDES
211ShockSIDER
212Sinus TachycardiaSIDER
213Sinus bradycardiaOFFSIDES
214Somnambulism453369CTD
215SomnolenceSIDER
216Speech Disorders3805338
3953878
6470193		CTD
217Status Epilepticus6798885
9663805		CTD
OFFSIDES
218Stevens-Johnson SyndromeSIDER
219Stomach scan abnormalOFFSIDES
220StomatitisSIDER
221SyncopeSIDER
222TachycardiaSIDER
223Temperature intoleranceOFFSIDES
224TensionSIDER
225Therapeutic product ineffectiveOFFSIDES
226ThrombocytopeniaSIDER
227TinnitusSIDER
228Torsades de Pointes

View details

6695810
6829452
8762914
11987023
15345781
 		CTD
229Toxic Epidermal NecrolysisSIDER
230Tremor101269
791194		CTD
SIDER
231Urinary Incontinence6470193CTD
232Urinary RetentionSIDER
233Urine output increasedOFFSIDES
234UrticariaSIDER
235Vascular purpuraSIDER
236Vasculitis, Leukocytoclastic, Cutaneous3161496CTD
237Ventricular FibrillationSIDER
238Vision Disorders3805338
6805342		CTD
239Visual brightnessOFFSIDES
240VomitingSIDER
241Weight decreasedSIDER
242Xerostomia3805338
6805342		CTD
243jaundiceSIDER
244nervous system disorderSIDER
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