MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Doxepin

(ODQWQRRAPPTVAG-GZTJUZNOSA-N)

Structure

SMILES: CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C
Molecular Formula:: C19H21NO
Molecular Weight:: 279.376
Log P:: 3.9624
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 12.47
CAS Number(s):: 1229-29-4; 1668-19-5; 3607-34-9

Synonym(s)

Doxepin

Apo-Doxepin

Aponal

Deptran

Desidox

Doneurin

Doxepia

Doxepin Hydrochloride

Doxepin Hydrochloride, Cis-Trans Isomer Mixture (approximately 1:5)

10.

Doxepin beta

11.

Doxepin-RPh

12.

Espadox

13.

Mareen

14.

Novo-Doxepin

15.

Prudoxin

16.

Quitaxon

17.

Sinequan

18.

Sinquan

19.

Xepin

20.

Zonalon

21.

Apo Doxepin

22.

ApoDoxepin

23.

Doxepin RPh

24.

Hydrochloride, Doxepin

25.

Novo Doxepin

External Link(s)

MeSH	D004316
PubChem Compound	667477
BindingDB	112780 50240484
CHEMBL	CHEMBL860
IUPHAR/BPS Guide to PHARMACOLOGY	3958 1225
KEGG	cpd:C06971 dr:D07875
Therapeutic Target Database	D06EUH D06FES
ZINC	1331

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 19 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
2	Completed Suicide	FAERS: 16 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
3	Somnolence	FAERS: 11 Canada Vigilance: 5		Canada Vigilance SIDER US FAERS
4	Toxicity to various agents	FAERS: 11		US FAERS
5	Urticaria	FAERS: 7		SIDER US FAERS
6	Bradycardia	FAERS: 6	241887 22744888	CTD SIDER US FAERS
7	Dizziness	FAERS: 6 Canada Vigilance: 4	3882676 9004052	CTD OFFSIDES SIDER Canada Vigilance US FAERS
8	Drug abuse	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
9	Medication Error	FAERS: 6		US FAERS
10	Syncope	FAERS: 6 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
11	Vomiting	FAERS: 6 Canada Vigilance: 1	6326931	CTD SIDER Canada Vigilance US FAERS
12	Anxiety	FAERS: 5 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
13	Delirium	FAERS: 5	7359747	CTD US FAERS
14	Depressed Level of Consciousness	FAERS: 5		OFFSIDES US FAERS
15	Overdose	FAERS: 5		OFFSIDES US FAERS
16	Respiratory Depression	FAERS: 5		SIDER US FAERS
17	Acute kidney injury	FAERS: 4	2925599	CTD US FAERS
18	Agitation	FAERS: 4 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
19	Drug withdrawal syndrome	FAERS: 4		SIDER US FAERS
20	Eye pain	FAERS: 4		OFFSIDES SIDER US FAERS
21	Headache	FAERS: 4		SIDER US FAERS
22	Neuralgia	FAERS: 4		US FAERS
23	Pruritus	FAERS: 4 Canada Vigilance: 2	10192169	CTD SIDER Canada Vigilance US FAERS
24	Weight decreased	FAERS: 4		US FAERS
25	Cardiac Arrest	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
26	Exposure via breast milk	FAERS: 3		US FAERS
27	Hypotension	FAERS: 3 Canada Vigilance: 1	455914	CTD SIDER Canada Vigilance US FAERS
28	Limb discomfort	FAERS: 3		US FAERS
29	Myalgia	FAERS: 3		SIDER US FAERS
30	Photophobia	FAERS: 3		US FAERS
31	Poor sucking reflex	FAERS: 3		US FAERS
32	Restlessness	FAERS: 3		US FAERS
33	Abdominal discomfort	FAERS: 2		OFFSIDES US FAERS
34	Antidepressant drug level increased	FAERS: 2		OFFSIDES US FAERS
35	Chest Pain	FAERS: 2		OFFSIDES SIDER US FAERS
36	Chills	FAERS: 2 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
37	Constipation	FAERS: 2 Canada Vigilance: 1	2858187 3882676	CTD SIDER Canada Vigilance US FAERS
38	Diabetes Mellitus	FAERS: 2		US FAERS
39	Erectile dysfunction	FAERS: 2		SIDER US FAERS
40	Feeling abnormal	FAERS: 2		SIDER US FAERS
41	Foreign body sensation in eyes	FAERS: 2		US FAERS
42	Leukocytosis	FAERS: 2		US FAERS
43	Metabolic acidosis	FAERS: 2		OFFSIDES US FAERS
44	Musculoskeletal discomfort	FAERS: 2		SIDER US FAERS
45	Nausea	FAERS: 2		OFFSIDES SIDER US FAERS
46	No adverse event	FAERS: 2		US FAERS
47	Oral pain	FAERS: 2		US FAERS
48	Product quality issue	FAERS: 2		US FAERS
49	Product substitution issue	FAERS: 2		US FAERS
50	Rhabdomyolysis	FAERS: 2		US FAERS
51	Suicide attempt	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
52	Tachycardia	FAERS: 2	241887	CTD SIDER US FAERS
53	Tinnitus	FAERS: 2 Canada Vigilance: 2	6612411	CTD OFFSIDES SIDER Canada Vigilance US FAERS
54	Unresponsive to stimuli	FAERS: 2		US FAERS
55	Ventricular arrhythmia	FAERS: 2		US FAERS
56	Abdominal Pain	FAERS: 1		OFFSIDES SIDER US FAERS
57	Accidental exposure	FAERS: 1		US FAERS
58	Ageusia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
59	Alcohol poisoning	FAERS: 1		OFFSIDES US FAERS
60	Aneurysm	FAERS: 1		OFFSIDES US FAERS
61	Anger	FAERS: 1		US FAERS
62	Ankle Fracture	FAERS: 1		OFFSIDES US FAERS
63	Anosmia	FAERS: 1		US FAERS
64	Antidepressant drug level above therapeutic	FAERS: 1		OFFSIDES US FAERS
65	Asthenopia	FAERS: 1		OFFSIDES US FAERS
66	Blood pH increased	FAERS: 1		US FAERS
67	Blood potassium increased	FAERS: 1		US FAERS
68	Blood sodium increased	FAERS: 1		OFFSIDES US FAERS
69	Capsule physical issue	FAERS: 1		US FAERS
70	Cardiomegaly	FAERS: 1		US FAERS
71	Chest discomfort	FAERS: 1		US FAERS
72	Chronic Spontaneous Urticaria	FAERS: 1		US FAERS
73	Depressed mood	FAERS: 1		US FAERS
74	Depression suicidal	FAERS: 1		US FAERS
75	Drug Dependence	FAERS: 1		US FAERS
76	Drug dispensing error	FAERS: 1		OFFSIDES US FAERS
77	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
78	Drug level increased	FAERS: 1		US FAERS
79	Drug toxicity	FAERS: 1		OFFSIDES US FAERS
80	Dysarthria	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
81	Dyspepsia	FAERS: 1		OFFSIDES SIDER US FAERS
82	Dysuria	FAERS: 1		OFFSIDES SIDER US FAERS
83	Electrocardiogram abnormal	FAERS: 1		US FAERS
84	Epilepsy	FAERS: 1		US FAERS
85	Expired drug administered	FAERS: 1		US FAERS
86	Exposure during breast feeding	FAERS: 1		US FAERS
87	Fatigue	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
88	Head discomfort	FAERS: 1		US FAERS
89	Hunger	FAERS: 1		US FAERS
90	Hypersensitivity	FAERS: 1		SIDER US FAERS
91	Impaired driving ability	FAERS: 1		US FAERS
92	Incorrect dose administered	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
93	Intentional self-injury	FAERS: 1		US FAERS
94	Left Ventricular Hypertrophy	FAERS: 1		US FAERS
95	Malaise	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
96	Maternal exposure during pregnancy	FAERS: 1		US FAERS
97	Memory impairment	FAERS: 1		US FAERS
98	Mental impairment	FAERS: 1		US FAERS
99	Mood swings	FAERS: 1		US FAERS
100	Optic Atrophy	FAERS: 1		US FAERS
101	Palpitations	FAERS: 1		SIDER US FAERS
102	Poisoning	FAERS: 1		US FAERS
103	Respiratory arrest	FAERS: 1		US FAERS
104	Rheumatoid factor increased	FAERS: 1		OFFSIDES US FAERS
105	Sciatica	FAERS: 1		US FAERS
106	Smoker	FAERS: 1		OFFSIDES US FAERS
107	Suprapubic pain	FAERS: 1		US FAERS
108	Tension	FAERS: 1		SIDER US FAERS
109	Tremor	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
110	Unevaluable event	FAERS: 1		OFFSIDES US FAERS
111	Urinary Retention	FAERS: 1		SIDER US FAERS
112	Wrong drug administered	FAERS: 1		OFFSIDES US FAERS
113	Abdominal Infection			OFFSIDES
114	Abnormal vision			OFFSIDES
115	Abscess			OFFSIDES
116	Abuse			OFFSIDES
117	Accidental death			OFFSIDES
118	Accidental overdose			OFFSIDES
119	Acid reflux			OFFSIDES
120	Acne			OFFSIDES
121	Activated partial thromboplastin time abnormal			OFFSIDES
122	Acute Coronary Syndrome			OFFSIDES
123	Acute bronchitis			OFFSIDES
124	Acute intermittent porphyria			OFFSIDES
125	Acute myocardial infarction			OFFSIDES
126	Acute psychosis			OFFSIDES
127	Acute sinusitis			OFFSIDES
128	Adenitis			SIDER
129	Adenoma			OFFSIDES
130	Aggressive reaction			SIDER
131	Agoraphobia			OFFSIDES
132	Agranulocytosis			SIDER
133	Alanine Aminotransferase Increased			OFFSIDES SIDER
134	Alanine aminotransferase abnormal			OFFSIDES
135	Alcohol consumption			OFFSIDES
136	Alopecia	Canada Vigilance: 1		Canada Vigilance SIDER
137	Altered visual depth perception			OFFSIDES
138	Alveolitis			OFFSIDES
139	Ammonia increased			OFFSIDES
140	Ammonia			OFFSIDES
141	Amnesia			OFFSIDES
142	Amphetamines			OFFSIDES
143	Analgesia			OFFSIDES
144	Anemia, Hemolytic		2925599	CTD
145	Angiomyolipoma			OFFSIDES
146	Anhedonia			OFFSIDES
147	Anhidrosis			OFFSIDES
148	Animal scratch			OFFSIDES
149	Anorexia			SIDER
150	Anticholinergic Syndrome			OFFSIDES
151	Antidepressant drug level			OFFSIDES
152	Antimicrobial susceptibility test resistant			OFFSIDES
153	Antiviral drug level above therapeutic			OFFSIDES
154	Anxiety Disorders		2858187 7034025	CTD
155	Aphthous Stomatitis			OFFSIDES SIDER
156	Application site reaction			SIDER
157	Arthralgia			SIDER
158	Arthritis			OFFSIDES
159	Arthropathy	Canada Vigilance: 1		Canada Vigilance
160	Ascites		6326931	CTD
161	Asphyxia			OFFSIDES
162	Asthenia	Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER
163	Asthma			OFFSIDES SIDER
164	Astigmatism			OFFSIDES
165	Ataxia	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
166	Atelectasis			OFFSIDES
167	Atrial tachycardia			OFFSIDES
168	Atrioventricular Block			SIDER
169	Aura			OFFSIDES
170	Back Pain			SIDER
171	Back disorder			OFFSIDES
172	Bacterial disease carrier			OFFSIDES
173	Basal cell carcinoma			OFFSIDES
174	Benign Prostatic Hyperplasia			OFFSIDES
175	Benign neoplasm of spinal cord			OFFSIDES
176	Bereavement			OFFSIDES
177	Biliary cirrhosis			OFFSIDES
178	Biopsy bladder abnormal			OFFSIDES
179	Bipolar Disorder		View details 2107764 2293776 9921884 10846716 15708425	CTD
180	Bipolar I disorder			OFFSIDES
181	Bipolar II disorder			OFFSIDES
182	Bladder cancer recurrent			OFFSIDES
183	Blepharitis			OFFSIDES
184	Blepharoptosis			OFFSIDES
185	Blepharospasm			OFFSIDES SIDER
186	Blood Glucose			OFFSIDES
187	Blood alcohol increased			OFFSIDES
188	Blood alkaline phosphatase			OFFSIDES
189	Blood and lymphatic system disorders			SIDER
190	Blood chloride abnormal			OFFSIDES
191	Blood cholesterol abnormal			OFFSIDES
192	Blood cholesterol			OFFSIDES
193	Blood cortisol abnormal			OFFSIDES
194	Blood creatine phosphokinase MB increased			OFFSIDES
195	Blood creatine phosphokinase increased			OFFSIDES
196	Blood creatinine decreased			OFFSIDES
197	Blood fibrinogen abnormal			OFFSIDES
198	Blood glucose decreased			OFFSIDES
199	Blood glucose fluctuation			OFFSIDES
200	Blood glucose increased			SIDER
201	Blood iron increased			OFFSIDES
202	Blood magnesium decreased			OFFSIDES
203	Blood pH decreased			OFFSIDES
204	Blood phosphorus decreased			OFFSIDES
205	Blood potassium			OFFSIDES
206	Blood pressure inadequately controlled			SIDER
207	Blood prolactin increased			OFFSIDES
208	Blood sodium abnormal			OFFSIDES
209	Blood thyroid stimulating hormone			OFFSIDES
210	Blood triglycerides increased			OFFSIDES
211	Blurred vision			OFFSIDES
212	Body Temperature			OFFSIDES
213	Bone density decreased			OFFSIDES
214	Bone erosion			OFFSIDES
215	Bone lesion			OFFSIDES
216	Bone marrow depression			SIDER
217	Bone scan abnormal			OFFSIDES
218	Bone swelling			OFFSIDES
219	Brain Death			OFFSIDES
220	Breast Cyst			SIDER
221	Breast tenderness			OFFSIDES
222	Bronchitis			OFFSIDES SIDER
223	Bronchopleural Fistula			OFFSIDES
224	Bronchopneumonia			OFFSIDES
225	Bulbar palsy			OFFSIDES
226	Caffeine consumption			OFFSIDES
227	Candiduria			OFFSIDES
228	Cardiac Death			SIDER
229	Cardiac enzymes increased			OFFSIDES
230	Cardiac perforation			OFFSIDES
231	Cardiac ventricular disorder			OFFSIDES
232	Cardioactive drug level increased			OFFSIDES
233	Cardiovascular insufficiency			OFFSIDES
234	Cartilage injury			OFFSIDES
235	Cataract operation			OFFSIDES
236	Catheter related infection			OFFSIDES
237	Cellulitis			OFFSIDES
238	Cerebral Arteriosclerosis			OFFSIDES
239	Cerebral Atherosclerosis			OFFSIDES
240	Cerebrovascular accident			SIDER
241	Chemical and Drug Induced Liver Injury		8297287	CTD
242	Chemotherapeutic drug level increased			OFFSIDES
243	Chest wall pain			OFFSIDES
244	Choking sensation			OFFSIDES
245	Cholecystitis			OFFSIDES
246	Choledochal Cyst			OFFSIDES
247	Chronic Insomnia			SIDER
248	Chronic Obstructive Airway Disease			OFFSIDES
249	Circumstance or information capable of leading to medication error			OFFSIDES
250	Cirrhosis			OFFSIDES
251	Clonus			OFFSIDES
252	Clostridium difficile colitis			OFFSIDES
253	Cognition Disorders		2966613	CTD
254	Cold sweat			SIDER
255	Complex partial seizures			OFFSIDES
256	Confabulation			OFFSIDES
257	Congenital mitochondrial cytopathy			OFFSIDES
258	Conjunctivitis	Canada Vigilance: 1		Canada Vigilance
259	Contracture			OFFSIDES
260	Corneal Ulcer			OFFSIDES
261	Crying			OFFSIDES
262	Culture tissue specimen			OFFSIDES
263	Cyanosis			OFFSIDES
264	Cyst			OFFSIDES SIDER
265	Deafness			OFFSIDES SIDER
266	Debridement			OFFSIDES
267	Decreased Libido			OFFSIDES
268	Dehydration			OFFSIDES
269	Demyelination			OFFSIDES
270	Dental abscess			OFFSIDES
271	Dental caries			OFFSIDES
272	Dental prosthesis placement			OFFSIDES
273	Dependence			OFFSIDES
274	Depressive disorder		View details 507219 1150909 2293776 2857709 2858187 2883085 3988967 4589400 6963177 7034025 12586234 15014590 15708425	CTD
275	Dermatitis			SIDER
276	Device dislocation			OFFSIDES
277	Diabetes			OFFSIDES
278	Diabetes mellitus inadequate control			OFFSIDES
279	Diabetic Retinopathy			OFFSIDES
280	Diabetic ulcer			OFFSIDES
281	Diplopia			OFFSIDES SIDER
282	Discomfort			SIDER
283	Disease Progression			OFFSIDES
284	Disease recurrence			OFFSIDES
285	Disorders of Excessive Somnolence		2858187 2966613	CTD
286	Disorientation			SIDER
287	Disruptive, Impulse Control, and Conduct Disorders		1358090	CTD
288	Disturbance in sexual arousal			SIDER
289	Diverticular perforation			OFFSIDES
290	Diverticulitis			OFFSIDES
291	Diverticulosis			OFFSIDES
292	Diverticulum			OFFSIDES
293	Drowning			OFFSIDES
294	Drowsiness			OFFSIDES SIDER
295	Drug Overdose		11529713	CTD
296	Drug Tolerance			OFFSIDES
297	Drug abuser			OFFSIDES
298	Drug addict			OFFSIDES
299	Drug screen negative			OFFSIDES
300	Drug screen positive			OFFSIDES
301	Drug withdrawal convulsions			OFFSIDES
302	Drug withdrawal headache			OFFSIDES
303	Dysdiadochokinesis	Canada Vigilance: 1		Canada Vigilance
304	Dysgeusia			SIDER
305	Dyspareunia			OFFSIDES
306	Dysphonia	Canada Vigilance: 1		Canada Vigilance
307	Dysthymic Disorder			OFFSIDES
308	Dystonia		3358469	CTD
309	Ear and labyrinth disorders			SIDER
310	Ear congestion			OFFSIDES
311	Ear discharge			OFFSIDES
312	Ear discomfort			OFFSIDES
313	Economic problem			OFFSIDES
314	Eczema			SIDER
315	Electrocardiogram QRS complex			OFFSIDES
316	Electrocardiogram ST-T segment abnormal			SIDER
317	Electrocardiogram change			SIDER
318	Elevated mood			SIDER
319	Emotional disorder			OFFSIDES
320	Emotional distress			OFFSIDES
321	Empyema			OFFSIDES
322	Endodontic procedure			OFFSIDES
323	Endoscopy abnormal			OFFSIDES
324	Enteritis			OFFSIDES
325	Enuresis			SIDER
326	Eosinophilia			SIDER
327	Epigastric distress			SIDER
328	Erythema	Canada Vigilance: 1		Canada Vigilance SIDER
329	Erythrodermic psoriasis			OFFSIDES
330	Esophageal and Gastric Varices		6326931	CTD
331	Essential Hypertension			OFFSIDES
332	Exacerbation of asthma			SIDER
333	Excoriation			OFFSIDES
334	Exfoliative rash			OFFSIDES
335	Eye Infection			OFFSIDES SIDER
336	Eye Redness			SIDER
337	Fatty Liver			OFFSIDES
338	Fear of weight gain			OFFSIDES
339	Fibromyalgia			OFFSIDES
340	Fibrosis		6326931	CTD
341	Flatulence			SIDER
342	Fluid overload			OFFSIDES
343	Fluid replacement			OFFSIDES
344	Flushing	Canada Vigilance: 1		Canada Vigilance SIDER
345	Foaming at mouth			OFFSIDES
346	Folliculitis			OFFSIDES SIDER
347	Formication			OFFSIDES
348	Fracture			SIDER
349	Galactorrhea			OFFSIDES
350	Gas Poisoning			OFFSIDES
351	Gastric Bypass			OFFSIDES
352	Gastroenteritis			OFFSIDES SIDER
353	Gastrointestinal Pain			SIDER
354	Gastrointestinal inflammation			OFFSIDES
355	Gastrointestinal motility disorder			OFFSIDES
356	Gastrointestinal perforation			OFFSIDES
357	Gene Mutation			OFFSIDES
358	General physical condition			OFFSIDES
359	General symptom			OFFSIDES
360	Gingival Hypertrophy			OFFSIDES
361	Gingival Recession			SIDER
362	Gingival erythema			OFFSIDES
363	Glaucoma	Canada Vigilance: 1		Canada Vigilance SIDER
364	Glutamate dehydrogenase increased			OFFSIDES
365	Hallucinations, mixed			OFFSIDES
366	Hallucinations		6963177	CTD
367	Hay fever			OFFSIDES
368	Head titubation			OFFSIDES
369	Heart Block		1869496	CTD
370	Heart failure		1928479	CTD
371	Hemiparesis			OFFSIDES
372	Hepatic Infection			OFFSIDES
373	Hepatitis A			OFFSIDES
374	Hepatitis C			OFFSIDES
375	Hepatitis	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
376	Hepatomegaly		6326931	CTD
377	Hepatosplenomegaly			OFFSIDES
378	Histoplasmosis			OFFSIDES
379	Hoarseness		507219	CTD
380	Homicide			OFFSIDES
381	Hydronephrosis			OFFSIDES
382	Hydropneumothorax			OFFSIDES
383	Hyperparathyroidism			OFFSIDES
384	Hyperpyrexia			SIDER
385	Hypertensive heart disease			OFFSIDES
386	Hyperventilation			OFFSIDES
387	Hypomania			OFFSIDES SIDER
388	Hypophagia			OFFSIDES
389	Hyporeflexia			OFFSIDES
390	Hypotension, Orthostatic		1869496	CTD
391	Hypoxia			OFFSIDES
392	Hysterectomy			OFFSIDES
393	Immobile			OFFSIDES
394	Impaired work ability			OFFSIDES
395	Incisional hernia			OFFSIDES
396	Incontinence			OFFSIDES
397	Increased bronchial secretion			OFFSIDES
398	Infection			SIDER
399	Infective tenosynovitis			SIDER
400	Infestation			SIDER
401	Influenza			SIDER
402	Infusion site mobility decreased			OFFSIDES
403	Initial insomnia			OFFSIDES
404	Injection site erythema			OFFSIDES
405	Injection site infection			OFFSIDES
406	Intention tremor			OFFSIDES
407	Intentional drug misuse			OFFSIDES
408	Intentional misuse			OFFSIDES
409	Intervertebral Disc Degeneration			OFFSIDES
410	Intestinal Fistula			OFFSIDES
411	Joint Instability			OFFSIDES
412	Joint Range of Motion Decreased			OFFSIDES SIDER
413	Joint injury			OFFSIDES
414	Joint sprain			OFFSIDES SIDER
415	Joint stiffness			OFFSIDES
416	Laceration			OFFSIDES SIDER
417	Lacrimation decreased			SIDER
418	Lacrimation			SIDER
419	Laryngitis			SIDER
420	Laryngospasm	Canada Vigilance: 1		Canada Vigilance
421	Lentigo			OFFSIDES
422	Lethargy			SIDER
423	Leukopenia	Canada Vigilance: 1		Canada Vigilance SIDER
424	Leukoplakia			OFFSIDES
425	Lichen Planus			OFFSIDES
426	Ligament rupture			OFFSIDES
427	Limb injury			OFFSIDES
428	Liver Cirrhosis		6326931	CTD
429	Liver transplant rejection			OFFSIDES
430	Long QT Syndrome		9004052 16144878 16178046	CTD
431	Lower respiratory tract infection			SIDER
432	Lumbar radiculopathy			OFFSIDES
433	Lymphadenitis			SIDER
434	Lymphedema			OFFSIDES
435	Macrocytosis			OFFSIDES
436	Malnutrition			SIDER
437	Mass excision			OFFSIDES
438	Mastication disorder			OFFSIDES
439	Medical device removal			OFFSIDES
440	Medication residue			OFFSIDES
441	Meniscus removal			OFFSIDES
442	Mental disorder due to a general medical condition			OFFSIDES
443	Mental disorders		16856516	CTD
444	Mental status changes			OFFSIDES
445	Metamorphopsia			OFFSIDES
446	Metastases to thorax			OFFSIDES
447	Mitochondrial DNA deletion			OFFSIDES
448	Motion Sickness			SIDER
449	Multiple Sclerosis			OFFSIDES
450	Multiple drug overdose			OFFSIDES
451	Multiple drug overdose intentional			OFFSIDES
452	Mumps			OFFSIDES
453	Muscle Weakness		6326931	CTD OFFSIDES
454	Muscle flap operation			OFFSIDES
455	Muscle necrosis			OFFSIDES
456	Muscle strain			OFFSIDES
457	Mycobacterium fortuitum infection			OFFSIDES
458	Mycosis Fungoides			OFFSIDES
459	Mydriasis			SIDER
460	Myocardial Infarction	Canada Vigilance: 1		Canada Vigilance
461	Myoclonus		831550 9921884	CTD
462	Myopia			OFFSIDES
463	Nasopharyngitis			SIDER
464	Neck Pain			SIDER
465	Nephrolithiasis			OFFSIDES
466	Nervous tension			OFFSIDES
467	Nervousness			SIDER
468	Neurodermatitis			OFFSIDES
469	Neuroleptic Malignant Syndrome			OFFSIDES
470	Neurologic Manifestations		11985371	CTD
471	Neutropenic infection			OFFSIDES
472	Neutrophil count decreased			SIDER
473	Night sweats	Canada Vigilance: 1		Canada Vigilance
474	Nocturia			OFFSIDES SIDER
475	Nodular regenerative hyperplasia			OFFSIDES
476	Numbness of tongue			SIDER
477	Numbness			SIDER
478	Nystagmus	Canada Vigilance: 1		Canada Vigilance
479	Obsessive thoughts			OFFSIDES
480	Occult blood positive			OFFSIDES
481	Occupational physical problem			OFFSIDES
482	Ocular Motility Disorders		7259127	CTD
483	Onychomycosis			SIDER
484	Open wound			OFFSIDES
485	Ophthalmoplegia		6538026	CTD
486	Optic Neuropathy			OFFSIDES
487	Oral fungal infection			OFFSIDES
488	Oral torus			OFFSIDES
489	Osteomyelitis			OFFSIDES
490	Osteopenia			OFFSIDES
491	Osteoradionecrosis			OFFSIDES
492	Overweight			OFFSIDES
493	Pain		11785926 16861436 18402621	CTD OFFSIDES SIDER
494	Pallor			SIDER
495	Pancreatic Insufficiency			OFFSIDES
496	Pancreatitis			OFFSIDES
497	Pancytopenia			SIDER
498	Paresthesia of limbs			SIDER
499	Parkinsonian rest tremor			OFFSIDES
500	Parotid swelling			SIDER
501	Pelvic Floor Muscle Weakness			OFFSIDES
502	Personality Change			OFFSIDES
503	Petechiae			SIDER
504	Pharyngitis			SIDER
505	Pharyngolaryngeal Pain			OFFSIDES SIDER
506	Phonophobia			OFFSIDES
507	Physical assault			OFFSIDES
508	Pleurisy			OFFSIDES
509	Pneumonia			SIDER
510	Polyneuropathy			OFFSIDES
511	Polysubstance abuse			OFFSIDES
512	Polysubstance dependence			OFFSIDES
513	Polyuria			OFFSIDES
514	Poor dental condition			OFFSIDES
515	Poor peripheral circulation			OFFSIDES
516	Poor personal hygiene			OFFSIDES
517	Poor quality sleep			OFFSIDES
518	Post procedural complication			OFFSIDES
519	Presbyopia			OFFSIDES
520	Prescribed overdose			OFFSIDES
521	Presyncope			SIDER
522	Primary sequestrum			OFFSIDES
523	Proctitis			OFFSIDES
524	Product physical issue	Canada Vigilance: 1		Canada Vigilance
525	Productive Cough			OFFSIDES
526	Pseudocyst			OFFSIDES
527	Psoriasis			OFFSIDES
528	Psychotic Disorders		2293776	CTD
529	Pulmonary artery thrombosis			OFFSIDES
530	Pulmonary congestion			OFFSIDES
531	Pulmonary function test decreased			SIDER
532	Punctate keratitis			OFFSIDES
533	Purpura			SIDER
534	Pyelonephritis			OFFSIDES
535	QRS axis abnormal			SIDER
536	Radiation skin injury			OFFSIDES
537	Radiotherapy to brain			OFFSIDES
538	Rales			SIDER
539	Rectal polyp			OFFSIDES
540	Regurgitation of food			OFFSIDES
541	Renal cyst			OFFSIDES
542	Retinal Degeneration			OFFSIDES
543	Retrocollis			OFFSIDES
544	Rhinitis			OFFSIDES
545	Rosacea			SIDER
546	Schizoaffective Disorder			OFFSIDES
547	Schizophrenia			OFFSIDES
548	Scotoma			OFFSIDES
549	Scrotal cyst			OFFSIDES
550	Secondary sequestrum			OFFSIDES
551	Seizures		1803 2107764	CTD
552	Seminal vesicular disorder			OFFSIDES
553	Sequestrectomy			OFFSIDES
554	Seroma			OFFSIDES
555	Shock			SIDER
556	Shoulder Pain			OFFSIDES
557	Sinus operation			OFFSIDES
558	Sinusitis			OFFSIDES SIDER
559	Skin Induration			OFFSIDES
560	Skin hypertrophy			OFFSIDES
561	Skin irritation			SIDER
562	Skin laceration			OFFSIDES SIDER
563	Skin lesion			OFFSIDES
564	Skin tightness			OFFSIDES
565	Sleep Initiation and Maintenance Disorders		15341891	CTD
566	Sleep Paralysis			SIDER
567	Sleep Wake Disorders		1150909	CTD
568	Snoring			OFFSIDES
569	Sopor			OFFSIDES
570	Spinal column stenosis			OFFSIDES
571	Spinal haemangioma			OFFSIDES
572	Spondylolisthesis			OFFSIDES
573	Staphylococcal abscess			OFFSIDES
574	Staring			OFFSIDES
575	Stevens-Johnson Syndrome			OFFSIDES
576	Stomatitis			SIDER
577	Stress			OFFSIDES
578	Subcutaneous Abscess			OFFSIDES
579	Subileus			OFFSIDES
580	Substance Withdrawal Syndrome		7352585	CTD
581	Suicide			SIDER
582	Superinfection bacterial			OFFSIDES
583	Sweating			SIDER
584	Tachycardia, Ventricular		6943946	CTD
585	Tardive Dyskinesia	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
586	Taste peculiar			SIDER
587	Temperature intolerance			OFFSIDES
588	Tension Headache			OFFSIDES
589	Therapeutic response unexpected with drug substitution			OFFSIDES
590	Therapy non-responder			OFFSIDES
591	Thirst	Canada Vigilance: 1		Canada Vigilance
592	Thoracotomy			OFFSIDES
593	Thrombocytopenia		2925599	CTD SIDER
594	Thrombocytosis			SIDER
595	Tooth Extraction			OFFSIDES
596	Tooth Infection			SIDER
597	Torsades de Pointes		6184690 11529713 16178046	CTD
598	Toxicologic test abnormal			OFFSIDES
599	Transaminases increased			OFFSIDES SIDER
600	Transient Insomnia			SIDER
601	Tympanic Membrane Perforation			SIDER
602	Ulcer			OFFSIDES
603	Urinary Incontinence	Canada Vigilance: 1	2795725	CTD Canada Vigilance
604	Urinary tract infection			SIDER
605	Urination Disorders		1530081	CTD
606	Urine flow decreased			OFFSIDES
607	Urine ketone body			OFFSIDES
608	Uterine Cancer			OFFSIDES
609	VIIth nerve paralysis			OFFSIDES
610	Vascular anomaly			OFFSIDES
611	Vascular purpura			SIDER
612	Venous angioma of brain			OFFSIDES
613	Ventricular hypokinesia			OFFSIDES
614	Vertigo			SIDER
615	Visceral congestion			OFFSIDES
616	Vitamin B 12 Deficiency			OFFSIDES
617	Vitreous Detachment			OFFSIDES
618	Vulvovaginal dryness			OFFSIDES
619	Weight Gain			OFFSIDES
620	Wheelchair user			OFFSIDES
621	Wheezing			SIDER
622	Wound infection staphylococcal			OFFSIDES
623	Wrong technique in product usage process	Canada Vigilance: 1		Canada Vigilance
624	Xerostomia		2858187 3882676	CTD
625	colonoscopy			OFFSIDES
626	effusion			OFFSIDES
627	fibroma			OFFSIDES
628	jaundice	Canada Vigilance: 2		Canada Vigilance SIDER
629	muscle injury			OFFSIDES
630	nervous system disorder			SIDER
631	prostatitis			OFFSIDES

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