MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Fluvoxamine

(CJOFXWAVKWHTFT-XSFVSMFZSA-N)

Structure

SMILES: NCCO/N=C(/c1ccc(cc1)C(F)(F)F)\CCCCOC
Type(s): Approved; Investigational
ATC code(s): N06AB08
Molecular Formula:: C15H21F3N2O2
Molecular Weight:: 318.335
Log P:: 3.9018
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 56.84
CAS Number(s):: 54739-18-3; 917096-37-8

Synonym(s)

Fluvoxamine

DU-23000

Desiflu

Dumirox

Faverin

Fevarin

Floxyfral

Fluvoxadura

Fluvoxamin AL

10.

Fluvoxamin Stada

11.

Fluvoxamin beta

12.

Fluvoxamin-neuraxpharm

13.

Fluvoxamin-ratiopharm

14.

Fluvoxamina Geminis

15.

Fluvoxamine Maleate

16.

Fluvoxamine Maleate, (E)-Isomer

17.

Fluvoxamine, (Z)-Isomer

18.

Luvox

19.

Novo-Fluvoxamine

20.

Nu-Fluvoxamine

21.

PMS-Fluvoxamine

22.

ratio-Fluvoxamine

23.

DU 23000

24.

DU23000

25.

Fluvoxamin neuraxpharm

26.

Fluvoxamin ratiopharm

27.

Geminis, Fluvoxamina

28.

Novo Fluvoxamine

29.

Nu Fluvoxamine

30.

PMS Fluvoxamine

31.

ratio Fluvoxamine

External Link(s)

MeSH	D016666
PubChem Compound	5324346 3404
BindingDB	50028091
ChEBI	5138
CHEMBL	CHEMBL814
DrugBank	DB00176
DrugCentral	1230
KEGG	cpd:C07571 dr:D07984
Therapeutic Target Database	D03HFG
ZINC	12466082

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Agitation	FAERS: 5 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
2	Oculogyric crisis	FAERS: 5		US FAERS
3	Drug ineffective	FAERS: 4 Canada Vigilance: 7		Canada Vigilance OFFSIDES US FAERS
4	Exposure during breast feeding	FAERS: 4		US FAERS
5	Sexual Dysfunction	FAERS: 4		SIDER US FAERS
6	Crying	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
7	Overdose	FAERS: 3		US FAERS
8	Toxicity to various agents	FAERS: 3		US FAERS
9	Vomiting	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
10	Arthralgia	FAERS: 2		SIDER US FAERS
11	Arthritis	FAERS: 2		SIDER US FAERS
12	Cardiac Arrest	FAERS: 2		SIDER US FAERS
13	Depressed Level of Consciousness	FAERS: 2		OFFSIDES SIDER US FAERS
14	Dystonia	FAERS: 2	10200869	CTD US FAERS
15	Product substitution issue	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
16	Status Epilepticus	FAERS: 2		US FAERS
17	Tremor	FAERS: 2	8986013 9864083 19050415	CTD SIDER US FAERS
18	Abdominal discomfort	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
19	Alopecia	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
20	Anorgasmia	FAERS: 1		SIDER US FAERS
21	Astigmatism	FAERS: 1		US FAERS
22	Bradycardia	FAERS: 1	7804678	CTD OFFSIDES SIDER US FAERS
23	Bradyphrenia	FAERS: 1		US FAERS
24	Cardiotoxicity	FAERS: 1		US FAERS
25	Cataract	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
26	Completed Suicide	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
27	Depressed mood	FAERS: 1		OFFSIDES US FAERS
28	Dizziness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
29	Drug abuse	FAERS: 1		US FAERS
30	Eczema	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
31	Electrocardiogram abnormal	FAERS: 1		US FAERS
32	Erectile dysfunction	FAERS: 1	9805292	CTD SIDER US FAERS
33	Euphoric mood	FAERS: 1		SIDER US FAERS
34	Exposure via breast milk	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
35	Fatigue	FAERS: 1	8698682	CTD SIDER US FAERS
36	Feeling abnormal	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
37	Gaze palsy	FAERS: 1		US FAERS
38	Hepatitis	FAERS: 1		SIDER US FAERS
39	Hunger	FAERS: 1		US FAERS
40	Hypersomnia	FAERS: 1		SIDER US FAERS
41	Malaise	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
42	Maternal exposure during pregnancy	FAERS: 1		US FAERS
43	Metabolic acidosis	FAERS: 1		US FAERS
44	Nausea	FAERS: 1	View details 8698682 8835705 8986013 9164424	CTD SIDER US FAERS
45	Neuroleptic Malignant Syndrome	FAERS: 1	15800166	CTD OFFSIDES SIDER US FAERS
46	Postmortem blood drug level increased	FAERS: 1		US FAERS
47	Product appearance confusion	FAERS: 1		US FAERS
48	Product name confusion	FAERS: 1		US FAERS
49	Product prescribing error	FAERS: 1		US FAERS
50	Rhabdomyolysis	FAERS: 1		OFFSIDES SIDER US FAERS
51	Sneezing	FAERS: 1		US FAERS
52	Somnolence	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
53	Splenomegaly	FAERS: 1		US FAERS
54	Suicide attempt	FAERS: 1		SIDER US FAERS
55	Tachycardia	FAERS: 1		SIDER US FAERS
56	Therapeutic response unexpected with drug substitution	FAERS: 1		US FAERS
57	Therapy change	FAERS: 1		US FAERS
58	Thermal burn	FAERS: 1		US FAERS
59	Unresponsive to stimuli	FAERS: 1		US FAERS
60	Abdominal Pain			SIDER
61	Abdominal cavity drainage			OFFSIDES
62	Abnormal ejaculation			SIDER
63	Abnormal vision			SIDER
64	Abscess			SIDER
65	Accidental drug intake by child			OFFSIDES
66	Ache			SIDER
67	Acidosis			OFFSIDES
68	Acne			SIDER
69	Activation syndrome			SIDER
70	Acute Coronary Syndrome			OFFSIDES SIDER
71	Administration site reaction			SIDER
72	Ageusia			SIDER
73	Agoraphobia			SIDER
74	Agranulocytosis			SIDER
75	Akathisia, Drug-Induced		View details 1906498 7673653 9864083 24568368	CTD
76	Akathisia			SIDER
77	Akinesia			SIDER
78	Alanine Aminotransferase Increased			OFFSIDES
79	Alcohol Intolerance			SIDER
80	Altered state of consciousness			OFFSIDES
81	Amblyopia			SIDER
82	Amnesia		11778459 17026779	CTD OFFSIDES SIDER
83	Amphetamines			OFFSIDES
84	Anaphylactic shock			SIDER
85	Anger			SIDER
86	Angina Pectoris			SIDER
87	Angioedema			SIDER
88	Angle Closure Glaucoma			OFFSIDES
89	Anhidrosis			OFFSIDES
90	Anorectal discomfort			SIDER
91	Anorexia			OFFSIDES SIDER
92	Anticholinergic Syndrome			OFFSIDES
93	Antipsychotic drug level above therapeutic			OFFSIDES
94	Antipsychotic drug level below therapeutic			OFFSIDES
95	Anuria			OFFSIDES SIDER
96	Anxiety Disorders		11778459 19364290	CTD
97	Anxiety	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
98	Apathy			OFFSIDES SIDER
99	Aphthous Stomatitis			OFFSIDES
100	Application site reaction			SIDER
101	Arthropathy			SIDER
102	Aseptic Meningitis			OFFSIDES
103	Asthenia	Canada Vigilance: 1	9164424	CTD OFFSIDES SIDER Canada Vigilance
104	Asthma			SIDER
105	Ataxia			SIDER
106	Atelectasis			OFFSIDES
107	Athetosis			OFFSIDES
108	Atrial Flutter			OFFSIDES
109	Atrioventricular Block			SIDER
110	Atrophic vulvovaginitis			OFFSIDES
111	Attention Deficit and Disruptive Behavior Disorders		11765279	CTD
112	Autistic Disorder		12607287 18775368 19232924	CTD
113	Back Pain			SIDER
114	Basal Ganglia Diseases		1583525	CTD
115	Basophil count abnormal			OFFSIDES
116	Bicytopenia			OFFSIDES
117	Bile Duct Stenosis			OFFSIDES
118	Biliary Colic			SIDER
119	Bilirubin conjugated increased			OFFSIDES
120	Biopsy breast abnormal			OFFSIDES
121	Biopsy lymph gland abnormal			OFFSIDES
122	Bipolar Disorder		2107954 10440473	CTD OFFSIDES
123	Bladder pain			SIDER
124	Blepharitis			SIDER
125	Blepharospasm			OFFSIDES
126	Blood alkaline phosphatase decreased			OFFSIDES
127	Blood alkaline phosphatase increased			OFFSIDES
128	Blood and lymphatic system disorders			SIDER
129	Blood cholesterol			OFFSIDES
130	Blood creatine increased			OFFSIDES
131	Blood creatine phosphokinase increased			OFFSIDES
132	Blood creatinine increased			OFFSIDES
133	Blood glucose decreased			OFFSIDES
134	Blood glucose increased			SIDER
135	Blood lactate dehydrogenase decreased			OFFSIDES
136	Blood lactate dehydrogenase increased			OFFSIDES SIDER
137	Blood pH increased			OFFSIDES
138	Blood parathyroid hormone increased			OFFSIDES
139	Blood sodium increased			OFFSIDES
140	Blood thyroid stimulating hormone increased			OFFSIDES
141	Blood triglycerides increased			OFFSIDES
142	Blood urea increased			OFFSIDES
143	Body Temperature			OFFSIDES
144	Bone density decreased			OFFSIDES
145	Bone pain			OFFSIDES SIDER
146	Brain Diseases		1429480	CTD
147	Breast hyperplasia			OFFSIDES
148	Bronchitis			SIDER
149	Bruxism			OFFSIDES SIDER
150	Bulbar palsy			OFFSIDES
151	Bulimia Nervosa		15763129	CTD
152	Bullous eruption			SIDER
153	Bursitis			OFFSIDES SIDER
154	Calcinosis			OFFSIDES
155	Carotid pulse abnormal			OFFSIDES
156	Cellulitis			OFFSIDES
157	Cerebrovascular accident			SIDER
158	Chemical and Drug Induced Liver Injury		15930079	CTD
159	Chemotherapeutic drug level increased			OFFSIDES
160	Chest Pain			SIDER
161	Child Behavior Disorders		19364290	CTD
162	Chills			SIDER
163	Cholangiolitis			OFFSIDES
164	Cholecystitis			SIDER
165	Cholelithiasis			SIDER
166	Cirrhosis			OFFSIDES
167	Colitis			SIDER
168	Complex partial seizures			OFFSIDES
169	Compulsive Personality Disorder			SIDER
170	Confusion		1527234	CTD
171	Conjunctival deposit			OFFSIDES
172	Conjunctivitis			SIDER
173	Constipation			SIDER
174	Conversion disorder			SIDER
175	Coronary Artery Disease			SIDER
176	Cramps of lower extremities			SIDER
177	Cutaneous hypersensitivity			SIDER
178	Cyanosis			SIDER
179	Cystitis			SIDER
180	Deafness			SIDER
181	Dehydration			SIDER
182	Delirium			SIDER
183	Dental caries			SIDER
184	Depressive disorder		View details 1906498 3136836 8256637 8331091 8923094 9164424 12086550 19043277 19571598 19958758	CTD
185	Dermatitis			SIDER
186	Diabetes Mellitus			SIDER
187	Diabetes mellitus inadequate control			OFFSIDES
188	Diarrhea			OFFSIDES
189	Diplopia			SIDER
190	Discomfort			SIDER
191	Disease Progression			OFFSIDES
192	Disorders of Excessive Somnolence		9164424 9864083 15902588	CTD
193	Disorientation	Canada Vigilance: 1		Canada Vigilance
194	Disruptive, Impulse Control, and Conduct Disorders		12680750	CTD
195	Disseminated Intravascular Coagulation			OFFSIDES
196	Disturbance in sexual arousal			SIDER
197	Diuresis			SIDER
198	Drowsiness			OFFSIDES SIDER
199	Drug Eruptions		17644482	CTD
200	Drug toxicity			OFFSIDES
201	Drug withdrawal syndrome			SIDER
202	Dry skin			SIDER
203	Duodenal Ulcer			OFFSIDES
204	Duodenal perforation			OFFSIDES
205	Dysarthria		10200869	CTD SIDER
206	Dysgeusia			SIDER
207	Dyspepsia		9164424 9171912	CTD SIDER
208	Dysphonia			SIDER
209	Dysthymic Disorder		10434483	CTD OFFSIDES
210	Dysuria			SIDER
211	Ecchymosis			SIDER
212	Edema		27803785	CTD
213	Embolism			SIDER
214	Embolus			SIDER
215	Emotional disorder			OFFSIDES
216	Endometrial hypertrophy			OFFSIDES
217	Enlargement abdomen			SIDER
218	Enuresis		20119596	CTD OFFSIDES SIDER
219	Epiglottitis			OFFSIDES
220	Epilepsy		1958958	CTD
221	Epistaxis			SIDER
222	Eructation			SIDER
223	Erythema Multiforme			SIDER
224	Erythema Nodosum			OFFSIDES
225	Erythema			OFFSIDES
226	Exanthema		17644482	CTD
227	Eye pain			SIDER
228	Fatty Liver			OFFSIDES
229	Feeding and Eating Disorders		11439417	CTD
230	Feeling jittery	Canada Vigilance: 1		Canada Vigilance SIDER
231	Female sexual dysfunction			SIDER
232	Flat affect			SIDER
233	Flatulence			OFFSIDES SIDER
234	Fracture			SIDER
235	Furunculosis			SIDER
236	Gamma-Glutamyltransferase Increased			OFFSIDES
237	Gastritis			SIDER
238	Gastroenteritis			SIDER
239	Gastrointestinal Diseases		1600911 8923094	CTD
240	Gastrointestinal Pain			SIDER
241	Gastrointestinal carcinoma			SIDER
242	Gastrointestinal sounds abnormal			OFFSIDES
243	Gastrointestinal ulcer			SIDER
244	Gingivitis			SIDER
245	Glaucoma			SIDER
246	Glossitis			SIDER
247	Hallucinations		9864083 12923827 17026779	CTD
248	Headache	Canada Vigilance: 4	9164424	CTD SIDER Canada Vigilance
249	Heart alternation			SIDER
250	Hemiplegia			SIDER
251	Hepatitis C			OFFSIDES
252	Hepatorenal Syndrome		15930079	CTD
253	Hernia			SIDER
254	Herpes NOS			SIDER
255	Histiocytosis haematophagic			OFFSIDES
256	Hoarseness			SIDER
257	Hostility			SIDER
258	Hydronephrosis			OFFSIDES
259	Hyperacusis			SIDER
260	Hyperalgesia		18992286	CTD
261	Hyperkinesia			SIDER
262	Hyperparathyroidism			OFFSIDES
263	Hyperreflexia			OFFSIDES
264	Hypersensitivity			SIDER
265	Hyperventilation	Canada Vigilance: 1		Canada Vigilance SIDER
266	Hypochondriasis			SIDER
267	Hypokinesia			SIDER
268	Hyponatremia		8804257 11195401 12086550	CTD
269	Hypophagia			OFFSIDES
270	Hyporeflexia			SIDER
271	Hypotension, Orthostatic		1583525	CTD
272	Hypotension			SIDER
273	Hypothyroidism			SIDER
274	Hysteria			SIDER
275	Ileus			SIDER
276	Impaired work ability			OFFSIDES
277	Inappropriate affect	Canada Vigilance: 1		Canada Vigilance
278	Infection			SIDER
279	Influenza			SIDER
280	Infusion site erythema			OFFSIDES
281	Infusion site swelling			OFFSIDES
282	Intention tremor			OFFSIDES
283	Intentional self-injury			OFFSIDES SIDER
284	Intestinal Obstruction			SIDER
285	Intubation			OFFSIDES
286	Iridocyclitis			OFFSIDES
287	Lacrimal structural disorder			SIDER
288	Lactic dehydrogenase activity increased			SIDER
289	Laryngitis			SIDER
290	Laryngospasm			SIDER
291	Lethargy	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
292	Leukocytosis			SIDER
293	Leukopenia			SIDER
294	Leukorrhea			SIDER
295	Liver diseases		15349014	CTD
296	Long QT Syndrome		25560394	CTD
297	Lymphadenopathy			SIDER
298	Lymphocyte stimulation test positive			OFFSIDES
299	Macrocytosis			OFFSIDES
300	Malabsorption			OFFSIDES
301	Malignant syndrome NOS			SIDER
302	Malnutrition			SIDER
303	Manic psychosis			SIDER
304	Marasmus			OFFSIDES
305	Mastectomy			OFFSIDES
306	Meige Syndrome		18081639	CTD
307	Menopause			SIDER
308	Menorrhagia			SIDER
309	Mental disorders		16856516	CTD
310	Mental impairment	Canada Vigilance: 1		Canada Vigilance
311	Metaplasia			OFFSIDES
312	Metrorrhagia			SIDER
313	Mood Disorders		3918993	CTD
314	Mood swings			SIDER
315	Mucosal erosion			OFFSIDES
316	Multiple drug overdose intentional			OFFSIDES
317	Muscle Rigidity		9864083	CTD
318	Muscle relaxant therapy			SIDER
319	Musculoskeletal chest pain			OFFSIDES
320	Musculoskeletal discomfort			SIDER
321	Musculoskeletal stiffness			SIDER
322	Mutism			SIDER
323	Myalgia			SIDER
324	Mydriasis			SIDER
325	Myocardial Infarction			SIDER
326	Myoclonus	Canada Vigilance: 1	8530337 19050415	CTD SIDER Canada Vigilance
327	Myopathy			SIDER
328	Neck Pain			SIDER
329	Neck stiffness			SIDER
330	Nephrolithiasis			SIDER
331	Nervous tension			OFFSIDES
332	Nervousness	Canada Vigilance: 1		Canada Vigilance SIDER
333	Neuralgia			SIDER
334	Neuropathy			SIDER
335	Neutrophil count abnormal			OFFSIDES
336	Nocturia			SIDER
337	Nuchal Rigidity			SIDER
338	Nystagmus			OFFSIDES
339	Obesity		9183245	CTD SIDER
340	Obsessive thoughts			SIDER
341	Obsessive-Compulsive Disorder	Canada Vigilance: 1	View details 1906498 7568372 7592506 8151009 8828993 9232209 11098342 12456895 12823077 15253471 16146185 17630870	CTD Canada Vigilance
342	Oliguria			SIDER
343	Oropharyngeal blistering			OFFSIDES
344	Oropharyngeal pain			OFFSIDES
345	Osteopenia			OFFSIDES
346	Osteoporosis			OFFSIDES
347	Otitis Media			SIDER
348	PCO2 decreased			OFFSIDES
349	Pain		11166930	CTD SIDER
350	Pallor			SIDER
351	Palpitations			SIDER
352	Pancreatitis			SIDER
353	Panic Disorder		8256637 8835705	CTD
354	Paranoia			SIDER
355	Paranoid reaction			SIDER
356	Pelvic Pain			SIDER
357	Pericarditis			SIDER
358	Pharyngitis			SIDER
359	Phlebitis			SIDER
360	Photophobia			SIDER
361	Pneumonia			SIDER
362	Pneumothorax			OFFSIDES
363	Polyuria			SIDER
364	Post procedural bile leak			OFFSIDES
365	Postmenopausal bleeding			OFFSIDES
366	Premenstrual syndrome		8698682	CTD SIDER
367	Prescribed overdose			OFFSIDES
368	Priapism			SIDER
369	Protein total decreased			OFFSIDES
370	Prothrombin time ratio decreased			OFFSIDES
371	Pruritus			SIDER
372	Pseudobulbar Palsy			OFFSIDES
373	Psoriasis			SIDER
374	Psychotic Disorders		12923827	CTD
375	Pulmonary Infarction			SIDER
376	Pulse irregular			SIDER
377	Purpura			SIDER
378	REM Sleep Behavior Disorder		17644482	CTD
379	Rectal tenesmus			SIDER
380	Red cell distribution width abnormal			OFFSIDES
381	Reflux gastritis			OFFSIDES
382	Renal pain			SIDER
383	Renal tubular atrophy			OFFSIDES
384	Retinal Detachment			SIDER
385	Rheumatoid Arthritis			SIDER
386	Rhinitis			SIDER
387	Schizophrenia			OFFSIDES
388	Schizophrenic reaction			SIDER
389	Scotoma			SIDER
390	Screaming			SIDER
391	Secretion discharge			OFFSIDES
392	Seizures		View details 7568372 8473723 15349014 15763129	CTD
393	Seroma			OFFSIDES
394	Serotonin Syndrome		8127934 12456895	CTD SIDER
395	Shock			SIDER
396	Sinusitis			SIDER
397	Skin Induration			OFFSIDES
398	Skin hypertrophy			OFFSIDES
399	Skin tightness			OFFSIDES
400	Sleep Initiation and Maintenance Disorders		View details 8698682 9164424 10954064 11534878	CTD
401	Sleep Wake Disorders		2107954	CTD
402	Slurred speech			SIDER
403	Sprain			SIDER
404	Stevens-Johnson Syndrome		25811541	CTD OFFSIDES SIDER
405	Stomatitis			SIDER
406	Stupor			SIDER
407	Substance Withdrawal Syndrome		8486592 8889907	CTD
408	Sudden death			SIDER
409	Suicidal tendency			SIDER
410	Sweating			SIDER
411	Syncope			SIDER
412	Syndrome screaming			SIDER
413	Tardive Dyskinesia			SIDER
414	Tenosynovitis			SIDER
415	Tension			SIDER
416	Tetany			SIDER
417	Thirst			SIDER
418	Thrombocytopenia			SIDER
419	Tinea Pedis			OFFSIDES
420	Tinnitus			SIDER
421	Toothache			SIDER
422	Torticollis			SIDER
423	Toxic Epidermal Necrolysis			SIDER
424	Trismus			SIDER
425	Upper respiratory tract inflammation			OFFSIDES
426	Upset stomach			SIDER
427	Urinary Incontinence			SIDER
428	Urinary Retention			SIDER
429	Urinary tract infection			SIDER
430	Urine output increased			SIDER
431	Urine sodium normal			OFFSIDES
432	Urticaria			SIDER
433	Vaginal Discharge			SIDER
434	Vascular purpura			SIDER
435	Vasculitis			SIDER
436	Vertigo			SIDER
437	Visual Impairment			SIDER
438	Visual disturbance			SIDER
439	Weight decreased			SIDER
440	White blood cell count decreased			SIDER
441	Xerostomia		8698682 9164424	CTD
442	Yawning			SIDER
443	furuncle			SIDER
444	jaundice			SIDER
445	nervous system disorder			SIDER

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