MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Propofol Infusion Syndrome

(UMLS:C1328409)

Definition:: Rare and often fatal drug complication which affects patients undergoing long-term treatment with high doses of PROPOFOL. It is characterized by METABOLIC ACIDOSIS; HYPERLIPIDEMIA; RHABDOMYOLYSIS; cardiovascular CIRCULATORY COLLAPSE; CARDIAC FAILURE; and KIDNEY FAILURE.
UMLS ID:: C1328409
MeSH ID:: D000072736

Classification:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.100.844

Synonym(s)

Propofol Infusion Syndrome

Propofol infusion syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Propofol	FAERS: 165 Canada Vigilance: 2	Canada Vigilance OFFSIDES US FAERS
2	Dipyrone	FAERS: 1	US FAERS
3	Acetylcysteine		OFFSIDES
4	Atracurium		OFFSIDES
5	Cefazolin		OFFSIDES
6	Cefotaxime		OFFSIDES
7	Chlorhexidine		OFFSIDES
8	Cisapride		OFFSIDES
9	Colchicine		OFFSIDES
10	Cortisone		OFFSIDES
11	Docusate sodium		OFFSIDES
12	Epinephrine		OFFSIDES
13	Ketamine		OFFSIDES
14	Loxapine		OFFSIDES
15	Mannitol		OFFSIDES
16	Micafungin		OFFSIDES
17	Nicotine		OFFSIDES
18	Nifedipine		OFFSIDES
19	Nitrates		OFFSIDES
20	Norepinephrine		OFFSIDES
21	Phenobarbital		OFFSIDES
22	Phenylephrine		OFFSIDES
23	Piperacillin, Tazobactam Drug Combination		OFFSIDES
24	Piperacillin		OFFSIDES
25	Pirinitramide		OFFSIDES
26	Remifentanil		OFFSIDES
27	Spironolactone		OFFSIDES
28	Sufentanil		OFFSIDES
29	Tazobactam		OFFSIDES
30	Terbutaline		OFFSIDES
31	Thiopental		OFFSIDES
32	Topiramate		OFFSIDES
33	Vecuronium Bromide		OFFSIDES
34	chlorhexidine gluconate		OFFSIDES
35	cisatracurium		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Anticholinergic Syndrome	42.9%
2	Serotonin Syndrome	42.9%
3	Metabolic Side Effects of Drugs and Substances	28.6%
4	Chemical and Drug Induced Liver Injury	28.6%
5	Injection Site Reaction	27.9%
6	Infusion site reaction	27.9%
7	Poisoning	23.1%
8	Chemical and Drug Induced Liver Injury, Chronic	20.3%
9	Akathisia, Drug-Induced	17.1%
10	Cardiotoxicity	16.8%
11	Drug abuse	15.8%
12	Substance Dependence	15.8%
13	Substance-Related Disorders	15.8%
14	Drug Dependence	15.8%
15	Drug Eruptions	15.3%
16	Dyskinesia, Drug-Induced	14.6%
17	Fluoride Poisoning	14.3%
18	Food Poisoning	14.3%
19	Gas Poisoning	14.3%
20	Mycotoxicosis	14.3%
21	Plant Poisoning	14.3%
22	Organophosphate poisoning	14.3%
23	Mushroom Poisoning	13.6%
24	Acute Generalized Exanthematous Pustulosis	12.4%
25	Psychoses, Substance-Induced	11.3%
26	Cadmium poisoning	10.3%
27	Carbon Monoxide Poisoning	10.3%
28	Ciguatera Poisoning	10.3%
29	Ergotism	10.3%
30	Lead Poisoning	10.3%
31	Mercury Poisoning	10.3%
32	Alcohol-Induced Disorders	10.3%
33	Shellfish Poisoning	10.3%
34	Asthma, Aspirin-Induced	10.1%
35	Bites and Stings	10%
36	Neurotoxicity Syndromes	10%
37	Erythema Nodosum	9.9%
38	Serum Sickness	9.9%
39	Marijuana Abuse	9.5%
40	Opioid-Related Disorders	9.5%
41	Nicotine Dependence	9.5%
42	Opioid abuse	9.5%
43	Phencyclidine Abuse	9.5%
44	Substance Abuse, Intravenous	9.5%
45	Substance Withdrawal Syndrome	9.5%
46	Tobacco Use Disorder	9.5%
47	Alcohol-Related Disorders	9.5%
48	Amphetamine-Related Disorders	9.5%
49	Cocaine-Related Disorders	9.5%
50	Alcohol-Induced Disorders, Nervous System	9.4%
51	Water Intoxication	9.3%
52	Arsenic Poisoning	9.3%
53	Drug Overdose	9.2%
54	Tick Paralysis	7.6%
55	Alcohol Withdrawal Delirium	7.4%
56	Psychoses, Alcoholic	7.3%
57	Alcohol Withdrawal Seizures	7.3%
58	Neonatal Abstinence Syndrome	7.1%
59	Toxic Epidermal Necrolysis	7%
60	Stevens-Johnson Syndrome	7%
61	Insect Bites and Stings	7%
62	Alcohol Use Disorder	6.8%
63	Alcoholic Intoxication	6.8%
64	Argyria	6.8%
65	Heroin Dependence	6.8%
66	Morphine Dependence	6.8%
67	Alcohol abuse	6.8%
68	Manganese Poisoning	6.8%
69	Salmonella food poisoning	6.7%
70	Cardiomyopathy, Alcoholic	5.6%
71	Pancreatitis, Alcoholic	5.6%
72	Mercury Poisoning, Nervous System	5.6%
73	Lead Poisoning, Nervous System	5.6%
74	Neuroleptic Malignant Syndrome	5.1%
75	Binge Drinking	5%
76	Lead Poisoning, Nervous System, Childhood	5%
77	Lead Poisoning, Nervous System, Adult	5%
78	Fetal Alcohol Spectrum Disorders	4.3%
79	Botulism	4.1%
80	MPTP Poisoning	4%
81	Fatty Liver, Alcoholic	3.8%
82	Hepatitis, Alcoholic	3.8%
83	Liver Cirrhosis, Alcoholic	3.8%
84	Acrodynia	3.7%
85	Wernicke Encephalopathy	3.3%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234