MetaADEDB 2.0 @ LMMD
suvorexant
(JYTNQNCOQXFQPK-MRXNPFEDSA-N)
Structure
SMILES
Cc1ccc(c(c1)C(=O)N1CCN(CC[C@H]1C)c1oc2c(n1)cc(cc2)Cl)n1nccn1
Type(s)
Approved; Investigational
ATC code(s)
N05CM19
Molecular Formula:
C23H23ClN6O2
Molecular Weight:
450.921
Log P:
4.1142
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
0
TPSA:
80.29
CAS Number(s):
1030377-33-3
Synonym(s)
1.
suvorexant
2.
(4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone
3.
Belsomra
4.
MK 4305
5.
MK-4305
6.
MK4305
7.
methanone, ((7R)-4-(5-chloro-2-benzoxazolyl)hexahydro-7-methyl-1H-1,4-diazepin-1-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)-
External Link(s)
MeSHC551624
PubChem Compound24965990
BindingDB50318701
ChEBI82698
CHEMBLCHEMBL1083659
DrugBankDB09034
DrugCentral4881
IUPHAR/BPS Guide to PHARMACOLOGY2890
KEGGdr:D10082
Therapeutic Target DatabaseD00OVU
ZINC49036447
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 1718US FAERS
2SomnolenceFAERS: 353SIDER
US FAERS
3HeadacheFAERS: 262SIDER
US FAERS
4Feeling abnormalFAERS: 237US FAERS
5Sleep ParalysisFAERS: 161SIDER
US FAERS
6Adverse eventFAERS: 150US FAERS
7No adverse eventFAERS: 149US FAERS
8DizzinessFAERS: 114SIDER
US FAERS
9FatigueFAERS: 113US FAERS
10NauseaFAERS: 111US FAERS
11AnxietyFAERS: 105US FAERS
12Poor quality sleepFAERS: 103US FAERS
13Wrong technique in product usage processFAERS: 94US FAERS
14Drug effect incompleteFAERS: 92US FAERS
15SomnambulismFAERS: 92US FAERS
16Middle insomniaFAERS: 89US FAERS
17Drug dose omissionFAERS: 88US FAERS
18AgitationFAERS: 70US FAERS
19OverdoseFAERS: 64US FAERS
20MalaiseFAERS: 61US FAERS
21PalpitationsFAERS: 49US FAERS
22Product quality issueFAERS: 45US FAERS
23Product use issueFAERS: 41US FAERS
24Feeling jitteryFAERS: 37US FAERS
25Inappropriate schedule of drug administrationFAERS: 37US FAERS
26AmnesiaFAERS: 36US FAERS
27DeliriumFAERS: 35US FAERS
28Memory impairmentFAERS: 35US FAERS
29VomitingFAERS: 31US FAERS
30TremorFAERS: 28US FAERS
31Abdominal discomfortFAERS: 26US FAERS
32CataplexyFAERS: 26SIDER
US FAERS
33RestlessnessFAERS: 26US FAERS
34Drug effect delayedFAERS: 25US FAERS
35NervousnessFAERS: 25US FAERS
36PruritusFAERS: 24US FAERS
37Circumstance or information capable of leading to medication errorFAERS: 23US FAERS
38DysgeusiaFAERS: 23US FAERS
39Product dose omissionFAERS: 23US FAERS
40Night sweatsFAERS: 22US FAERS
41DisorientationFAERS: 21US FAERS
42Abnormal sleep-related eventFAERS: 20US FAERS
43PainFAERS: 20US FAERS
44Restless Legs SyndromeFAERS: 20US FAERS
45Initial insomniaFAERS: 19US FAERS
46Product packaging quantity issueFAERS: 18US FAERS
47Incorrect dose administeredFAERS: 17US FAERS
48Completed SuicideFAERS: 16US FAERS
49Drug administration errorFAERS: 16US FAERS
50Therapeutic response unexpectedFAERS: 16US FAERS
51AstheniaFAERS: 15US FAERS
52HypersomniaFAERS: 15US FAERS
53Intentional product misuseFAERS: 15US FAERS
54MyalgiaFAERS: 15US FAERS
55TinnitusFAERS: 15US FAERS
56Wrong technique in drug usage processFAERS: 15US FAERS
57UrticariaFAERS: 14US FAERS
58AngerFAERS: 11US FAERS
59Cerebrovascular accidentFAERS: 11US FAERS
60Depressed moodFAERS: 11US FAERS
61Chest PainFAERS: 10US FAERS
62DiscomfortFAERS: 10US FAERS
63Inability to afford medicationFAERS: 10US FAERS
64LethargyFAERS: 10US FAERS
65Chest discomfortFAERS: 9US FAERS
66CryingFAERS: 9US FAERS
67Head discomfortFAERS: 9US FAERS
68Suicide attemptFAERS: 9US FAERS
69Accidental overdoseFAERS: 8US FAERS
70Burning sensationFAERS: 8US FAERS
71Drug prescribing errorFAERS: 8US FAERS
72HypersensitivityFAERS: 8US FAERS
73NasopharyngitisFAERS: 8US FAERS
74ScreamingFAERS: 8US FAERS
75Sleep-related eating disorderFAERS: 8US FAERS
76SluggishnessFAERS: 8US FAERS
77SyncopeFAERS: 8US FAERS
78Therapeutic response delayedFAERS: 8US FAERS
79ConstipationFAERS: 7US FAERS
80Drug ToleranceFAERS: 7US FAERS
81Extra dose administeredFAERS: 7US FAERS
82InfluenzaFAERS: 7US FAERS
83NarcolepsyFAERS: 7US FAERS
84TachycardiaFAERS: 7US FAERS
85TachyphreniaFAERS: 7US FAERS
86Therapy non-responderFAERS: 7US FAERS
87Altered state of consciousnessFAERS: 6US FAERS
88Depressed Level of ConsciousnessFAERS: 6US FAERS
89Drug DependenceFAERS: 6US FAERS
90Drug screen positiveFAERS: 6US FAERS
91EnuresisFAERS: 6US FAERS
92Incorrect product storageFAERS: 6US FAERS
93Medication ErrorFAERS: 6US FAERS
94NocturiaFAERS: 6US FAERS
95Prescribed overdoseFAERS: 6US FAERS
96Product use in unapproved indicationFAERS: 6US FAERS
97StressFAERS: 6US FAERS
98VertigoFAERS: 6US FAERS
99Abdominal PainFAERS: 5US FAERS
100AphasiaFAERS: 5US FAERS
101Bipolar DisorderFAERS: 5US FAERS
102BradycardiaFAERS: 5US FAERS
103Cerebral InfarctionFAERS: 5US FAERS
104Cold sweatFAERS: 5US FAERS
105DiplegiaFAERS: 5US FAERS
106Drug effect variableFAERS: 5US FAERS
107DyspepsiaFAERS: 5US FAERS
108DysuriaFAERS: 5US FAERS
109ErythemaFAERS: 5US FAERS
110FlushingFAERS: 5US FAERS
111FormicationFAERS: 5US FAERS
112HypervigilanceFAERS: 5US FAERS
113Impaired driving abilityFAERS: 5US FAERS
114Intentional product use issueFAERS: 5US FAERS
115LacerationFAERS: 5US FAERS
116Mental impairmentFAERS: 5US FAERS
117Peripheral swellingFAERS: 5US FAERS
118PneumoniaFAERS: 5US FAERS
119Product blister packaging issueFAERS: 5US FAERS
120ArthritisFAERS: 4US FAERS
121ChillsFAERS: 4US FAERS
122Drug ineffective for unapproved indicationFAERS: 4US FAERS
123DysarthriaFAERS: 4US FAERS
124Euphoric moodFAERS: 4US FAERS
125Expired product administeredFAERS: 4US FAERS
126Lip swellingFAERS: 4US FAERS
127Muscle tightnessFAERS: 4US FAERS
128Musculoskeletal stiffnessFAERS: 4US FAERS
129Myocardial InfarctionFAERS: 4US FAERS
130Paradoxical drug reactionFAERS: 4US FAERS
131ParanoiaFAERS: 4US FAERS
132Prescription drug used without a prescriptionFAERS: 4US FAERS
133Product packaging issueFAERS: 4US FAERS
134Product storage errorFAERS: 4US FAERS
135Product use complaintFAERS: 4US FAERS
136Quality of life decreasedFAERS: 4US FAERS
137Sleep TalkingFAERS: 4US FAERS
138Urinary RetentionFAERS: 4US FAERS
139Visual ImpairmentFAERS: 4US FAERS
140Weight decreasedFAERS: 4US FAERS
141AbasiaFAERS: 3US FAERS
142Alcohol poisoningFAERS: 3US FAERS
143Apparent deathFAERS: 3US FAERS
144ArthralgiaFAERS: 3US FAERS
145AutoscopyFAERS: 3US FAERS
146Back PainFAERS: 3US FAERS
147Blood creatine phosphokinase increasedFAERS: 3US FAERS
148Blood glucose decreasedFAERS: 3US FAERS
149ChokingFAERS: 3US FAERS
150Contraindicated product administeredFAERS: 3US FAERS
151Emotional disorderFAERS: 3US FAERS
152Eye irritationFAERS: 3US FAERS
153Eye painFAERS: 3US FAERS
154FlatulenceFAERS: 3US FAERS
155Frustration tolerance decreasedFAERS: 3US FAERS
156Incorrect route of drug administrationFAERS: 3US FAERS
157LazinessFAERS: 3US FAERS
158Limb discomfortFAERS: 3US FAERS
159Limb injuryFAERS: 3US FAERS
160Panic DisorderFAERS: 3US FAERS
161ParasomniaFAERS: 3US FAERS
162Patient dissatisfaction with treatmentFAERS: 3US FAERS
163Poor quality drug administeredFAERS: 3US FAERS
164Product availability issueFAERS: 3US FAERS
165Product supply issueFAERS: 3US FAERS
166Product taste abnormalFAERS: 3US FAERS
167Respiratory DepressionFAERS: 3US FAERS
168Sleep sexFAERS: 3US FAERS
169StuporFAERS: 3US FAERS
170Toxicity to various agentsFAERS: 3US FAERS
171YawningFAERS: 3US FAERS
172Activities of daily living impairedFAERS: 2US FAERS
173Acute psychosisFAERS: 2US FAERS
174AkathisiaFAERS: 2US FAERS
175Alanine Aminotransferase IncreasedFAERS: 2US FAERS
176ArthropathyFAERS: 2US FAERS
177Back disorderFAERS: 2US FAERS
178BedriddenFAERS: 2US FAERS
179Blood alkaline phosphatase increasedFAERS: 2US FAERS
180Bone painFAERS: 2US FAERS
181BronchitisFAERS: 2US FAERS
182Cardiac FlutterFAERS: 2US FAERS
183Cerebral disorderFAERS: 2US FAERS
184DementiaFAERS: 2US FAERS
185Dreamy stateFAERS: 2US FAERS
186Drug withdrawal syndromeFAERS: 2US FAERS
187Economic problemFAERS: 2US FAERS
188EpistaxisFAERS: 2US FAERS
189Facial paralysisFAERS: 2US FAERS
190Feeling ColdFAERS: 2US FAERS
191FrustrationFAERS: 2US FAERS
192Gamma-Glutamyltransferase IncreasedFAERS: 2US FAERS
193HemiplegiaFAERS: 2US FAERS
194HyperphagiaFAERS: 2US FAERS
195Impaired work abilityFAERS: 2US FAERS
196Inappropriate schedule of product administrationFAERS: 2US FAERS
197IncoherentFAERS: 2US FAERS
198IncontinenceFAERS: 2US FAERS
199Joint InstabilityFAERS: 2US FAERS
200Malignant neoplasm progressionFAERS: 2US FAERS
201Mental status changesFAERS: 2US FAERS
202Mood swingsFAERS: 2US FAERS
203Musculoskeletal discomfortFAERS: 2US FAERS
204MyoclonusFAERS: 2US FAERS
205Neurological examination normalFAERS: 2US FAERS
206Obsessive-Compulsive DisorderFAERS: 2US FAERS
207Oropharyngeal discomfortFAERS: 2US FAERS
208Oropharyngeal painFAERS: 2US FAERS
209Physical product label issueFAERS: 2US FAERS
210Poor quality product administeredFAERS: 2US FAERS
211Post-Traumatic Stress DisorderFAERS: 2US FAERS
212Product physical issueFAERS: 2US FAERS
213Product prescribing errorFAERS: 2US FAERS
214Product prescribing issueFAERS: 2US FAERS
215Rash erythematousFAERS: 2US FAERS
216Rebound effectFAERS: 2US FAERS
217SchizophreniaFAERS: 2US FAERS
218Spontaneous penile erectionFAERS: 2US FAERS
219StomatitisFAERS: 2US FAERS
220SwellingFAERS: 2US FAERS
221TensionFAERS: 2US FAERS
222Therapeutic product effect incompleteFAERS: 2US FAERS
223Therapy cessationFAERS: 2US FAERS
224ThirstFAERS: 2US FAERS
225White blood cell count decreasedFAERS: 2US FAERS
226nervous system disorderFAERS: 2SIDER
US FAERS
227treatment failureFAERS: 2US FAERS
228AcneFAERS: 1US FAERS
229AgranulocytosisFAERS: 1US FAERS
230Alcohol abuseFAERS: 1US FAERS
231Alcohol interactionFAERS: 1US FAERS
232Alcohol withdrawal syndromeFAERS: 1US FAERS
233AlopeciaFAERS: 1US FAERS
234Amnestic DisorderFAERS: 1US FAERS
235Angina PectorisFAERS: 1US FAERS
236AngioedemaFAERS: 1US FAERS
237AnorgasmiaFAERS: 1US FAERS
238Antidepressant therapyFAERS: 1US FAERS
239AsphyxiaFAERS: 1US FAERS
240AsthenopiaFAERS: 1US FAERS
241Atrial FibrillationFAERS: 1US FAERS
242Atrioventricular BlockFAERS: 1US FAERS
243Bipolar I disorderFAERS: 1US FAERS
244Bladder dysfunctionFAERS: 1US FAERS
245Blood cholesterol abnormalFAERS: 1US FAERS
246Blood count abnormalFAERS: 1US FAERS
247Blood glucose increasedFAERS: 1US FAERS
248Blood sodium decreasedFAERS: 1US FAERS
249Breast FeedingFAERS: 1US FAERS
250Breast tendernessFAERS: 1US FAERS
251Breathing-related sleep disorderFAERS: 1US FAERS
252BruxismFAERS: 1US FAERS
253Cardiac ArrestFAERS: 1US FAERS
254Choking sensationFAERS: 1US FAERS
255Cholecystitis infectiveFAERS: 1US FAERS
256ConjunctivitisFAERS: 1US FAERS
257Contraindicated drug administeredFAERS: 1US FAERS
258Contrast media reactionFAERS: 1US FAERS
259Counterfeit drug administeredFAERS: 1US FAERS
260DeafnessFAERS: 1US FAERS
261DehydrationFAERS: 1US FAERS
262DissociationFAERS: 1US FAERS
263Dissociative disorderFAERS: 1US FAERS
264DroolingFAERS: 1US FAERS
265Drug effective for unapproved indicationFAERS: 1US FAERS
266Drug level increasedFAERS: 1US FAERS
267Drug resistanceFAERS: 1US FAERS
268Drug screen false positiveFAERS: 1US FAERS
269Drug-disease interactionFAERS: 1US FAERS
270Dry skinFAERS: 1US FAERS
271DysgraphiaFAERS: 1US FAERS
272DysphemiaFAERS: 1US FAERS
273DysphoniaFAERS: 1US FAERS
274Ear discomfortFAERS: 1US FAERS
275EncephalitisFAERS: 1US FAERS
276Epigastric discomfortFAERS: 1US FAERS
277Erectile dysfunctionFAERS: 1US FAERS
278Erection increasedFAERS: 1US FAERS
279Essential HypertensionFAERS: 1US FAERS
280Exaggerated startle responseFAERS: 1US FAERS
281Eyelids pruritusFAERS: 1US FAERS
282Feeling of body temperature changeFAERS: 1US FAERS
283Foaming at mouthFAERS: 1US FAERS
284Food cravingFAERS: 1US FAERS
285FractureFAERS: 1US FAERS
286Frontotemporal dementiaFAERS: 1US FAERS
287Gastric FistulaFAERS: 1US FAERS
288GastritisFAERS: 1US FAERS
289Gastrointestinal PainFAERS: 1US FAERS
290Gastrointestinal candidiasisFAERS: 1US FAERS
291Gastrointestinal motility disorderFAERS: 1US FAERS
292GastrostomyFAERS: 1US FAERS
293General physical condition abnormalFAERS: 1US FAERS
294General physical health deteriorationFAERS: 1US FAERS
295Genital infection fungalFAERS: 1US FAERS
296HemiparesisFAERS: 1US FAERS
297HerniaFAERS: 1US FAERS
298HyperventilationFAERS: 1US FAERS
299HypotensionFAERS: 1US FAERS
300Impaired self-careFAERS: 1US FAERS
301ImpatienceFAERS: 1US FAERS
302Insurance issueFAERS: 1US FAERS
303Intentional dose omissionFAERS: 1US FAERS
304Intentional self-injuryFAERS: 1US FAERS
305Intestinal ObstructionFAERS: 1US FAERS
306Intracranial HypotensionFAERS: 1US FAERS
307Irregular sleep phaseFAERS: 1US FAERS
308Joint stiffnessFAERS: 1US FAERS
309Joint swellingFAERS: 1US FAERS
310Lack of spontaneous speechFAERS: 1US FAERS
311LaryngitisFAERS: 1US FAERS
312Loss of dreamingFAERS: 1US FAERS
313Manufacturing production issueFAERS: 1US FAERS
314Maternal exposure during pregnancyFAERS: 1US FAERS
315Migraine with AuraFAERS: 1US FAERS
316MoaningFAERS: 1US FAERS
317MonoplegiaFAERS: 1US FAERS
318Muscle FatigueFAERS: 1US FAERS
319Muscle RigidityFAERS: 1US FAERS
320Myasthenia GravisFAERS: 1US FAERS
321MydriasisFAERS: 1US FAERS
322Neuroleptic Malignant SyndromeFAERS: 1US FAERS
323ObesityFAERS: 1US FAERS
324OliguriaFAERS: 1US FAERS
325Packaging design issueFAERS: 1US FAERS
326PallorFAERS: 1US FAERS
327Paranasal sinus discomfortFAERS: 1US FAERS
328Personality ChangeFAERS: 1US FAERS
329PertussisFAERS: 1US FAERS
330PharyngitisFAERS: 1US FAERS
331Phobia of drivingFAERS: 1US FAERS
332Physical assaultFAERS: 1US FAERS
333Pituitary enlargementFAERS: 1US FAERS
334PolydipsiaFAERS: 1US FAERS
335PolyuriaFAERS: 1US FAERS
336Postrenal failureFAERS: 1US FAERS
337Prescribed underdoseFAERS: 1US FAERS
338PriapismFAERS: 1US FAERS
339Product container issueFAERS: 1US FAERS
340Product dispensing issueFAERS: 1US FAERS
341Product distribution issueFAERS: 1US FAERS
342Product dosage form confusionFAERS: 1US FAERS
343Product formulation issueFAERS: 1US FAERS
344Product label confusionFAERS: 1US FAERS
345Product label issueFAERS: 1US FAERS
346Product outer packaging issueFAERS: 1US FAERS
347Product quality control issueFAERS: 1US FAERS
348Product selection errorFAERS: 1US FAERS
349Product shape issueFAERS: 1US FAERS
350Product size issueFAERS: 1US FAERS
351Product tamperingFAERS: 1US FAERS
352Pruritus allergicFAERS: 1US FAERS
353Psychiatric symptomFAERS: 1US FAERS
354Psychomotor skills impairedFAERS: 1US FAERS
355Pulmonary congestionFAERS: 1US FAERS
356PurpuraFAERS: 1US FAERS
357Renal tubular disorderFAERS: 1US FAERS
358Respiratory distressFAERS: 1US FAERS
359RhabdomyolysisFAERS: 1US FAERS
360Sedation complicationFAERS: 1US FAERS
361Sinus headacheFAERS: 1US FAERS
362SinusitisFAERS: 1US FAERS
363Sleep disorder due to general medical condition, insomnia typeFAERS: 1US FAERS
364SnoringFAERS: 1US FAERS
365Sudden deathFAERS: 1US FAERS
366Sudden onset of sleepFAERS: 1US FAERS
367Suicide threatFAERS: 1US FAERS
368Supraventricular tachycardiaFAERS: 1US FAERS
369TaciturnityFAERS: 1US FAERS
370Tension HeadacheFAERS: 1US FAERS
371Therapeutic product effect decreasedFAERS: 1US FAERS
372Therapy changeFAERS: 1US FAERS
373Thermal burnFAERS: 1US FAERS
374ThrombocytopeniaFAERS: 1US FAERS
375Tongue pruritusFAERS: 1US FAERS
376Tooth AnkylosisFAERS: 1US FAERS
377ToothacheFAERS: 1US FAERS
378TrichotillomaniaFAERS: 1US FAERS
379TuberculosisFAERS: 1US FAERS
380Unevaluable eventFAERS: 1US FAERS
381Unresponsive to stimuliFAERS: 1US FAERS
382Urinary IncontinenceFAERS: 1US FAERS
383Urine flow decreasedFAERS: 1US FAERS
384Violence-related symptomFAERS: 1US FAERS
385Viral upper respiratory tract infectionFAERS: 1US FAERS
386Vitamin D DeficiencyFAERS: 1US FAERS
387Waxy flexibilityFAERS: 1US FAERS
388Wrong scheduleFAERS: 1US FAERS
389furuncleFAERS: 1US FAERS
390prostatitisFAERS: 1US FAERS
391skin abrasionFAERS: 1US FAERS
392Blood cholesterol increasedSIDER
393InfectionSIDER
394InfestationSIDER
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