MetaADEDB 2.0 @ LMMD
rotigotine
(KFQYTPMOWPVWEJ-INIZCTEOSA-N)
Structure
SMILES
CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1
Type(s)
Approved
ATC code(s)
N04BC09
Molecular Formula:
C19H25NOS
Molecular Weight:
315.473
Log P:
4.2657
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
51.71
CAS Number(s):
99755-59-6
Synonym(s)
1.
rotigotine
2.
(+)-5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
3.
(+--)-5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol
4.
1-naphthalenol, 5,6,7,8-tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-
5.
2-(N-n-propyl-N-2-thienylethylamino)-5-hydroxytetralin
6.
N 0437
7.
N 0437, (+-)-isomer
8.
N 0437, (-)-isomer
9.
N 0437, (R)-isomer
10.
N 0437, hydrochloride, (R)-isomer
11.
N 0437, hydrochloride, (S)-isomer
12.
N 0923
13.
N 0924
14.
N-0437
15.
N-0923
16.
N-0924
17.
Neupro
18.
Rotigotine CDS
19.
racemic N-0437
20.
rotigotine (+-)-form
21.
rotigotine, (+)-
22.
rotigotine, (+--)-
External Link(s)
MeSHC047508
PubChem Compound59227
BindingDB50123626
ChEBI135351
CHEMBLCHEMBL1303
DrugBankDB05271
DrugCentral2407
IUPHAR/BPS Guide to PHARMACOLOGY941
KEGGdr:D05768
Therapeutic Target DatabaseD09OQV
D08XAW
ZINC4028
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 153
Canada Vigilance: 2
Canada Vigilance
US FAERS
2Application site erythemaFAERS: 121US FAERS
3Application site pruritusFAERS: 112US FAERS
4Product adhesion issueFAERS: 91
Canada Vigilance: 1
Canada Vigilance
US FAERS
5Application site rashFAERS: 63US FAERS
6Application site reactionFAERS: 63
Canada Vigilance: 1
Canada Vigilance
US FAERS
7Pharmaceutical product complaintFAERS: 61US FAERS
8OverdoseFAERS: 50US FAERS
9TremorFAERS: 47SIDER
US FAERS
10PneumoniaFAERS: 43US FAERS
11NauseaFAERS: 42SIDER
US FAERS
12Restless Legs SyndromeFAERS: 3817563266
18656214
CTD
US FAERS
13DizzinessFAERS: 35SIDER
US FAERS
14ErythemaFAERS: 31SIDER
US FAERS
15Application site vesiclesFAERS: 30US FAERS
16PruritusFAERS: 30SIDER
US FAERS
17Wrong technique in product usage processFAERS: 29US FAERS
18FatigueFAERS: 26SIDER
US FAERS
19Intentional product misuseFAERS: 26US FAERS
20Application site irritationFAERS: 25US FAERS
21VomitingFAERS: 25
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
22Product quality issueFAERS: 24US FAERS
23SomnolenceFAERS: 24SIDER
US FAERS
24Application site swellingFAERS: 19US FAERS
25MalaiseFAERS: 18SIDER
US FAERS
26Drug dose omissionFAERS: 17US FAERS
27Feeling abnormalFAERS: 17SIDER
US FAERS
28Unevaluable eventFAERS: 17US FAERS
29Urinary tract infectionFAERS: 17US FAERS
30AnxietyFAERS: 16US FAERS
31Application site painFAERS: 16US FAERS
32AstheniaFAERS: 16SIDER
US FAERS
33PainFAERS: 16SIDER
US FAERS
34Skin reactionFAERS: 15US FAERS
35AgitationFAERS: 12SIDER
US FAERS
36Cerebrovascular accidentFAERS: 12US FAERS
37HypersensitivityFAERS: 12SIDER
US FAERS
38No adverse eventFAERS: 12US FAERS
39Skin irritationFAERS: 12US FAERS
40Acute myocardial infarctionFAERS: 11US FAERS
41Application site hypersensitivityFAERS: 11US FAERS
42Application site urticariaFAERS: 11US FAERS
43SyncopeFAERS: 10SIDER
US FAERS
44Weight decreasedFAERS: 10SIDER
US FAERS
45HypotensionFAERS: 9SIDER
US FAERS
46Myocardial InfarctionFAERS: 9US FAERS
47VertigoFAERS: 9SIDER
US FAERS
48Wrong technique in drug usage processFAERS: 9US FAERS
49ArthralgiaFAERS: 8SIDER
US FAERS
50DementiaFAERS: 8US FAERS
51Drug DependenceFAERS: 8US FAERS
52Drug effect incompleteFAERS: 8US FAERS
53General physical health deteriorationFAERS: 8US FAERS
54HeadacheFAERS: 8
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
55Inappropriate schedule of drug administrationFAERS: 8US FAERS
56Cardiac ArrestFAERS: 7US FAERS
57Drug administration errorFAERS: 7US FAERS
58Neuroleptic Malignant SyndromeFAERS: 7US FAERS
59Obsessive-Compulsive DisorderFAERS: 7SIDER
US FAERS
60PalpitationsFAERS: 7US FAERS
61RestlessnessFAERS: 7US FAERS
62SepsisFAERS: 7US FAERS
63Suicide attemptFAERS: 7US FAERS
64Back PainFAERS: 6US FAERS
65ConstipationFAERS: 6SIDER
US FAERS
66DehydrationFAERS: 6US FAERS
67Incorrect drug administration durationFAERS: 6US FAERS
68Limb discomfortFAERS: 6US FAERS
69Muscle RigidityFAERS: 6US FAERS
70Musculoskeletal stiffnessFAERS: 6US FAERS
71Peripheral swellingFAERS: 6US FAERS
72Urinary RetentionFAERS: 6US FAERS
73Abdominal PainFAERS: 5US FAERS
74AmnesiaFAERS: 5US FAERS
75AngioedemaFAERS: 5SIDER
US FAERS
76DisorientationFAERS: 5SIDER
US FAERS
77InfectionFAERS: 5SIDER
US FAERS
78Medication ErrorFAERS: 5US FAERS
79Memory impairmentFAERS: 5US FAERS
80NervousnessFAERS: 5US FAERS
81Rash erythematousFAERS: 5US FAERS
82Sudden onset of sleepFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
83ThrombosisFAERS: 5US FAERS
84UrticariaFAERS: 5SIDER
US FAERS
85AbasiaFAERS: 4US FAERS
86Accidental overdoseFAERS: 4US FAERS
87Application site burnFAERS: 4US FAERS
88Atrial FibrillationFAERS: 4US FAERS
89BradycardiaFAERS: 4US FAERS
90Chest PainFAERS: 4US FAERS
91DeliriumFAERS: 4US FAERS
92Drug prescribing errorFAERS: 4US FAERS
93GlaucomaFAERS: 4US FAERS
94Hypertensive crisisFAERS: 4US FAERS
95Incorrect storage of drugFAERS: 4US FAERS
96Intentional drug misuseFAERS: 4US FAERS
97Mood swingsFAERS: 4US FAERS
98Neck PainFAERS: 4US FAERS
99Product administered at inappropriate siteFAERS: 4US FAERS
100Product packaging issueFAERS: 4US FAERS
101TachycardiaFAERS: 4US FAERS
102Abdominal discomfortFAERS: 3US FAERS
103Adverse eventFAERS: 3US FAERS
104Angina PectorisFAERS: 3US FAERS
105AnorexiaFAERS: 3SIDER
US FAERS
106Application site pustulesFAERS: 3US FAERS
107ArthritisFAERS: 3US FAERS
108ArthropathyFAERS: 3US FAERS
109BedriddenFAERS: 3US FAERS
110BronchospasmFAERS: 3US FAERS
111Completed SuicideFAERS: 3US FAERS
112DiscomfortFAERS: 3SIDER
US FAERS
113Drug ineffective for unapproved indicationFAERS: 3US FAERS
114DyspepsiaFAERS: 3SIDER
US FAERS
115Euphoric moodFAERS: 3US FAERS
116Eye painFAERS: 3US FAERS
117FractureFAERS: 3US FAERS
118Freezing phenomenonFAERS: 3US FAERS
119GamblingFAERS: 3US FAERS
120ImmobileFAERS: 3US FAERS
121InfluenzaFAERS: 3US FAERS
122Intestinal ObstructionFAERS: 3US FAERS
123Joint swellingFAERS: 3US FAERS
124LethargyFAERS: 3SIDER
US FAERS
125NephrolithiasisFAERS: 3US FAERS
126PancreatitisFAERS: 3US FAERS
127Poor quality sleepFAERS: 3US FAERS
128Post procedural complicationFAERS: 3US FAERS
129Product dose omissionFAERS: 3US FAERS
130Sexual abuseFAERS: 3US FAERS
131Therapeutic response unexpectedFAERS: 3US FAERS
132AkinesiaFAERS: 2US FAERS
133AlopeciaFAERS: 2US FAERS
134AneurysmFAERS: 2US FAERS
135AngerFAERS: 2US FAERS
136AphasiaFAERS: 2US FAERS
137BlindnessFAERS: 2US FAERS
138Blood creatine phosphokinase increasedFAERS: 2US FAERS
139Blood pressure fluctuationFAERS: 2US FAERS
140Cerebral InfarctionFAERS: 2US FAERS
141ChokingFAERS: 2US FAERS
142Compulsive shoppingFAERS: 2SIDER
US FAERS
143Depressed moodFAERS: 2US FAERS
144DiplegiaFAERS: 2US FAERS
145DiplopiaFAERS: 2US FAERS
146DisabilityFAERS: 2US FAERS
147Disease complicationFAERS: 2US FAERS
148Drug administered at inappropriate siteFAERS: 2US FAERS
149Drug delivery system malfunctionFAERS: 2US FAERS
150Drug dispensing errorFAERS: 2US FAERS
151Drug withdrawal syndromeFAERS: 2US FAERS
152Dry skinFAERS: 2US FAERS
153DysphoniaFAERS: 2US FAERS
154DystoniaFAERS: 2US FAERS
155EczemaFAERS: 2SIDER
US FAERS
156Emotional disorderFAERS: 2US FAERS
157ExcoriationFAERS: 2US FAERS
158Expired drug administeredFAERS: 2US FAERS
159Expired product administeredFAERS: 2US FAERS
160HypervigilanceFAERS: 2US FAERS
161Impaired driving abilityFAERS: 2US FAERS
162Incorrect product storageFAERS: 2US FAERS
163InfarctionFAERS: 2US FAERS
164InflammationFAERS: 2SIDER
US FAERS
165Initial insomniaFAERS: 2US FAERS
166Lip swellingFAERS: 2US FAERS
167Lower respiratory tract infectionFAERS: 2US FAERS
168Macular degenerationFAERS: 2US FAERS
169Maternal exposure before pregnancyFAERS: 2US FAERS
170Maternal exposure during pregnancyFAERS: 2US FAERS
171Miscarriage of partnerFAERS: 2US FAERS
172MyalgiaFAERS: 2US FAERS
173NarcolepsyFAERS: 2US FAERS
174NasopharyngitisFAERS: 2SIDER
US FAERS
175Nonspecific reactionFAERS: 2US FAERS
176OsteoporosisFAERS: 2US FAERS
177PancytopeniaFAERS: 2US FAERS
178ParanoiaFAERS: 2US FAERS
179Personality ChangeFAERS: 2US FAERS
180Pregnancy of partnerFAERS: 2US FAERS
181Prescribed overdoseFAERS: 2US FAERS
182Product physical issueFAERS: 2US FAERS
183Rehabilitation therapyFAERS: 2US FAERS
184Respiratory arrestFAERS: 2US FAERS
185Retinal telangiectasiaFAERS: 2US FAERS
186SciaticaFAERS: 2US FAERS
187Seizure like phenomenaFAERS: 2US FAERS
188Skin lesionFAERS: 2US FAERS
189Sleep TalkingFAERS: 2US FAERS
190Spinal column stenosisFAERS: 2US FAERS
191Spinal fusion surgeryFAERS: 2US FAERS
192Sputum retentionFAERS: 2US FAERS
193Sudden deathFAERS: 2US FAERS
194Thermal burnFAERS: 2US FAERS
195Accidental exposure to productFAERS: 1US FAERS
196Accidental exposureFAERS: 1US FAERS
197Activities of daily living impairedFAERS: 1US FAERS
198Acute kidney injuryFAERS: 1US FAERS
199AgnosiaFAERS: 1US FAERS
200Altered state of consciousnessFAERS: 1US FAERS
201Anaphylactic shockFAERS: 1US FAERS
202Ankle FractureFAERS: 1US FAERS
203Application site acneFAERS: 1US FAERS
204Application site dischargeFAERS: 1US FAERS
205Application site drynessFAERS: 1US FAERS
206Application site exfoliationFAERS: 1US FAERS
207Application site papulesFAERS: 1US FAERS
208Application site scabFAERS: 1US FAERS
209Application site scarFAERS: 1US FAERS
210Application site warmthFAERS: 1US FAERS
211AsphyxiaFAERS: 1US FAERS
212AsthmaFAERS: 1US FAERS
213AtaxiaFAERS: 1US FAERS
214AtelectasisFAERS: 1US FAERS
215Atrial FlutterFAERS: 1US FAERS
216Avulsion fractureFAERS: 1US FAERS
217Back disorderFAERS: 1US FAERS
218Benign Prostatic HyperplasiaFAERS: 1US FAERS
219Blood cholesterol increasedFAERS: 1US FAERS
220Blood creatinine increasedFAERS: 1US FAERS
221Blood sodium decreasedFAERS: 1US FAERS
222Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
223Blood urea abnormalFAERS: 1US FAERS
224Blood urea increasedFAERS: 1US FAERS
225Blood urine presentFAERS: 1US FAERS
226BradykinesiaFAERS: 1US FAERS
227Breech PresentationFAERS: 1US FAERS
228BronchitisFAERS: 1US FAERS
229Burning sensationFAERS: 1US FAERS
230CachexiaFAERS: 1US FAERS
231CamptocormiaFAERS: 1US FAERS
232Cardiovascular insufficiencyFAERS: 1US FAERS
233Cartilage injuryFAERS: 1US FAERS
234Catheter sepsisFAERS: 1US FAERS
235CellulitisFAERS: 1US FAERS
236Cerebral ThrombosisFAERS: 1US FAERS
237Cerebral disorderFAERS: 1US FAERS
238Chemical injuryFAERS: 1US FAERS
239ChoreoathetosisFAERS: 1US FAERS
240ConjunctivitisFAERS: 1US FAERS
241CryingFAERS: 1US FAERS
242CystitisFAERS: 1US FAERS
243CystoceleFAERS: 1US FAERS
244Deep Brain StimulationFAERS: 1US FAERS
245DependenceFAERS: 1US FAERS
246DermatitisFAERS: 1SIDER
US FAERS
247Device FailureFAERS: 1US FAERS
248Device adhesion issueFAERS: 1US FAERS
249Device malfunctionFAERS: 1US FAERS
250Device related infectionFAERS: 1US FAERS
251Diabetes MellitusFAERS: 1US FAERS
252DiathermyFAERS: 1US FAERS
253Disease ProgressionFAERS: 1US FAERS
254Disease recurrenceFAERS: 1US FAERS
255Drug delivery device implantationFAERS: 1US FAERS
256Drug dose titration not performedFAERS: 1US FAERS
257Drug effect variableFAERS: 1US FAERS
258Drug therapy enhancementFAERS: 1US FAERS
259Drug titration errorFAERS: 1US FAERS
260DysgeusiaFAERS: 1US FAERS
261DysuriaFAERS: 1US FAERS
262Ejection Fraction DecreasedFAERS: 1US FAERS
263Electroencephalogram abnormalFAERS: 1US FAERS
264Emergency CareFAERS: 1US FAERS
265Emotional distressFAERS: 1US FAERS
266EpilepsyFAERS: 1US FAERS
267ErysipelasFAERS: 1US FAERS
268Erythema NodosumFAERS: 1US FAERS
269Exposure during breast feedingFAERS: 1US FAERS
270Exposure via body fluidFAERS: 1US FAERS
271Extra dose administeredFAERS: 1US FAERS
272Eye irritationFAERS: 1US FAERS
273Facial ParesisFAERS: 1US FAERS
274Feeling ColdFAERS: 1US FAERS
275Fibrin increasedFAERS: 1US FAERS
276FibrosisFAERS: 1US FAERS
277FlushingFAERS: 1US FAERS
278Focal Nodular HyperplasiaFAERS: 1US FAERS
279Food cravingFAERS: 1US FAERS
280Foreign travelFAERS: 1US FAERS
281Gastric ulcerFAERS: 1US FAERS
282Gastroenteritis norovirusFAERS: 1US FAERS
283GastroenteritisFAERS: 1US FAERS
284Gastrointestinal PainFAERS: 1US FAERS
285GranulomaFAERS: 1US FAERS
286Growth retardationFAERS: 1US FAERS
287HemiparesisFAERS: 1US FAERS
288HepatotoxicityFAERS: 1US FAERS
289Hip surgeryFAERS: 1US FAERS
290HydrocephalusFAERS: 1US FAERS
291HyperventilationFAERS: 1US FAERS
292HypokinesiaFAERS: 1US FAERS
293Impaired gastric emptyingFAERS: 1US FAERS
294Incisional herniaFAERS: 1US FAERS
295IncontinenceFAERS: 1US FAERS
296Incorrect dose administered by deviceFAERS: 1US FAERS
297Incorrect dose administeredFAERS: 1US FAERS
298Injection site bruisingFAERS: 1US FAERS
299Injection site painFAERS: 1US FAERS
300Intestinal resectionFAERS: 1US FAERS
301Intracranial AneurysmFAERS: 1US FAERS
302KleptomaniaFAERS: 1US FAERS
303LacerationFAERS: 1US FAERS
304LeukodermaFAERS: 1US FAERS
305LeukopeniaFAERS: 1US FAERS
306Living in residential institutionFAERS: 1US FAERS
307Loss of personal independence in daily activitiesFAERS: 1US FAERS
308LymphomaFAERS: 1US FAERS
309MalabsorptionFAERS: 1US FAERS
310MalnutritionFAERS: 1SIDER
US FAERS
311Medical device battery replacementFAERS: 1US FAERS
312MeningiomaFAERS: 1US FAERS
313MetastasisFAERS: 1US FAERS
314Middle insomniaFAERS: 1US FAERS
315Migraine with AuraFAERS: 1US FAERS
316Multiple allergiesFAERS: 1US FAERS
317Muscle strainFAERS: 1US FAERS
318Muscle tightnessFAERS: 1US FAERS
319Musculoskeletal PainFAERS: 1SIDER
US FAERS
320Myoglobin blood increasedFAERS: 1US FAERS
321Nail bed disorderFAERS: 1US FAERS
322Night sweatsFAERS: 1US FAERS
323Obsessive thoughtsFAERS: 1US FAERS
324Open woundFAERS: 1US FAERS
325PallorFAERS: 1US FAERS
326Parkinsonian rest tremorFAERS: 1US FAERS
327PharyngitisFAERS: 1US FAERS
328PneumothoraxFAERS: 1US FAERS
329PoisoningFAERS: 1US FAERS
330Poor quality drug administeredFAERS: 1US FAERS
331PresyncopeFAERS: 1US FAERS
332Procedural complicationFAERS: 1US FAERS
333Product depositFAERS: 1US FAERS
334Product label issueFAERS: 1US FAERS
335Psychiatric symptomFAERS: 1US FAERS
336Psychomotor skills impairedFAERS: 1US FAERS
337Pulmonary HypertensionFAERS: 1US FAERS
338Pulmonary NocardiosisFAERS: 1US FAERS
339Rebound effectFAERS: 1US FAERS
340Respiratory FailureFAERS: 1US FAERS
341Respiratory distressFAERS: 1US FAERS
342Retinal DetachmentFAERS: 1US FAERS
343RhabdomyolysisFAERS: 1US FAERS
344RhinitisFAERS: 1US FAERS
345Sexual activity increasedFAERS: 1US FAERS
346SilicosisFAERS: 1US FAERS
347Sinus operationFAERS: 1US FAERS
348Skin ErosionFAERS: 1US FAERS
349Skin IndurationFAERS: 1US FAERS
350Skin UlcerFAERS: 1US FAERS
351Skin necrosisFAERS: 1US FAERS
352SluggishnessFAERS: 1US FAERS
353SomnambulismFAERS: 1US FAERS
354StarvationFAERS: 1US FAERS
355StrabismusFAERS: 1US FAERS
356StressFAERS: 1US FAERS
357Supraventricular tachycardiaFAERS: 1US FAERS
358SwellingFAERS: 1SIDER
US FAERS
359Temporal ArteritisFAERS: 1US FAERS
360Terminal stateFAERS: 1US FAERS
361Throat irritationFAERS: 1US FAERS
362ThrombocytopeniaFAERS: 1US FAERS
363Tobacco userFAERS: 1US FAERS
364TrismusFAERS: 1US FAERS
365UlcerFAERS: 1US FAERS
366Unresponsive to stimuliFAERS: 1US FAERS
367Upper respiratory tract inflammationFAERS: 1US FAERS
368Urinary IncontinenceFAERS: 1US FAERS
369Vascular ruptureFAERS: 1US FAERS
370Viral upper respiratory tract infectionFAERS: 1US FAERS
371Visual ImpairmentFAERS: 1SIDER
US FAERS
372Visual disturbanceFAERS: 1US FAERS
373VitiligoFAERS: 1US FAERS
374Vulvovaginal painFAERS: 1US FAERS
375Wheelchair userFAERS: 1US FAERS
376WheezingFAERS: 1US FAERS
377Wound infection bacterialFAERS: 1US FAERS
378Wrong patient received medicationFAERS: 1US FAERS
379skin abrasionFAERS: 1US FAERS
380Abnormal visionSIDER
381Application and instillation site reactionsSIDER
382Asthenic conditionsSIDER
383Disturbance in sexual arousalSIDER
384Ear and labyrinth disordersSIDER
385Erectile dysfunctionSIDER
386Excessive daytime sleepinessSIDER
387HyperpyrexiaSIDER
388Hypotension symptomaticSIDER
389InfestationSIDER
390Musculoskeletal discomfortSIDER
391PapuleSIDER
392Parkinson Disease17563266
23165154
CTD
393Pharyngolaryngeal PainSIDER
394PrurigoSIDER
395PundingSIDER
396ShockSIDER
397SinusitisSIDER
398TinnitusSIDER
399nervous system disorderSIDER
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