MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Fetal Membranes, Premature Rupture

(UMLS:C0015944)

Definition:: Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
UMLS ID:: C0015944
MeSH ID:: D005322

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.703.420.339

Synonym(s)

Fetal Membranes, Premature Rupture

Fetal membranes, premature rupture

MEMBRANE RUPTURE PREMATURE

PROM

PROM - Premature rupture of membranes

Prelabor Rupture of Membranes

Premature Rupture of Membrane

Premature Rupture of Membranes

Premature rupture of membranes

10.

Premature rupture of membranes, unspecified

11.

Premature;rupture of membranes

12.

Rupture of amniotic sac under 24 hours before onset of labor

13.

Rupture of amniotic sac under 24 hours before onset of labour

14.

Rupture of membranes prior to onset of labor

15.

Term Premature Rupture of Membranes

16.

membrane premature rupture

17.

membranes of premature rupture

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cocaine		11489591	CTD
2	Nitrates		18635574	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Dystocia	46.7%
2	Abruptio Placentae	44.4%
3	Placenta Accreta	44.4%
4	Premature Birth	34.4%
5	Uterine Inversion	34.1%
6	Postpartum Hemorrhage	33.1%
7	Polyhydramnios	31%
8	Ectopic Pregnancy	31%
9	Pregnancy, Prolonged	31%
10	Puerperal Disorders	31%
11	Oligohydramnios	31%
12	Prenatal Injuries	31%
13	Uterine Rupture	26.1%
14	Breech Presentation	23%
15	Fetal Diseases	22%
16	Pregnancy Complications, Cardiovascular	22%
17	Pregnancy Complications, Neoplastic	22%
18	Pregnancy Complications, Hematologic	20.9%
19	Pregnancy Complications, Infectious	20.9%
20	Fetal Death	20.5%
21	Perinatal death	20.5%
22	Morning Sickness	20.2%
23	Abortion, Habitual	20%
24	Eclampsia	20%
25	Placental Insufficiency	20%
26	Pre-Eclampsia	20%
27	Prenatal Exposure Delayed Effects	20%
28	Puerperal Infection	20%
29	HELLP Syndrome	20%
30	Placenta, Retained	20%
31	Female Urogenital Diseases	18.5%
32	Chorioamnionitis	16.1%
33	Gestational Diabetes	15.4%
34	Abortion, Veterinary	14.3%
35	Pregnancy Complications, Parasitic	14.3%
36	Lactation Disorder	13.3%
37	Mastitis	13.3%
38	Depression, Postpartum	13.3%
39	Embryo Loss	13.3%
40	Fetal Resorption	13.2%
41	Hyperemesis Gravidarum	13.1%
42	Uterine Cervical Incompetence	12.4%
43	Fetal Growth Retardation	10.2%
44	Trophoblastic Neoplasms	10.2%
45	Embolism, Amniotic Fluid	10.1%
46	Fetal Hypoxia	10.1%
47	Fetal Alcohol Spectrum Disorders	10.1%
48	Stillbirth	9.8%
49	Galactorrhea	9.8%
50	Urologic Diseases	7.3%
51	Meconium Aspiration Syndrome	6.9%
52	Endometriosis	6.7%
53	Uterine Diseases	6.7%
54	Vaginal Diseases	6.7%
55	Vulvar Diseases	6.7%
56	Endometrioma	6.7%
57	Hydatidiform Mole	6%
58	Endometritis	5.9%
59	Choriocarcinoma	5.9%
60	Urogenital Abnormalities	5.5%
61	Salpingitis	5.4%
62	Vulvovaginitis	5.4%
63	Endometrial Hyperplasia	4.9%
64	Pyometra	4.9%
65	Vaginitis	4.9%
66	Vulvitis	4.9%
67	Vaginal Discharge	4.9%
68	Vulvodynia	4.9%
69	Uterine Neoplasms	4.9%
70	Vaginal Neoplasms	4.9%
71	Vulvar Neoplasms	4.9%
72	Uterine Cancer	4.9%
73	Urinary Bladder Diseases	4.5%
74	Infertility	4.5%
75	Kidney Diseases	4.5%
76	Ureteral Diseases	4.5%
77	Urethral Diseases	4.5%
78	Urination Disorders	4.5%
79	Urolithiasis	4.5%
80	Fallopian Tube Neoplasms	4.5%
81	Genital Neoplasms, Female	4.4%
82	Uterine Cervicitis	4.1%
83	Leukorrhea	4.1%
84	Oophoritis	4.1%
85	Parametritis	4.1%
86	Endometrial Neoplasms	4%
87	Vesicovaginal Fistula	4%
88	Anuria	3.9%
89	Ureterolithiasis	3.9%
90	Nephrolithiasis	3.9%
91	Bladder Exstrophy	3.9%
92	Epispadias	3.9%
93	Tuberculosis, Renal	3.9%
94	Hydrops Fetalis	3.7%
95	Candidiasis, Vulvovaginal	3.6%
96	Multicystic Dysplastic Kidney	3.6%
97	Bladder neck obstruction	3.6%
98	Urinary tract infection	3.4%
99	Urologic Neoplasms	3.4%
100	Horseshoe Kidney	3.4%
101	Ovarian Diseases	3.4%
102	Adnexitis	3.3%
103	Cystitis	3.3%
104	Hydronephrosis	3.3%
105	Hyperoxaluria	3.3%
106	Kidney Cortex Necrosis	3.3%
107	Kidney Papillary Necrosis	3.3%
108	Nephritis	3.3%
109	Nephrosclerosis	3.3%
110	Nephrosis	3.3%
111	Perinephritis	3.3%
112	Pruritus Vulvae	3.3%
113	Kidney Failure	3.3%
114	Uremia	3.3%
115	Ureteral obstruction	3.3%
116	Ureterocele	3.3%
117	Urethral Obstruction	3.3%
118	Urethritis	3.3%
119	Uterine hemorrhage	3.3%
120	Vaginal Fistula	3.3%
121	Vesico-Ureteral Reflux	3.3%
122	Urinary Retention	3.3%
123	Pelvic Inflammatory Disease	3.3%
124	Oxalosis	3.3%
125	Renal Insufficiency	3.3%
126	Urinary Bladder Fistula	3.3%
127	Bladder Neoplasm	3.3%
128	Kidney Neoplasm	3.3%
129	Ureteral Neoplasms	3.3%
130	Urethral Neoplasms	3.3%
131	Uterine Prolapse	3.3%
132	Vaginal Prolapse	3.3%
133	Carcinoma, Endometrioid	3.2%
134	Pyelocystitis	3%
135	ovarian neoplasm	3%
136	Kidney Calculi	3%
137	Ureteral Calculi	3%
138	Pyelonephritis	2.9%
139	Sexually Transmitted Diseases	2.9%
140	Bacterial Vaginosis	2.8%
141	Hermaphroditism	2.7%
142	Disorders of Sex Development	2.7%
143	Endometrial Stromal Sarcoma	2.7%
144	Trichomonas Vaginitis	2.7%
145	Uterine Perforation	2.7%
146	Ovarian Hyperstimulation Syndrome	2.7%
147	Glomerulonephritis	2.7%
148	Metrorrhagia	2.7%
149	Nephritis, Interstitial	2.7%
150	Lipoid nephrosis	2.7%
151	Nephrotic Syndrome	2.7%
152	Pyelitis	2.7%
153	Pyonephrosis	2.7%
154	Urethral Stenosis	2.7%
155	Nephrogenic Diabetes Insipidus	2.7%
156	Congenital Nephrogenic Diabetes Insipidus	2.7%
157	Hypospadias	2.7%
158	Acute kidney injury	2.7%
159	Urethral stricture	2.7%
160	Genital Herpes	2.7%
161	Diabetes Insipidus	2.5%
162	Hepatorenal Syndrome	2.5%
163	Dyspareunia	2.5%
164	Bacteriuria	2.5%
165	Diabetic Nephropathy	2.5%
166	Glycosuria	2.5%
167	Hematuria	2.5%
168	Renal hypertension	2.5%
169	Oliguria	2.5%
170	Polyuria	2.5%
171	Proteinuria	2.5%
172	Pyuria	2.5%
173	Renal Artery Obstruction	2.5%
174	Renal Artery Stenosis	2.5%
175	Urinary Calculi	2.5%
176	Cystocele	2.5%
177	Nephrocalcinosis	2.5%
178	Urinary Incontinence	2.5%
179	Balkan Nephropathy	2.4%
180	Focal glomerulosclerosis	2.4%
181	Kidney Failure, Chronic	2.4%
182	Mesoblastic Nephroma	2.3%
183	Renal Cell Carcinoma	2.3%
184	Papillary Renal Cell Carcinoma	2.3%
185	granulosa cell tumor	2.2%
186	Carcinoma, Ovarian Epithelial	2.2%
187	Corpus Luteum Cyst	2.1%
188	Ovarian Cysts	2.1%
189	Azotemia	2.1%
190	Anovulation	2%
191	Menorrhagia	2%
192	Albuminuria	2%
193	Hemoglobinuria	2%
194	Hypertension, Renovascular	2%
195	Glycosuria, Renal	2%
196	Premature Menopause	2%
197	Urge Incontinence	2%
198	Enuresis	2%
199	Gonadal Dysgenesis	2%
200	Adrenogenital Syndrome	2%
201	Ovotesticular Disorders of Sex Development	2%
202	Glomerulonephritis, Membranoproliferative	1.9%
203	Polycystic Ovary Syndrome	1.8%
204	Nephroblastoma	1.8%
205	Hyperandrogenism	1.8%
206	Denys-Drash Syndrome	1.7%
207	Polycystic Kidney Diseases	1.6%
208	AIDS-Associated Nephropathy	1.6%
209	Diurnal Enuresis	1.6%
210	Renal Aminoacidurias	1.6%
211	Fanconi Syndrome	1.6%
212	Pseudohypoaldosteronism	1.6%
213	Liddle Syndrome	1.6%
214	Hemolytic-Uremic Syndrome	1.6%
215	Anti-Glomerular Basement Membrane Disease	1.5%
216	Lupus Nephritis	1.5%
217	Polycystic Kidney, Autosomal Dominant	1.4%
218	Cystinuria	1.4%
219	Atypical Hemolytic Uremic Syndrome	1.4%
220	Chlamydia Infections	1.4%
221	Gonorrhea	1.4%
222	Renal tubular acidosis	1.3%
223	Renal Osteodystrophy	1.2%
224	Renal rickets	1.2%
225	Lymphogranuloma Venereum	1.2%
226	Kallmann Syndrome	1.2%
227	Syphilis	1.2%
228	Turner Syndrome	1.2%
229	Hyperphosphaturia	1%
230	Klinefelter Syndrome	1%
231	Zellweger Syndrome	0.9%
232	Familial Hypophosphatemic Rickets	0.6%

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