MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pyonephrosis

(UMLS:C0034216)

Definition:: Distention of KIDNEY with the presence of PUS and suppurative destruction of the renal parenchyma. It is often associated with renal obstruction and can lead to total or nearly total loss of renal function.
UMLS ID:: C0034216
MeSH ID:: D053018

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.307.500

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.307.500

Synonym(s)

Pyonephrosis

pyonephrosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ketamine	FAERS: 2	US FAERS
2	Tacrolimus	FAERS: 2	US FAERS
3	empagliflozin	FAERS: 2	US FAERS
4	Arthrotec	FAERS: 1	US FAERS
5	Epoprostenol	FAERS: 1	US FAERS
6	Prednisolone	FAERS: 1	US FAERS
7	Acebutolol		OFFSIDES
8	Atazanavir Sulfate		OFFSIDES
9	Carnitine		OFFSIDES
10	Didanosine		OFFSIDES
11	Erythromycin		OFFSIDES
12	Stavudine		OFFSIDES
13	abacavir		OFFSIDES
14	erythromycin lactobionate		OFFSIDES
15	gadoversetamide		OFFSIDES
16	urapidil		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperoxaluria	35.2%
2	Kidney Cortex Necrosis	35.2%
3	Kidney Papillary Necrosis	35.2%
4	Nephritis	35.2%
5	Nephrosclerosis	35.2%
6	Nephrosis	35.2%
7	Perinephritis	35.2%
8	Kidney Failure	35.2%
9	Uremia	35.2%
10	Oxalosis	35.2%
11	Renal Insufficiency	35.2%
12	Anuria	34.1%
13	Nephrolithiasis	34.1%
14	Diabetes Insipidus	28.7%
15	Hepatorenal Syndrome	28.7%
16	Diabetic Nephropathy	28.3%
17	Renal hypertension	28.3%
18	Renal Artery Obstruction	28.3%
19	Renal Artery Stenosis	28.3%
20	Nephrocalcinosis	28.2%
21	Urinary Bladder Diseases	27%
22	Ureteral Diseases	27%
23	Urethral Diseases	27%
24	Urination Disorders	27%
25	Urolithiasis	27%
26	Tuberculosis, Renal	26.2%
27	Kidney Neoplasm	23.7%
28	Glomerulonephritis	23.2%
29	Nephritis, Interstitial	23.2%
30	Lipoid nephrosis	23.2%
31	Nephrotic Syndrome	23.2%
32	Pyelitis	23.2%
33	Nephrogenic Diabetes Insipidus	23.2%
34	Congenital Nephrogenic Diabetes Insipidus	23.2%
35	Acute kidney injury	23.2%
36	Pyelonephritis	23%
37	Urinary tract infection	21.9%
38	Ureterolithiasis	21.1%
39	AIDS-Associated Nephropathy	20.1%
40	Kidney Calculi	19.6%
41	Multicystic Dysplastic Kidney	19.5%
42	Azotemia	19%
43	Hypertension, Renovascular	18.6%
44	Pyelocystitis	18.5%
45	Bladder neck obstruction	17.5%
46	Balkan Nephropathy	17.3%
47	Focal glomerulosclerosis	17.3%
48	Kidney Failure, Chronic	17.3%
49	Cystitis	15.8%
50	Ureteral obstruction	15.8%
51	Ureterocele	15.8%
52	Urethral Obstruction	15.8%
53	Urethritis	15.8%
54	Urogenital Abnormalities	15.8%
55	Vesico-Ureteral Reflux	15.8%
56	Urinary Retention	15.8%
57	Polycystic Kidney Diseases	15.7%
58	Renal Osteodystrophy	15.6%
59	Renal rickets	15.6%
60	Renal Aminoacidurias	15.5%
61	Fanconi Syndrome	15.5%
62	Pseudohypoaldosteronism	15.5%
63	Liddle Syndrome	15.5%
64	Hemolytic-Uremic Syndrome	15.5%
65	Bladder Exstrophy	15.1%
66	Epispadias	15.1%
67	Glycosuria, Renal	15%
68	Glomerulonephritis, Membranoproliferative	14.5%
69	Ureteral Calculi	13.9%
70	Mesoblastic Nephroma	13.7%
71	Renal Cell Carcinoma	13.6%
72	Papillary Renal Cell Carcinoma	13.6%
73	Renal tubular acidosis	13.3%
74	Bacteriuria	12.7%
75	Glycosuria	12.7%
76	Hematuria	12.7%
77	Oliguria	12.7%
78	Polyuria	12.7%
79	Proteinuria	12.7%
80	Pyuria	12.7%
81	Urinary Calculi	12.7%
82	Cystocele	12.6%
83	Urinary Incontinence	12.6%
84	Urinary Bladder Fistula	12.5%
85	Bladder Neoplasm	12.5%
86	Ureteral Neoplasms	12.5%
87	Urethral Neoplasms	12.5%
88	Anti-Glomerular Basement Membrane Disease	11.8%
89	Zellweger Syndrome	11.8%
90	Lupus Nephritis	11.7%
91	Polycystic Kidney, Autosomal Dominant	11.6%
92	Cystinuria	11.5%
93	Atypical Hemolytic Uremic Syndrome	11.5%
94	Nephroblastoma	11.1%
95	Enuresis	10.7%
96	Genital Diseases, Male	10.4%
97	Urethral Stenosis	10.4%
98	Urethral stricture	10.4%
99	Infertility	10.4%
100	Hyperphosphaturia	10.4%
101	Pregnancy Complications	9.8%
102	Hypospadias	8.6%
103	Albuminuria	8.3%
104	Hemoglobinuria	8.3%
105	Urge Incontinence	8.3%
106	Urologic Neoplasms	8.3%
107	Horseshoe Kidney	8.3%
108	Endometriosis	8.1%
109	Uterine Diseases	8.1%
110	Vaginal Diseases	8.1%
111	Vulvar Diseases	8.1%
112	Endometrioma	8.1%
113	Sexually Transmitted Diseases	7.2%
114	Hermaphroditism	7%
115	Disorders of Sex Development	7%
116	Diurnal Enuresis	7%
117	Denys-Drash Syndrome	7%
118	Genital Herpes	6.9%
119	Genital Neoplasms, Male	6.7%
120	Genital Neoplasms, Female	6.1%
121	Endometritis	6%
122	Vesicovaginal Fistula	5.9%
123	Uterine Neoplasms	5.8%
124	Vaginal Neoplasms	5.8%
125	Vulvar Neoplasms	5.8%
126	Uterine Cancer	5.8%
127	Uterine Inversion	5.7%
128	Epididymitis	5.5%
129	Penile Diseases	5.5%
130	Prostatic Diseases	5.5%
131	Spermatic Cord Torsion	5.5%
132	Hemospermia	5.5%
133	Testicular Hydrocele	5.5%
134	Polyhydramnios	5%
135	Obstetric Labor Complications	5%
136	Ectopic Pregnancy	5%
137	Pregnancy, Prolonged	5%
138	Puerperal Disorders	5%
139	Oligohydramnios	5%
140	Prenatal Injuries	5%
141	Dyspareunia	5%
142	Familial Hypophosphatemic Rickets	4.9%
143	Penile Neoplasms	4.9%
144	Prostatic Neoplasms	4.9%
145	Endometrial Hyperplasia	4.8%
146	Pyometra	4.8%
147	Vaginitis	4.8%
148	Vulvitis	4.8%
149	Vaginal Discharge	4.8%
150	Vulvodynia	4.8%
151	Fallopian Tube Neoplasms	4.8%
152	Salpingitis	4.8%
153	Vulvovaginitis	4.8%
154	Uterine Rupture	4.6%
155	Cryptorchidism	4.4%
156	Testicular Diseases	4.2%
157	Varicocele	4.2%
158	Spermatocele	4.1%
159	Abruptio Placentae	4.1%
160	Placenta Accreta	4.1%
161	Gonadal Dysgenesis	4.1%
162	Adrenogenital Syndrome	4.1%
163	Ovotesticular Disorders of Sex Development	4.1%
164	Fetal Diseases	3.9%
165	Pregnancy Complications, Cardiovascular	3.9%
166	Pregnancy Complications, Neoplastic	3.9%
167	Oophoritis	3.9%
168	Endometrial Neoplasms	3.8%
169	Pregnancy Complications, Hematologic	3.8%
170	Pregnancy Complications, Infectious	3.8%
171	Fetal Death	3.7%
172	Perinatal death	3.7%
173	Ovarian Diseases	3.7%
174	Morning Sickness	3.7%
175	Adnexitis	3.6%
176	Pruritus Vulvae	3.6%
177	Uterine hemorrhage	3.6%
178	Vaginal Fistula	3.6%
179	Pelvic Inflammatory Disease	3.6%
180	Uterine Prolapse	3.6%
181	Vaginal Prolapse	3.6%
182	Uterine Cervical Incompetence	3.6%
183	Chorioamnionitis	3.6%
184	ovarian neoplasm	3.5%
185	Puerperal Infection	3.3%
186	Postpartum Hemorrhage	3.3%
187	Balanitis	3.2%
188	Benign prostatic hypertrophy	3.2%
189	Phimosis	3.2%
190	Priapism	3.2%
191	prostatitis	3.2%
192	Prostatic Adenoma	3.2%
193	Benign Prostatic Hyperplasia	3.2%
194	Prostatic Hypertrophy	3.2%
195	Prostatic Hyperplasia	3.2%
196	Prostatic Neoplasms, Castration-Resistant	3.2%
197	Hyperandrogenism	3.2%
198	Uterine Cervicitis	3.2%
199	Leukorrhea	3.2%
200	Parametritis	3.2%
201	Gestational Diabetes	3%
202	Carcinoma, Endometrioid	3%
203	Candidiasis, Vulvovaginal	2.9%
204	Abortion, Habitual	2.7%
205	Dystocia	2.7%
206	Eclampsia	2.7%
207	Fetal Membranes, Premature Rupture	2.7%
208	Placental Insufficiency	2.7%
209	Pre-Eclampsia	2.7%
210	Prenatal Exposure Delayed Effects	2.7%
211	HELLP Syndrome	2.7%
212	Placenta, Retained	2.7%
213	Premature Ejaculation	2.5%
214	Erectile dysfunction	2.5%
215	Testicular Neoplasms	2.5%
216	Bacterial Vaginosis	2.5%
217	Orchitis	2.4%
218	Trichomonas Vaginitis	2.4%
219	Uterine Perforation	2.4%
220	Ovarian Hyperstimulation Syndrome	2.4%
221	Metrorrhagia	2.4%
222	Chlamydia Infections	2.3%
223	Gonorrhea	2.3%
224	Abortion, Veterinary	2.1%
225	Pregnancy Complications, Parasitic	2.1%
226	Turner Syndrome	2.1%
227	Azoospermia	2.1%
228	Oligospermia	2.1%
229	Impotence, Vasculogenic	2.1%
230	Asthenozoospermia	2.1%
231	Teratozoospermia	2.1%
232	Aspermia	2.1%
233	granulosa cell tumor	2.1%
234	Carcinoma, Ovarian Epithelial	2.1%
235	Lactation Disorder	2%
236	Mastitis	2%
237	Depression, Postpartum	2%
238	Embryo Loss	2%
239	Kallmann Syndrome	2%
240	Fetal Resorption	2%
241	Hyperemesis Gravidarum	2%
242	Syphilis	2%
243	Endometrial Stromal Sarcoma	2%
244	Corpus Luteum Cyst	2%
245	Ovarian Cysts	2%
246	Anovulation	1.9%
247	Menorrhagia	1.9%
248	Premature Menopause	1.9%
249	Klinefelter Syndrome	1.8%
250	Lymphogranuloma Venereum	1.7%
251	Fetal Growth Retardation	1.7%
252	Trophoblastic Neoplasms	1.7%
253	Embolism, Amniotic Fluid	1.7%
254	Fetal Hypoxia	1.7%
255	Fetal Alcohol Spectrum Disorders	1.7%
256	Breech Presentation	1.6%
257	Stillbirth	1.6%
258	Premature Birth	1.6%
259	Polycystic Ovary Syndrome	1.4%
260	Meconium Aspiration Syndrome	1.2%
261	Galactorrhea	1.2%
262	Leydig Cell Tumor	1.1%
263	Choriocarcinoma	0.8%
264	Hydatidiform Mole	0.6%
265	Hydrops Fetalis	0.5%

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