MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Ectopic Pregnancy

(UMLS:C0032987)

Definition:: A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).
UMLS ID:: C0032987
MeSH ID:: D011271

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.703.733

Synonym(s)

Ectopic Pregnancy

ECTOPIC PREGNANCY

EP - Ectopic pregnancy

Ectopic pregnancy

Ectopic pregnancy, NOS

Ectopic pregnancy, unspecified

Extrauterine Pregnancy

PREGNANCY ECTOPIC

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 574 Canada Vigilance: 27	Canada Vigilance SIDER US FAERS
2	etonogestrel	FAERS: 78	SIDER US FAERS
3	Copper	FAERS: 75	SIDER US FAERS
4	NuvaRing	FAERS: 57	US FAERS
5	Isotretinoin	FAERS: 40	US FAERS
6	Clomiphene	FAERS: 29 Canada Vigilance: 4	Canada Vigilance US FAERS
7	Medroxyprogesterone Acetate	FAERS: 29	US FAERS
8	Ortho Evra	FAERS: 17	US FAERS
9	Glatiramer Acetate	FAERS: 16	US FAERS
10	Dimethyl Fumarate	FAERS: 14	US FAERS
11	Qlaira	FAERS: 11	US FAERS
12	Ethinyl Estradiol-Norgestrel Combination	FAERS: 10 Canada Vigilance: 1	Canada Vigilance US FAERS
13	Lamotrigine	FAERS: 9	US FAERS
14	Simvastatin	FAERS: 9	US FAERS
15	Aripiprazole	FAERS: 8	US FAERS
16	Metformin	FAERS: 8	US FAERS
17	Methotrexate	FAERS: 7 Canada Vigilance: 2	Canada Vigilance US FAERS
18	Risperidone	FAERS: 7	US FAERS
19	entecavir	FAERS: 7	US FAERS
20	4-hydroxybutyric acid	FAERS: 6	US FAERS
21	Fingolimod Hydrochloride	FAERS: 6	US FAERS
22	Imatinib Mesylate	FAERS: 6	US FAERS
23	Norethindrone	FAERS: 6	US FAERS
24	Orlistat	FAERS: 6 Canada Vigilance: 1	Canada Vigilance US FAERS
25	sibutramine	FAERS: 6	US FAERS
26	Cabergoline	FAERS: 5	US FAERS
27	Thyroxine	FAERS: 5	US FAERS
28	Valproic Acid	FAERS: 5	US FAERS
29	ulipristal acetate	FAERS: 5	US FAERS
30	Buprenorphine	FAERS: 4	US FAERS
31	Lamivudine	FAERS: 4	US FAERS
32	Levetiracetam	FAERS: 4	US FAERS
33	Metformin	FAERS: 4	US FAERS
34	Varenicline	FAERS: 4	US FAERS
35	efavirenz	FAERS: 4	US FAERS
36	Bromocriptine	FAERS: 3	US FAERS
37	Cyclosporine	FAERS: 3 Canada Vigilance: 3	Canada Vigilance US FAERS
38	Progesterone	FAERS: 3	US FAERS
39	Telbivudine	FAERS: 3	US FAERS
40	Valproic Acid	FAERS: 3	US FAERS
41	telithromycin	FAERS: 3	US FAERS
42	Albuterol	FAERS: 2	US FAERS
43	Aspirin	FAERS: 2	US FAERS
44	Desogestrel	FAERS: 2	US FAERS
45	Duloxetine Hydrochloride	FAERS: 2	US FAERS
46	Estrogens, Conjugated (USP)	FAERS: 2	US FAERS
47	Junel 1/20	FAERS: 2	US FAERS
48	Ketoconazole	FAERS: 2	US FAERS
49	Leflunomide	FAERS: 2	US FAERS
50	Letrozole	FAERS: 2	US FAERS
51	Leuprolide	FAERS: 2	US FAERS
52	Methylphenidate	FAERS: 2	US FAERS
53	Ondansetron	FAERS: 2	US FAERS
54	Paroxetine	FAERS: 2	US FAERS
55	Pregabalin	FAERS: 2	US FAERS
56	Sumatriptan	FAERS: 2	US FAERS
57	Tenofovir	FAERS: 2	US FAERS
58	Thyroxine	FAERS: 2	US FAERS
59	Valproic Acid	FAERS: 2	US FAERS
60	cetrorelix	FAERS: 2	US FAERS
61	rofecoxib	FAERS: 2	US FAERS
62	sapropterin	FAERS: 2	US FAERS
63	teriflunomide	FAERS: 2	US FAERS
64	4-Aminopyridine	FAERS: 1	US FAERS
65	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
66	Azithromycin	FAERS: 1	US FAERS
67	Balcoltra	FAERS: 1	US FAERS
68	Butorphanol	FAERS: 1	US FAERS
69	Carbamazepine	FAERS: 1	US FAERS
70	Ceftriaxone	FAERS: 1	US FAERS
71	Cefuroxime	FAERS: 1	US FAERS
72	Citalopram	FAERS: 1	US FAERS
73	Citalopram	FAERS: 1	US FAERS
74	Clomifene citrate	FAERS: 1	US FAERS
75	Clomiphene	FAERS: 1	SIDER US FAERS
76	Deferasirox	FAERS: 1	US FAERS
77	Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 1	US FAERS
78	Epoprostenol	FAERS: 1	US FAERS
79	Esomeprazole	FAERS: 1	US FAERS
80	Exenatide	FAERS: 1	US FAERS
81	F8 protein, human	FAERS: 1	US FAERS
82	Fluoxetine	FAERS: 1	US FAERS
83	Fluoxetine	FAERS: 1	US FAERS
84	Goserelin	FAERS: 1	US FAERS
85	Indinavir	FAERS: 1	US FAERS
86	Insulin Glargine	FAERS: 1	US FAERS
87	Lansoprazole	FAERS: 1	US FAERS
88	Levofloxacin	FAERS: 1	US FAERS
89	Lisdexamfetamine Dimesylate	FAERS: 1	US FAERS
90	Lurasidone Hydrochloride	FAERS: 1	US FAERS
91	Mefloquine	FAERS: 1	US FAERS
92	Miconazole	FAERS: 1	US FAERS
93	Mifepristone	FAERS: 1	US FAERS
94	Mirtazapine	FAERS: 1	US FAERS
95	Nicotine	FAERS: 1	US FAERS
96	Octreotide	FAERS: 1	US FAERS
97	Oseltamivir	FAERS: 1	US FAERS
98	Paliperidone Palmitate	FAERS: 1	US FAERS
99	Sugammadex	FAERS: 1	US FAERS
100	Tacrolimus	FAERS: 1	US FAERS
101	Tamoxifen	FAERS: 1	US FAERS
102	Tiagabine	FAERS: 1	US FAERS
103	Tramadol	FAERS: 1	US FAERS
104	Triptorelin Pamoate	FAERS: 1	US FAERS
105	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
106	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
107	Voriconazole	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
108	apremilast	FAERS: 1	US FAERS
109	eltrombopag	FAERS: 1	US FAERS
110	fesoterodine	FAERS: 1	US FAERS
111	lamivudine, zidovudine drug combination	FAERS: 1	US FAERS
112	norgestimate, ethinyl estradiol drug combination	FAERS: 1	US FAERS
113	reviparin	FAERS: 1	US FAERS
114	sofosbuvir-velpatasvir drug combination	FAERS: 1	US FAERS
115	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	Canada Vigilance: 1	Canada Vigilance
116	Gonadotropin-Releasing Hormone		SIDER
117	Medroxyprogesterone		SIDER
118	Urofollitropin		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Polyhydramnios	42.9%
2	Obstetric Labor Complications	42.9%
3	Pregnancy, Prolonged	42.9%
4	Puerperal Disorders	42.9%
5	Oligohydramnios	42.9%
6	Prenatal Injuries	42.9%
7	Abruptio Placentae	40.9%
8	Placenta Accreta	40.9%
9	Chorioamnionitis	34.7%
10	Abortion, Habitual	31%
11	Dystocia	31%
12	Eclampsia	31%
13	Fetal Membranes, Premature Rupture	31%
14	Placental Insufficiency	31%
15	Pre-Eclampsia	31%
16	Prenatal Exposure Delayed Effects	31%
17	HELLP Syndrome	31%
18	Placenta, Retained	31%
19	Puerperal Infection	30.5%
20	Postpartum Hemorrhage	30.3%
21	Fetal Diseases	30%
22	Pregnancy Complications, Cardiovascular	30%
23	Pregnancy Complications, Neoplastic	30%
24	Pregnancy Complications, Hematologic	28.6%
25	Pregnancy Complications, Infectious	28.6%
26	Fetal Death	27.9%
27	Perinatal death	27.9%
28	Morning Sickness	27.6%
29	Uterine Inversion	25.8%
30	Premature Birth	25.4%
31	Female Urogenital Diseases	23.1%
32	Abortion, Veterinary	22%
33	Pregnancy Complications, Parasitic	22%
34	Uterine Cervical Incompetence	21.5%
35	Gestational Diabetes	20.9%
36	Lactation Disorder	20.5%
37	Mastitis	20.5%
38	Depression, Postpartum	20.5%
39	Embryo Loss	20.5%
40	Fetal Resorption	20.2%
41	Hyperemesis Gravidarum	20.1%
42	Uterine Rupture	19.7%
43	Galactorrhea	16.7%
44	Fetal Growth Retardation	15.5%
45	Trophoblastic Neoplasms	15.5%
46	Embolism, Amniotic Fluid	15.4%
47	Fetal Hypoxia	15.4%
48	Fetal Alcohol Spectrum Disorders	15.4%
49	Breech Presentation	15%
50	Stillbirth	14.9%
51	Hydatidiform Mole	11.1%
52	Endometritis	10.5%
53	Meconium Aspiration Syndrome	10.5%
54	Endometriosis	10.3%
55	Uterine Diseases	10.3%
56	Vaginal Diseases	10.3%
57	Vulvar Diseases	10.3%
58	Endometrioma	10.3%
59	Urologic Diseases	10%
60	Choriocarcinoma	9.9%
61	Salpingitis	9.9%
62	Vulvovaginitis	9.9%
63	Endometrial Hyperplasia	8.5%
64	Pyometra	8.5%
65	Vaginitis	8.5%
66	Vulvitis	8.5%
67	Vaginal Discharge	8.5%
68	Vulvodynia	8.5%
69	Uterine Neoplasms	8.3%
70	Vaginal Neoplasms	8.3%
71	Vulvar Neoplasms	8.3%
72	Uterine Cancer	8.3%
73	Fallopian Tube Neoplasms	7.8%
74	Uterine Cervicitis	7.6%
75	Leukorrhea	7.6%
76	Parametritis	7.6%
77	Oophoritis	7.4%
78	Urogenital Abnormalities	7.4%
79	Endometrial Neoplasms	7.3%
80	Vesicovaginal Fistula	7.3%
81	Candidiasis, Vulvovaginal	7%
82	Urinary Bladder Diseases	7%
83	Infertility	7%
84	Kidney Diseases	7%
85	Ureteral Diseases	7%
86	Urethral Diseases	7%
87	Urination Disorders	7%
88	Urolithiasis	7%
89	Genital Neoplasms, Female	6.8%
90	Anuria	6.7%
91	Ureterolithiasis	6.7%
92	Nephrolithiasis	6.7%
93	Bladder neck obstruction	6.3%
94	Hydrops Fetalis	6.2%
95	Bladder Exstrophy	6.2%
96	Epispadias	6.2%
97	Tuberculosis, Renal	6.1%
98	Carcinoma, Endometrioid	6%
99	Multicystic Dysplastic Kidney	5.9%
100	Ovarian Diseases	5.7%
101	Pyelocystitis	5.7%
102	Adnexitis	5.6%
103	Cystitis	5.6%
104	Hydronephrosis	5.6%
105	Hyperoxaluria	5.6%
106	Kidney Cortex Necrosis	5.6%
107	Kidney Papillary Necrosis	5.6%
108	Nephritis	5.6%
109	Nephrosclerosis	5.6%
110	Nephrosis	5.6%
111	Perinephritis	5.6%
112	Pruritus Vulvae	5.6%
113	Kidney Failure	5.6%
114	Uremia	5.6%
115	Ureteral obstruction	5.6%
116	Ureterocele	5.6%
117	Urethral Obstruction	5.6%
118	Urethritis	5.6%
119	Uterine hemorrhage	5.6%
120	Vaginal Fistula	5.6%
121	Vesico-Ureteral Reflux	5.6%
122	Urinary Retention	5.6%
123	Pelvic Inflammatory Disease	5.6%
124	Oxalosis	5.6%
125	Renal Insufficiency	5.6%
126	Uterine Prolapse	5.6%
127	Vaginal Prolapse	5.6%
128	Urinary Bladder Fistula	5.5%
129	Bladder Neoplasm	5.5%
130	Kidney Neoplasm	5.5%
131	Ureteral Neoplasms	5.5%
132	Urethral Neoplasms	5.5%
133	Pyelonephritis	5.5%
134	Kidney Calculi	5.5%
135	Ureteral Calculi	5.5%
136	Endometrial Stromal Sarcoma	5.4%
137	ovarian neoplasm	5.3%
138	Urinary tract infection	5.3%
139	Urologic Neoplasms	5.2%
140	Horseshoe Kidney	5.2%
141	Bacterial Vaginosis	5.1%
142	Trichomonas Vaginitis	5%
143	Uterine Perforation	5%
144	Ovarian Hyperstimulation Syndrome	5%
145	Glomerulonephritis	5%
146	Metrorrhagia	5%
147	Nephritis, Interstitial	5%
148	Lipoid nephrosis	5%
149	Nephrotic Syndrome	5%
150	Pyelitis	5%
151	Pyonephrosis	5%
152	Urethral Stenosis	5%
153	Nephrogenic Diabetes Insipidus	5%
154	Congenital Nephrogenic Diabetes Insipidus	5%
155	Acute kidney injury	5%
156	Urethral stricture	5%
157	Balkan Nephropathy	4.7%
158	Focal glomerulosclerosis	4.7%
159	Kidney Failure, Chronic	4.7%
160	Sexually Transmitted Diseases	4.3%
161	Diabetes Insipidus	4.3%
162	Hepatorenal Syndrome	4.3%
163	Dyspareunia	4.3%
164	Bacteriuria	4.2%
165	Diabetic Nephropathy	4.2%
166	Glycosuria	4.2%
167	Hematuria	4.2%
168	Renal hypertension	4.2%
169	Oliguria	4.2%
170	Polyuria	4.2%
171	Proteinuria	4.2%
172	Pyuria	4.2%
173	Renal Artery Obstruction	4.2%
174	Renal Artery Stenosis	4.2%
175	Urinary Calculi	4.2%
176	Mesoblastic Nephroma	4.2%
177	Renal Cell Carcinoma	4.2%
178	Cystocele	4.2%
179	Hermaphroditism	4.2%
180	Nephrocalcinosis	4.2%
181	Disorders of Sex Development	4.2%
182	Urinary Incontinence	4.2%
183	Papillary Renal Cell Carcinoma	4.2%
184	Hypospadias	4.1%
185	granulosa cell tumor	4.1%
186	Carcinoma, Ovarian Epithelial	4.1%
187	Genital Herpes	4.1%
188	Corpus Luteum Cyst	3.8%
189	Ovarian Cysts	3.8%
190	Azotemia	3.8%
191	Anovulation	3.7%
192	Menorrhagia	3.7%
193	Albuminuria	3.7%
194	Hemoglobinuria	3.7%
195	Hypertension, Renovascular	3.7%
196	Premature Menopause	3.7%
197	Urge Incontinence	3.7%
198	Glomerulonephritis, Membranoproliferative	3.7%
199	Glycosuria, Renal	3.7%
200	Polycystic Ovary Syndrome	3.5%
201	Enuresis	3.4%
202	Gonadal Dysgenesis	3.3%
203	Adrenogenital Syndrome	3.3%
204	Ovotesticular Disorders of Sex Development	3.3%
205	Nephroblastoma	3.3%
206	Hyperandrogenism	3.2%
207	Denys-Drash Syndrome	3.2%
208	Polycystic Kidney Diseases	3%
209	Diurnal Enuresis	3%
210	Renal Aminoacidurias	3%
211	Fanconi Syndrome	3%
212	Pseudohypoaldosteronism	3%
213	Liddle Syndrome	3%
214	Hemolytic-Uremic Syndrome	2.9%
215	Anti-Glomerular Basement Membrane Disease	2.8%
216	Lupus Nephritis	2.8%
217	Polycystic Kidney, Autosomal Dominant	2.8%
218	Cystinuria	2.8%
219	AIDS-Associated Nephropathy	2.8%
220	Atypical Hemolytic Uremic Syndrome	2.8%
221	Chlamydia Infections	2.5%
222	Gonorrhea	2.5%
223	Renal tubular acidosis	2.5%
224	Lymphogranuloma Venereum	2.3%
225	Kallmann Syndrome	2.1%
226	Syphilis	2.1%
227	Turner Syndrome	2.1%
228	Renal Osteodystrophy	2%
229	Renal rickets	2%
230	Hyperphosphaturia	1.8%
231	Klinefelter Syndrome	1.8%
232	Zellweger Syndrome	1.5%
233	Familial Hypophosphatemic Rickets	1%

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