MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

HELLP Syndrome

(UMLS:C0162739)

Definition:: A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
UMLS ID:: C0162739
MeSH ID:: D017359

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.703.395.186

Synonym(s)

HELLP Syndrome

HELLP

HELLP - Syndrome of haemolysis, elevated liver enzymes and low platelet

HELLP - Syndrome of hemolysis, elevated liver enzymes and low platelet

HELLP SYNDROME

HELLP syndrome

Hemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Hemolysis-elevated liver enzymes-low platelet count syndrome

Syndrome of haemolysis, elevated liver enzymes and low platelet

10.

Syndrome of hemolysis, elevated liver enzymes and low platelet

11.

hellp syndrome

12.

syndrome hellp

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Hydralazine	FAERS: 5	OFFSIDES US FAERS
2	Lamotrigine	FAERS: 4	US FAERS
3	17 alpha-Hydroxyprogesterone Caproate	FAERS: 3	US FAERS
4	Acetaminophen	FAERS: 3	US FAERS
5	NuvaRing	FAERS: 3	OFFSIDES US FAERS
6	Carbamazepine	FAERS: 2	US FAERS
7	Fluoxetine	FAERS: 2	US FAERS
8	Olanzapine	FAERS: 2	OFFSIDES US FAERS
9	Ondansetron	FAERS: 2	US FAERS
10	Rosuvastatin Calcium	FAERS: 2	US FAERS
11	Sertraline	FAERS: 2	US FAERS
12	naratriptan	FAERS: 2	US FAERS
13	Acyclovir	FAERS: 1	US FAERS
14	Aspirin	FAERS: 1	US FAERS
15	Buprenorphine	FAERS: 1	US FAERS
16	Ciprofloxacin	FAERS: 1	US FAERS
17	Citalopram	FAERS: 1	US FAERS
18	Diazepam	FAERS: 1	US FAERS
19	Diltiazem	FAERS: 1	US FAERS
20	Erlotinib Hydrochloride	FAERS: 1	US FAERS
21	Fingolimod Hydrochloride	FAERS: 1	US FAERS
22	Fluconazole	FAERS: 1	US FAERS
23	Fluoxetine	FAERS: 1	US FAERS
24	Glatiramer Acetate	FAERS: 1	US FAERS
25	Hydralazine	FAERS: 1	US FAERS
26	Indomethacin	FAERS: 1	US FAERS
27	Isotretinoin	FAERS: 1	US FAERS
28	Leuprolide	FAERS: 1	US FAERS
29	Lopinavir	FAERS: 1	US FAERS
30	Misoprostol	FAERS: 1	US FAERS
31	Nifedipine	FAERS: 1	US FAERS
32	Norgestrel	FAERS: 1	US FAERS
33	Ortho Evra	FAERS: 1	US FAERS
34	Oseltamivir	FAERS: 1	US FAERS
35	Oxcarbazepine	FAERS: 1	US FAERS
36	Paroxetine	FAERS: 1	US FAERS
37	Prednisolone	FAERS: 1	US FAERS
38	Sunitinib	FAERS: 1	US FAERS
39	Tacrolimus	FAERS: 1	US FAERS
40	Tadalafil	FAERS: 1	US FAERS
41	Tinzaparin	FAERS: 1	US FAERS
42	Ursodeoxycholic Acid	FAERS: 1	US FAERS
43	betamethasone acetate phosphate	FAERS: 1	US FAERS
44	ferric gluconate	FAERS: 1	US FAERS
45	ganirelix	FAERS: 1	US FAERS
46	rizatriptan	FAERS: 1	US FAERS
47	Alfentanil		OFFSIDES
48	Biperiden		OFFSIDES
49	Famciclovir		OFFSIDES
50	Lofepramine		OFFSIDES
51	Methyldopa		OFFSIDES
52	Nicardipine		OFFSIDES
53	Prazepam		OFFSIDES
54	Ritodrine		OFFSIDES
55	Saquinavir		OFFSIDES
56	Sulfate		OFFSIDES
57	Tenofovir		OFFSIDES
58	Zolpidem		OFFSIDES
59	dipropylacetamide		OFFSIDES
60	lamivudine, zidovudine drug combination		OFFSIDES
61	naratriptan		OFFSIDES
62	periciazine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Eclampsia	46.7%
2	Pre-Eclampsia	46.7%
3	Polyhydramnios	31%
4	Obstetric Labor Complications	31%
5	Ectopic Pregnancy	31%
6	Pregnancy, Prolonged	31%
7	Puerperal Disorders	31%
8	Oligohydramnios	31%
9	Prenatal Injuries	31%
10	Abruptio Placentae	26.7%
11	Placenta Accreta	26.7%
12	Chorioamnionitis	22.1%
13	Fetal Diseases	22%
14	Pregnancy Complications, Cardiovascular	22%
15	Pregnancy Complications, Neoplastic	22%
16	Pregnancy Complications, Hematologic	20.9%
17	Pregnancy Complications, Infectious	20.9%
18	Fetal Death	20.5%
19	Perinatal death	20.5%
20	Morning Sickness	20.2%
21	Abortion, Habitual	20%
22	Dystocia	20%
23	Fetal Membranes, Premature Rupture	20%
24	Placental Insufficiency	20%
25	Prenatal Exposure Delayed Effects	20%
26	Puerperal Infection	20%
27	Placenta, Retained	20%
28	Postpartum Hemorrhage	19.8%
29	Female Urogenital Diseases	18.5%
30	Uterine Inversion	16.5%
31	Gestational Diabetes	15.4%
32	Premature Birth	14.8%
33	Abortion, Veterinary	14.3%
34	Pregnancy Complications, Parasitic	14.3%
35	Lactation Disorder	13.3%
36	Mastitis	13.3%
37	Depression, Postpartum	13.3%
38	Embryo Loss	13.3%
39	Fetal Resorption	13.2%
40	Hyperemesis Gravidarum	13.1%
41	Uterine Rupture	12.6%
42	Uterine Cervical Incompetence	12.4%
43	Fetal Growth Retardation	10.2%
44	Trophoblastic Neoplasms	10.2%
45	Embolism, Amniotic Fluid	10.1%
46	Fetal Hypoxia	10.1%
47	Fetal Alcohol Spectrum Disorders	10.1%
48	Breech Presentation	9.9%
49	Stillbirth	9.8%
50	Galactorrhea	9.8%
51	Urologic Diseases	7.3%
52	Meconium Aspiration Syndrome	6.9%
53	Endometriosis	6.7%
54	Uterine Diseases	6.7%
55	Vaginal Diseases	6.7%
56	Vulvar Diseases	6.7%
57	Endometrioma	6.7%
58	Hydatidiform Mole	6%
59	Endometritis	5.9%
60	Choriocarcinoma	5.9%
61	Urogenital Abnormalities	5.5%
62	Salpingitis	5.4%
63	Vulvovaginitis	5.4%
64	Endometrial Hyperplasia	4.9%
65	Pyometra	4.9%
66	Vaginitis	4.9%
67	Vulvitis	4.9%
68	Vaginal Discharge	4.9%
69	Vulvodynia	4.9%
70	Uterine Neoplasms	4.9%
71	Vaginal Neoplasms	4.9%
72	Vulvar Neoplasms	4.9%
73	Uterine Cancer	4.9%
74	Urinary Bladder Diseases	4.5%
75	Infertility	4.5%
76	Kidney Diseases	4.5%
77	Ureteral Diseases	4.5%
78	Urethral Diseases	4.5%
79	Urination Disorders	4.5%
80	Urolithiasis	4.5%
81	Fallopian Tube Neoplasms	4.5%
82	Genital Neoplasms, Female	4.4%
83	Uterine Cervicitis	4.1%
84	Leukorrhea	4.1%
85	Oophoritis	4.1%
86	Parametritis	4.1%
87	Endometrial Neoplasms	4%
88	Vesicovaginal Fistula	4%
89	Anuria	3.9%
90	Ureterolithiasis	3.9%
91	Nephrolithiasis	3.9%
92	Bladder Exstrophy	3.9%
93	Epispadias	3.9%
94	Tuberculosis, Renal	3.9%
95	Hydrops Fetalis	3.7%
96	Candidiasis, Vulvovaginal	3.6%
97	Multicystic Dysplastic Kidney	3.6%
98	Bladder neck obstruction	3.6%
99	Urinary tract infection	3.4%
100	Urologic Neoplasms	3.4%
101	Horseshoe Kidney	3.4%
102	Ovarian Diseases	3.4%
103	Adnexitis	3.3%
104	Cystitis	3.3%
105	Hydronephrosis	3.3%
106	Hyperoxaluria	3.3%
107	Kidney Cortex Necrosis	3.3%
108	Kidney Papillary Necrosis	3.3%
109	Nephritis	3.3%
110	Nephrosclerosis	3.3%
111	Nephrosis	3.3%
112	Perinephritis	3.3%
113	Pruritus Vulvae	3.3%
114	Kidney Failure	3.3%
115	Uremia	3.3%
116	Ureteral obstruction	3.3%
117	Ureterocele	3.3%
118	Urethral Obstruction	3.3%
119	Urethritis	3.3%
120	Uterine hemorrhage	3.3%
121	Vaginal Fistula	3.3%
122	Vesico-Ureteral Reflux	3.3%
123	Urinary Retention	3.3%
124	Pelvic Inflammatory Disease	3.3%
125	Oxalosis	3.3%
126	Renal Insufficiency	3.3%
127	Urinary Bladder Fistula	3.3%
128	Bladder Neoplasm	3.3%
129	Kidney Neoplasm	3.3%
130	Ureteral Neoplasms	3.3%
131	Urethral Neoplasms	3.3%
132	Uterine Prolapse	3.3%
133	Vaginal Prolapse	3.3%
134	Carcinoma, Endometrioid	3.2%
135	Pyelocystitis	3%
136	ovarian neoplasm	3%
137	Kidney Calculi	3%
138	Ureteral Calculi	3%
139	Pyelonephritis	2.9%
140	Sexually Transmitted Diseases	2.9%
141	Bacterial Vaginosis	2.8%
142	Hermaphroditism	2.7%
143	Disorders of Sex Development	2.7%
144	Endometrial Stromal Sarcoma	2.7%
145	Trichomonas Vaginitis	2.7%
146	Uterine Perforation	2.7%
147	Ovarian Hyperstimulation Syndrome	2.7%
148	Glomerulonephritis	2.7%
149	Metrorrhagia	2.7%
150	Nephritis, Interstitial	2.7%
151	Lipoid nephrosis	2.7%
152	Nephrotic Syndrome	2.7%
153	Pyelitis	2.7%
154	Pyonephrosis	2.7%
155	Urethral Stenosis	2.7%
156	Nephrogenic Diabetes Insipidus	2.7%
157	Congenital Nephrogenic Diabetes Insipidus	2.7%
158	Hypospadias	2.7%
159	Acute kidney injury	2.7%
160	Urethral stricture	2.7%
161	Genital Herpes	2.7%
162	Diabetes Insipidus	2.5%
163	Hepatorenal Syndrome	2.5%
164	Dyspareunia	2.5%
165	Bacteriuria	2.5%
166	Diabetic Nephropathy	2.5%
167	Glycosuria	2.5%
168	Hematuria	2.5%
169	Renal hypertension	2.5%
170	Oliguria	2.5%
171	Polyuria	2.5%
172	Proteinuria	2.5%
173	Pyuria	2.5%
174	Renal Artery Obstruction	2.5%
175	Renal Artery Stenosis	2.5%
176	Urinary Calculi	2.5%
177	Cystocele	2.5%
178	Nephrocalcinosis	2.5%
179	Urinary Incontinence	2.5%
180	Balkan Nephropathy	2.4%
181	Focal glomerulosclerosis	2.4%
182	Kidney Failure, Chronic	2.4%
183	Mesoblastic Nephroma	2.3%
184	Renal Cell Carcinoma	2.3%
185	Papillary Renal Cell Carcinoma	2.3%
186	granulosa cell tumor	2.2%
187	Carcinoma, Ovarian Epithelial	2.2%
188	Corpus Luteum Cyst	2.1%
189	Ovarian Cysts	2.1%
190	Azotemia	2.1%
191	Anovulation	2%
192	Menorrhagia	2%
193	Albuminuria	2%
194	Hemoglobinuria	2%
195	Hypertension, Renovascular	2%
196	Glycosuria, Renal	2%
197	Premature Menopause	2%
198	Urge Incontinence	2%
199	Enuresis	2%
200	Gonadal Dysgenesis	2%
201	Adrenogenital Syndrome	2%
202	Ovotesticular Disorders of Sex Development	2%
203	Glomerulonephritis, Membranoproliferative	1.9%
204	Polycystic Ovary Syndrome	1.8%
205	Nephroblastoma	1.8%
206	Hyperandrogenism	1.8%
207	Denys-Drash Syndrome	1.7%
208	Polycystic Kidney Diseases	1.6%
209	AIDS-Associated Nephropathy	1.6%
210	Diurnal Enuresis	1.6%
211	Renal Aminoacidurias	1.6%
212	Fanconi Syndrome	1.6%
213	Pseudohypoaldosteronism	1.6%
214	Liddle Syndrome	1.6%
215	Hemolytic-Uremic Syndrome	1.6%
216	Anti-Glomerular Basement Membrane Disease	1.5%
217	Lupus Nephritis	1.5%
218	Polycystic Kidney, Autosomal Dominant	1.4%
219	Cystinuria	1.4%
220	Atypical Hemolytic Uremic Syndrome	1.4%
221	Chlamydia Infections	1.4%
222	Gonorrhea	1.4%
223	Renal tubular acidosis	1.3%
224	Renal Osteodystrophy	1.2%
225	Renal rickets	1.2%
226	Lymphogranuloma Venereum	1.2%
227	Kallmann Syndrome	1.2%
228	Syphilis	1.2%
229	Turner Syndrome	1.2%
230	Hyperphosphaturia	1%
231	Klinefelter Syndrome	1%
232	Zellweger Syndrome	0.9%
233	Familial Hypophosphatemic Rickets	0.6%

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